ATE323699T1 - Nicht-peptidische verbindungen, welche die wirkung des gonadotropin-freisetzenden hormons (gnrh) beeinflussen - Google Patents

Nicht-peptidische verbindungen, welche die wirkung des gonadotropin-freisetzenden hormons (gnrh) beeinflussen

Info

Publication number
ATE323699T1
ATE323699T1 AT03250563T AT03250563T ATE323699T1 AT E323699 T1 ATE323699 T1 AT E323699T1 AT 03250563 T AT03250563 T AT 03250563T AT 03250563 T AT03250563 T AT 03250563T AT E323699 T1 ATE323699 T1 AT E323699T1
Authority
AT
Austria
Prior art keywords
releasing hormone
gnrh
affect
effects
gonadotropin releasing
Prior art date
Application number
AT03250563T
Other languages
English (en)
Inventor
Mark B Anderson
Lance C Christie
Jun Feng
Yufeng Hong
Haitao Li
Ved P Pathak
Ranjan Rajapakse
Eileen Tompkins
Haresh N Vazir
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Application granted granted Critical
Publication of ATE323699T1 publication Critical patent/ATE323699T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/16—Masculine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A61P5/04—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin for decreasing, blocking or antagonising the activity of the hypothalamic hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Anesthesiology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT03250563T 2002-02-12 2003-01-30 Nicht-peptidische verbindungen, welche die wirkung des gonadotropin-freisetzenden hormons (gnrh) beeinflussen ATE323699T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US35656102P 2002-02-12 2002-02-12

Publications (1)

Publication Number Publication Date
ATE323699T1 true ATE323699T1 (de) 2006-05-15

Family

ID=27613554

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03250563T ATE323699T1 (de) 2002-02-12 2003-01-30 Nicht-peptidische verbindungen, welche die wirkung des gonadotropin-freisetzenden hormons (gnrh) beeinflussen

Country Status (10)

Country Link
US (1) US6833372B2 (de)
EP (1) EP1334972B1 (de)
JP (1) JP2004002309A (de)
AT (1) ATE323699T1 (de)
AU (1) AU2003202115A1 (de)
BR (1) BR0300599A (de)
CA (1) CA2418712A1 (de)
DE (1) DE60304609D1 (de)
MX (1) MXPA03001320A (de)
WO (1) WO2003068769A1 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7205307B2 (en) * 2002-02-14 2007-04-17 Icagen, Inc. Pyrimidines as novel openers of potassium ion channels
EA007272B1 (ru) * 2002-03-13 2006-08-25 Янссен Фармацевтика Н. В. Новые ингибиторы гистондеацетилазы
CN101404986B (zh) 2002-05-17 2011-09-28 赛奎拉公司 用于诊断和治疗感染性疾病的组合物和制药方法
US7456222B2 (en) 2002-05-17 2008-11-25 Sequella, Inc. Anti tubercular drug: compositions and methods
US20040033986A1 (en) 2002-05-17 2004-02-19 Protopopova Marina Nikolaevna Anti tubercular drug: compositions and methods
BR0312123A (pt) 2002-06-13 2005-03-29 Pfizer Agentes de gnrh não peptìdicos, composições farmacêuticas e métodos para o seu uso
EP1562611B1 (de) * 2002-11-20 2006-08-02 Paradigm Therapeutics Ltd. Heterozyklische siliziumverbindungen und deren verwendung zur behandlung von krankheiten oder zuständen, die mit gonadotropin-freisetzenden hormon assoziiert sind
SG145701A1 (en) 2003-07-30 2008-09-29 Xenon Pharmaceuticals Inc Piperazine derivatives and their use as therapeutic agents
US7884097B2 (en) 2003-09-05 2011-02-08 Sequella, Inc. Methods and compositions comprising diamines as new anti-tubercular therapeutics
KR100751314B1 (ko) * 2003-10-14 2007-08-22 삼성에스디아이 주식회사 어드레싱 전력을 최소화한 방전 디스플레이 장치 및 그구동 방법
US20050089559A1 (en) 2003-10-23 2005-04-28 Istvan Szelenyi Combinations of potassium channel openers and sodium channel inhibitors or sodium channel-influencing active compounds for treating pains
CA2613162A1 (en) * 2005-06-28 2007-01-04 Takeda Cambridge Limited Heterocyclic non-peptide gnrh antagonists
US7683058B2 (en) 2005-09-09 2010-03-23 H. Lundbeck A/S Substituted pyrimidine derivatives
JP2009507052A (ja) * 2005-09-09 2009-02-19 ハー・ルンドベック・アクチエゼルスカベット ピリミジン誘導体およびそのｋｃｎｑカリウムチャネル開口薬としての使用
US7960436B2 (en) 2006-06-05 2011-06-14 Valeant Pharmaceuticals International Substituted arylamino-1,2,3,4-tetrahydro naphthalenes and-2,3-dihydro-1H-indenes as potassium channel modulators
NZ575652A (en) 2006-08-23 2011-08-26 Valeant Pharmaceuticals Int Derivatives of 4-(n-azacycloalkyl) anilides as potassium channel modulators
US8993593B2 (en) 2006-08-23 2015-03-31 Valeant Pharmaceuticals International N-(4-(6-fluoro-3,4-dihydroisoquinolin-2(1H)-yl)-2,6-dimethylphenyl)-3,3-dimethylbutanamide as potassium channel modulators
US8722929B2 (en) 2006-10-10 2014-05-13 Valeant Pharmaceuticals International N-[2-amino-4-(phenylmethoxy)phenyl] amides and related compounds as potassium channel modulators
CN101578259A (zh) 2006-11-28 2009-11-11 威朗国际制药公司 作为钾通道调节剂的1,4-二氨基双环瑞替加滨类似物
US8367684B2 (en) * 2007-06-13 2013-02-05 Valeant Pharmaceuticals International Derivatives of 4-(N-azacycloalkyl) anilides as potassium channel modulators
US8563566B2 (en) 2007-08-01 2013-10-22 Valeant Pharmaceuticals International Naphthyridine derivatives as potassium channel modulators
US7786146B2 (en) 2007-08-13 2010-08-31 Valeant Pharmaceuticals International Derivatives of 5-amino-4,6-disubstituted indole and 5-amino-4,6-disubstituted indoline as potassium channel modulators
TW201008933A (en) * 2008-08-29 2010-03-01 Hutchison Medipharma Entpr Ltd Pyrimidine compounds
JP6162694B2 (ja) 2011-07-18 2017-07-12 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ ベンズアミド類
WO2014184682A1 (en) * 2013-04-19 2014-11-20 Oslo Universitetssykehus Hf Radiolabeled gnrh antagonists as pet imaging agents
CN108164397B (zh) * 2018-01-18 2020-11-13 暨南大学 一类邻苯二酚衍生物及其制备方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2112566A1 (en) 1991-07-01 1993-02-18 Graham J. Moore Non-desensitizing analogs of gnrh and other biologically active ligands
EP0822939A1 (de) 1995-04-28 1998-02-11 Takeda Chemical Industries, Ltd. Zyklische pentapeptid-lh-rh-rezeptor-antagonisten
CA2213510A1 (en) 1995-06-01 1996-12-05 Takeda Chemical Industries, Ltd. Diazepinones, their production and use
US6200957B1 (en) 1995-12-14 2001-03-13 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
WO1997021704A1 (en) 1995-12-14 1997-06-19 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
KR19990072124A (ko) 1995-12-14 1999-09-27 애쉬톤 왈레이스 티 고나도트로핀 방출 호르몬의 길항제
AU707277B2 (en) 1995-12-14 1999-07-08 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
WO1997021435A1 (en) 1995-12-14 1997-06-19 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
BR9908619A (pt) 1998-03-05 2001-10-02 Agouron Pharma Composto e seu processo de produção, composição farmacêutica, e método para regular a secreção de gonadotropinas em mamìferos
US5972898A (en) 1998-03-27 1999-10-26 Abbott Laboratories 3',3-N-bis-substituted macrolide LHRH antagonists
ES2237966T3 (es) * 1998-08-20 2005-08-01 Agouron Pharmaceuticals, Inc. Agentes de gnrh no peptidicos, metodos y compuestos intermedios para su preparacion.
US6387885B1 (en) 1998-08-26 2002-05-14 Abbott Laboratories 3′,3′-N-bis-desmethyl-3′-N-cycloalkyl erythromycin derivatives as LHRH antagonists
US6020521A (en) 1998-08-26 2000-02-01 Abbott Laboratories Macrolide LHRH antagonists
US5981521A (en) * 1998-11-13 1999-11-09 Abbott Laboratories Tetrahydroisoquinoline derivatives as LHRH antagonists
FR2793594B1 (fr) 1999-05-11 2001-12-07 Axon Cable Sa Cable passe-bas
CA2386942A1 (en) 1999-10-15 2001-04-26 Neurocrine Biosciences, Inc. Gonadotropin-releasing hormone receptor antagonists and methods relating thereto

Also Published As

Publication number Publication date
JP2004002309A (ja) 2004-01-08
CA2418712A1 (en) 2003-08-12
AU2003202115A1 (en) 2003-09-04
EP1334972B1 (de) 2006-04-19
US6833372B2 (en) 2004-12-21
DE60304609D1 (de) 2006-05-24
EP1334972A1 (de) 2003-08-13
US20040053951A1 (en) 2004-03-18
WO2003068769A1 (en) 2003-08-21
BR0300599A (pt) 2005-03-29
MXPA03001320A (es) 2003-08-21

Similar Documents

Publication Publication Date Title
ATE323699T1 (de) Nicht-peptidische verbindungen, welche die wirkung des gonadotropin-freisetzenden hormons (gnrh) beeinflussen
AP2001002053A0 (en) No-peptide GnRH agents, methods and intermediates for their preparation.
LV12631A (en) Non-peptide gnrh agents
ATE266028T1 (de) 1,1-dioxoisothiazolidin-substituierte indazole als inhibitoren der zellproliferation
BR0208626A (pt) Composição antifúngica com biodisponibilidade intensificada
TNSN01130A1 (fr) Formulations a liberation prolongee pour des secretagogues d'hormone de croissance
ES2194567A1 (es) Imidazotriazinonas 2-fenil sustituidas como inhibidores de fosfodiesterasas
ATE256681T1 (de) N-heterozyklische derivate als nos inhibitoren
DE602004016516D1 (de) Pyrimidin-2,4-dion-derivate als gonadotropin freisetzende hormon-rezeptor-antagonisten
DE602004026053D1 (de)
EP1721609A3 (de) Pyridylpyrimidinderivate als effektive Verbindungen gegen Prioninfektionen und prion Erkrankungen
DE602004020638D1 (de) Pyrimidin-2,4-dion-derivate als gonadotropin freisetzende hormon-rezeptor-antagonisten
JP2004511522A5 (de)
DK1370243T3 (da) Fremgangsmåde til at opnå mikropartikler, der indeholder en H+,K+-ATPase-inhibitor
PE20020843A1 (es) Metodo combinado para tratar trastornos hormonales dependientes
BR0312123A (pt) Agentes de gnrh não peptìdicos, composições farmacêuticas e métodos para o seu uso
BR0210191A (pt) Agentes não peptìdicos da gnrh, composições farmacêuticas e métodos para o seu uso, e processos para os preparar e aos seus intermediários
IT1317031B1 (it) Procedimento migliorato per la preparazione di (e,z)3-(2-amminoetossimmino)-androstano-6, 17-dione e di suoi analoghi.
DE60318716D1 (de) Thieno-pyrrole verbindungen als antagonisten der gonadotropin-freisetzenden hormonrezeptoren
IL156811A0 (en) Bisaryl derivatives and pharmaceutical compositions containing the same
ATE277926T1 (de) Trizyclische vasopressin agoniste
ATE401331T1 (de) 6h-thienä2,3-büpyrrolderivate als antagonisten des gonadotropin-freisetzenden hormons (gnrh)
BR0308890A (pt) Composto
HUP0102805A2 (hu) Tienopiridin-származékok, előállításuk és alkalmazásuk
DE60122575D1 (de) 7-HETEROCYCLYL-SUBSTITUIERTE CHINOLIN- UND THIENOi2,3-BöPYRIDIN-DERIVATE ALS ANTAGONISTEN DES GONADOTROPIN-FREISETZENDEN HORMONS

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties