DK1121146T3 - Påvirkning af hyperaktive T-celler med proteolytiske enzymer - Google Patents
Påvirkning af hyperaktive T-celler med proteolytiske enzymerInfo
- Publication number
- DK1121146T3 DK1121146T3 DK99953778T DK99953778T DK1121146T3 DK 1121146 T3 DK1121146 T3 DK 1121146T3 DK 99953778 T DK99953778 T DK 99953778T DK 99953778 T DK99953778 T DK 99953778T DK 1121146 T3 DK1121146 T3 DK 1121146T3
- Authority
- DK
- Denmark
- Prior art keywords
- hyperactive
- cells
- influence
- proteolytic enzymes
- proteolytic
- Prior art date
Links
- 108091005804 Peptidases Proteins 0.000 title abstract 3
- 102000035195 Peptidases Human genes 0.000 title abstract 3
- 210000001744 T-lymphocyte Anatomy 0.000 title abstract 2
- 229940024999 proteolytic enzymes for treatment of wounds and ulcers Drugs 0.000 title abstract 2
- 239000004365 Protease Substances 0.000 abstract 2
- JMGZEFIQIZZSBH-UHFFFAOYSA-N Bioquercetin Natural products CC1OC(OCC(O)C2OC(OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5)C(O)C2O)C(O)C(O)C1O JMGZEFIQIZZSBH-UHFFFAOYSA-N 0.000 abstract 1
- 108010004032 Bromelains Proteins 0.000 abstract 1
- 108090000526 Papain Proteins 0.000 abstract 1
- 102000004142 Trypsin Human genes 0.000 abstract 1
- 108090000631 Trypsin Proteins 0.000 abstract 1
- 235000019835 bromelain Nutrition 0.000 abstract 1
- IVTMALDHFAHOGL-UHFFFAOYSA-N eriodictyol 7-O-rutinoside Natural products OC1C(O)C(O)C(C)OC1OCC1C(O)C(O)C(O)C(OC=2C=C3C(C(C(O)=C(O3)C=3C=C(O)C(O)=CC=3)=O)=C(O)C=2)O1 IVTMALDHFAHOGL-UHFFFAOYSA-N 0.000 abstract 1
- 229940055729 papain Drugs 0.000 abstract 1
- 235000019834 papain Nutrition 0.000 abstract 1
- FDRQPMVGJOQVTL-UHFFFAOYSA-N quercetin rutinoside Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 FDRQPMVGJOQVTL-UHFFFAOYSA-N 0.000 abstract 1
- IKGXIBQEEMLURG-BKUODXTLSA-N rutin Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@@H]1OC[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 IKGXIBQEEMLURG-BKUODXTLSA-N 0.000 abstract 1
- ALABRVAAKCSLSC-UHFFFAOYSA-N rutin Natural products CC1OC(OCC2OC(O)C(O)C(O)C2O)C(O)C(O)C1OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5 ALABRVAAKCSLSC-UHFFFAOYSA-N 0.000 abstract 1
- 235000005493 rutin Nutrition 0.000 abstract 1
- 229960004555 rutoside Drugs 0.000 abstract 1
- 239000012588 trypsin Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/4826—Trypsin (3.4.21.4) Chymotrypsin (3.4.21.1)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/4873—Cysteine endopeptidases (3.4.22), e.g. stem bromelain, papain, ficin, cathepsin H
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A61K38/57—Protease inhibitors from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21004—Trypsin (3.4.21.4)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/22—Cysteine endopeptidases (3.4.22)
- C12Y304/22002—Papain (3.4.22.2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/22—Cysteine endopeptidases (3.4.22)
- C12Y304/22033—Fruit bromelain (3.4.22.33), i.e. juice bromelain
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Zoology (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Transplantation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Medicines Containing Plant Substances (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19847114A DE19847114A1 (de) | 1998-10-13 | 1998-10-13 | Beeinflussung von hyperaktiven T-Zellen durch proteolytische Enzyme |
| EP99953778A EP1121146B1 (de) | 1998-10-13 | 1999-10-12 | Beeinflussung von hyperaktiven t-zellen durch proteolytische enzyme |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1121146T3 true DK1121146T3 (da) | 2004-10-25 |
Family
ID=7884290
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK99953778T DK1121146T3 (da) | 1998-10-13 | 1999-10-12 | Påvirkning af hyperaktive T-celler med proteolytiske enzymer |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP1121146B1 (da) |
| AT (1) | ATE270109T1 (da) |
| DE (2) | DE19847114A1 (da) |
| DK (1) | DK1121146T3 (da) |
| ES (1) | ES2223187T3 (da) |
| PT (1) | PT1121146E (da) |
| WO (1) | WO2000021547A2 (da) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10018980A1 (de) * | 2000-04-17 | 2001-11-08 | Mucos Pharma Gmbh & Co | Prophylaxe und Therapie von Diabetes mellitus I mit Hilfe proteolytischer Enzyme |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4130221C2 (de) * | 1991-09-11 | 1997-08-07 | Mucos Pharma Gmbh | Verwendung von proteolytischen Enzymen zur Herstellung eines Medikaments zur Behandlung von Autoimmun-Krankheiten, an deren Entstehung Proteine mit einer C¶H¶2-Domäne beteiligt sind |
| DE4302060A1 (de) * | 1993-01-26 | 1994-07-28 | Mucos Pharma Gmbh & Co | Verwendung von Bromelain zur Krebstherapie und/oder Metastasen-Prophylaxe |
| GB9412711D0 (en) * | 1994-06-24 | 1994-08-17 | Cortecs Ltd | Medical use of bromelain |
| DE19726253C2 (de) * | 1997-06-20 | 2000-03-16 | Mucos Pharma Gmbh & Co | Verwendung von mindestens einem proteolytischen Enzym und Rutosid zur Behandlung von Glomerulonephritis |
| DE19726255C2 (de) * | 1997-06-20 | 2000-03-16 | Mucos Pharma Gmbh & Co | Beeinflussung von Cytokinen durch proteolytische Enzyme und Rutosid |
-
1998
- 1998-10-13 DE DE19847114A patent/DE19847114A1/de not_active Ceased
-
1999
- 1999-10-12 PT PT99953778T patent/PT1121146E/pt unknown
- 1999-10-12 ES ES99953778T patent/ES2223187T3/es not_active Expired - Lifetime
- 1999-10-12 EP EP99953778A patent/EP1121146B1/de not_active Expired - Lifetime
- 1999-10-12 WO PCT/EP1999/007634 patent/WO2000021547A2/de active IP Right Grant
- 1999-10-12 DE DE59909869T patent/DE59909869D1/de not_active Expired - Fee Related
- 1999-10-12 DK DK99953778T patent/DK1121146T3/da active
- 1999-10-12 AT AT99953778T patent/ATE270109T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ATE270109T1 (de) | 2004-07-15 |
| DE19847114A1 (de) | 2000-04-20 |
| PT1121146E (pt) | 2004-10-29 |
| EP1121146A2 (de) | 2001-08-08 |
| EP1121146B1 (de) | 2004-06-30 |
| ES2223187T3 (es) | 2005-02-16 |
| WO2000021547A3 (de) | 2000-09-08 |
| WO2000021547A2 (de) | 2000-04-20 |
| DE59909869D1 (de) | 2004-08-05 |
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