ATE299701T1 - Antibakteriell wirksame hydroxamsäure-derivate - Google Patents
Antibakteriell wirksame hydroxamsäure-derivateInfo
- Publication number
- ATE299701T1 ATE299701T1 AT00901231T AT00901231T ATE299701T1 AT E299701 T1 ATE299701 T1 AT E299701T1 AT 00901231 T AT00901231 T AT 00901231T AT 00901231 T AT00901231 T AT 00901231T AT E299701 T1 ATE299701 T1 AT E299701T1
- Authority
- AT
- Austria
- Prior art keywords
- group
- acid derivatives
- represents hydrogen
- hydroxamic acid
- alkyl
- Prior art date
Links
- NEAQRZUHTPSBBM-UHFFFAOYSA-N 2-hydroxy-3,3-dimethyl-7-nitro-4h-isoquinolin-1-one Chemical compound C1=C([N+]([O-])=O)C=C2C(=O)N(O)C(C)(C)CC2=C1 NEAQRZUHTPSBBM-UHFFFAOYSA-N 0.000 title 1
- 239000002253 acid Substances 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 abstract 1
- 208000035143 Bacterial infection Diseases 0.000 abstract 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract 1
- 125000004450 alkenylene group Chemical group 0.000 abstract 1
- 150000001370 alpha-amino acid derivatives Chemical class 0.000 abstract 1
- 235000008206 alpha-amino acids Nutrition 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 208000022362 bacterial infectious disease Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000000524 functional group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- -1 hydroxy, amino, methyl Chemical group 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 150000007970 thio esters Chemical group 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/255—Esters, e.g. nitroglycerine, selenocyanates of sulfoxy acids or sulfur analogues thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9901863.2A GB9901863D0 (en) | 1999-01-29 | 1999-01-29 | Antibacterial agents |
| PCT/GB2000/000233 WO2000044373A1 (en) | 1999-01-29 | 2000-01-27 | Antibacterial hydroxamic acid derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE299701T1 true ATE299701T1 (de) | 2005-08-15 |
Family
ID=10846641
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00901231T ATE299701T1 (de) | 1999-01-29 | 2000-01-27 | Antibakteriell wirksame hydroxamsäure-derivate |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6545051B1 (de) |
| EP (1) | EP1146867B1 (de) |
| JP (1) | JP2002535362A (de) |
| AT (1) | ATE299701T1 (de) |
| AU (1) | AU2118900A (de) |
| DE (1) | DE60021347T2 (de) |
| GB (1) | GB9901863D0 (de) |
| WO (1) | WO2000044373A1 (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1169031A1 (de) * | 1999-04-09 | 2002-01-09 | British Biotech Pharmaceuticals Limited | Antimikrobielles mittel |
| GB0208579D0 (en) * | 2002-04-13 | 2002-05-22 | British Biotech Pharm | Antibacterial agents |
| SG159388A1 (en) | 2003-01-08 | 2010-03-30 | Chiron Corp | Antibacterial agents |
| KR100648133B1 (ko) * | 2005-04-25 | 2006-11-23 | 일동제약주식회사 | 펩티드 데포르밀라제 저해제로서 신규의 히드록사믹 산유도체 및 그 제조방법 |
| CA2934114A1 (en) | 2007-06-12 | 2008-12-18 | Achaogen, Inc. | Antibacterial agents |
| EP2847168A1 (de) | 2012-05-10 | 2015-03-18 | Achaogen, Inc. | Antibakterielle wirkstoffe |
| RU2738413C1 (ru) * | 2017-06-29 | 2020-12-14 | Кимберли-Кларк Ворлдвайд, Инк. | Противомикробная композиция, содержащая дигидроксамовую кислоту, и способы подавления микробного роста посредством ее применения |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8921326D0 (en) * | 1989-09-21 | 1989-11-08 | Beecham Group Plc | Novel treatment |
| JPH03157372A (ja) | 1989-11-13 | 1991-07-05 | Yamanouchi Pharmaceut Co Ltd | Ｙｌ―０１８６９ｐ物質及びその製造法 |
| NZ262447A (en) * | 1993-03-16 | 1996-07-26 | British Biotech Pharm | Hydroxamic acid derivatives and their use as pharmaceutical agents |
| GB9320660D0 (en) * | 1993-10-07 | 1993-11-24 | British Bio Technology | Inhibition of cytokine production |
| GB9401129D0 (en) * | 1994-01-21 | 1994-03-16 | British Bio Technology | Hydroxamic acid derivatives as metalloproteinase inhibitors |
| GB9613547D0 (en) * | 1996-06-27 | 1996-08-28 | Pharmacia Spa | Matrix metalloproteinase inhibitors |
| NZ333923A (en) | 1996-09-10 | 2000-11-24 | British Biotech Pharm | Cytostatic hydroxamic acid derivatives for inhibiting proliferation of tumour cells |
| GB9803005D0 (en) | 1998-02-12 | 1998-04-08 | British Biotech Pharm | Anti-inflammatory agents |
| GB9804777D0 (en) | 1998-03-07 | 1998-04-29 | British Biotech Pharm | Anti-inflammatory agents |
| IL137774A0 (en) | 1998-03-12 | 2001-10-31 | British Biotech Pharm | Cytostatic agents |
-
1999
- 1999-01-29 GB GBGB9901863.2A patent/GB9901863D0/en not_active Ceased
-
2000
- 2000-01-27 DE DE60021347T patent/DE60021347T2/de not_active Expired - Fee Related
- 2000-01-27 AU AU21189/00A patent/AU2118900A/en not_active Abandoned
- 2000-01-27 WO PCT/GB2000/000233 patent/WO2000044373A1/en not_active Ceased
- 2000-01-27 EP EP00901231A patent/EP1146867B1/de not_active Expired - Lifetime
- 2000-01-27 US US09/889,801 patent/US6545051B1/en not_active Expired - Fee Related
- 2000-01-27 JP JP2000595676A patent/JP2002535362A/ja active Pending
- 2000-01-27 AT AT00901231T patent/ATE299701T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AU2118900A (en) | 2000-08-18 |
| EP1146867A1 (de) | 2001-10-24 |
| JP2002535362A (ja) | 2002-10-22 |
| WO2000044373A1 (en) | 2000-08-03 |
| GB9901863D0 (en) | 1999-03-17 |
| EP1146867B1 (de) | 2005-07-20 |
| US6545051B1 (en) | 2003-04-08 |
| DE60021347D1 (de) | 2005-08-25 |
| DE60021347T2 (de) | 2006-05-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |