ATE311881T1 - Stabilisierte arzneizusammensetzungen von oxapenem-3-carbonsäuren durch gefriertrocknen mit pharmazeutischen trägermitteln - Google Patents
Stabilisierte arzneizusammensetzungen von oxapenem-3-carbonsäuren durch gefriertrocknen mit pharmazeutischen trägermittelnInfo
- Publication number
- ATE311881T1 ATE311881T1 AT01974492T AT01974492T ATE311881T1 AT E311881 T1 ATE311881 T1 AT E311881T1 AT 01974492 T AT01974492 T AT 01974492T AT 01974492 T AT01974492 T AT 01974492T AT E311881 T1 ATE311881 T1 AT E311881T1
- Authority
- AT
- Austria
- Prior art keywords
- oxapenem
- freeze
- drying
- medicinal compositions
- carbonic acids
- Prior art date
Links
- 238000004108 freeze drying Methods 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- CREMABGTGYGIQB-UHFFFAOYSA-N carbon carbon Chemical compound C.C CREMABGTGYGIQB-UHFFFAOYSA-N 0.000 abstract 1
- 239000011203 carbon fibre reinforced carbon Substances 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0046—Ear
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/424—Oxazoles condensed with heterocyclic ring systems, e.g. clavulanic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Otolaryngology (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP00309207A EP1199077A1 (de) | 2000-10-19 | 2000-10-19 | Stabilisierte Oxapenem-3-carbonsäure enthaltende Arzneimittel durch Gefriergetrocknen mit pharmazeutischen Trägern |
| PCT/GB2001/004530 WO2002032424A1 (en) | 2000-10-19 | 2001-10-11 | Stable compositions of oxapenem-3-carboxylic acids by co-lyophilisation with pharmaceutical carriers |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE311881T1 true ATE311881T1 (de) | 2005-12-15 |
Family
ID=8173326
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01974492T ATE311881T1 (de) | 2000-10-19 | 2001-10-11 | Stabilisierte arzneizusammensetzungen von oxapenem-3-carbonsäuren durch gefriertrocknen mit pharmazeutischen trägermitteln |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20040043980A1 (de) |
| EP (2) | EP1199077A1 (de) |
| JP (1) | JP2004511520A (de) |
| AT (1) | ATE311881T1 (de) |
| AU (1) | AU2001294007A1 (de) |
| CY (1) | CY1106058T1 (de) |
| DE (1) | DE60115687T2 (de) |
| DK (1) | DK1326608T3 (de) |
| ES (1) | ES2250483T3 (de) |
| HK (1) | HK1053612A1 (de) |
| WO (1) | WO2002032424A1 (de) |
| ZA (1) | ZA200302804B (de) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002032423A1 (en) * | 2000-10-19 | 2002-04-25 | Amura Limited | Pharmaceutical compositions containing oxapenem-3-carboxylic acids |
| GB0106428D0 (en) * | 2001-03-15 | 2001-05-02 | Amura Ltd | Antibacterial composition |
| AR039475A1 (es) * | 2002-05-01 | 2005-02-23 | Wyeth Corp | 6-alquiliden-penems triciclicos como inhibidores de beta-lactamasa |
| AR039774A1 (es) * | 2002-05-01 | 2005-03-02 | Wyeth Corp | 6-alquiliden-penems biciclicos como inhibidores de beta-lactamasas |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US43980A (en) * | 1864-08-30 | Improvement in horse-rakes | ||
| US176349A (en) * | 1876-04-18 | Improvement in carbureters | ||
| GB2045236A (en) * | 1979-03-26 | 1980-10-29 | Hoechst Uk Ltd | Oxapenem derivatives |
| US4293555A (en) * | 1979-04-17 | 1981-10-06 | Merck & Co., Inc. | 6- and 6,6-Disubstituted-2-substituted-oxapen-2-em-3-carboxylic acids |
| DE2925009A1 (de) * | 1979-06-21 | 1981-01-08 | Basf Ag | Zubereitung fuer substanzen, verfahren zu deren herstellung und deren verwendung |
| DE3725375A1 (de) * | 1987-07-31 | 1989-02-09 | Bayer Ag | Stabile oxapenem-3-carbonsaeuren |
| DE3833693A1 (de) * | 1988-10-04 | 1990-04-05 | Bayer Ag | Stabile oxapenem-3-carbonsaeuren und ihre verwendung als ss-lactamasehemmer |
| DE4027928A1 (de) * | 1990-09-04 | 1992-03-05 | Bayer Ag | Neue 2-tert.substituierte methyl-oxapenem-3-carbonsaeuren und -ester, verfahren zu ihrer herstellung und ihre verwendung |
| DE4142423A1 (de) * | 1991-12-20 | 1993-06-24 | Pfaendler Hans Rudolf | ((ls)-hydroxyalkyl)oxapenem-3-carbonsaeuren und ihre verwendung als betalactamasehemmer |
| JP3865770B2 (ja) * | 1994-04-25 | 2007-01-10 | スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー | ベータ−ラクタム抗生物質と組み合わせてベータ−ラクタマーゼ阻害性ペネムを含有する医薬製剤および細菌感染の治療におけるそれらの使用 |
| AU5985596A (en) * | 1995-05-31 | 1996-12-18 | Microcide Pharmaceuticals, Inc. | Cephalosporin antibiotics |
-
2000
- 2000-10-19 EP EP00309207A patent/EP1199077A1/de not_active Withdrawn
-
2001
- 2001-10-11 ES ES01974492T patent/ES2250483T3/es not_active Expired - Lifetime
- 2001-10-11 DK DK01974492T patent/DK1326608T3/da active
- 2001-10-11 AT AT01974492T patent/ATE311881T1/de not_active IP Right Cessation
- 2001-10-11 AU AU2001294007A patent/AU2001294007A1/en not_active Abandoned
- 2001-10-11 EP EP01974492A patent/EP1326608B1/de not_active Expired - Lifetime
- 2001-10-11 WO PCT/GB2001/004530 patent/WO2002032424A1/en active IP Right Grant
- 2001-10-11 DE DE60115687T patent/DE60115687T2/de not_active Expired - Fee Related
- 2001-10-11 JP JP2002535662A patent/JP2004511520A/ja active Pending
- 2001-10-11 US US10/399,703 patent/US20040043980A1/en not_active Abandoned
-
2003
- 2003-04-10 ZA ZA200302804A patent/ZA200302804B/en unknown
- 2003-08-21 HK HK03105980A patent/HK1053612A1/xx not_active IP Right Cessation
-
2005
- 2005-12-14 CY CY20051101547T patent/CY1106058T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA200302804B (en) | 2005-02-23 |
| DK1326608T3 (da) | 2006-02-06 |
| JP2004511520A (ja) | 2004-04-15 |
| EP1199077A1 (de) | 2002-04-24 |
| CY1106058T1 (el) | 2011-04-06 |
| EP1326608A1 (de) | 2003-07-16 |
| HK1053612A1 (en) | 2003-10-31 |
| EP1326608B1 (de) | 2005-12-07 |
| WO2002032424A1 (en) | 2002-04-25 |
| DE60115687D1 (de) | 2006-01-12 |
| ES2250483T3 (es) | 2006-04-16 |
| AU2001294007A1 (en) | 2002-04-29 |
| US20040043980A1 (en) | 2004-03-04 |
| DE60115687T2 (de) | 2006-06-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1326608 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |