ATE333465T1 - Methoden und mittel zur hemmung der cdk4- aktivität - Google Patents

Methoden und mittel zur hemmung der cdk4- aktivität

Info

Publication number
ATE333465T1
ATE333465T1 AT97920857T AT97920857T ATE333465T1 AT E333465 T1 ATE333465 T1 AT E333465T1 AT 97920857 T AT97920857 T AT 97920857T AT 97920857 T AT97920857 T AT 97920857T AT E333465 T1 ATE333465 T1 AT E333465T1
Authority
AT
Austria
Prior art keywords
cdk4
activity
methods
sup
cdk4 activity
Prior art date
Application number
AT97920857T
Other languages
German (de)
English (en)
Inventor
Kathryn L Ball
David P Lane
Original Assignee
Cyclacel Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9609521.1A external-priority patent/GB9609521D0/en
Priority claimed from GBGB9621314.5A external-priority patent/GB9621314D0/en
Application filed by Cyclacel Ltd filed Critical Cyclacel Ltd
Application granted granted Critical
Publication of ATE333465T1 publication Critical patent/ATE333465T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT97920857T 1996-05-08 1997-05-08 Methoden und mittel zur hemmung der cdk4- aktivität ATE333465T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9609521.1A GB9609521D0 (en) 1996-05-08 1996-05-08 Substances and their therapeutic use
GBGB9621314.5A GB9621314D0 (en) 1996-10-09 1996-10-09 Substances and their therapeutic use

Publications (1)

Publication Number Publication Date
ATE333465T1 true ATE333465T1 (de) 2006-08-15

Family

ID=26309279

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97920857T ATE333465T1 (de) 1996-05-08 1997-05-08 Methoden und mittel zur hemmung der cdk4- aktivität

Country Status (7)

Country Link
US (3) US6962792B1 (enExample)
EP (1) EP0898580B9 (enExample)
JP (1) JP4205165B2 (enExample)
AT (1) ATE333465T1 (enExample)
AU (1) AU2707797A (enExample)
DE (2) DE69736351D1 (enExample)
WO (1) WO1997042222A1 (enExample)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69736351D1 (de) 1996-05-08 2006-08-31 Cyclacel Ltd Methoden und mittel zur hemmung der cdk4-aktivität
GB9727277D0 (en) * 1997-12-23 1998-02-25 Medical Res Council Assay
US6521407B1 (en) * 1998-02-18 2003-02-18 Theryte Limited Methods for determining chemosensitivity of cancer cells based upon expression of negative and positive signal transduction factors
EP1338652A3 (en) * 1998-03-23 2004-05-19 E.I.Du pont de nemours and company Plant cell cyclin genes
BR9907965A (pt) * 1998-03-23 2000-12-12 Du Pont Fragmento de ácido nucléico isolado, gene quimérico, célula hospedeira transformada, polipetìdios, processo de alteração do nìvel de expressão de uma proteìna ciclina em uma célula hospedeira, método de obtenção de um fragmento de ácido nucleìco, produto e método de avaliação de pelo menos um composto quanto à sua capacidade de inibir a atividade de uma proteìna ciclina
AU762006B2 (en) * 1998-12-24 2003-06-19 Ucb Peptidic product, process and composition
EP1165793A2 (en) * 1999-04-07 2002-01-02 E.I. Du Pont De Nemours And Company Cyclin dependent kinase inhibitor genes from plants
GB2369823B (en) * 1999-11-30 2003-06-04 Cyclacel Ltd Assays for cyclin-interacting compounds
GB9928323D0 (en) * 1999-11-30 2000-01-26 Cyclacel Ltd Peptides
US20050153894A1 (en) * 1999-11-30 2005-07-14 Cyclacel Limited p21 peptides
US7449544B2 (en) 1999-11-30 2008-11-11 Cyclacel Limited p21 peptides
GB0012528D0 (en) * 2000-05-23 2000-07-12 Univ Palackeho Triterpenoid derivatives
GB0030378D0 (en) 2000-12-13 2001-01-24 Cyclacel Ltd Compound
WO2004015071A2 (en) * 2002-08-07 2004-02-19 Exelixis, Inc. CSNK1GS AS MODIFIERS OF THE p21 PATHWAY AND METHODS OF USE
GB0229151D0 (en) 2002-12-13 2003-01-15 St Georges Entpr Ltd Product and method
EP1687331A1 (en) * 2003-10-20 2006-08-09 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Tyrosine phosphorylation of cdk inhibitor proteins of the cip/kip family
AU2004285745A1 (en) * 2003-10-21 2005-05-12 Cyclacel Limited Pyrimidin-4-YL-3, 4-thione compounds and their use in therapy
GB0402653D0 (en) * 2004-02-06 2004-03-10 Cyclacel Ltd Compounds
GB0411791D0 (en) * 2004-05-26 2004-06-30 Cyclacel Ltd Compounds
AU2005276231A1 (en) 2004-08-27 2006-03-02 Cyclacel Limited Purine and pyrimidine CDK inhibitors and their use for the treatment of autoimmune diseases
US20090286738A1 (en) * 2005-06-29 2009-11-19 St. George's Enterprises Limited Gene Regulation
EP2224961A1 (en) * 2007-11-26 2010-09-08 The Research Foundation of the State University of New York Small molecule cancer treatments that cause necrosis in cancer cells but do not affect normal cells
US9040046B2 (en) 2011-01-31 2015-05-26 Kai Xu Sodium pump antibody agonists and methods of treating heart disease using the same
AU2019247554A1 (en) 2018-04-06 2020-11-26 Oncolyze, Inc. Compositions for use in lysis of selective cancer cells
HUE070338T2 (hu) 2018-09-10 2025-05-28 Mirati Therapeutics Inc Kombinációs terápiák
CN118324906A (zh) * 2024-06-14 2024-07-12 上海交通大学医学院附属上海儿童医学中心 p21特异性修饰的抗体及制备方法和应用

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2759164A1 (de) 1977-12-31 1979-07-12 Basf Ag Photopolymerisierbare ueberzugs- und aufzeichnungsmaterialien, enthaltend einen photoinitiator und eine organische halogenverbindung
US5229018A (en) 1986-02-24 1993-07-20 Forrest Gabriel T Completion and workover fluid for oil and gas wells comprising ground peanut hulls
FR2662698A1 (fr) * 1990-06-05 1991-12-06 Centre Nat Rech Scient Nouveaux facteurs de croissance neurotropes comprenant un peptide homeoboite.
WO1994009135A1 (en) 1992-10-16 1994-04-28 Cold Spring Harbor Laboratory Cyclin complex rearrangement and uses related thereto
US5302706A (en) 1991-12-16 1994-04-12 Baylor College Of Medicine Senescent cell derived inhibitors of DNA synthesis
WO1995006415A1 (en) 1993-08-30 1995-03-09 Baylor College Of Medicine Senescent cell-derived inhibitors of dna synthesis
US5596079A (en) 1991-12-16 1997-01-21 Smith; James R. Mimetics of senescent cell derived inhibitors of DNA synthesis
GB9305448D0 (en) 1993-03-17 1993-05-05 British Tech Group Semiconductor structure and method of manufacturing same
WO1995013375A1 (en) 1993-11-10 1995-05-18 The Johns Hopkins University Tumor suppressor waf1
AU2644495A (en) 1994-05-24 1995-12-18 Baylor College Of Medicine Mimetics of senescent cell derived inhibitors of dna synthesis
GB9422175D0 (en) 1994-11-03 1994-12-21 Univ Dundee Indentification of the p21 waf1-pcna interaction site and therapeutic applications thereof
GB9509557D0 (en) 1995-05-11 1995-07-05 Univ Dundee PCNA binding substance
WO1997003681A1 (en) 1995-07-20 1997-02-06 Worcester Foundation For Biomedical Research, Inc. Methods for selectively killing or inhibiting the growth of cells expressing the waf1 gene
US5672508A (en) 1996-01-23 1997-09-30 Mitotix, Inc. Inhibitors of cell-cycle progression, and uses related thereto
DE69736351D1 (de) 1996-05-08 2006-08-31 Cyclacel Ltd Methoden und mittel zur hemmung der cdk4-aktivität

Also Published As

Publication number Publication date
EP0898580B3 (en) 2008-10-29
DE69736351T4 (de) 2009-07-23
DE69736351T2 (de) 2007-07-12
AU2707797A (en) 1997-11-26
US20080249025A1 (en) 2008-10-09
JP4205165B2 (ja) 2009-01-07
US6962792B1 (en) 2005-11-08
EP0898580A1 (en) 1999-03-03
EP0898580B9 (en) 2009-08-12
WO1997042222A1 (en) 1997-11-13
US20040214765A1 (en) 2004-10-28
EP0898580B1 (en) 2006-07-19
DE69736351D1 (de) 2006-08-31
JP2000513805A (ja) 2000-10-17

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