NO992197D0 - FremgangsmÕte for Õ behandle bronkitt med uridintrifosfater og relaterte forbindelser - Google Patents
FremgangsmÕte for Õ behandle bronkitt med uridintrifosfater og relaterte forbindelserInfo
- Publication number
- NO992197D0 NO992197D0 NO992197A NO992197A NO992197D0 NO 992197 D0 NO992197 D0 NO 992197D0 NO 992197 A NO992197 A NO 992197A NO 992197 A NO992197 A NO 992197A NO 992197 D0 NO992197 D0 NO 992197D0
- Authority
- NO
- Norway
- Prior art keywords
- uridine
- bronchi
- clearance
- bronchioles
- utp
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 5
- DRTQHJPVMGBUCF-XVFCMESISA-N Uridine Natural products O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-XVFCMESISA-N 0.000 title 1
- DRTQHJPVMGBUCF-PSQAKQOGSA-N beta-L-uridine Natural products O[C@H]1[C@@H](O)[C@H](CO)O[C@@H]1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-PSQAKQOGSA-N 0.000 title 1
- 206010006451 bronchitis Diseases 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 239000001226 triphosphate Substances 0.000 title 1
- 235000011178 triphosphate Nutrition 0.000 title 1
- DRTQHJPVMGBUCF-UHFFFAOYSA-N uracil arabinoside Natural products OC1C(O)C(CO)OC1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-UHFFFAOYSA-N 0.000 title 1
- 229940045145 uridine Drugs 0.000 title 1
- -1 uridine triphosphates Chemical class 0.000 title 1
- PGAVKCOVUIYSFO-XVFCMESISA-N UTP Chemical compound O[C@@H]1[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]1N1C(=O)NC(=O)C=C1 PGAVKCOVUIYSFO-XVFCMESISA-N 0.000 abstract 3
- 210000000621 bronchi Anatomy 0.000 abstract 3
- PGAVKCOVUIYSFO-UHFFFAOYSA-N uridine-triphosphate Natural products OC1C(O)C(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)OC1N1C(=O)NC(=O)C=C1 PGAVKCOVUIYSFO-UHFFFAOYSA-N 0.000 abstract 3
- 210000003123 bronchiole Anatomy 0.000 abstract 2
- 230000000717 retained effect Effects 0.000 abstract 2
- 206010011224 Cough Diseases 0.000 abstract 1
- DJJCXFVJDGTHFX-UHFFFAOYSA-N Uridinemonophosphate Natural products OC1C(O)C(COP(O)(O)=O)OC1N1C(=O)NC(=O)C=C1 DJJCXFVJDGTHFX-UHFFFAOYSA-N 0.000 abstract 1
- YDHWWBZFRZWVHO-UHFFFAOYSA-H [oxido-[oxido(phosphonatooxy)phosphoryl]oxyphosphoryl] phosphate Chemical compound [O-]P([O-])(=O)OP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O YDHWWBZFRZWVHO-UHFFFAOYSA-H 0.000 abstract 1
- 239000000443 aerosol Substances 0.000 abstract 1
- 239000012530 fluid Substances 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 239000006194 liquid suspension Substances 0.000 abstract 1
- 230000000420 mucociliary effect Effects 0.000 abstract 1
- 239000007923 nasal drop Substances 0.000 abstract 1
- 229940100662 nasal drops Drugs 0.000 abstract 1
- 239000007922 nasal spray Substances 0.000 abstract 1
- 229940097496 nasal spray Drugs 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000006187 pill Substances 0.000 abstract 1
- 230000001737 promoting effect Effects 0.000 abstract 1
- 230000028327 secretion Effects 0.000 abstract 1
- 239000000829 suppository Substances 0.000 abstract 1
- DJJCXFVJDGTHFX-XVFCMESISA-N uridine 5'-monophosphate Chemical compound O[C@@H]1[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]1N1C(=O)NC(=O)C=C1 DJJCXFVJDGTHFX-XVFCMESISA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/10—Expectorants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/12—Mucolytics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/744,367 US6159952A (en) | 1996-11-07 | 1996-11-07 | Method of treating bronchitis with uridine triphosphate and related compounds |
| PCT/US1997/018766 WO1998019685A1 (en) | 1996-11-07 | 1997-10-21 | Method of treating bronchitis with uridine triphosphates and related compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO992197D0 true NO992197D0 (no) | 1999-05-05 |
| NO992197L NO992197L (no) | 1999-07-05 |
Family
ID=24992452
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO992197A NO992197L (no) | 1996-11-07 | 1999-05-05 | FremgangsmÕte for behandling av bronkitt med uridintrifosfater og relaterte forbindelser |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US6159952A (no) |
| EP (1) | EP0941099B1 (no) |
| JP (1) | JP2001505553A (no) |
| KR (1) | KR100518066B1 (no) |
| CN (1) | CN1115152C (no) |
| AT (1) | ATE249833T1 (no) |
| AU (1) | AU744981B2 (no) |
| BR (1) | BR9714312A (no) |
| CA (1) | CA2271126C (no) |
| DE (1) | DE69724991T2 (no) |
| ES (1) | ES2207723T3 (no) |
| NO (1) | NO992197L (no) |
| NZ (1) | NZ335540A (no) |
| WO (1) | WO1998019685A1 (no) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5968913A (en) * | 1996-07-03 | 1999-10-19 | Inspire Pharmaceuticals, Inc. | Pharmaceutical compositions of uridine triphosphate |
| US6319908B1 (en) | 1996-07-03 | 2001-11-20 | Inspire Pharmaceuticals, Inc. | Method for large-scale production of di(uridine 5′-tetraphosphate) and salts thereof |
| US5763447C1 (en) | 1996-07-23 | 2002-05-07 | Inspire Pharmaceuticals | Method of preventing or treating pneumonia in immobilized patients with uridine triphosphates and related compounds |
| US6872710B2 (en) * | 1997-07-25 | 2005-03-29 | Inspire Pharmaceuticals, Inc. | Di(uridine 5′)-tetraphosphate and salts thereof |
| TW593331B (en) | 1997-07-25 | 2004-06-21 | Inspire Pharmaceuticals Inc | Method for large-scale production of di(uridine 5')-tetraphosphate and salts thereof |
| EP1012154B1 (en) | 1997-07-25 | 2004-03-17 | Inspire Pharmaceuticals, Inc. | Salts of di(uridine 5'-tetraphosphate), method for preparation and uses thereof |
| US6251693B1 (en) | 1998-07-30 | 2001-06-26 | Micron Technology, Inc. | Semiconductor processing methods and semiconductor defect detection methods |
| AR023088A1 (es) * | 1999-02-26 | 2002-09-04 | Inspire Pharmaceuticals Inc | Uso de disfosfatos de uridina, adenina y citidina y analogos de los mismos para la manufactura de un medicamento para la estimulacion de la hidratacion delas mucosas. |
| US6867199B2 (en) | 2000-08-21 | 2005-03-15 | Inspire Pharmaceuticals, Inc. | Dinucleoside polyphosphate compositions and their therapeutic use |
| US7452870B2 (en) * | 2000-08-21 | 2008-11-18 | Inspire Pharmaceuticals, Inc. | Drug-eluting stents coated with P2Y12 receptor antagonist compound |
| US7018985B1 (en) | 2000-08-21 | 2006-03-28 | Inspire Pharmaceuticals, Inc. | Composition and method for inhibiting platelet aggregation |
| US6555675B2 (en) | 2000-08-21 | 2003-04-29 | Inspire Pharmaceuticals, Inc. | Dinucleoside polyphosphate compositions and their therapuetic use as purinergic receptor agonists |
| GB2394419B (en) | 2001-06-25 | 2005-09-07 | Inspire Pharmaceuticals Inc | Joint lubrication with p2y purinergic receptor agonists |
| CA2465894A1 (en) * | 2001-11-06 | 2003-05-15 | Inspire Pharmaceuticals, Inc. | Method for treating or preventing inflammatory diseases |
| CA2502600A1 (en) * | 2002-10-18 | 2004-05-06 | Molichem Medicines, Inc. | Methods of treating dry eye disease with lantibiotics |
| EP1750740A4 (en) * | 2004-05-06 | 2009-06-10 | Molichem Medicines Inc | TREATMENT OF MEMBRANE-ASSOCIATED DISEASES AND DISORDERS USING COMPOSITIONS CONTAINING LANTIBIOTICS |
| EP1753445A4 (en) * | 2004-05-06 | 2009-05-20 | Molichem Medicines Inc | TREATMENT OF EYE DISEASES AND EYE TREATMENTS WITH LANTIBIOTIC COMPOSITIONS |
| US7368439B2 (en) * | 2005-06-15 | 2008-05-06 | Bar - Ilan University | Dinucleoside poly(borano)phosphate derivatives and uses thereof |
| US7851456B2 (en) * | 2005-06-29 | 2010-12-14 | Inspire Pharmaceuticals, Inc. | P2Y6 receptor agonists for treating lung diseases |
| US20070249556A1 (en) * | 2006-04-21 | 2007-10-25 | Brubaker Kurt E | Method of treating inflammation |
| JP2011026204A (ja) * | 2007-11-26 | 2011-02-10 | Rei Furukawa | タバコの煙を吸入することにより引き起こされる疾患の予防及び／又は治療用組成物 |
| WO2019112383A1 (ko) * | 2017-12-08 | 2019-06-13 | 윤주석 | 금속 미네랄 디아미네이트 및 이의 제조방법 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2122529A1 (de) * | 1971-05-06 | 1972-12-14 | Max Planck Gesellschaft zur Förde rung der Wissenschaften e V , 3400 Gottin gen | Thiophosphatanaloge der Nucleosid di und tnphosphate sowie Verfahren zu ihrer Herstellung |
| US3960840A (en) * | 1972-12-29 | 1976-06-01 | University Of Illinois Foundaton | Fluorescent derivatives of adenine-containing compounds |
| US4501729A (en) * | 1982-12-13 | 1985-02-26 | Research Corporation | Aerosolized amiloride treatment of retained pulmonary secretions |
| GB9027968D0 (en) * | 1990-12-22 | 1991-02-13 | Fisons Plc | Method of treatment |
| DE69204717T2 (de) * | 1991-04-06 | 1996-04-25 | Astra Pharmaceuticals Limited, Kings Langley, Herts | ATP-Analogen. |
| FR2684299B1 (fr) * | 1991-12-02 | 1995-03-24 | Synthelabo | Compositions pharmaceutiques contenant de l'adenosine-5-triphosphate disodique et de l'amiloride. |
| FR2677250B1 (fr) * | 1991-06-05 | 1995-01-20 | Synthelabo | Compositions pharmaceutiques contenant de l'adenosine-5-triphosphate disodique. |
| EP0517573A1 (fr) * | 1991-06-05 | 1992-12-09 | Synthelabo | Compositions pharmaceutiques pour le traitement des affections des voies respiratoires |
| US5292498A (en) * | 1991-06-19 | 1994-03-08 | The University Of North Carolina At Chapel Hill | Method of treating lung disease with uridine triphosphates |
| US5635160A (en) * | 1995-06-07 | 1997-06-03 | The University Of North Carolina At Chapel Hill | Dinucleotides useful for the treatment of cystic fibrosis and for hydrating mucus secretions |
| US5628984A (en) * | 1995-07-31 | 1997-05-13 | University Of North Carolina At Chapel Hill | Method of detecting lung disease |
-
1996
- 1996-11-07 US US08/744,367 patent/US6159952A/en not_active Expired - Lifetime
-
1997
- 1997-10-21 JP JP52141998A patent/JP2001505553A/ja active Pending
- 1997-10-21 BR BR9714312-0A patent/BR9714312A/pt not_active Application Discontinuation
- 1997-10-21 ES ES97912761T patent/ES2207723T3/es not_active Expired - Lifetime
- 1997-10-21 KR KR10-1999-7004018A patent/KR100518066B1/ko not_active Expired - Fee Related
- 1997-10-21 AT AT97912761T patent/ATE249833T1/de not_active IP Right Cessation
- 1997-10-21 NZ NZ335540A patent/NZ335540A/en unknown
- 1997-10-21 WO PCT/US1997/018766 patent/WO1998019685A1/en not_active Ceased
- 1997-10-21 DE DE69724991T patent/DE69724991T2/de not_active Expired - Lifetime
- 1997-10-21 EP EP97912761A patent/EP0941099B1/en not_active Expired - Lifetime
- 1997-10-21 CN CN97199444A patent/CN1115152C/zh not_active Expired - Lifetime
- 1997-10-21 CA CA002271126A patent/CA2271126C/en not_active Expired - Lifetime
- 1997-10-21 AU AU49866/97A patent/AU744981B2/en not_active Expired
-
1999
- 1999-05-05 NO NO992197A patent/NO992197L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NO992197L (no) | 1999-07-05 |
| CN1115152C (zh) | 2003-07-23 |
| BR9714312A (pt) | 2000-05-02 |
| ES2207723T3 (es) | 2004-06-01 |
| JP2001505553A (ja) | 2001-04-24 |
| NZ335540A (en) | 2001-05-25 |
| AU744981B2 (en) | 2002-03-07 |
| CA2271126A1 (en) | 1998-05-14 |
| AU4986697A (en) | 1998-05-29 |
| ATE249833T1 (de) | 2003-10-15 |
| DE69724991D1 (de) | 2003-10-23 |
| US6159952A (en) | 2000-12-12 |
| CN1236318A (zh) | 1999-11-24 |
| EP0941099A1 (en) | 1999-09-15 |
| WO1998019685A1 (en) | 1998-05-14 |
| DE69724991T2 (de) | 2004-11-11 |
| CA2271126C (en) | 2008-04-08 |
| KR100518066B1 (ko) | 2005-09-28 |
| EP0941099B1 (en) | 2003-09-17 |
| KR20000053094A (ko) | 2000-08-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |