DE60304609D1 - Nicht-peptidische Verbindungen, welche die Wirkung des Gonadotropin-freisetzenden Hormons (GnRH) beeinflussen - Google Patents

Nicht-peptidische Verbindungen, welche die Wirkung des Gonadotropin-freisetzenden Hormons (GnRH) beeinflussen

Info

Publication number
DE60304609D1
DE60304609D1 DE60304609T DE60304609T DE60304609D1 DE 60304609 D1 DE60304609 D1 DE 60304609D1 DE 60304609 T DE60304609 T DE 60304609T DE 60304609 T DE60304609 T DE 60304609T DE 60304609 D1 DE60304609 D1 DE 60304609D1
Authority
DE
Germany
Prior art keywords
releasing hormone
gnrh
affect
action
gonadotropin releasing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60304609T
Other languages
English (en)
Inventor
Mark B Anderson
Lance C Christie
Jun Feng
Yufeng Hong
Haitao Li
Ved P Pathak
Ranjan Rajapakse
Eileen Tompkins
Haresh N Vazir
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Application granted granted Critical
Publication of DE60304609D1 publication Critical patent/DE60304609D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/16—Masculine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A61P5/04—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin for decreasing, blocking or antagonising the activity of the hypothalamic hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Pregnancy & Childbirth (AREA)
  • Urology & Nephrology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Anesthesiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE60304609T 2002-02-12 2003-01-30 Nicht-peptidische Verbindungen, welche die Wirkung des Gonadotropin-freisetzenden Hormons (GnRH) beeinflussen Expired - Lifetime DE60304609D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US35656102P 2002-02-12 2002-02-12

Publications (1)

Publication Number Publication Date
DE60304609D1 true DE60304609D1 (de) 2006-05-24

Family

ID=27613554

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60304609T Expired - Lifetime DE60304609D1 (de) 2002-02-12 2003-01-30 Nicht-peptidische Verbindungen, welche die Wirkung des Gonadotropin-freisetzenden Hormons (GnRH) beeinflussen

Country Status (10)

Country Link
US (1) US6833372B2 (de)
EP (1) EP1334972B1 (de)
JP (1) JP2004002309A (de)
AT (1) ATE323699T1 (de)
AU (1) AU2003202115A1 (de)
BR (1) BR0300599A (de)
CA (1) CA2418712A1 (de)
DE (1) DE60304609D1 (de)
MX (1) MXPA03001320A (de)
WO (1) WO2003068769A1 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7205307B2 (en) * 2002-02-14 2007-04-17 Icagen, Inc. Pyrimidines as novel openers of potassium ion channels
WO2003075929A1 (en) * 2002-03-13 2003-09-18 Janssen Pharmaceutica N.V. Inhibitors of histone deacetylase
US20040033986A1 (en) 2002-05-17 2004-02-19 Protopopova Marina Nikolaevna Anti tubercular drug: compositions and methods
US7652039B2 (en) 2002-05-17 2010-01-26 Sequella, Inc. Methods of use and compositions for the diagnosis and treatment of infectious disease
US7456222B2 (en) 2002-05-17 2008-11-25 Sequella, Inc. Anti tubercular drug: compositions and methods
JP2005538064A (ja) * 2002-06-13 2005-12-15 ファイザー・インク 非ペプチドＧｎＲＨ剤、医薬組成物、およびそれらの使用方法
CA2507532A1 (en) * 2002-11-20 2004-06-03 Paradigm Therapeutics Ltd. Heterocyclic silicon compounds and their use in the treatment of diseases or conditions associated with gnrh (gonadotropin-releasing hormone)
CN101693697A (zh) 2003-07-30 2010-04-14 泽农医药公司 哌嗪衍生物和它们作为治疗剂的用途
EP1670314A4 (de) 2003-09-05 2009-02-25 Sequella Inc Verfahren und zusammensetzungen enthaltend diamine als neue therapeutika für tuberkulose
US7799832B2 (en) 2003-10-23 2010-09-21 Valeant Pharmaceuticals North America Combinations of retigabine and sodium channel inhibitors or sodium channel-influencing active compounds for treating pains
KR100751314B1 (ko) * 2003-10-14 2007-08-22 삼성에스디아이 주식회사 어드레싱 전력을 최소화한 방전 디스플레이 장치 및 그구동 방법
US20090209522A1 (en) * 2005-06-28 2009-08-20 Graham Andrew Showell Heterocyclic Non-Peptide GNRH Antagonists
BRPI0615631A2 (pt) * 2005-09-09 2011-05-24 Lundbeck & Co As H composto, composição farmacêutica, e, uso de uma composição farmacêutica
US7683058B2 (en) 2005-09-09 2010-03-23 H. Lundbeck A/S Substituted pyrimidine derivatives
US7960436B2 (en) 2006-06-05 2011-06-14 Valeant Pharmaceuticals International Substituted arylamino-1,2,3,4-tetrahydro naphthalenes and-2,3-dihydro-1H-indenes as potassium channel modulators
US8993593B2 (en) 2006-08-23 2015-03-31 Valeant Pharmaceuticals International N-(4-(6-fluoro-3,4-dihydroisoquinolin-2(1H)-yl)-2,6-dimethylphenyl)-3,3-dimethylbutanamide as potassium channel modulators
SG174095A1 (en) 2006-08-23 2011-09-29 Valeant Pharmaceuticals Int Derivatives of 4-(n-azacycloalkyl) anilides as potassium channel modulators
US8722929B2 (en) 2006-10-10 2014-05-13 Valeant Pharmaceuticals International N-[2-amino-4-(phenylmethoxy)phenyl] amides and related compounds as potassium channel modulators
BRPI0719590A2 (pt) 2006-11-28 2014-01-21 Valeant Pharmaceuticals Int Análogos de retigabina 1,4 diamino bicíclica como modulares de canal de potássio
US8367684B2 (en) 2007-06-13 2013-02-05 Valeant Pharmaceuticals International Derivatives of 4-(N-azacycloalkyl) anilides as potassium channel modulators
US8563566B2 (en) 2007-08-01 2013-10-22 Valeant Pharmaceuticals International Naphthyridine derivatives as potassium channel modulators
US7786146B2 (en) 2007-08-13 2010-08-31 Valeant Pharmaceuticals International Derivatives of 5-amino-4,6-disubstituted indole and 5-amino-4,6-disubstituted indoline as potassium channel modulators
US7737157B2 (en) * 2008-08-29 2010-06-15 Hutchison Medipharma Enterprises Limited Pyrimidine compounds
EP3263568B1 (de) 2011-07-18 2021-08-25 Merck Patent GmbH Benzamide
WO2014184682A1 (en) * 2013-04-19 2014-11-20 Oslo Universitetssykehus Hf Radiolabeled gnrh antagonists as pet imaging agents
CN108164397B (zh) * 2018-01-18 2020-11-13 暨南大学 一类邻苯二酚衍生物及其制备方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993003058A2 (en) 1991-07-01 1993-02-18 University Technologies International Inc. NON-DESENSITIZING ANALOGS OF GnRH AND OTHER BIOLOGICALLY ACTIVE LIGANDS
CA2215737A1 (en) 1995-04-28 1996-10-31 Koichi Kato Lh-rh receptor antagonists
CA2213510A1 (en) 1995-06-01 1996-12-05 Takeda Chemical Industries, Ltd. Diazepinones, their production and use
AU704937B2 (en) 1995-12-14 1999-05-06 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
HUP9902121A3 (en) 1995-12-14 2001-05-28 Merck & Co Inc Indole derivatives as antagonists of gonadotropin releasing hormone and pharmaceutical compositions containing them
EA000992B1 (ru) 1995-12-14 2000-08-28 Мерк Энд Ко., Инк. Антагонисты гормона, высвобождающего гонадотропин
US6200957B1 (en) 1995-12-14 2001-03-13 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
EA000828B1 (ru) 1995-12-14 2000-04-24 Мерк Энд Ко., Инк. Антагонисты гонадотропин-высвобождающего фактора
SI20424A (sl) 1998-03-05 2001-06-30 Agouron Pharmaceuticals, Inc. Nepeptidna GnRH sredstva
US5972898A (en) 1998-03-27 1999-10-26 Abbott Laboratories 3',3-N-bis-substituted macrolide LHRH antagonists
HUP0103622A3 (en) * 1998-08-20 2003-01-28 Agouron Pharmaceuticals Inc La Non-peptide gnrh agents, methods and intermediates for their preparation and medicaments containing them
US6387885B1 (en) 1998-08-26 2002-05-14 Abbott Laboratories 3′,3′-N-bis-desmethyl-3′-N-cycloalkyl erythromycin derivatives as LHRH antagonists
US6020521A (en) 1998-08-26 2000-02-01 Abbott Laboratories Macrolide LHRH antagonists
US5981521A (en) 1998-11-13 1999-11-09 Abbott Laboratories Tetrahydroisoquinoline derivatives as LHRH antagonists
FR2793594B1 (fr) 1999-05-11 2001-12-07 Axon Cable Sa Cable passe-bas
DE60022769T2 (de) 1999-10-15 2006-07-06 Neurocrine Biosciences, Inc., San Diego Gonadotropin freisetzenden hormon rezeptor antagonisten und ihre verwandten verwendungen

Also Published As

Publication number Publication date
CA2418712A1 (en) 2003-08-12
ATE323699T1 (de) 2006-05-15
AU2003202115A1 (en) 2003-09-04
US6833372B2 (en) 2004-12-21
US20040053951A1 (en) 2004-03-18
EP1334972A1 (de) 2003-08-13
MXPA03001320A (es) 2003-08-21
BR0300599A (pt) 2005-03-29
EP1334972B1 (de) 2006-04-19
JP2004002309A (ja) 2004-01-08
WO2003068769A1 (en) 2003-08-21

Similar Documents

Publication Publication Date Title
DE60304609D1 (de) Nicht-peptidische Verbindungen, welche die Wirkung des Gonadotropin-freisetzenden Hormons (GnRH) beeinflussen
AP2001002053A0 (en) No-peptide GnRH agents, methods and intermediates for their preparation.
LV12631A (en) Non-peptide gnrh agents
BR0102893A (pt) Misturas estabilizadoras
DE602004026053D1 (de)
BR0208626A (pt) Composição antifúngica com biodisponibilidade intensificada
DE60103147D1 (de) 1,1-dioxoisothiazolidin-substituierte indazole als inhibitoren der zellproliferation
ES2194567A1 (es) Imidazotriazinonas 2-fenil sustituidas como inhibidores de fosfodiesterasas
TNSN01130A1 (fr) Formulations a liberation prolongee pour des secretagogues d'hormone de croissance
ATE256681T1 (de) N-heterozyklische derivate als nos inhibitoren
PE20010911A1 (es) Forma en estado solido de celecoxib que tiene una biodisponibilidad mejorada
DK1370243T3 (da) Fremgangsmåde til at opnå mikropartikler, der indeholder en H+,K+-ATPase-inhibitor
WO2002098363A3 (en) NON-PEPTIDE GnRH AGENTS, PHARMACEUTICAL COMPOSITIONS AND METHODS FOR THEIR USES, AND PROCESSES FOR PREPARING THEM
PE20020843A1 (es) Metodo combinado para tratar trastornos hormonales dependientes
EP1146873A4 (de) Anti-androgene und verfahren zur behandlung von krankheiten
BR0312123A (pt) Agentes de gnrh não peptìdicos, composições farmacêuticas e métodos para o seu uso
AR036533A1 (es) Compuestos agonistas de retinoides de alquil urea, su utilizacion, composiciones farmaceuticas que los comprenden y medicamentos basados en dichos compuestos
DE60318716D1 (de) Thieno-pyrrole verbindungen als antagonisten der gonadotropin-freisetzenden hormonrezeptoren
ATE277926T1 (de) Trizyclische vasopressin agoniste
IL156811A0 (en) Bisaryl derivatives and pharmaceutical compositions containing the same
DE60122575D1 (de) 7-HETEROCYCLYL-SUBSTITUIERTE CHINOLIN- UND THIENOi2,3-BöPYRIDIN-DERIVATE ALS ANTAGONISTEN DES GONADOTROPIN-FREISETZENDEN HORMONS
HUP0102805A2 (hu) Tienopiridin-származékok, előállításuk és alkalmazásuk
YU31499A (sh) Proces za dobijanje jedinjenja pirolidinil hidroksamske kiseline
WO2000066620A3 (en) Morphogen-induced enhancement of fertility
BR0309539A (pt) Composições de catalisadores misturados para a produção de poliolefinas e seu uso

Legal Events

Date Code Title Description
8332 No legal effect for de