ATE320314T1 - Verfahren zur modifikation von ausgewählten zellen in einer magnetischen zelltrennungsäule - Google Patents

Verfahren zur modifikation von ausgewählten zellen in einer magnetischen zelltrennungsäule

Info

Publication number
ATE320314T1
ATE320314T1 AT00974736T AT00974736T ATE320314T1 AT E320314 T1 ATE320314 T1 AT E320314T1 AT 00974736 T AT00974736 T AT 00974736T AT 00974736 T AT00974736 T AT 00974736T AT E320314 T1 ATE320314 T1 AT E320314T1
Authority
AT
Austria
Prior art keywords
selected cells
cell separation
separation column
magnetic cell
modifying selected
Prior art date
Application number
AT00974736T
Other languages
English (en)
Inventor
Stefan Miltenyi
Mario Assenmacher
Juergen Schmitz
Original Assignee
Miltenyi Biotec Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Miltenyi Biotec Gmbh filed Critical Miltenyi Biotec Gmbh
Application granted granted Critical
Publication of ATE320314T1 publication Critical patent/ATE320314T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N13/00—Treatment of microorganisms or enzymes with electrical or wave energy, e.g. magnetism, sonic waves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00—Magnetic separation
    • B03C1/002—High gradient magnetic separation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00—Magnetic separation
    • B03C1/005—Pretreatment specially adapted for magnetic separation
    • B03C1/01—Pretreatment specially adapted for magnetic separation by addition of magnetic adjuvants
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00—Magnetic separation
    • B03C1/02—Magnetic separation acting directly on the substance being separated
    • B03C1/025—High gradient magnetic separators
    • B03C1/031—Component parts; Auxiliary operations
    • B03C1/033—Component parts; Auxiliary operations characterised by the magnetic circuit
    • B03C1/034—Component parts; Auxiliary operations characterised by the magnetic circuit characterised by the matrix elements
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/806—Electrical property or magnetic property

Landscapes

  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
AT00974736T 1999-09-03 2000-09-01 Verfahren zur modifikation von ausgewählten zellen in einer magnetischen zelltrennungsäule ATE320314T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US15240899P 1999-09-03 1999-09-03

Publications (1)

Publication Number Publication Date
ATE320314T1 true ATE320314T1 (de) 2006-04-15

Family

ID=22542799

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00974736T ATE320314T1 (de) 1999-09-03 2000-09-01 Verfahren zur modifikation von ausgewählten zellen in einer magnetischen zelltrennungsäule

Country Status (9)

Country Link
US (1) US6468432B1 (de)
EP (1) EP1207961B1 (de)
JP (1) JP4612982B2 (de)
AT (1) ATE320314T1 (de)
AU (1) AU778569B2 (de)
CA (1) CA2383791C (de)
DE (1) DE60026729T2 (de)
ES (1) ES2260063T3 (de)
WO (1) WO2001017687A2 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6649419B1 (en) * 2000-11-28 2003-11-18 Large Scale Proteomics Corp. Method and apparatus for protein manipulation
JP2005502727A (ja) * 2001-09-21 2005-01-27 カプリオン ファーマシューティカルズ インコーポレーティッド 高度に精製された原形質膜の調製方法
US20030099954A1 (en) * 2001-11-26 2003-05-29 Stefan Miltenyi Apparatus and method for modification of magnetically immobilized biomolecules
USD490531S1 (en) 2002-11-22 2004-05-25 Stemcell Technologies Inc. Magnetic separator housing
US20040142384A1 (en) * 2003-01-16 2004-07-22 Cohen Barb Ariel Magnetic separator
DE10339905B4 (de) * 2003-08-29 2009-04-23 Kist-Europe Forschungsgesellschaft Mbh Implantierbarer Mikrozellprozessor zur Krankheitsbehandlung
US20050266394A1 (en) * 2003-12-24 2005-12-01 Massachusette Institute Of Technology Magnetophoretic cell clarification
GB2425498A (en) * 2005-04-25 2006-11-01 Dynal Biotech Asa A magnetic separation device
US20090208981A1 (en) * 2005-05-03 2009-08-20 Jia-Ming Chang Method for Analysis of Interaction Between Small Molecules and Cells and Apparatus thereof
US20090081750A1 (en) * 2007-02-14 2009-03-26 Bio-Rad Laboratories, Inc. Transfection in magnetically driven continuous flow
US8071395B2 (en) * 2007-12-12 2011-12-06 The Board Of Trustees Of The Leland Stanford Junior University Methods and apparatus for magnetic separation of cells
KR101384142B1 (ko) * 2007-12-28 2014-04-14 삼성디스플레이 주식회사 표시기판, 이의 제조방법 및 이를 갖는 표시장치
US8790916B2 (en) 2009-05-14 2014-07-29 Genestream, Inc. Microfluidic method and system for isolating particles from biological fluid
JP5678565B2 (ja) 2009-12-08 2015-03-04 Jnc株式会社 磁性微粒子およびその製造方法
DE102010042723A1 (de) * 2010-10-20 2012-04-26 Miltenyi Biotec Gmbh Vorrichtung und Verfahren zur Separation von Neél- und Brown-magnetischen Partikeln
US8695618B2 (en) 2010-12-22 2014-04-15 Carnegie Mellon University 3D chemical pattern control in 2D fluidics devices
EP2518504A1 (de) * 2011-04-29 2012-10-31 Miltenyi Biotec GmbH Verfahren zur quantitativen und qualitativen Charakterisierung von antigenspezifischen T-Zellen, die ein spezifischen Antigen erkennen
CN108375676B (zh) * 2011-07-21 2022-01-07 詹森诊断器材有限责任公司 从血液中捕获和检测循环多发性骨髓瘤的测定法
EP3037170A1 (de) * 2014-12-27 2016-06-29 Miltenyi Biotec GmbH Multisort-Zelltrennverfahren
JP6734283B2 (ja) 2015-01-21 2020-08-05 フレッド ハッチンソン キャンサー リサーチ センター 遺伝子治療用ポイントオブケア及び／又はポータブルプラットフォーム
CN109459571A (zh) * 2018-11-08 2019-03-12 浙江大学 基于微流控和化学发光免疫分析的超顺磁纳米微粒外泌体分离检测系统及其应用
US20220220504A1 (en) * 2019-05-28 2022-07-14 Miltenyi Biotec B.V. & Co. KG Method for Generation of Genetically Modified T Cells
CN116064368A (zh) * 2021-10-29 2023-05-05 京东方科技集团股份有限公司 用于捕获cd138阳性细胞的捕获剂及制备方法、捕获方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE114507T1 (de) * 1988-12-28 1994-12-15 Stefan Miltenyi Verfahren sowie materialien zur hochgraduierten magnetischen abspaltung biologischer materialien.
US5200084A (en) 1990-09-26 1993-04-06 Immunicon Corporation Apparatus and methods for magnetic separation
US5622831A (en) * 1990-09-26 1997-04-22 Immunivest Corporation Methods and devices for manipulation of magnetically collected material
WO1994011078A1 (en) * 1992-11-16 1994-05-26 Immunivest Corporation Magnetic immobilization and manipulation of biological entities
CA2146974C (en) * 1992-10-21 2010-02-02 Andreas Radbruch Direct selection of cells by secretion product
US5514340A (en) 1994-01-24 1996-05-07 Magnetix Biotechnology, Inc. Device for separating magnetically labelled cells
GB9413029D0 (en) 1994-06-29 1994-08-17 Common Services Agency Stem cell immobilisation
US5705059A (en) 1995-02-27 1998-01-06 Miltenyi; Stefan Magnetic separation apparatus
US6190870B1 (en) * 1995-08-28 2001-02-20 Amcell Corporation Efficient enrichment and detection of disseminated tumor cells
GB9523045D0 (en) 1995-11-10 1996-01-10 Genera Tech Ltd Methods of capture and asssy procedures
US6228624B1 (en) * 1996-08-02 2001-05-08 Immunivest Corporation Method to select and transfect cell subpopulations
JPH10179165A (ja) * 1996-12-27 1998-07-07 Norin Suisansyo Chikusan Shikenjo 抗体磁気ビーズを用いた生殖幹細胞の分離、精製と幹細胞株の樹立方法

Also Published As

Publication number Publication date
JP4612982B2 (ja) 2011-01-12
DE60026729T2 (de) 2006-12-14
EP1207961A2 (de) 2002-05-29
CA2383791C (en) 2012-11-06
AU778569B2 (en) 2004-12-09
US6468432B1 (en) 2002-10-22
WO2001017687A3 (en) 2002-01-17
WO2001017687A2 (en) 2001-03-15
EP1207961B1 (de) 2006-03-15
CA2383791A1 (en) 2001-03-15
ES2260063T3 (es) 2006-11-01
DE60026729D1 (de) 2006-05-11
AU1294801A (en) 2001-04-10
JP2003508073A (ja) 2003-03-04

Similar Documents

Publication Publication Date Title
DE60026729D1 (de) Verfahren zur modifikation von ausgewählten zellen in einer magnetischen zelltrennungsäule
ATE414783T1 (de) Verfahren zur isolierung von stammzellen
PT82219B (pt) Processo para a extraccao e purificacao de proteinas a partir de meios de cultura que as produzem
DE68917736D1 (de) System zur magnetischen affinitäts-separation von zellen aus zellkonzentraten.
EP1023451A4 (de) Methoden zur replikation von viren in von monozyten abgeleiteten makrophagenkulturen
DE69417011D1 (de) Verfahren zur herstellung von kathoden komponenten und zu ihrer verwendung in elektrochemischen zellen
ID28595A (id) Bahan pembawa termodifikasi, katalisoksida kompleks dan proses pembuatan asam akrilat
DE69807157D1 (de) Verfahren zur Rückgewinnung von Acrylsäure
DE69332926D1 (de) Kontinuierliches zentrifugationsverfahren zum abtrennen von biologischen komponenten aus heterogenen zellpopulationen
DE69420438D1 (de) Verfahren zur Werkstoffrückgewinnung von Lithiumzellen
DE59803651D1 (de) Verfahren zur herstellung von acrylsäure und methacrylsäure
DE69931085D1 (de) System und Verfahren zum Separieren von biologischen Zellen
DE3788026D1 (de) Verfahren und Vorrichtung zur Kultivierung von Zellen.
ID17599A (id) Proses memproduksi asam tereftalat berkemurnian tinggi dengan menggunakan peralatan pengganti media dispersi
DE69721893D1 (de) Verfahren zur Abscheidung von Zellen aus Blut
DE69801797D1 (de) Verfahren zur Herstellung von Acrylsäure
DE69817476D1 (de) Verfahren zur Herstellung von modifiziertem Acrylkautschuk
DE69837041D1 (de) Verfahren und mikroorganism zur herstellung von purin-nukleosiden durch fermentation
DE68919856D1 (de) Nachrichtenvermittlungselement zur übertragung von zellen unterteilt in teilzellen.
AU2926497A (en) Nanoconstructions of geometrical objects and lattices from antiparallel nucleic acid double crossover molecules
DE59704610D1 (de) Verfahren zur entsorgung von bei der acrylsäure- oder methacrylsäure-herstellung anfallenden nebenkomponenten
DE69524369D1 (de) Verfahren zur Extraktion von Karotenoiden aus Bakterienzellen
NO20005198D0 (no) FremgangsmÕte for separasjon av magnetiske partikler blandet i fluid, samt separasjonssystem og separator
DE69820668T2 (de) Wasserfreie mononukleare tris(beta-diketonat)bismut-zubereitungen zur abscheidung von bismuthaltigen filmen und verfahren zu ihrer herstellung
DE69504419D1 (de) Lesbare Information aufweisenden Etikettenträger und Verfahren zur dessen Herstellung

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties