ATE316333T1 - Verfahren zur in-vivo abgabe therapeutischer agenzien mittels liposomen - Google Patents

Verfahren zur in-vivo abgabe therapeutischer agenzien mittels liposomen

Info

Publication number
ATE316333T1
ATE316333T1 AT95917788T AT95917788T ATE316333T1 AT E316333 T1 ATE316333 T1 AT E316333T1 AT 95917788 T AT95917788 T AT 95917788T AT 95917788 T AT95917788 T AT 95917788T AT E316333 T1 ATE316333 T1 AT E316333T1
Authority
AT
Austria
Prior art keywords
liposomes
liposome
therapeutic agents
luminal
sendai virus
Prior art date
Application number
AT95917788T
Other languages
English (en)
Inventor
Victor J Dzau
Kaneda Yasufumi
Original Assignee
Victor J Dzau
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Victor J Dzau filed Critical Victor J Dzau
Application granted granted Critical
Publication of ATE316333T1 publication Critical patent/ATE316333T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT95917788T 1994-05-10 1995-04-28 Verfahren zur in-vivo abgabe therapeutischer agenzien mittels liposomen ATE316333T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/241,372 US5631237A (en) 1992-12-22 1994-05-10 Method for producing in vivo delivery of therapeutic agents via liposomes

Publications (1)

Publication Number Publication Date
ATE316333T1 true ATE316333T1 (de) 2006-02-15

Family

ID=22910461

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95917788T ATE316333T1 (de) 1994-05-10 1995-04-28 Verfahren zur in-vivo abgabe therapeutischer agenzien mittels liposomen

Country Status (5)

Country Link
US (1) US5631237A (de)
EP (1) EP0759694B1 (de)
AT (1) ATE316333T1 (de)
DE (1) DE69534760D1 (de)
WO (1) WO1995030330A1 (de)

Families Citing this family (111)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6465188B1 (en) * 1990-06-11 2002-10-15 Gilead Sciences, Inc. Nucleic acid ligand complexes
DE69435100D1 (de) 1993-10-29 2008-06-26 Brigham & Womens Hospital Therapeutische verwendung von cis-element-fallen in vivo
US5670347A (en) 1994-05-11 1997-09-23 Amba Biosciences Llc Peptide-mediated gene transfer
FR2730637B1 (fr) 1995-02-17 1997-03-28 Rhone Poulenc Rorer Sa Composition pharmaceutique contenant des acides nucleiques, et ses utilisations
US8071737B2 (en) * 1995-05-04 2011-12-06 Glead Sciences, Inc. Nucleic acid ligand complexes
US6699843B2 (en) * 1995-06-07 2004-03-02 Gilead Sciences, Inc. Method for treatment of tumors using nucleic acid ligands to PDGF
US6007838A (en) † 1995-06-07 1999-12-28 The United States Of America As Represented By The Secretary Of The Army Process for making liposome preparation
US6229002B1 (en) * 1995-06-07 2001-05-08 Nexstar Pharmaceuticlas, Inc. Platelet derived growth factor (PDGF) nucleic acid ligand complexes
US5994315A (en) * 1995-06-07 1999-11-30 East Carolina University Low adenosine agent, composition, kit and method for treatment of airway disease
FR2739292B1 (fr) * 1995-09-28 1997-10-31 Rhone Poulenc Rorer Sa Composition pharmaceutique utile pour la transfection d'acides nucleiques et ses utilisations
US6344436B1 (en) * 1996-01-08 2002-02-05 Baylor College Of Medicine Lipophilic peptides for macromolecule delivery
US6096336A (en) * 1996-01-30 2000-08-01 The Stehlin Foundation For Cancer Research Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs
US6077834A (en) * 1996-02-09 2000-06-20 Cheng; Pi-Wan Receptor ligand-facilitated delivery of biologically active molecules
EP0906123A4 (de) * 1996-03-15 1999-05-26 Univ Florida ANGIOTENSINOGEN-mRNA SPEZIFISCHE OLIGONUKLEOTIDE
AU710170B2 (en) 1996-05-08 1999-09-16 Nika Health Products Limited Cationic virosomes as transfer system for genetic material
US6080728A (en) * 1996-07-16 2000-06-27 Mixson; A. James Carrier: DNA complexes containing DNA encoding anti-angiogenic peptides and their use in gene therapy
EP1342477A1 (de) * 1996-07-16 2003-09-10 Archibald James Mixson, M.D. Kationisches Vehikel: DNS Komplexe und ihre Verwendung in Gentherapie
US5837283A (en) 1997-03-12 1998-11-17 The Regents Of The University Of California Cationic lipid compositions targeting angiogenic endothelial cells
US7112338B2 (en) 1997-03-12 2006-09-26 The Regents Of The University Of California Cationic liposome delivery of taxanes to angiogenic blood vessels
US6126965A (en) * 1997-03-21 2000-10-03 Georgetown University School Of Medicine Liposomes containing oligonucleotides
US7262173B2 (en) 1997-03-21 2007-08-28 Georgetown University Chemosensitizing with liposomes containing oligonucleotides
EP1012331B1 (de) * 1997-07-01 2006-03-29 Isis Pharmaceuticals, Inc. Zusammensetzungen und verfahren zur verabreichung von oligonukleotiden über die speiseröhre
WO1999015643A2 (en) * 1997-09-25 1999-04-01 University Of Florida ANTISENSE OLIGONUCLEOTIDE COMPOSITIONS TARGETED TO ANGIOTENSI N CONVERTING ENZYME mRNA AND METHODS OF USE
US6734171B1 (en) * 1997-10-10 2004-05-11 Inex Pharmaceuticals Corp. Methods for encapsulating nucleic acids in lipid bilayers
US6221425B1 (en) 1998-01-30 2001-04-24 Advanced Cardiovascular Systems, Inc. Lubricious hydrophilic coating for an intracorporeal medical device
US6472375B1 (en) 1998-04-16 2002-10-29 John Wayne Cancer Institute DNA vaccine and methods for its use
US6432925B1 (en) 1998-04-16 2002-08-13 John Wayne Cancer Institute RNA cancer vaccine and methods for its use
US6129757A (en) * 1998-05-18 2000-10-10 Scimed Life Systems Implantable members for receiving therapeutically useful compositions
WO1999060012A1 (en) * 1998-05-21 1999-11-25 Isis Pharmaceuticals, Inc. Compositions and methods for non-parenteral delivery of oligonucleotides
US7241617B2 (en) * 1998-07-03 2007-07-10 Dnavec Research, Inc. Sendai viral vectors comprising foreign genes inserted between the R1 and R2 Loci
US6135976A (en) 1998-09-25 2000-10-24 Ekos Corporation Method, device and kit for performing gene therapy
US6958147B1 (en) 1998-10-26 2005-10-25 Licentia Ltd Use of VEGF-C to prevent restenosis
AU764660B2 (en) 1999-01-08 2003-08-28 Lonza Cologne Ag Use of the cell's own transport system for transferring nucleic acids across the nuclear membrane
WO2000058511A1 (en) 1999-03-26 2000-10-05 Ludwig Institute For Cancer Research Screening and therapy for lymphatic disorders involving the flt4 receptor tyrosine kinase (vegfr-3)
US6764820B2 (en) * 1999-03-26 2004-07-20 Ludwig Institute For Cancer Research Screening for lymphatic disorders involving the FLT4 receptor tyrosine kinase (VEGFR-3)
AU4206200A (en) 1999-04-05 2000-10-23 Adherex Technologies Inc. Compounds and methods for stimulating beta-catenin mediated gene expression and differentiation
US6352996B1 (en) 1999-08-03 2002-03-05 The Stehlin Foundation For Cancer Research Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs
US6586411B1 (en) * 2000-08-16 2003-07-01 Mayo Foundation For Medical Education And Research System for monitoring the location of transgenes
CA2381941A1 (en) * 1999-08-17 2001-02-22 Mayo Foundation For Medical Education And Research System for monitoring the expression and/or location of transgenes
US6632800B1 (en) 1999-08-17 2003-10-14 Mayo Foundation For Medical Education And Research System for monitoring the expression of transgenes
WO2001017511A1 (fr) * 1999-09-03 2001-03-15 Chugai Seiyaku Kabushiki Kaisha Procede de liberation intracellulaire prolongee de medicaments et de preparations
PT1142590E (pt) * 1999-10-29 2008-10-27 Anges Mg Inc Terapêutica génica para doença isquémica diabética
WO2001043778A1 (en) * 1999-12-17 2001-06-21 Gene Therapy Systems, Inc. Use of cationic lipids for intracellular protein delivery
US20030170210A1 (en) * 2000-01-19 2003-09-11 Ichiro Masaki Use of paramyxovirus vector in gene transfer into blood vessel
US6965010B2 (en) * 2000-02-25 2005-11-15 Licentia, Ltd. Materials and methods involving hybrid vascular endothelial growth factor DNAs and proteins
WO2002007776A1 (en) * 2000-07-26 2002-01-31 University Of Maryland Baltimore The protein kinase domain of the large subunit of herpes simplex type 2 ribonucleotide reductase (icp10pk) has anti-apoptopic activity
JP2002142770A (ja) * 2000-11-08 2002-05-21 Dnavec Research Inc 循環系への遺伝子送達用パラミクソウイルスベクター
EP1361896A2 (de) * 2001-01-23 2003-11-19 Boston Scientific Corporation Methode zur lokalen myocardialen injektion zur behandlung ischämischen myocardiums
US6509027B2 (en) 2001-02-12 2003-01-21 Supergen, Inc. Injectable pharmaceutical composition comprising coated particles of camptothecin
US6497896B2 (en) 2001-02-12 2002-12-24 Supergen, Inc. Method for administering camptothecins via injection of a pharmaceutical composition comprising microdroplets containing a camptothecin
US20040253272A1 (en) * 2001-08-02 2004-12-16 Yasufumi Kaneda Process for producing inactivated virus envelopes
US20040249130A1 (en) * 2002-06-18 2004-12-09 Martin Stanton Aptamer-toxin molecules and methods for using same
US20040022727A1 (en) * 2002-06-18 2004-02-05 Martin Stanton Aptamer-toxin molecules and methods for using same
JPWO2004035779A1 (ja) * 2002-08-27 2006-02-16 アンジェスＭｇ株式会社 ウイルスエンベロープを用いた生体分子の導入方法ならびにそのための組成物およびシステム
US20060099597A1 (en) * 2002-11-21 2006-05-11 Yasufumi Kaneda Method of isolating nucleic acid having desired functional property and kit therefor
US8853376B2 (en) 2002-11-21 2014-10-07 Archemix Llc Stabilized aptamers to platelet derived growth factor and their use as oncology therapeutics
US20040204435A1 (en) * 2003-04-09 2004-10-14 Joachim Liehr Alternating treatment with topoisomerase I and topoisomerase II inhibitors
AU2003252493A1 (en) * 2003-07-09 2005-01-28 Anges Mg, Inc. Pharmaceutical composition containing decoy and method of using the same
ES2357772T3 (es) * 2004-06-14 2011-04-29 Ishihara Sangyo Kaisha, Ltd. Composición liofilizada de envuelta viral inactivada con actividad de fusión de membrana.
EP2110667A1 (de) 2005-01-20 2009-10-21 University Of Rochester Mit Thioredoxin interagierendes Protein (TXNIP) als Regulator der Gefäßfunktion
EP1919944B1 (de) 2005-08-15 2011-03-23 Vegenics Pty Ltd Modifizierte vegf und pdgf mit verbesserten angiogenen eigenschaften
US7875602B2 (en) * 2005-10-21 2011-01-25 Sutter West Bay Hospitals Camptothecin derivatives as chemoradiosensitizing agents
EP1969003B8 (de) 2005-12-14 2010-11-10 Hermo Pharma Ltd. Verwendungen eines neurotrophischen Faktors
FI20070808A0 (fi) 2007-10-25 2007-10-25 Mart Saarma GDNF:n silmukointivariantit ja niiden käytöt
FI20080326A0 (fi) 2008-04-30 2008-04-30 Licentia Oy Neurotroofinen tekijä MANF ja sen käytöt
EP2345415B1 (de) 2008-09-16 2015-01-21 GenomIdea Inc. Therapeutisches/prophylaktisches mittel gegen prostatakrebs
WO2010040023A2 (en) 2008-10-03 2010-04-08 Government Of The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Methods and compositions for protein delivery
EP2440234A4 (de) 2009-06-10 2013-11-06 Univ New York Immunologische anzielung pathologischer tau-proteine
EP3252068A3 (de) 2009-10-12 2018-03-14 Larry J. Smith Verfahren und zusammensetzungen zur modulation der genexpression unter verwendung in-vivo- oder in-vitro-verabreichten arzneistoffen auf oligonukleotidbasis
US9951117B2 (en) 2010-09-02 2018-04-24 Mayo Foundation For Medical Education And Research Vesicular stomatitis viruses
CA2847413C (en) 2010-09-02 2018-05-22 Mayo Foundation For Medical Education And Research Vesicular stomatitis viruses
WO2012092341A1 (en) 2010-12-28 2012-07-05 University Of Rochester Methods of modifying insulin signaling using biliverdin reductase (bvr) and bvr derived peptides
ES2586411T3 (es) 2011-03-04 2016-10-14 New York University Macrociclos sustitutos de enlace de hidrógeno como moduladores de Ras
EP2710037B1 (de) 2011-05-19 2019-07-31 The Regents of The University of Michigan Alpha-2-integrin-bindemittel und verwendung zur hemmung der krebszellenproliferation
SI2753346T1 (sl) 2011-09-07 2020-09-30 Mount Sinai School Of Medicine Ceramidaza in diferenciacija celic
HUE049729T2 (hu) 2011-11-30 2020-10-28 Ludwig Inst For Cancer Res Ltd INKT cella modulátorok és ezek alkalmazásának módszerei
GB201120860D0 (en) 2011-12-05 2012-01-18 Cambridge Entpr Ltd Cancer immunotherapy
US9255086B2 (en) 2012-02-16 2016-02-09 New York University Control of hypoxia-inducible gene expression with oligooxopiperazine nonpeptidic helix mimetics
JP2015527296A (ja) 2012-03-26 2015-09-17 アメリカ合衆国 哺乳動物細胞へのパッケージングされたｒｎａの新規の送達
CA2874146C (en) 2012-06-01 2023-03-21 Icahn School Of Medicine At Mount Sinai Ceramide levels in the treatment and prevention of infections
US9321749B1 (en) 2012-07-25 2016-04-26 Globavir Biosciences, Inc. Heterocyclic compounds and uses thereof
US9499817B2 (en) 2012-09-06 2016-11-22 The University Of Chicago Antisense polynucleotides to induce exon skipping and methods of treating dystrophies
WO2014063155A1 (en) 2012-10-21 2014-04-24 University Of Rochester Thy1 (cd90) as a novel therapy to control adipose tissue accumulation
US20140287932A1 (en) 2012-10-25 2014-09-25 Whitehead Institute For Biomedical Research Super-enhancers and methods of use thereof
EP2956159A1 (de) 2013-02-14 2015-12-23 UCL Business Plc. Mittel zur induzierung von lymphangiogenese zur verwendung bei der behandlung von zystennierenerkrankungen
HUE048687T2 (hu) 2013-02-18 2020-08-28 Vegenics Pty Ltd Ligandum kötõ molekulák és alkalmazásaik
CA2905449A1 (en) 2013-03-14 2014-10-02 Icahn School Of Medicine At Mount Sinai Therapeutic acid ceramidase compositions and methods of making and using them
WO2014191630A2 (en) 2013-05-28 2014-12-04 Helsingin Yliopisto Non-human animal model encoding a non-functional manf gene
ES2864667T3 (es) 2013-08-16 2021-10-14 Univ Rochester Péptidos diseñados para la modulación de la barrera de unión estrecha
KR102467982B1 (ko) 2013-12-16 2022-11-16 더 유나이티드 스테이츠 오브 어메리카, 애즈 리프리젠티드 바이 더 세크러테리, 디파트먼트 오브 헬쓰 앤드 휴먼 서비씨즈 Vlp-레플리콘을 이용한 클래스 ii mhc 항원의 전달에 의한 암 면역요법
HUE052604T2 (hu) 2015-04-08 2021-05-28 Univ Chicago Készítmények és eljárások 2C típusú végtag-öv izomdisztrófia javítására exon-átugrás alkalmazásával
DK3288379T3 (da) 2015-05-01 2022-02-07 Univ Michigan Regents Peptidsammensætninger og anvendelsesmåder
EP3371211A4 (de) 2015-11-04 2019-08-21 Icahn School of Medicine at Mount Sinai Verfahren zur behandlung von tumoren und krebs sowie identifizierung von kandidatenpatienten für solch eine behandlung
WO2017189730A1 (en) 2016-04-26 2017-11-02 Icahn School Of Medicine At Mount Sinai Treatment of hippo pathway mutant tumors and methods of identifying subjects as candidates for treatment
EP3536329B1 (de) 2016-11-01 2022-08-31 Osaka University Antikrebsmittel mit hvj-e und neutralisierenden antikörpers gegen pd-1
CN110072537B (zh) 2016-12-06 2023-03-14 国立大学法人大阪大学 朊病毒样蛋白病用治疗药
CA3090354A1 (en) 2018-03-27 2019-10-03 Enzyvant Therapeutics Gmbh Farber disease markers and uses thereof
CN112654366A (zh) 2018-06-21 2021-04-13 罗切斯特大学 治疗或抑制亨廷顿病发作的方法
US20220088158A1 (en) 2019-01-23 2022-03-24 Aceragen, Inc. Method of ameliorating a pro-inflammatory immunophenotype in farber disease subjects by repeated administration of a recombinant human acid ceramidase
EP3923962A2 (de) 2019-02-13 2021-12-22 University of Rochester Gennetzwerke, die die remyelinisierung des menschlichen gehirns vermitteln
US20220249364A1 (en) 2019-06-05 2022-08-11 University Of Rochester Designed Inhibitors of Tight Junction Formation
US20230372397A1 (en) 2020-10-06 2023-11-23 Iovance Biotherapeutics, Inc. Treatment of nsclc patients with tumor infiltrating lymphocyte therapies
WO2022076606A1 (en) 2020-10-06 2022-04-14 Iovance Biotherapeutics, Inc. Treatment of nsclc patients with tumor infiltrating lymphocyte therapies
WO2022133149A1 (en) 2020-12-17 2022-06-23 Iovance Biotherapeutics, Inc. Treatment of cancers with tumor infiltrating lymphocytes
JP2023554395A (ja) 2020-12-17 2023-12-27 アイオバンス バイオセラピューティクス，インコーポレイテッド Ｃｔｌａ－４及びｐｄ－１阻害剤と併用した腫瘍浸潤リンパ球療法による治療
WO2022225981A2 (en) 2021-04-19 2022-10-27 Iovance Biotherapeutics, Inc. Chimeric costimulatory receptors, chemokine receptors, and the use of same in cellular immunotherapies
WO2023009716A1 (en) 2021-07-28 2023-02-02 Iovance Biotherapeutics, Inc. Treatment of cancer patients with tumor infiltrating lymphocyte therapies in combination with kras inhibitors
AR127482A1 (es) 2021-10-27 2024-01-31 Iovance Biotherapeutics Inc Sistemas y métodos para coordinar la fabricación de células para inmunoterapia específica de paciente
US20230270818A1 (en) 2021-11-02 2023-08-31 University Of Rochester Tcf7l2 mediated remyelination in the brain
WO2023086803A1 (en) 2021-11-10 2023-05-19 Iovance Biotherapeutics, Inc. Methods of expansion treatment utilizing cd8 tumor infiltrating lymphocytes
WO2023192998A1 (en) 2022-04-01 2023-10-05 Icahn School Of Medicine At Mount Sinai Treating orthopedic injury with a vector driving expression of acid ceramidase

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4377567A (en) * 1978-10-02 1983-03-22 The Procter & Gamble Company Lipid membrane drug delivery
US4871488A (en) * 1985-04-22 1989-10-03 Albany Medical College Of Union University Reconstituting viral glycoproteins into large phospholipid vesicles
US4663161A (en) * 1985-04-22 1987-05-05 Mannino Raphael J Liposome methods and compositions
US5077211A (en) * 1988-07-06 1991-12-31 Applied Genetics, Inc. Purification and administration of dna repair enzymes
US5264618A (en) * 1990-04-19 1993-11-23 Vical, Inc. Cationic lipids for intracellular delivery of biologically active molecules

Also Published As

Publication number Publication date
US5631237A (en) 1997-05-20
DE69534760D1 (de) 2006-04-13
WO1995030330A1 (en) 1995-11-16
EP0759694A1 (de) 1997-03-05
EP0759694B1 (de) 2006-01-25
EP0759694A4 (de) 2000-11-08

Similar Documents

Publication Publication Date Title
DE69534760D1 (de) Verfahren zur in-vivo abgabe therapeutischer agenzien mittels liposomen
DE69837274D1 (de) Verfahren zur verkapselung von nukleinsäuren in lipiddoppelschichten
DE69616523T2 (de) Verfahren zur baladung von lipidvesikeln
DE69708919D1 (de) Neue liposomkomplexe mit erhöhter systemischer verabreichung
WO1998019709A3 (en) Cationic reagents for transfection
FI971776A0 (fi) Yhdisteet ja koostumukset aktiivisten aineiden antamiseksi
EA199700197A1 (ru) Стабильные белково-фосфолипидные составы и способы их получения
ATE340560T1 (de) Verfahren und zusammensetzungen für nichtvirale gentherapie zur behandlung von hyperproliferativen krankheiten
EP0986372A4 (de) Vesikuläre komplexe und verfahren zu deren herstellung und verwendung
ES2119250T3 (es) Composiciones y metodos para estimular el crecimiento y diferenciacion de megacariocitos.
DE69906977D1 (de) In liposomen verkapselte nukleinsäurekomplexe
FI962799A (fi) Nukleiinihappoja sisältävä valmiste, sen valmistus ja käyttö
CA2259179A1 (en) Emulsion formulations for hydrophilic active agents
AU1724097A (en) Lipids and their use, for example, in liposomes
BR0108959A (pt) Composições de polox‰mero ou poloxamina melhoradas para distribuição de ácido nucléico
FI955319A (fi) 2-pyridyylimetyleenipolyatsamakrosyklofosfonihappoja, niiden komplekseja ja johdannaisia käytettäväksi vasta-aineina
ATE226430T1 (de) Verfahren zur herstellung hydro-monobenzoporhyrin photosensibilisatoren enthaltender liposomen
DK0749317T3 (da) Terapeutiske anvendelser af dimerprodukter af baktericidt/permeabilitetsforøgende protein
ATE445417T1 (de) Ex vivo verfahren und zusammensetzungen zur nukleinsäureverabreichung
ATE362991T1 (de) Kondensierte plasmid-liposome komplex zur transfektion
Nakamura et al. Uptake and gene expression of naked plasmid DNA in cultured brain microvessel endothelial cells
ATE233321T1 (de) Verbesserungen in der herstellung von proteinen in wirtszellen
WO1999065461A3 (en) Cationic amphiphile micellar complexes
RAHMAN et al. CATIONIC AND ANIONIC LIPOSOMAL VECTORS: A COMPARATIVE STUDY
DE59704883D1 (de) Komplex aus antigen und zellbestandteil, verfahren zur dessen herstellung und therapeutische verwendungen

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties