ATE308548T1 - Glycerophosphoinositol-derivate als cytosolic a2 phospholipase modulatoren - Google Patents

Glycerophosphoinositol-derivate als cytosolic a2 phospholipase modulatoren

Info

Publication number
ATE308548T1
ATE308548T1 AT00981612T AT00981612T ATE308548T1 AT E308548 T1 ATE308548 T1 AT E308548T1 AT 00981612 T AT00981612 T AT 00981612T AT 00981612 T AT00981612 T AT 00981612T AT E308548 T1 ATE308548 T1 AT E308548T1
Authority
AT
Austria
Prior art keywords
modulators
derivatives
glycerophosphoinositol
cytosolic
phospholipase
Prior art date
Application number
AT00981612T
Other languages
English (en)
Inventor
D Corda
Original Assignee
I R B Istituto Di Ricerche Bio
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by I R B Istituto Di Ricerche Bio filed Critical I R B Istituto Di Ricerche Bio
Application granted granted Critical
Publication of ATE308548T1 publication Critical patent/ATE308548T1/de

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/117—Esters of phosphoric acids with cycloaliphatic alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
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    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/10—Phosphatides, e.g. lecithin
    • C07F9/106—Adducts, complexes, salts of phosphatides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/16—Esters of thiophosphoric acids or thiophosphorous acids
    • C07F9/165—Esters of thiophosphoric acids
    • C07F9/177—Esters of thiophosphoric acids with cycloaliphatic alcohols

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Psychiatry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Obesity (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Virology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Addiction (AREA)
  • Child & Adolescent Psychology (AREA)
  • Nutrition Science (AREA)
  • Orthopedic Medicine & Surgery (AREA)
AT00981612T 2000-11-07 2000-11-07 Glycerophosphoinositol-derivate als cytosolic a2 phospholipase modulatoren ATE308548T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IT2000/000447 WO2002038575A1 (en) 2000-11-07 2000-11-07 Glycerophosphoinositol derivatives as modulators of cytosolic a2 phospholipase

Publications (1)

Publication Number Publication Date
ATE308548T1 true ATE308548T1 (de) 2005-11-15

Family

ID=11133577

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00981612T ATE308548T1 (de) 2000-11-07 2000-11-07 Glycerophosphoinositol-derivate als cytosolic a2 phospholipase modulatoren

Country Status (11)

Country Link
US (1) US7625883B1 (de)
EP (1) EP1332149B1 (de)
JP (1) JP2004513176A (de)
CN (1) CN1300155C (de)
AT (1) ATE308548T1 (de)
AU (1) AU2001218841A1 (de)
CA (1) CA2427352C (de)
DE (1) DE60023758T2 (de)
ES (1) ES2252079T3 (de)
IL (2) IL155619A0 (de)
WO (1) WO2002038575A1 (de)

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* Cited by examiner, † Cited by third party
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AUPS282602A0 (en) 2002-06-07 2002-06-27 Garvan Institute Of Medical Research Method of inhibiting cell proliferation
KR101201935B1 (ko) * 2004-07-09 2012-11-16 바스큘라 바이오제닉스 리미티드 산화 인지질류의 개선된 제조 방법
GB0510463D0 (en) * 2005-05-23 2005-06-29 Britania Pharmaceuticals Ltd Improvements in or relating to organic materials
EP2035010B1 (de) * 2006-06-09 2012-10-03 Erasmus University Medical Center Rotterdam Modulation des immunsystems durch inositol-phospholipide
US8093268B2 (en) 2007-01-24 2012-01-10 Glaxo Group Limited Pharmaceutical compositions comprising 2-methoxy-5-(5-trifluoromethyl-tetrazol-1-yl-benzyl)-(2S-phenylpiperidin-3S-yl-)
CN101951921A (zh) * 2007-09-17 2011-01-19 比奥尼里斯有限责任公司 用于治疗恶病质的方法和手段
JP5420848B2 (ja) * 2008-02-28 2014-02-19 株式会社コーセー 美白剤及び美白用皮膚外用剤
JP2009269851A (ja) * 2008-05-07 2009-11-19 Nikko Chemical Co Ltd プロスタグランジンｅ２産生抑制剤及びその利用
WO2012158591A1 (en) * 2011-05-18 2012-11-22 The Research Foundation Of State University Of New York Anti-blepharitis products and methods
JP5670858B2 (ja) * 2011-10-14 2015-02-18 イ．エルレ．ビ．イスティトゥト ディ リチェルケ ビオテクノロジケ ソチエタ ペル アツィオニ サイトゾルのホスホリパーゼのモジュレーターとしてのグリセロホスホイノシトール誘導体
ITRM20120473A1 (it) 2012-10-04 2014-04-05 Consiglio Nazionale Ricerche Use of glycerophosphoinositols for the treatment of septic shock
JP5701371B2 (ja) 2012-12-28 2015-04-15 花王株式会社 スフィンゴミエリン含有サプリメント
RU2580280C2 (ru) * 2014-07-08 2016-04-10 Общество с ограниченной ответственностью "НИТРОЗДРАВ" Композиция для местного применения для снижения или снятия болевого синдрома
CA2962103A1 (en) * 2014-09-24 2016-03-31 ISTITUTO PROFILATTICO E FARMACEUTICO CANDIOLI & C. SPA in abbreviated form CANDIOLI FARMACEUTICI SPA Compositions useful for the prevention and/or treatment of infections and inflammations
CN104447856A (zh) * 2014-12-11 2015-03-25 河南省农科院农副产品加工研究所 一种甘油磷脂酰肌醇的制备方法
IT202200010199A1 (it) * 2022-05-17 2023-11-17 Plantarei Biotech S R L Glicerofosfoinositolo nella prevenzione e nel trattamento di infezioni da covid-19 e metodo per il suo ottenimento

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Publication number Priority date Publication date Assignee Title
DE2659048A1 (de) * 1976-12-27 1978-07-06 Nattermann A & Cie Neue inositphosphatid-derivate und verfahren zur herstellung dieser verbindungen
FR2517310A1 (fr) * 1981-11-27 1983-06-03 Unilever Nv Derives d'a-glycerophosphatidester, procede pour leur preparation, composition cosmetique ou pharmaceutique les contenant
US4585762A (en) * 1982-07-30 1986-04-29 Fujisawa Pharmaceutical Co., Ltd. Phospholipid derivatives, processes for use thereof and pharmaceutical composition of the same
US4997761A (en) * 1987-10-06 1991-03-05 Houston Biotechnology Incorporated Phosphatidyl treatment of viral disease
IT1239474B (it) * 1989-10-27 1993-11-02 Depha Team Srl Composizioni farmaceutiche a base di l-alfa-glicerofosforil-d-myo- inositolo o suoi sali alcalini o alcalino-terrosi per la terapia delleneuropatie periferiche di origine dismetabolica o tossica, e delle cerebropatie su base organica e funzionale
IT1238683B (it) * 1990-02-09 1993-09-01 Istituto Chemioterapico Procedimento di preparazione di l-a-glicerilfosforil-d-myoinositolo e suoi sali da fosfatidi grezzi o parzialmente purificati
IT1247093B (it) * 1991-01-22 1994-12-12 Flarer S R L Ora Castellini S Derivati salini del gliceril fosforil mioinositolo ad attivita' terapeutica, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono
US5464754A (en) * 1993-08-17 1995-11-07 The Regents Of The University Of California Assay and substrate for arachidonoyl-specific phospholipase A2
US5478857A (en) * 1993-12-23 1995-12-26 Eli Lilly And Company Use of PLA2 inhibitors as treatment for alzheimer's disease
DE19623950A1 (de) * 1996-06-15 1997-12-18 Boehringer Ingelheim Kg Pharmazeutische Zubereitung in Form von Liposomen
US6801860B1 (en) * 1999-02-15 2004-10-05 Genetics Institute, Llc Crystal structure of cPLA2 and methods of identifying agonists and antagonists using same
SE532388C2 (sv) * 2008-03-14 2010-01-12 Tetra Laval Holdings & Finance Förpackningslaminat och -behållare med två separata gasbarriärskikt samt metod för deras framställning

Also Published As

Publication number Publication date
AU2001218841A1 (en) 2002-05-21
US7625883B1 (en) 2009-12-01
ES2252079T3 (es) 2006-05-16
WO2002038575A1 (en) 2002-05-16
IL155619A0 (en) 2003-11-23
DE60023758T2 (de) 2006-12-07
EP1332149B1 (de) 2005-11-02
CN1300155C (zh) 2007-02-14
CN1455779A (zh) 2003-11-12
JP2004513176A (ja) 2004-04-30
CA2427352C (en) 2010-10-12
CA2427352A1 (en) 2002-05-16
IL155619A (en) 2010-06-30
DE60023758D1 (en) 2005-12-08
EP1332149A1 (de) 2003-08-06

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