ATE326986T1 - Pharmazeutische zusammnesetzung zur verbesserten in-vivo genübertragung - Google Patents
Pharmazeutische zusammnesetzung zur verbesserten in-vivo genübertragungInfo
- Publication number
- ATE326986T1 ATE326986T1 AT03718854T AT03718854T ATE326986T1 AT E326986 T1 ATE326986 T1 AT E326986T1 AT 03718854 T AT03718854 T AT 03718854T AT 03718854 T AT03718854 T AT 03718854T AT E326986 T1 ATE326986 T1 AT E326986T1
- Authority
- AT
- Austria
- Prior art keywords
- pharmaceutical composition
- improved
- vivo gene
- gene transmission
- formula
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 230000005540 biological transmission Effects 0.000 title 1
- 238000001727 in vivo Methods 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- 229920001577 copolymer Polymers 0.000 abstract 3
- JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 abstract 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
- 108091006629 SLC13A2 Proteins 0.000 abstract 1
- 125000002091 cationic group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000008103 glucose Substances 0.000 abstract 1
- 229910052500 inorganic mineral Inorganic materials 0.000 abstract 1
- 239000011707 mineral Substances 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
- A61K48/0025—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
- A61K48/0041—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid the non-active part being polymeric
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/765—Polymers containing oxygen
- A61K31/77—Polymers containing oxygen of oxiranes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/785—Polymers containing nitrogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0201584A FR2835749B1 (fr) | 2002-02-08 | 2002-02-08 | Composition pharmaceutique ameliorant le transfert de gene in vivo |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE326986T1 true ATE326986T1 (de) | 2006-06-15 |
Family
ID=27620039
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03718854T ATE326986T1 (de) | 2002-02-08 | 2003-02-07 | Pharmazeutische zusammnesetzung zur verbesserten in-vivo genübertragung |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US7709452B2 (https=) |
| EP (1) | EP1471944B1 (https=) |
| JP (1) | JP4613011B2 (https=) |
| AT (1) | ATE326986T1 (https=) |
| AU (1) | AU2003222896A1 (https=) |
| CA (1) | CA2473212C (https=) |
| DE (1) | DE60305443T2 (https=) |
| ES (1) | ES2265569T3 (https=) |
| FR (1) | FR2835749B1 (https=) |
| WO (1) | WO2003066104A2 (https=) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2868953B1 (fr) * | 2004-04-16 | 2006-06-30 | Inst Nat Sante Rech Med | Composition pour le transfert intracellulaire d'un acide nucleique. |
| EP2076257A4 (en) * | 2006-09-15 | 2014-04-16 | Belrose Pharma Inc | POLYMER CONJUGATES WITH POSITIVELY LOADED PARTS |
| DE102006051623A1 (de) | 2006-11-02 | 2008-07-31 | Horn, Peter A. | Verfahren und Stoffgemisch zur Verbesserung eines in vivo Genfransfers |
| US8790664B2 (en) | 2008-09-05 | 2014-07-29 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Multimodular assembly useful for intracellular delivery |
| WO2012019168A2 (en) | 2010-08-06 | 2012-02-09 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| RU2013120302A (ru) | 2010-10-01 | 2014-11-20 | Модерна Терапьютикс, Инк. | Сконструированные нуклеиновые кислоты и способы их применения |
| EP2691101A2 (en) | 2011-03-31 | 2014-02-05 | Moderna Therapeutics, Inc. | Delivery and formulation of engineered nucleic acids |
| US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| RU2648950C2 (ru) | 2011-10-03 | 2018-04-02 | Модерна Терапьютикс, Инк. | Модифицированные нуклеозиды, нуклеотиды и нуклеиновые кислоты и их применение |
| CN104114572A (zh) | 2011-12-16 | 2014-10-22 | 现代治疗公司 | 经修饰的核苷、核苷酸和核酸组合物 |
| WO2013106558A1 (en) | 2012-01-10 | 2013-07-18 | Merial Limited | Lipid based adjuvants for dna - plasmid vaccines |
| WO2013128424A1 (en) | 2012-03-02 | 2013-09-06 | Institut National De La Sante Et De La Recherche Medicale | Vaccine for prophylaxis or treatment of an allergen-driven and/or a chronic airways disease |
| US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
| US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
| AU2013243948A1 (en) | 2012-04-02 | 2014-10-30 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of proteins associated with human disease |
| US9254311B2 (en) | 2012-04-02 | 2016-02-09 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of proteins |
| US20150182620A1 (en) | 2012-06-15 | 2015-07-02 | Inserm (Institut De La Sante Et De La Recherche Medicale) | Polypeptides for use in the Prophylactic Treatment of Allergic Asthma |
| WO2014081507A1 (en) | 2012-11-26 | 2014-05-30 | Moderna Therapeutics, Inc. | Terminally modified rna |
| US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
| US10023626B2 (en) | 2013-09-30 | 2018-07-17 | Modernatx, Inc. | Polynucleotides encoding immune modulating polypeptides |
| JP2016538829A (ja) | 2013-10-03 | 2016-12-15 | モデルナ セラピューティクス インコーポレイテッドＭｏｄｅｒｎａ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． | 低密度リポタンパク質受容体をコードするポリヌクレオチド |
| JP6774878B2 (ja) * | 2014-04-01 | 2020-10-28 | アンスティチュート ナショナル デ ラ サンテ エ デ ラ レシェルシュ メディカル（アンセルム） | Ｒｎａの細胞内送達のための、キャップされた及びキャップされていないｒｎａ分子およびブロックコポリマー |
| EP3225246A1 (en) | 2016-03-31 | 2017-10-04 | Klinikum der Universität München | Synthetic compound for improving efficiency of transfection |
| US20210000917A1 (en) | 2018-03-05 | 2021-01-07 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and composition for the treatment of allergic asthma |
| AU2020234003B2 (en) * | 2019-03-11 | 2026-02-12 | Evaxion A/S | Nucleic acid vaccination using neo-epitope encoding constructs |
| AU2021202658A1 (en) | 2021-04-28 | 2022-11-17 | Fondazione Telethon | Gene therapy |
| GB202206346D0 (en) | 2022-04-29 | 2022-06-15 | Ospedale San Raffaele Srl | Gene therapy |
| EP4704818A1 (en) | 2023-03-30 | 2026-03-11 | Vivadju | Pvax14 nucleic acid in combination with all-trans retinoic acid (atra) and a checkpoint inhibitor for the treatment of cancer |
| EP4704856A1 (en) | 2023-03-30 | 2026-03-11 | Vivadju | Pvax14 nucleic acid formulated with nano-vehicle in combination with all-trans retinoic acid (atra) for activating immune pathways |
| WO2025129128A1 (en) | 2023-12-15 | 2025-06-19 | Vivasor, Inc. | Compositions and methods for non-viral delivery of therapeutic compounds |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5470568A (en) * | 1992-02-13 | 1995-11-28 | Arch Development Corporation | Methods and compositions of a polymer (poloxamer) for cell repair |
| GB9216082D0 (en) * | 1992-07-28 | 1992-09-09 | Univ Nottingham | Lymphatic delivery composition |
| US5656611A (en) * | 1994-11-18 | 1997-08-12 | Supratek Pharma Inc. | Polynucleotide compositions |
| US6359054B1 (en) * | 1994-11-18 | 2002-03-19 | Supratek Pharma Inc. | Polynucleotide compositions for intramuscular administration |
| US6221959B1 (en) * | 1994-11-18 | 2001-04-24 | Supratek Pharma, Inc. | Polynucleotide compositions |
| US6040295A (en) * | 1995-01-13 | 2000-03-21 | Genemedicine, Inc. | Formulated nucleic acid compositions and methods of administering the same for gene therapy |
| JP2003528024A (ja) * | 1997-12-16 | 2003-09-24 | バレンティス・インコーポレーテッド | 製剤化された核酸分子の無針注入 |
| GB9904627D0 (en) * | 1999-03-02 | 1999-04-21 | Danbiosyst Uk | Polymer compositions for polynucleotide delivery |
| WO2001005913A1 (en) | 1999-07-16 | 2001-01-25 | Reatech | Phosphor addition in gasification |
| AU6389000A (en) * | 1999-07-28 | 2001-02-19 | Valentis, Inc. | Sonoporation of tumors |
| AU2001238485A1 (en) * | 2000-02-18 | 2001-08-27 | The Immune Response Corporation | Methods and compositions for gene delivery |
| CA2401239A1 (en) * | 2000-03-03 | 2001-09-13 | Valentis, Inc. | Improved poloxamer and poloxamine compositions for nucleic acid delivery |
| WO2002061040A2 (en) * | 2000-10-20 | 2002-08-08 | Valentis, Inc. | Gene delivery formulations and methods for treatment of ischemic conditions |
-
2002
- 2002-02-08 FR FR0201584A patent/FR2835749B1/fr not_active Expired - Lifetime
-
2003
- 2003-02-07 US US10/502,973 patent/US7709452B2/en not_active Expired - Lifetime
- 2003-02-07 AT AT03718854T patent/ATE326986T1/de not_active IP Right Cessation
- 2003-02-07 JP JP2003565527A patent/JP4613011B2/ja not_active Expired - Lifetime
- 2003-02-07 AU AU2003222896A patent/AU2003222896A1/en not_active Abandoned
- 2003-02-07 EP EP03718854A patent/EP1471944B1/fr not_active Expired - Lifetime
- 2003-02-07 ES ES03718854T patent/ES2265569T3/es not_active Expired - Lifetime
- 2003-02-07 WO PCT/FR2003/000407 patent/WO2003066104A2/fr not_active Ceased
- 2003-02-07 CA CA2473212A patent/CA2473212C/fr not_active Expired - Lifetime
- 2003-02-07 DE DE60305443T patent/DE60305443T2/de not_active Expired - Lifetime
-
2010
- 2010-03-15 US US12/659,618 patent/US8367631B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE60305443D1 (de) | 2006-06-29 |
| FR2835749B1 (fr) | 2006-04-14 |
| AU2003222896A8 (en) | 2003-09-02 |
| CA2473212C (fr) | 2013-04-23 |
| CA2473212A1 (fr) | 2003-08-14 |
| DE60305443T2 (de) | 2007-05-10 |
| AU2003222896A1 (en) | 2003-09-02 |
| EP1471944B1 (fr) | 2006-05-24 |
| US20050152870A1 (en) | 2005-07-14 |
| US20100179212A1 (en) | 2010-07-15 |
| JP4613011B2 (ja) | 2011-01-12 |
| WO2003066104A3 (fr) | 2004-03-25 |
| US8367631B2 (en) | 2013-02-05 |
| JP2005522433A (ja) | 2005-07-28 |
| FR2835749A1 (fr) | 2003-08-15 |
| ES2265569T3 (es) | 2007-02-16 |
| WO2003066104A2 (fr) | 2003-08-14 |
| US7709452B2 (en) | 2010-05-04 |
| EP1471944A2 (fr) | 2004-11-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |