ATE327250T1 - Kristallstruktur von ribosomen und proteinsynthese-inhibitoren - Google Patents

Kristallstruktur von ribosomen und proteinsynthese-inhibitoren

Info

Publication number
ATE327250T1
ATE327250T1 AT01306825T AT01306825T ATE327250T1 AT E327250 T1 ATE327250 T1 AT E327250T1 AT 01306825 T AT01306825 T AT 01306825T AT 01306825 T AT01306825 T AT 01306825T AT E327250 T1 ATE327250 T1 AT E327250T1
Authority
AT
Austria
Prior art keywords
methods
protein synthesis
synthesis inhibitors
ligands
ribosomes
Prior art date
Application number
AT01306825T
Other languages
English (en)
Inventor
Thomas A Steitz
Peter B Moore
Nenad Ban
Poul Nissen
Jeffrey Hansen
Original Assignee
Univ Yale
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/635,708 external-priority patent/US6638908B1/en
Application filed by Univ Yale filed Critical Univ Yale
Application granted granted Critical
Publication of ATE327250T1 publication Critical patent/ATE327250T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5355—Non-condensed oxazines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/215—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Halobacteriaceae (F)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Information Retrieval, Db Structures And Fs Structures Therefor (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
AT01306825T 2000-08-09 2001-08-09 Kristallstruktur von ribosomen und proteinsynthese-inhibitoren ATE327250T1 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US22397700P 2000-08-09 2000-08-09
US09/635,708 US6638908B1 (en) 2000-08-09 2000-08-09 Crystals of the large ribosomal subunit
US30699601P 2001-07-20 2001-07-20
US30928101P 2001-08-01 2001-08-01
US09/922,251 US6947844B2 (en) 2000-08-09 2001-08-03 Modulators of ribosomal function and identification thereof

Publications (1)

Publication Number Publication Date
ATE327250T1 true ATE327250T1 (de) 2006-06-15

Family

ID=27539870

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01306825T ATE327250T1 (de) 2000-08-09 2001-08-09 Kristallstruktur von ribosomen und proteinsynthese-inhibitoren

Country Status (8)

Country Link
US (3) US6947844B2 (de)
EP (1) EP1188769B1 (de)
JP (1) JP3836702B2 (de)
AT (1) ATE327250T1 (de)
AU (1) AU768033B2 (de)
CA (1) CA2354051A1 (de)
DE (2) DE60119853T2 (de)
IL (1) IL144830A0 (de)

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US6947844B2 (en) 2000-08-09 2005-09-20 Yale University Modulators of ribosomal function and identification thereof
US6638908B1 (en) * 2000-08-09 2003-10-28 Yale University Crystals of the large ribosomal subunit
WO2002046392A2 (en) * 2000-12-09 2002-06-13 The Regents Of The University Of California X ray crystal structures at 5.5 a resolution of functional complexes of the bacterial ribosome containing transfer rna and model messenger rnas
US6555581B1 (en) 2001-02-15 2003-04-29 Jones Pharma, Inc. Levothyroxine compositions and methods
US6952650B2 (en) 2001-08-03 2005-10-04 Yale University Modulators of ribosomal function and identification thereof
EP1308457B1 (de) * 2001-08-03 2013-12-04 Yale University Struktur von ribosomen und proteinsynthese-inhibitoren
IL151012A0 (en) * 2001-08-03 2003-02-12 Ribosomes Structure And Protei Ribosomes structure and protein synthesis inhibitors
AU2003290304A1 (en) 2002-12-23 2004-07-14 Astex Technology Limited Synthesis and screening of ligands using x-ray crystallography
EP1611546B1 (de) 2003-04-04 2013-01-02 Icosystem Corporation Verfahren und systeme zur interaktiven evolutionären datenverarbeitung (iec)
US8374794B1 (en) 2003-06-02 2013-02-12 Rib-X Pharmaceuticals, Inc. Protein synthesis modulators
US8428884B1 (en) * 2003-07-14 2013-04-23 Rib-X Pharmaceuticals, Inc. Protein synthesis modulators
US7333960B2 (en) 2003-08-01 2008-02-19 Icosystem Corporation Methods and systems for applying genetic operators to determine system conditions
US7356518B2 (en) * 2003-08-27 2008-04-08 Icosystem Corporation Methods and systems for multi-participant interactive evolutionary computing
WO2005047520A2 (en) * 2003-11-07 2005-05-26 Dna Software, Inc. System and methods for three dimensional molecular structural analysis
EP1773389A4 (de) * 2004-05-07 2008-09-10 Massachusetts Inst Technology Verfahren und zusammensetzungen zur krebsbehandlung auf basis der erkennung von brca1-brct-domänen von phosphoryliertem bach1
US7707220B2 (en) 2004-07-06 2010-04-27 Icosystem Corporation Methods and apparatus for interactive searching techniques
WO2006121703A2 (en) * 2005-05-06 2006-11-16 The Board Of Trustees Of The University Of Illinois Mapping new sites for antibiotic action in the ribosome
EP1927058A4 (de) 2005-09-21 2011-02-02 Icosystem Corp System und verfahren zur unterstützung des produktentwurfs und zum quantifizieren der akzeptanz
US7792816B2 (en) 2007-02-01 2010-09-07 Icosystem Corporation Method and system for fast, generic, online and offline, multi-source text analysis and visualization
WO2014170786A1 (en) 2013-04-17 2014-10-23 Pfizer Inc. N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases
CN103217674B (zh) * 2013-04-22 2015-10-14 西北工业大学 一种逆合成孔径雷达的目标三维散射中心重构方法
US10556934B2 (en) 2015-01-29 2020-02-11 Yeda Research And Development Co. Ltd. Crystal structure of the large ribosomal subunit from S. aureus
JP7261346B1 (ja) * 2022-12-20 2023-04-19 賢三 小俣 アミデーション反応のシミュレーション方法

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US5336768A (en) * 1988-05-24 1994-08-09 Hoffmann-La Roche Inc. Antibacterial cephalosporin compounds
US5180719A (en) * 1988-10-24 1993-01-19 Norwich Eaton Pharmaceuticals, Inc. Antimicrobial quinolonyl lactam esters
US5466681A (en) * 1990-02-23 1995-11-14 Microcarb, Inc. Receptor conjugates for targeting penicillin antibiotics to bacteria
US6446032B1 (en) * 1990-09-21 2002-09-03 Massachusetts Institute Of Technology Designing compounds specifically inhibiting ribonucleic acid by binding to the minor groove
BR9206590A (pt) * 1991-10-01 1995-04-25 Procter & Gamble Pharma Processo para a obtenção de quinolonil lactamas antimicrobianas
MY115155A (en) 1993-09-09 2003-04-30 Upjohn Co Substituted oxazine and thiazine oxazolidinone antimicrobials.
IT1276901B1 (it) 1994-12-13 1997-11-03 Zambon Spa Derivati dell'eritromicina a 9-0-ossina dotati di attivita' antibiotica
US5693791A (en) * 1995-04-11 1997-12-02 Truett; William L. Antibiotics and process for preparation
WO1997035195A1 (en) 1996-03-19 1997-09-25 The Salk Institute For Biological Studies In vitro methods for identifying modulators of members of the steroid/thyroid superfamily of receptors
UA51730C2 (uk) * 1996-09-04 2002-12-16 Ебботт Лабораторіз 6-o-заміщені кетоліди з антибактеріальною активністю, спосіб їх одержання (варіанти), фармацевтична композиція та спосіб регулювання бактеріальної інфекції у ссавців
US6437119B1 (en) * 1998-05-07 2002-08-20 William Lawrence Truett Compounds formed from two or three antibiotics and their processes of preparation
US6288234B1 (en) 1998-06-08 2001-09-11 Advanced Medicine, Inc. Multibinding inhibitors of microsomal triglyceride transferase protein
IT1301968B1 (it) * 1998-07-30 2000-07-20 Zambon Spa Derivati di eritromicina ad attivita' antibiotica
AU1830000A (en) 1998-11-30 2000-06-19 Ribogene, Inc. Methods and compositions for identification of inhibitors of ribosome assembly
US6380356B1 (en) * 1999-12-07 2002-04-30 Advanced Medicine, Inc. Multivalent polymyxin antibiotics
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US6638908B1 (en) * 2000-08-09 2003-10-28 Yale University Crystals of the large ribosomal subunit
US6947844B2 (en) 2000-08-09 2005-09-20 Yale University Modulators of ribosomal function and identification thereof
WO2002046392A2 (en) 2000-12-09 2002-06-13 The Regents Of The University Of California X ray crystal structures at 5.5 a resolution of functional complexes of the bacterial ribosome containing transfer rna and model messenger rnas
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IL151012A0 (en) * 2001-08-03 2003-02-12 Ribosomes Structure And Protei Ribosomes structure and protein synthesis inhibitors
US6952650B2 (en) * 2001-08-03 2005-10-04 Yale University Modulators of ribosomal function and identification thereof
US20030027315A1 (en) 2001-09-24 2003-02-06 Ada Yonath Methods of growing crystals of free and antibiotic complexed large ribosomal subunits, and methods of rationally designing or identifying antibiotics using structure coordinate data derived from such crystals
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Also Published As

Publication number Publication date
DE60119853T2 (de) 2007-05-10
EP1188769A3 (de) 2002-07-10
IL144830A0 (en) 2002-06-30
EP1188769A2 (de) 2002-03-20
EP1188769B1 (de) 2006-05-24
US20020086308A1 (en) 2002-07-04
DE01306825T1 (de) 2005-03-31
AU5784601A (en) 2002-02-14
AU768033B2 (en) 2003-11-27
CA2354051A1 (en) 2002-02-09
DE60119853D1 (de) 2006-06-29
US20050234227A1 (en) 2005-10-20
JP2003212896A (ja) 2003-07-30
US20100131258A1 (en) 2010-05-27
EP1188769A8 (de) 2003-09-03
JP3836702B2 (ja) 2006-10-25
US6947844B2 (en) 2005-09-20

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