DE69332926D1 - Kontinuierliches zentrifugationsverfahren zum abtrennen von biologischen komponenten aus heterogenen zellpopulationen - Google Patents

Kontinuierliches zentrifugationsverfahren zum abtrennen von biologischen komponenten aus heterogenen zellpopulationen

Info

Publication number
DE69332926D1
DE69332926D1 DE69332926T DE69332926T DE69332926D1 DE 69332926 D1 DE69332926 D1 DE 69332926D1 DE 69332926 T DE69332926 T DE 69332926T DE 69332926 T DE69332926 T DE 69332926T DE 69332926 D1 DE69332926 D1 DE 69332926D1
Authority
DE
Germany
Prior art keywords
cell populations
biological components
centrifugation method
continuous centrifugation
separating biological
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69332926T
Other languages
English (en)
Other versions
DE69332926T2 (de
Inventor
C Lake
Richard Giesler
Epps Dennis Van
R Chapman
A Martinson
R Ellis
Frederick Aono
F Bischof
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Baxter International Inc
Original Assignee
Baxter International Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxter International Inc filed Critical Baxter International Inc
Application granted granted Critical
Publication of DE69332926D1 publication Critical patent/DE69332926D1/de
Publication of DE69332926T2 publication Critical patent/DE69332926T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • G01N33/56972—White blood cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3618—Magnetic separation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/362—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits changing physical properties of target cells by binding them to added particles to facilitate their subsequent separation from other cells, e.g. immunoaffinity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
    • A61M1/3696—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/24—Methods of sampling, or inoculating or spreading a sample; Methods of physically isolating an intact microorganisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Vascular Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Anesthesiology (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • External Artificial Organs (AREA)
DE69332926T 1993-05-28 1993-06-15 Kontinuierliches zentrifugationsverfahren zum abtrennen von biologischen komponenten aus heterogenen zellpopulationen Expired - Lifetime DE69332926T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6907793A 1993-05-28 1993-05-28
US69077 1993-05-28
PCT/US1993/005735 WO1994027698A2 (en) 1993-05-28 1993-06-15 Continuous centrifugation process for the separation of biologic components from heterogeneous cell populations

Publications (2)

Publication Number Publication Date
DE69332926D1 true DE69332926D1 (de) 2003-06-05
DE69332926T2 DE69332926T2 (de) 2004-03-11

Family

ID=22086589

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69332926T Expired - Lifetime DE69332926T2 (de) 1993-05-28 1993-06-15 Kontinuierliches zentrifugationsverfahren zum abtrennen von biologischen komponenten aus heterogenen zellpopulationen

Country Status (5)

Country Link
EP (1) EP0653062B1 (de)
JP (1) JP3331398B2 (de)
CA (1) CA2140455A1 (de)
DE (1) DE69332926T2 (de)
WO (1) WO1994027698A2 (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1271593B (it) * 1994-11-30 1997-06-04 Sanitaria Scaligera Spa Procedimento ed apparecchiatura per l'immunoadsorbimento specifico di virus hiv, di antigene gp120 e complesso cd4-gp120.
US6053856A (en) * 1995-04-18 2000-04-25 Cobe Laboratories Tubing set apparatus and method for separation of fluid components
US6022306A (en) * 1995-04-18 2000-02-08 Cobe Laboratories, Inc. Method and apparatus for collecting hyperconcentrated platelets
US5951877A (en) * 1995-04-18 1999-09-14 Cobe Laboratories, Inc. Particle filter method
US5674173A (en) * 1995-04-18 1997-10-07 Cobe Laboratories, Inc. Apparatus for separating particles
EP0824380B1 (de) * 1995-04-18 2002-01-09 Gambro, Inc., Verfahren zur teilchentrennung
DE29708743U1 (de) * 1997-05-16 1998-09-17 Dr. Kübler GmbH, 81675 München Apheresevorrichtung
US6051146A (en) * 1998-01-20 2000-04-18 Cobe Laboratories, Inc. Methods for separation of particles
WO2000073794A2 (en) * 1999-05-28 2000-12-07 Stemcell Technologies Inc. Method for separating cells using immunorosettes
DE10136375A1 (de) * 2001-07-26 2003-02-13 Cellgenix Technologie Transfer Verfahren zur Anreicherung von Zellen
US7771716B2 (en) 2001-12-07 2010-08-10 Cytori Therapeutics, Inc. Methods of using regenerative cells in the treatment of musculoskeletal disorders
US7651684B2 (en) 2001-12-07 2010-01-26 Cytori Therapeutics, Inc. Methods of using adipose tissue-derived cells in augmenting autologous fat transfer
US9597395B2 (en) 2001-12-07 2017-03-21 Cytori Therapeutics, Inc. Methods of using adipose tissue-derived cells in the treatment of cardiovascular conditions
US7585670B2 (en) 2001-12-07 2009-09-08 Cytori Therapeutics, Inc. Automated methods for isolating and using clinically safe adipose derived regenerative cells
KR100930139B1 (ko) * 2001-12-07 2009-12-07 사이토리 테라퓨틱스, 인크. 처리된 리포애스퍼레이트 세포로 환자를 치료하기 위한시스템 및 방법
US20050095228A1 (en) 2001-12-07 2005-05-05 Fraser John K. Methods of using regenerative cells in the treatment of peripheral vascular disease and related disorders
US7595043B2 (en) 2001-12-07 2009-09-29 Cytori Therapeutics, Inc. Method for processing and using adipose-derived stem cells
US8105580B2 (en) 2001-12-07 2012-01-31 Cytori Therapeutics, Inc. Methods of using adipose derived stem cells to promote wound healing
US7514075B2 (en) 2001-12-07 2009-04-07 Cytori Therapeutics, Inc. Systems and methods for separating and concentrating adipose derived stem cells from tissue
JP3803078B2 (ja) * 2002-09-20 2006-08-02 独立行政法人科学技術振興機構 血液分析装置及び血漿分離方法
JP2006520606A (ja) * 2003-03-19 2006-09-14 アルファ ワッサーマン インコーポレイテッド 細胞内成分の分離および蓄積、およびそれに由来するタンパク質
EP2380970B1 (de) 2003-06-25 2017-12-20 Cytori Therapeutics, Inc. Systeme und Verfahren zum Trennen und Konzentrieren regenerativer Zellen aus Gewebe
EP1507147A1 (de) * 2003-08-12 2005-02-16 Erasmus University Medical Center Rotterdam Verfahren zum Nachweiss von niedrigem Gehalt an Fusionsprotein
JP2005312376A (ja) * 2004-04-30 2005-11-10 Asahi Kasei Corp 細胞表面消化度検出用化合物
EP1893253B1 (de) * 2005-03-23 2010-05-19 Biosafe S.A. Integriertes system zum sammeln, bearbeiten und transplantieren von zell-subsets, einschliesslich adulter stammzellen, für die regenerative medizin
JP4881306B2 (ja) 2005-04-18 2012-02-22 三井化学株式会社 樹脂組成物および光学部品
WO2010021993A1 (en) 2008-08-19 2010-02-25 Cytori Therapeutics, Inc. Methods of using adipose tissue-derived cells in the treatment of the lymphatic system and malignant disease
US8309343B2 (en) 2008-12-01 2012-11-13 Baxter International Inc. Apparatus and method for processing biological material
AU2010242780B2 (en) 2009-05-01 2016-04-21 Puregraft Llc Systems, methods and compositions for optimizing tissue and cell enriched grafts
EP2309266A1 (de) * 2009-09-21 2011-04-13 F. Hoffmann-La Roche AG Verfahren zur Durchführung von Reaktionen in einer Analysevorrichtung
WO2013058742A1 (en) * 2011-10-18 2013-04-25 Empire Technology Development Llc Closed-cycle continuous flow separators, systems and methods for the continuous isolation of target cells
CN104620093B (zh) * 2012-08-23 2018-04-20 干细胞技术公司 用于快速可逆生物分子标记的组合物和方法
WO2014127122A1 (en) 2013-02-18 2014-08-21 Terumo Bct, Inc. System for blood separation with a separation chamber having an internal gravity valve

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4146172A (en) * 1977-10-18 1979-03-27 Baxter Travenol Laboratories, Inc. Centrifugal liquid processing system
IL63220A (en) * 1981-07-01 1985-09-29 Yeda Res & Dev Process for production of polyacrolein microspheres
US4722790A (en) * 1982-09-13 1988-02-02 Cawley Leo P On-line plasma modification means
US4935147A (en) * 1985-12-20 1990-06-19 Syntex (U.S.A.) Inc. Particle separation method
US4927749A (en) * 1986-04-09 1990-05-22 Jeanette Simpson Reagent for cell separation

Also Published As

Publication number Publication date
DE69332926T2 (de) 2004-03-11
WO1994027698A2 (en) 1994-12-08
JPH09506501A (ja) 1997-06-30
WO1994027698A3 (en) 1996-10-10
EP0653062A1 (de) 1995-05-17
EP0653062A4 (de) 1997-12-03
EP0653062B1 (de) 2003-05-02
JP3331398B2 (ja) 2002-10-07
CA2140455A1 (en) 1994-12-08

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