ATE314461T1 - Vermehrte und genetisch modifizierte populationen menschlicher hämatopoitischer stammzellen - Google Patents
Vermehrte und genetisch modifizierte populationen menschlicher hämatopoitischer stammzellenInfo
- Publication number
- ATE314461T1 ATE314461T1 AT99907460T AT99907460T ATE314461T1 AT E314461 T1 ATE314461 T1 AT E314461T1 AT 99907460 T AT99907460 T AT 99907460T AT 99907460 T AT99907460 T AT 99907460T AT E314461 T1 ATE314461 T1 AT E314461T1
- Authority
- AT
- Austria
- Prior art keywords
- stem cells
- human
- genetically modified
- hematopoietic stem
- modified populations
- Prior art date
Links
- 210000000130 stem cell Anatomy 0.000 title 1
- 102000036693 Thrombopoietin Human genes 0.000 abstract 3
- 108010041111 Thrombopoietin Proteins 0.000 abstract 3
- 210000003958 hematopoietic stem cell Anatomy 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 3
- 102000004889 Interleukin-6 Human genes 0.000 abstract 2
- 108090001005 Interleukin-6 Proteins 0.000 abstract 2
- 108700014844 flt3 ligand Proteins 0.000 abstract 2
- 229940100601 interleukin-6 Drugs 0.000 abstract 2
- 210000004027 cell Anatomy 0.000 abstract 1
- 238000012258 culturing Methods 0.000 abstract 1
- 238000001476 gene delivery Methods 0.000 abstract 1
- 230000003394 haemopoietic effect Effects 0.000 abstract 1
- 102000040430 polynucleotide Human genes 0.000 abstract 1
- 108091033319 polynucleotide Proteins 0.000 abstract 1
- 239000002157 polynucleotide Substances 0.000 abstract 1
- 230000001737 promoting effect Effects 0.000 abstract 1
- 230000004083 survival effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/125—Stem cell factor [SCF], c-kit ligand [KL]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/145—Thrombopoietin [TPO]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/26—Flt-3 ligand (CD135L, flk-2 ligand)
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Hematology (AREA)
- Biotechnology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Developmental Biology & Embryology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1942898A | 1998-02-05 | 1998-02-05 | |
| US7683698P | 1998-03-04 | 1998-03-04 | |
| US09/237,291 US20030044978A1 (en) | 1998-02-05 | 1999-01-25 | Expanded and genetically modified populations of human hematopoietic stem cells |
| PCT/EP1999/000597 WO1999040180A2 (en) | 1998-02-05 | 1999-01-29 | Expanded and genetically modified populations of human hematopoietic stem cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE314461T1 true ATE314461T1 (de) | 2006-01-15 |
Family
ID=27361219
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99907460T ATE314461T1 (de) | 1998-02-05 | 1999-01-29 | Vermehrte und genetisch modifizierte populationen menschlicher hämatopoitischer stammzellen |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP1053302B1 (de) |
| JP (1) | JP2002502599A (de) |
| AT (1) | ATE314461T1 (de) |
| AU (1) | AU755344B2 (de) |
| CA (1) | CA2318819A1 (de) |
| DE (1) | DE69929174T2 (de) |
| ES (1) | ES2252932T3 (de) |
| IL (1) | IL137304A (de) |
| NZ (2) | NZ505997A (de) |
| WO (1) | WO1999040180A2 (de) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7547674B2 (en) * | 2001-06-06 | 2009-06-16 | New York Medical College | Methods and compositions for the repair and/or regeneration of damaged myocardium |
| US7862810B2 (en) | 2000-07-31 | 2011-01-04 | New York Medical College | Methods and compositions for the repair and/or regeneration of damaged myocardium |
| AU2001284695A1 (en) | 2000-07-31 | 2002-02-13 | New York Medical College | Methods and compositions for the repair and/or regeneration of damaged myocardium |
| AU2001294577A1 (en) * | 2000-09-21 | 2002-04-02 | Schering Corporation | Methods for preparing interferon producing dentitric cells |
| US20060153813A1 (en) * | 2003-07-06 | 2006-07-13 | Quesenberry Peter J | Methods of producing differentiated hematopoietic cells for treatment of cytopenia |
| GB0329449D0 (en) * | 2003-12-19 | 2004-01-28 | Omnicyte Ltd | Stem cells |
| EP1773981A1 (de) * | 2004-07-12 | 2007-04-18 | Sorin Group Italia S.R.L. | Vorrichtung und verfahren zur anzucht menschlicher zellen |
| ES2538305T3 (es) | 2004-10-25 | 2015-06-18 | Cellerant Therapeutics, Inc. | Métodos para expandir poblaciones de células mieloides y usos de las mismas |
| JP5341525B2 (ja) | 2006-02-14 | 2013-11-13 | セルラント セラピューティクス，インコーポレイティド | 造血幹細胞の生着を増強するための方法および組成物 |
| US9115341B2 (en) | 2007-12-05 | 2015-08-25 | Nissan Chemical Industries, Ltd. | Method for expanding hematopoietic stem cells using heterocyclic compound |
| JP5573160B2 (ja) * | 2007-12-05 | 2014-08-20 | 日産化学工業株式会社 | ヘテロ環化合物による造血幹細胞の増幅方法 |
| WO2009072624A1 (ja) * | 2007-12-05 | 2009-06-11 | Nissan Chemical Industries, Ltd. | ヘテロ環化合物による造血幹細胞の増幅方法 |
| GB0818725D0 (en) | 2008-10-13 | 2008-11-19 | Habib Nagy A | Pharmaceutical composition |
| ES2336637B1 (es) * | 2009-11-02 | 2011-01-21 | Banc De Sang I Teixits | Procedimiento parala expansion indiferenciada u orientada a linaje mieloide de celulas madre hematopoyeticas procedentes de sangre de cordonumbilical, sangre periferica movilizada o medula osea. |
| DK3194602T3 (da) * | 2014-09-18 | 2020-02-17 | Univ Montreal | Forbindelser og fremgangsmåder til at forstærke virusgenoverførsel til humane hæmatopoietiske celler |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ314644A (en) * | 1993-05-24 | 2000-11-24 | Immunex Corp | Use of flt3-ligands as a growth stimulator of stem cells in the transplantation of tissue |
| US6060052A (en) * | 1995-10-30 | 2000-05-09 | Systemix, Inc. | Methods for use of Mpl ligands with primitive human hematopoietic stem cells |
-
1999
- 1999-01-29 IL IL13730499A patent/IL137304A/xx not_active IP Right Cessation
- 1999-01-29 NZ NZ505997A patent/NZ505997A/en unknown
- 1999-01-29 WO PCT/EP1999/000597 patent/WO1999040180A2/en not_active Ceased
- 1999-01-29 JP JP2000530594A patent/JP2002502599A/ja active Pending
- 1999-01-29 CA CA002318819A patent/CA2318819A1/en not_active Abandoned
- 1999-01-29 DE DE69929174T patent/DE69929174T2/de not_active Expired - Fee Related
- 1999-01-29 AT AT99907460T patent/ATE314461T1/de not_active IP Right Cessation
- 1999-01-29 AU AU27212/99A patent/AU755344B2/en not_active Ceased
- 1999-01-29 EP EP99907460A patent/EP1053302B1/de not_active Expired - Lifetime
- 1999-01-29 ES ES99907460T patent/ES2252932T3/es not_active Expired - Lifetime
-
2003
- 2003-02-18 NZ NZ524254A patent/NZ524254A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1053302B1 (de) | 2005-12-28 |
| AU755344B2 (en) | 2002-12-12 |
| IL137304A0 (en) | 2001-07-24 |
| WO1999040180A3 (en) | 1999-10-28 |
| WO1999040180A2 (en) | 1999-08-12 |
| WO1999040180A9 (en) | 1999-11-25 |
| AU2721299A (en) | 1999-08-23 |
| IL137304A (en) | 2005-09-25 |
| DE69929174D1 (de) | 2006-02-02 |
| JP2002502599A (ja) | 2002-01-29 |
| ES2252932T3 (es) | 2006-05-16 |
| DE69929174T2 (de) | 2006-08-31 |
| CA2318819A1 (en) | 1999-08-12 |
| NZ505997A (en) | 2003-08-29 |
| NZ524254A (en) | 2004-11-26 |
| EP1053302A2 (de) | 2000-11-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |