HK1053612A1 - Stabile compositions of oxapenem-3-carboxylic acids by colyophilisation with pharmaceutical carriers - Google Patents
Stabile compositions of oxapenem-3-carboxylic acids by colyophilisation with pharmaceutical carriersInfo
- Publication number
- HK1053612A1 HK1053612A1 HK03105980A HK03105980A HK1053612A1 HK 1053612 A1 HK1053612 A1 HK 1053612A1 HK 03105980 A HK03105980 A HK 03105980A HK 03105980 A HK03105980 A HK 03105980A HK 1053612 A1 HK1053612 A1 HK 1053612A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- colyophilisation
- oxapenem
- carboxylic acids
- pharmaceutical carriers
- pharmaceutically acceptable
- Prior art date
Links
- 239000003937 drug carrier Substances 0.000 title abstract 2
- NTSDTZZTKYEUBA-YFKPBYRVSA-N (5S)-7-oxo-6-oxa-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid Chemical group OC(=O)C1=CS[C@@H]2OC(=O)N12 NTSDTZZTKYEUBA-YFKPBYRVSA-N 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- CREMABGTGYGIQB-UHFFFAOYSA-N carbon carbon Chemical compound C.C CREMABGTGYGIQB-UHFFFAOYSA-N 0.000 abstract 1
- 239000011203 carbon fibre reinforced carbon Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0046—Ear
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/424—Oxazoles condensed with heterocyclic ring systems, e.g. clavulanic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Otolaryngology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP00309207A EP1199077A1 (en) | 2000-10-19 | 2000-10-19 | Stable compositions of oxapenem-3-carboxylic acids by Co-lyophilisation with pharmaceutical carriers |
| PCT/GB2001/004530 WO2002032424A1 (en) | 2000-10-19 | 2001-10-11 | Stable compositions of oxapenem-3-carboxylic acids by co-lyophilisation with pharmaceutical carriers |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1053612A1 true HK1053612A1 (en) | 2003-10-31 |
Family
ID=8173326
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK03105980A HK1053612A1 (en) | 2000-10-19 | 2003-08-21 | Stabile compositions of oxapenem-3-carboxylic acids by colyophilisation with pharmaceutical carriers |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20040043980A1 (xx) |
| EP (2) | EP1199077A1 (xx) |
| JP (1) | JP2004511520A (xx) |
| AT (1) | ATE311881T1 (xx) |
| AU (1) | AU2001294007A1 (xx) |
| CY (1) | CY1106058T1 (xx) |
| DE (1) | DE60115687T2 (xx) |
| DK (1) | DK1326608T3 (xx) |
| ES (1) | ES2250483T3 (xx) |
| HK (1) | HK1053612A1 (xx) |
| WO (1) | WO2002032424A1 (xx) |
| ZA (1) | ZA200302804B (xx) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU9400401A (en) * | 2000-10-19 | 2002-04-29 | Amura Ltd | Pharmaceutical compositions containing oxapenem-3-carboxylic acids |
| GB0106428D0 (en) * | 2001-03-15 | 2001-05-02 | Amura Ltd | Antibacterial composition |
| AR039774A1 (es) * | 2002-05-01 | 2005-03-02 | Wyeth Corp | 6-alquiliden-penems biciclicos como inhibidores de beta-lactamasas |
| AR039475A1 (es) * | 2002-05-01 | 2005-02-23 | Wyeth Corp | 6-alquiliden-penems triciclicos como inhibidores de beta-lactamasa |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US176349A (en) * | 1876-04-18 | Improvement in carbureters | ||
| US43980A (en) * | 1864-08-30 | Improvement in horse-rakes | ||
| GB2045236A (en) * | 1979-03-26 | 1980-10-29 | Hoechst Uk Ltd | Oxapenem derivatives |
| US4293555A (en) * | 1979-04-17 | 1981-10-06 | Merck & Co., Inc. | 6- and 6,6-Disubstituted-2-substituted-oxapen-2-em-3-carboxylic acids |
| DE2925009A1 (de) * | 1979-06-21 | 1981-01-08 | Basf Ag | Zubereitung fuer substanzen, verfahren zu deren herstellung und deren verwendung |
| DE3725375A1 (de) * | 1987-07-31 | 1989-02-09 | Bayer Ag | Stabile oxapenem-3-carbonsaeuren |
| DE3833693A1 (de) * | 1988-10-04 | 1990-04-05 | Bayer Ag | Stabile oxapenem-3-carbonsaeuren und ihre verwendung als ss-lactamasehemmer |
| DE4027928A1 (de) * | 1990-09-04 | 1992-03-05 | Bayer Ag | Neue 2-tert.substituierte methyl-oxapenem-3-carbonsaeuren und -ester, verfahren zu ihrer herstellung und ihre verwendung |
| DE4142423A1 (de) * | 1991-12-20 | 1993-06-24 | Pfaendler Hans Rudolf | ((ls)-hydroxyalkyl)oxapenem-3-carbonsaeuren und ihre verwendung als betalactamasehemmer |
| WO1995028935A1 (en) * | 1994-04-25 | 1995-11-02 | Smithkline Beecham Plc | Pharmaceutical formulations containing a beta-lactamase inhibiting penem in combination with a beta-lactam antibiotic and their use in the treatment of bacterial infections |
| WO1996038450A1 (en) * | 1995-05-31 | 1996-12-05 | Microcide Pharmaceuticals, Inc. | Cephalosporin antibiotics |
-
2000
- 2000-10-19 EP EP00309207A patent/EP1199077A1/en not_active Withdrawn
-
2001
- 2001-10-11 DK DK01974492T patent/DK1326608T3/da active
- 2001-10-11 AU AU2001294007A patent/AU2001294007A1/en not_active Abandoned
- 2001-10-11 DE DE60115687T patent/DE60115687T2/de not_active Expired - Fee Related
- 2001-10-11 AT AT01974492T patent/ATE311881T1/de not_active IP Right Cessation
- 2001-10-11 EP EP01974492A patent/EP1326608B1/en not_active Expired - Lifetime
- 2001-10-11 ES ES01974492T patent/ES2250483T3/es not_active Expired - Lifetime
- 2001-10-11 WO PCT/GB2001/004530 patent/WO2002032424A1/en active IP Right Grant
- 2001-10-11 US US10/399,703 patent/US20040043980A1/en not_active Abandoned
- 2001-10-11 JP JP2002535662A patent/JP2004511520A/ja active Pending
-
2003
- 2003-04-10 ZA ZA200302804A patent/ZA200302804B/en unknown
- 2003-08-21 HK HK03105980A patent/HK1053612A1/xx not_active IP Right Cessation
-
2005
- 2005-12-14 CY CY20051101547T patent/CY1106058T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2002032424A1 (en) | 2002-04-25 |
| US20040043980A1 (en) | 2004-03-04 |
| ZA200302804B (en) | 2005-02-23 |
| EP1326608A1 (en) | 2003-07-16 |
| EP1199077A1 (en) | 2002-04-24 |
| DE60115687T2 (de) | 2006-06-29 |
| DE60115687D1 (de) | 2006-01-12 |
| CY1106058T1 (el) | 2011-04-06 |
| ES2250483T3 (es) | 2006-04-16 |
| AU2001294007A1 (en) | 2002-04-29 |
| EP1326608B1 (en) | 2005-12-07 |
| DK1326608T3 (da) | 2006-02-06 |
| ATE311881T1 (de) | 2005-12-15 |
| JP2004511520A (ja) | 2004-04-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20091011 |