ATE334121T1 - Verfahren zur herstellung von threo-1,2-epoxy-3- amino-4-phenylbutan-derivaten - Google Patents

Verfahren zur herstellung von threo-1,2-epoxy-3- amino-4-phenylbutan-derivaten

Info

Publication number
ATE334121T1
ATE334121T1 AT00901998T AT00901998T ATE334121T1 AT E334121 T1 ATE334121 T1 AT E334121T1 AT 00901998 T AT00901998 T AT 00901998T AT 00901998 T AT00901998 T AT 00901998T AT E334121 T1 ATE334121 T1 AT E334121T1
Authority
AT
Austria
Prior art keywords
amino
epoxy
threo
phenylbutane
derivatives
Prior art date
Application number
AT00901998T
Other languages
English (en)
Inventor
Katsuji Maehara
Yukinori Tokuda
Hiroshi Murao
Yasuyoshi Ueda
Original Assignee
Kaneka Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kaneka Corp filed Critical Kaneka Corp
Application granted granted Critical
Publication of ATE334121T1 publication Critical patent/ATE334121T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D301/00—Preparation of oxiranes
    • C07D301/02—Synthesis of the oxirane ring
    • C07D301/24—Synthesis of the oxirane ring by splitting off HAL—Y from compounds containing the radical HAL—C—C—OY
    • C07D301/26—Y being hydrogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/36—Compounds containing oxirane rings with hydrocarbon radicals, substituted by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Epoxy Compounds (AREA)
AT00901998T 1999-01-29 2000-01-31 Verfahren zur herstellung von threo-1,2-epoxy-3- amino-4-phenylbutan-derivaten ATE334121T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2164099 1999-01-29
JP23972099 1999-08-26

Publications (1)

Publication Number Publication Date
ATE334121T1 true ATE334121T1 (de) 2006-08-15

Family

ID=26358729

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00901998T ATE334121T1 (de) 1999-01-29 2000-01-31 Verfahren zur herstellung von threo-1,2-epoxy-3- amino-4-phenylbutan-derivaten

Country Status (8)

Country Link
US (1) US6344572B1 (de)
EP (2) EP1661893A3 (de)
AT (1) ATE334121T1 (de)
AU (1) AU2322600A (de)
CA (1) CA2325919C (de)
DE (1) DE60029517T2 (de)
ES (1) ES2267494T3 (de)
WO (1) WO2000044736A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100708221B1 (ko) 1999-08-31 2007-04-17 아지노모토 가부시키가이샤 에폭사이드 결정의 제조방법
GB2369356B (en) 2000-09-18 2004-02-04 Phoenix Chemicals Ltd Process
JP4651178B2 (ja) * 2000-10-23 2011-03-16 三菱レイヨン株式会社 ２−グリシジルオキシエチル（メタ）アクリレートの製造方法
JPWO2002044136A1 (ja) * 2000-11-30 2004-04-02 味の素株式会社 Ｎ保護−β−アミノアルコールの製造法およびＮ保護−β−アミノエポキシドの製造法
US6764545B2 (en) 2000-12-12 2004-07-20 Ajinomoto Co., Inc. Production method of epoxide crystal
AU2002322762B2 (en) 2001-07-31 2008-10-16 Wayne State University Hybrid proteins with neuregulin heparin-binding domain for targeting to heparan sulfate proteoglycans
JP4818124B2 (ja) 2003-12-23 2011-11-16 テイボテク・フアーマシユーチカルズ・リミテツド （３Ｒ，３ａＳ，６ａＲ）−ヘキサヒドロフロ〔２，３−ｂ〕フラン−３−イル（１Ｓ，１Ｒ）−３−〔〔（４−アミノフェニル）スルホニル〕（イソブチル）アミノ〕−１−ベンジル−２−ヒドロキシプロピルカルバマートの製造方法
MXPA06007211A (es) 2003-12-23 2006-08-18 Tibotec Pharm Ltd Procedimiento para la preparacion de (3r, 3as, 6ar)-hexahidrofuro [2, 3-b]furan-3- il(1s, 2r)-3 -[[(4-amonofenil) sulfonil] (isobutil) amino]-1 -bencil-2- hidroxipropilcarbamato.
US7582468B2 (en) * 2005-05-25 2009-09-01 Bristol-Myers Squibb Company Process for preparing (2R,3S)-1,2-epoxy-3-(protected)amino-4-substituted butane and intermediates thereof
RU2464266C2 (ru) 2006-11-09 2012-10-20 Тиботек Фармасьютикалз Лтд. СПОСОБЫ ПОЛУЧЕНИЯ ГЕКСАГИДРОФУРО[2,3-b] ФУРАН-3-ОЛА
CA2682616A1 (en) 2007-04-27 2008-11-06 Tibotec Pharmaceuticals Ltd. Methods for the preparation of n-isobutyl-n-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitrobenzenesulfonylamide derivatives
JP2010530889A (ja) * 2007-06-22 2010-09-16 ブリストル−マイヤーズ スクイブ カンパニー アタザナビルを含む錠剤組成物
ATE503467T1 (de) * 2007-06-22 2011-04-15 Bristol Myers Squibb Co Tablettierte atazanavirhaltige zusammensetzungen
JP2010530890A (ja) * 2007-06-22 2010-09-16 ブリストル−マイヤーズ スクイブ カンパニー アタザナビルを含む錠剤組成物
PL2170292T3 (pl) * 2007-06-22 2014-06-30 Bristol Myers Squibb Holdings Ireland Tabletkowane kompozycje zawierające atazanawir
US20110178305A1 (en) * 2008-05-08 2011-07-21 Ranbaxy Laboratories Limited Process for the preparation of 3,4-epoxy-2-amino-1-substituted butane derivatives and intermediate compounds thereof
AR073248A1 (es) 2008-09-01 2010-10-20 Tibotec Pharm Ltd Proceso para la preparacion de (1s, 2r)-3- ((4-aminofenil) sulfonil) ( isobutil) amino)-1- bencil-2- hidroxipropilcarbamato de (3r, 3as,6ar)- hexahidrofuro-(2,3-b) furan-3- ilo (darunavir) y compuestos intermediarios utiles en dicho proceso.
US8921415B2 (en) 2009-01-29 2014-12-30 Mapi Pharma Ltd. Polymorphs of darunavir
MX2012008627A (es) 2010-01-28 2012-09-21 Mapi Pharma Ltd Proceso para la preparacion de darunavir e intermedios de darunavir.

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2130754C (en) * 1992-03-11 2005-02-08 Damian W. Grobelny Amine derivatives of oxo- and hydroxy-substituted hydrocarbons
US5559256A (en) * 1992-07-20 1996-09-24 E. R. Squibb & Sons, Inc. Aminediol protease inhibitors
US5481011A (en) * 1994-12-13 1996-01-02 Bristol-Myers Squibb Company Process for preparing N-protected amino acid α-halomethyl ketones and alcohols from N-protected amino acid esters
WO1996023756A1 (en) * 1995-02-03 1996-08-08 Kaneka Corporation PROCESSES FOR PRODUCING α-HALO KETONES, α-HALOHYDRINS AND EPOXIDES
CA2190570C (en) * 1995-11-17 2005-05-03 Yutaka Honda Process for producing 3-amino-2-oxo-1-halogenopropane derivatives
JPH09323960A (ja) * 1996-06-05 1997-12-16 Ajinomoto Co Inc ３−アミノ−１，２−オキシランの製造方法

Also Published As

Publication number Publication date
EP1067125A4 (de) 2004-06-16
ES2267494T3 (es) 2007-03-16
US6344572B1 (en) 2002-02-05
WO2000044736A1 (en) 2000-08-03
CA2325919A1 (en) 2000-08-03
AU2322600A (en) 2000-08-18
EP1067125A1 (de) 2001-01-10
EP1067125B1 (de) 2006-07-26
DE60029517T2 (de) 2006-11-23
EP1661893A2 (de) 2006-05-31
EP1661893A3 (de) 2006-06-07
CA2325919C (en) 2009-07-21
DE60029517D1 (de) 2006-09-07

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