ATE315576T1 - Verbesserte chemische anknüpfung mit drei oder mehreren bestandteilen - Google Patents

Verbesserte chemische anknüpfung mit drei oder mehreren bestandteilen

Info

Publication number
ATE315576T1
ATE315576T1 AT02749204T AT02749204T ATE315576T1 AT E315576 T1 ATE315576 T1 AT E315576T1 AT 02749204 T AT02749204 T AT 02749204T AT 02749204 T AT02749204 T AT 02749204T AT E315576 T1 ATE315576 T1 AT E315576T1
Authority
AT
Austria
Prior art keywords
ligation
ingredients
chemical bonding
improved chemical
intermediates
Prior art date
Application number
AT02749204T
Other languages
English (en)
Inventor
Matteo Villain
Hubert Gaertner
Original Assignee
Geneprot Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Geneprot Inc filed Critical Geneprot Inc
Application granted granted Critical
Publication of ATE315576T1 publication Critical patent/ATE315576T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
    • C07K1/026—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution by fragment condensation in solution
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Chemical And Physical Treatments For Wood And The Like (AREA)
AT02749204T 2001-06-05 2002-05-31 Verbesserte chemische anknüpfung mit drei oder mehreren bestandteilen ATE315576T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0113657.1A GB0113657D0 (en) 2001-06-05 2001-06-05 Improved native chemical ligation with three or more components

Publications (1)

Publication Number Publication Date
ATE315576T1 true ATE315576T1 (de) 2006-02-15

Family

ID=9915947

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02749204T ATE315576T1 (de) 2001-06-05 2002-05-31 Verbesserte chemische anknüpfung mit drei oder mehreren bestandteilen

Country Status (8)

Country Link
US (1) US7662914B2 (de)
EP (1) EP1392718B1 (de)
JP (1) JP4327589B2 (de)
AT (1) ATE315576T1 (de)
CA (1) CA2446152A1 (de)
DE (1) DE60208684T2 (de)
GB (1) GB0113657D0 (de)
WO (1) WO2002098902A2 (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002074956A2 (en) * 2001-03-20 2002-09-26 Prescient Neuropharma Inc. Dopaminergic neuronal survival-promoting factors and uses thereof
CA2487342A1 (en) * 2002-06-10 2003-12-24 Geneprot, Inc. Post-cleavage sulfur deprotection for convergent protein synthesis by chemical ligation
US7452969B2 (en) 2002-08-30 2008-11-18 Licentia Ltd Neurotrophic factor protein and uses thereof
WO2007068784A1 (en) 2005-12-14 2007-06-21 Licentia Ltd Novel neurotrophic factor protein and uses thereof
US7638491B2 (en) 2004-12-22 2009-12-29 Ambrx, Inc. Therapies using non-natural amino acids and polypeptides
MX2007007580A (es) 2004-12-22 2007-12-11 Ambrx Inc Hormona del crecimiento humana modificada.
JP5517450B2 (ja) 2005-03-10 2014-06-11 バイオンテック アーゲー 二量体または多量体のマイクロタンパク質
EA013121B1 (ru) 2005-03-31 2010-02-26 Амилин Фармасьютикалз, Инк. Амилин и агонисты амилина для лечения психиатрических заболеваний и расстройств
PT2339014E (pt) 2005-11-16 2015-10-13 Ambrx Inc Métodos e composições compreendendo aminoácidos não-naturais
CN106008699A (zh) 2006-09-08 2016-10-12 Ambrx公司 经修饰的人类血浆多肽或Fc骨架和其用途
WO2008097536A2 (en) 2007-02-05 2008-08-14 Amylin Pharmaceuticals, Inc. Compositions and methods for treating psychiatric diseases and disorders
EP2068909B1 (de) 2007-03-30 2012-04-25 Ambrx, Inc. Modifizierte fgf-21 polypeptide und ihre verwendung
AU2008247815B2 (en) 2007-05-02 2012-09-06 Ambrx, Inc. Modified interferon beta polypeptides and their uses
JP2010537984A (ja) * 2007-08-28 2010-12-09 イプセン ファルマ ソシエテ パール アクシオン サンプリフィエ ポリペプチドおよび蛋白質の化学合成のための方法および中間体
JP2010538063A (ja) * 2007-09-04 2010-12-09 イプセン ファルマ ソシエテ パール アクシオン サンプリフィエ ポリペプチドおよび蛋白質の化学的合成のための方法および中間体
JP5547083B2 (ja) 2007-11-20 2014-07-09 アンブルックス，インコーポレイテッド 修飾されたインスリンポリペプチドおよびそれらの使用
US10138283B2 (en) 2008-07-23 2018-11-27 Ambrx, Inc. Modified bovine G-CSF polypeptides and their uses
MX348657B (es) 2008-09-26 2017-06-21 Ambrx Inc Microorganismos y vacunas dependientes de replicacion de aminoacidos no naturales.
BRPI1016151B1 (pt) * 2009-06-26 2021-01-19 Glytech, Inc. processo para produção de um tioéster de peptídeo, processos para a produção de um polipeptídeo, processo para a produção de um segundo intermediário utilizado para o processo para a produção do tioéster de peptídeo e processo para a remoção de uma marca para a purificação adicionada a um lado terminal c de uma proteína recombinante
AU2010341516B2 (en) 2009-12-21 2014-01-16 Ambrx, Inc. Modified bovine somatotropin polypeptides and their uses
CA2784800A1 (en) 2009-12-21 2011-07-21 Ambrx, Inc. Modified porcine somatotropin polypeptides and their uses
US20110187875A1 (en) * 2010-02-04 2011-08-04 Intouch Technologies, Inc. Robot face used in a sterile environment
US9023957B2 (en) 2010-07-06 2015-05-05 Nanyang Technological University Compound for use in peptide synthesis
SG10201506443TA (en) 2010-08-17 2015-10-29 Ambrx Inc Modified relaxin polypeptides and their uses
AR083006A1 (es) 2010-09-23 2013-01-23 Lilly Co Eli Formulaciones para el factor estimulante de colonias de granulocitos (g-csf) bovino y variantes de las mismas
LT3412302T (lt) 2014-10-24 2021-07-26 Bristol-Myers Squibb Company Modifikuoti fgf-21 polipeptidai ir jų panaudojimai
CN107903306B (zh) * 2017-12-27 2020-07-03 无限极（中国）有限公司 一种合成多肽及其合成方法和应用
CN110183509A (zh) * 2019-04-18 2019-08-30 湖州泽溪源生物科技有限公司 一种选择性脱除多肽中半胱氨酸上巯基的新方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60142952A (ja) * 1983-12-28 1985-07-29 Nippon Kayaku Co Ltd 光学活性システインの製造法
US5589356A (en) * 1993-06-21 1996-12-31 Vanderbilt University Litigation of sidechain unprotected peptides via a masked glycoaldehyde ester and O,N-acyl rearrangement
WO1996034878A1 (en) * 1995-05-04 1996-11-07 The Scripps Research Institute Synthesis of proteins by native chemical ligation
JP4358307B2 (ja) * 1996-12-24 2009-11-04 ザ スクリップス リサーチ インスティテュート 一般的化学結合
AU745094B2 (en) * 1997-06-13 2002-03-14 Gryphon Sciences Solid phase native chemical ligation of unprotected or N-terminal cysteine protected peptides in aqueous solution
DE19919336A1 (de) 1999-04-27 2000-11-16 Consortium Elektrochem Ind Verfahren zur Ringspaltung von Thiazolidinderivaten

Also Published As

Publication number Publication date
WO2002098902A3 (en) 2003-06-05
EP1392718A2 (de) 2004-03-03
JP4327589B2 (ja) 2009-09-09
WO2002098902A2 (en) 2002-12-12
GB0113657D0 (en) 2001-07-25
DE60208684D1 (de) 2006-04-06
DE60208684T2 (de) 2006-08-31
US7662914B2 (en) 2010-02-16
JP2005515160A (ja) 2005-05-26
CA2446152A1 (en) 2002-12-12
US20050064538A1 (en) 2005-03-24
EP1392718B1 (de) 2006-01-11

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