ATE302844T1 - Verfahren zur aufreinigung eines enzyms und hiernach hergestelltes, aufgereinigtes enzym sowie verwendung des enzyms - Google Patents
Verfahren zur aufreinigung eines enzyms und hiernach hergestelltes, aufgereinigtes enzym sowie verwendung des enzymsInfo
- Publication number
- ATE302844T1 ATE302844T1 AT02782420T AT02782420T ATE302844T1 AT E302844 T1 ATE302844 T1 AT E302844T1 AT 02782420 T AT02782420 T AT 02782420T AT 02782420 T AT02782420 T AT 02782420T AT E302844 T1 ATE302844 T1 AT E302844T1
- Authority
- AT
- Austria
- Prior art keywords
- enzyme
- purifying
- produced therefrom
- purified
- base
- Prior art date
Links
- 102000004190 Enzymes Human genes 0.000 title abstract 5
- 108090000790 Enzymes Proteins 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 3
- 238000004587 chromatography analysis Methods 0.000 abstract 2
- 238000000855 fermentation Methods 0.000 abstract 2
- 230000004151 fermentation Effects 0.000 abstract 2
- CHRJZRDFSQHIFI-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;styrene Chemical compound C=CC1=CC=CC=C1.C=CC1=CC=CC=C1C=C CHRJZRDFSQHIFI-UHFFFAOYSA-N 0.000 abstract 1
- 241000193159 Hathewaya histolytica Species 0.000 abstract 1
- 239000000919 ceramic Substances 0.000 abstract 1
- 229910052588 hydroxylapatite Inorganic materials 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/22—Cysteine endopeptidases (3.4.22)
- C12Y304/22008—Clostripain (3.4.22.8)
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10131994 | 2001-07-02 | ||
| DE10134347A DE10134347B4 (de) | 2001-07-02 | 2001-07-14 | Verfahren zur Aufreinigung eines Enzyms |
| PCT/EP2002/006021 WO2003004628A2 (de) | 2001-07-02 | 2002-06-01 | Verfahren zur aufreinigung eines enzyms und hiernach hergestelltes, aufgereinigtes enzym sowie verwendung des enzyms |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE302844T1 true ATE302844T1 (de) | 2005-09-15 |
Family
ID=26009625
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02782420T ATE302844T1 (de) | 2001-07-02 | 2002-06-01 | Verfahren zur aufreinigung eines enzyms und hiernach hergestelltes, aufgereinigtes enzym sowie verwendung des enzyms |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7083964B2 (enExample) |
| EP (1) | EP1402008B1 (enExample) |
| JP (1) | JP4266817B2 (enExample) |
| CN (1) | CN1308442C (enExample) |
| AT (1) | ATE302844T1 (enExample) |
| AU (1) | AU2002354696A1 (enExample) |
| CA (1) | CA2447818C (enExample) |
| WO (1) | WO2003004628A2 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7622562B2 (en) | 2002-06-26 | 2009-11-24 | Zimmer Orthobiologics, Inc. | Rapid isolation of osteoinductive protein mixtures from mammalian bone tissue |
| DE10331171A1 (de) * | 2003-07-09 | 2005-01-27 | Nordmark Arzneimittel Gmbh & Co. Kg | Neutrale Protease (NP) und Produkt unter Verwendung von neutraler Protease für Gewebedissoziation sowie Verfahren zu dessen Herstellung |
| EP2335650B1 (en) | 2003-12-11 | 2012-10-03 | Isto Technologies Inc. | Particulate cartilage system |
| JP5292533B2 (ja) | 2005-08-26 | 2013-09-18 | ジンマー・インコーポレイテッド | インプラントおよび関節疾患の治療、置換および治療方法 |
| US20070181479A1 (en) * | 2005-11-21 | 2007-08-09 | Pentax Corporation | Column and method of manufacturing the column |
| US7811560B2 (en) * | 2006-01-30 | 2010-10-12 | Auxilium Us Holdings, Llc | Compositions and methods for treating collagen-mediated diseases |
| US8163549B2 (en) | 2006-12-20 | 2012-04-24 | Zimmer Orthobiologics, Inc. | Method of obtaining viable small tissue particles and use for tissue repair |
| EP2134297B1 (en) | 2007-04-12 | 2017-03-08 | Zimmer, Inc. | Apparatus for tissue repair |
| US10071143B1 (en) | 2007-05-03 | 2018-09-11 | The Research Foundation For The State University Of New York | Methods for non-surgical treatment of carpal tunnel syndrome |
| US20100159564A1 (en) * | 2007-11-30 | 2010-06-24 | Dwulet Francis E | Protease resistant recombinant bacterial collagenases |
| WO2009093255A2 (en) * | 2008-01-21 | 2009-07-30 | Ganga Raju Gokaraju | A new nutraceutical composition from garcinia mangostana |
| EP2130551B1 (en) | 2008-06-02 | 2012-06-06 | Roche Diagnostics GmbH | Improved purification of collagenases from clostridium histolyticum liquid culture |
| EP4772625A2 (en) | 2012-01-12 | 2026-07-08 | Endo Biologics Limited | Clostridium histolyticum enzyme |
| US9636385B2 (en) | 2012-10-24 | 2017-05-02 | The Research Foundation For The State University Of New York | Use of collagenase to treat glaucoma |
| US20140178343A1 (en) | 2012-12-21 | 2014-06-26 | Jian Q. Yao | Supports and methods for promoting integration of cartilage tissue explants |
| GB201507207D0 (en) * | 2015-04-24 | 2015-06-10 | Givaudan Sa | Enzymes and applications thereof |
| DK3589204T3 (da) | 2017-03-01 | 2025-06-30 | Endo Operations Ltd | Apparat og fremgangsmåde til vurdering og behandling af cellulitis |
| KR20250171475A (ko) | 2017-03-28 | 2025-12-08 | 엔도 오퍼레이션즈 리미티드 | 개선된 콜라게나제 생성 방법 |
| EP3887386A4 (en) * | 2018-11-26 | 2022-11-30 | North Carolina State University | PEPTIDE LIGANDS FOR CAPTURE OF HOST CELL PROTEINS |
| JP7808965B2 (ja) * | 2019-02-14 | 2026-01-30 | ノルドマルク ファーマ ゲーエムベーハー | コラゲナーゼタイプｉ、コラゲナーゼタイプｉｉ、中性プロテアーゼ、およびクロストリパインからなる群から選択される少なくとも１種の酵素のクロマトグラフィー精製 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5332503A (en) * | 1993-04-16 | 1994-07-26 | Baxter International Inc. | Process for purifying collagenase |
| DE4445891A1 (de) * | 1994-12-22 | 1996-06-27 | Boehringer Mannheim Gmbh | Rekombinante Proteinase aus Clostridium histolyticum und ihre Verwendung zur Isolierung von Zellen und Zellverbänden |
-
2002
- 2002-06-01 CA CA2447818A patent/CA2447818C/en not_active Expired - Lifetime
- 2002-06-01 WO PCT/EP2002/006021 patent/WO2003004628A2/de not_active Ceased
- 2002-06-01 AT AT02782420T patent/ATE302844T1/de not_active IP Right Cessation
- 2002-06-01 US US10/478,545 patent/US7083964B2/en not_active Expired - Lifetime
- 2002-06-01 AU AU2002354696A patent/AU2002354696A1/en not_active Abandoned
- 2002-06-01 EP EP02782420A patent/EP1402008B1/de not_active Expired - Lifetime
- 2002-06-01 CN CNB028131347A patent/CN1308442C/zh not_active Expired - Lifetime
- 2002-06-01 JP JP2003510787A patent/JP4266817B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU2002354696A1 (en) | 2003-01-21 |
| WO2003004628A3 (de) | 2003-09-18 |
| JP4266817B2 (ja) | 2009-05-20 |
| EP1402008B1 (de) | 2005-08-24 |
| CA2447818A1 (en) | 2003-01-16 |
| EP1402008A2 (de) | 2004-03-31 |
| US20040137596A1 (en) | 2004-07-15 |
| US7083964B2 (en) | 2006-08-01 |
| CA2447818C (en) | 2011-01-04 |
| CN1529751A (zh) | 2004-09-15 |
| JP2004535197A (ja) | 2004-11-25 |
| WO2003004628A2 (de) | 2003-01-16 |
| CN1308442C (zh) | 2007-04-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| REN | Ceased due to non-payment of the annual fee |