ATE314366T1 - Neue ester hydroxy-substituierter stickstoffheterocyclen als antagonisten des muskarinischen m3 rezeptors, verfahren zu deren herstellung sowie deren verwendung als arzneimittel - Google Patents

Neue ester hydroxy-substituierter stickstoffheterocyclen als antagonisten des muskarinischen m3 rezeptors, verfahren zu deren herstellung sowie deren verwendung als arzneimittel

Info

Publication number
ATE314366T1
ATE314366T1 AT03717295T AT03717295T ATE314366T1 AT E314366 T1 ATE314366 T1 AT E314366T1 AT 03717295 T AT03717295 T AT 03717295T AT 03717295 T AT03717295 T AT 03717295T AT E314366 T1 ATE314366 T1 AT E314366T1
Authority
AT
Austria
Prior art keywords
alkyl
new
quaternized
halo
formula
Prior art date
Application number
AT03717295T
Other languages
German (de)
English (en)
Inventor
Michael P Pieper
Gerald Pohl
Georg Speck
Matthias Grauert
Steffen Breitfelder
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Application granted granted Critical
Publication of ATE314366T1 publication Critical patent/ATE314366T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT03717295T 2002-04-13 2003-04-11 Neue ester hydroxy-substituierter stickstoffheterocyclen als antagonisten des muskarinischen m3 rezeptors, verfahren zu deren herstellung sowie deren verwendung als arzneimittel ATE314366T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10216339A DE10216339A1 (de) 2002-04-13 2002-04-13 Neue Ester hydroxy-substituierter Stickstoffheterocyclen, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel
PCT/EP2003/003765 WO2003087096A1 (de) 2002-04-13 2003-04-11 Neue ester hydroxy-substituierter stickstoffheterocyclen als antagonisten des muskarinischen m3 rezeptors, vefahren zu deren herstellung sowie deren verwendung als arzneimittel

Publications (1)

Publication Number Publication Date
ATE314366T1 true ATE314366T1 (de) 2006-01-15

Family

ID=28458782

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03717295T ATE314366T1 (de) 2002-04-13 2003-04-11 Neue ester hydroxy-substituierter stickstoffheterocyclen als antagonisten des muskarinischen m3 rezeptors, verfahren zu deren herstellung sowie deren verwendung als arzneimittel

Country Status (8)

Country Link
EP (1) EP1497288B1 (enExample)
JP (1) JP4589006B2 (enExample)
AT (1) ATE314366T1 (enExample)
AU (1) AU2003222290A1 (enExample)
CA (1) CA2482637C (enExample)
DE (2) DE10216339A1 (enExample)
ES (1) ES2254925T3 (enExample)
WO (1) WO2003087096A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1626970B1 (en) 2003-05-28 2009-07-08 Theravance, Inc. Azabicycloalkane compounds as muscarinic receptor antagonists
CN101553493B (zh) 2006-07-19 2012-07-04 阿斯利康(瑞典)有限公司 三环螺哌啶化合物、它们的合成和它们作为趋化因子受体活性调节剂的用途
BRPI0816219B8 (pt) 2007-09-07 2021-05-25 Theravance Biopharma R&D Ip Llc compostos contendo guanidina úteis como antagonistas de receptor muscarínico, composição farmacêutica e uso
SI2297106T1 (sl) 2008-05-27 2014-09-30 Astrazeneca Ab Fenoksipiridinilamid derivati in njih uporaba pri zdravljenju PDE4 posredovanih bolezenskih stanj
CA2788364C (en) * 2010-01-28 2017-10-31 Theron Pharmaceuticals, Inc. 7-azoniabicyclo[2.2.1]heptane derivatives, methods of production, and pharmaceutical uses thereof
US10342786B2 (en) 2017-10-05 2019-07-09 Fulcrum Therapeutics, Inc. P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD
CA3078232A1 (en) 2017-10-05 2019-04-11 Fulcrum Therapeutics, Inc. Use of p38 inhibitors to reduce expression of dux4

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4108393A1 (de) * 1991-03-15 1992-09-17 Boehringer Ingelheim Kg Neue ester bi- und tricyclischer aminoalkohole, ihre herstellung und ihre verwendung in arzneimitteln
CA2415468A1 (en) * 2000-07-11 2003-01-10 Yoshio Ogino Ester derivatives

Also Published As

Publication number Publication date
CA2482637A1 (en) 2003-10-23
JP4589006B2 (ja) 2010-12-01
EP1497288B1 (de) 2005-12-28
DE50302065D1 (de) 2006-02-02
CA2482637C (en) 2011-09-20
WO2003087096A1 (de) 2003-10-23
DE10216339A1 (de) 2003-10-23
JP2005529110A (ja) 2005-09-29
AU2003222290A1 (en) 2003-10-27
ES2254925T3 (es) 2006-06-16
EP1497288A1 (de) 2005-01-19

Similar Documents

Publication Publication Date Title
DE50103666D1 (de) Kristallines monohydrat von tiotropiumbromid, verfahren zu dessen herstellung und dessen verwendung zur herstellung eines arzneimittels
ATE86110T1 (de) Behandlung von gastrointestinalkrankheiten durch anwendung von 5-ht3-antagonisten.
NO20061833L (no) Aerosolformulgering for inhalering, inneholdende anticholinergt middel
RU93058534A (ru) Применение производных тетрагидрокарбазола в качестве антагонистов 5-нт*001 рецептора, производные тетрагидрокарбазола, способ их получения, способ лечения и фармацевтическая композиция
AR047557A1 (es) Compuestos derivados de piridazina y su uso como agentes terapeuticos
HK1046686A1 (zh) 喹唑啉衍生物及其作為藥物的應用
CA2523261A1 (en) Fused pyrimidine derivatives with crf activity
ATE359268T1 (de) Derivate von n-(phenyl(alkylpiperidin-2- yl)methyl)benzamid, verfahren zu deren herstellung und deren anwendung in therapeutika
ATE314366T1 (de) Neue ester hydroxy-substituierter stickstoffheterocyclen als antagonisten des muskarinischen m3 rezeptors, verfahren zu deren herstellung sowie deren verwendung als arzneimittel
DE50307659D1 (de) Inhalative arzneimittel enthaltend ein neues anticholinergikum in kombination mit corticosteroiden und betamimetika
EP1657242A4 (en) imidazopyridine
WO2002085861A8 (en) Imidazolidine compounds and their use as cxcr3 antagonists
JP2012513390A5 (enExample)
WO2005040345A3 (en) 4-azole substituted imidazole compositions useful as inhibitors or c-met receptor tyrosine kinase
MY137045A (en) Medicaments comprising steroids and a novel anticholinergic
DE69230141D1 (de) Von pyridin und imidazol abgeleitete mittel für kardiovaskuläre krankheiten
DE3864636D1 (de) Amidverbindungen, verfahren zu ihrer herstellung und zusammensetzung zur aktivierung gastromotorischer funktionen.
MX2008008694A (es) Compuestos conjugados de amina terapeutica-arilsulfonamida.
ZA200409676B (en) Novel drug compositions based on novel anticholinergics and inhibitors of EGFR-kinase
DK0556813T3 (da) Amfotere tricykliske forbindelser som antihistaminske og antiallergiske midler
SE0104333D0 (sv) Therapeutic agents
PL182857B1 (pl) Nowe pochodne tetraliny, sposób wytwarzania nowych pochodnych tetraliny oraz kompozycja farmaceutyczna
ATE341547T1 (de) Difurylglykolsäuretropenolester als anticholinergika
KR870003098A (ko) 치환된 3-(4-페닐-1-피페라지닐)알킬퀴나졸린-2,4-(1h,3h)디온의 제조방법
ATE123493T1 (de) 3-(1h-indazol-3-yl)-4-pyridiname, verfahren und zwischenprodukte zu ihrer herstellung und ihre verwendung als arzneimittel.