ES2051652A6 - Procedimiento para la preparacion de compuestos inhibidores de fosfolipasa a2 - Google Patents

Procedimiento para la preparacion de compuestos inhibidores de fosfolipasa a2

Info

Publication number
ES2051652A6
ES2051652A6 ES08803704A ES8803704A ES2051652A6 ES 2051652 A6 ES2051652 A6 ES 2051652A6 ES 08803704 A ES08803704 A ES 08803704A ES 8803704 A ES8803704 A ES 8803704A ES 2051652 A6 ES2051652 A6 ES 2051652A6
Authority
ES
Spain
Prior art keywords
haloloweralkyl
hydrogen
image
lower alkyl
phospholipase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES08803704A
Other languages
English (en)
Inventor
Lisa Ann Marshall
Kurt Edric Steiner
Guy Alan Schiehser
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Original Assignee
American Home Products Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Products Corp filed Critical American Home Products Corp
Publication of ES2051652A6 publication Critical patent/ES2051652A6/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/48—Compounds containing oxirane rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE COMPUESTOS INHIBIDORES DE FOSFOLIPASA ASI2 SC, DE FORMULA GENERAL (I) EN DONDE RBS1 SC Y RBS2 SC SON CADA UNO, INDEPENDIENTEMENTE, HIDROGENO, HIDROXILO, ALQUILO INFERIOR, ALCOXILO INFERIOR, HALOALQUILO INFERIOR, HALO ALQUILSULFONILO INFERIOR, HALO O NITRO; RBS3 SC ES HIDROGENO, ALQUILO INFERIOR O ARILO CON 6-10 CARBONES; X ES FORMULA M ES 0-8; N ES 0-7, CON LA SALVEDAD DE QUE M+N = 8. ESTOS PRODUCTOS SE OBTIENEN HACIENDO REACCIONAR UN ALDEHIDO DE FORMULA (IV) CON METILACRILATO, SEGUIDO DE PASOS SUCESIVOS DE FLUORACION EPOXIDACION Y SEPARACION CROMATOGRAFICA. ESTOS PRODUCTOS SON LOS QUE PROVOCAN LA INHIBICION DE LA ENZIMA PLASI2 SC, EVITANDO LA FORMACION DE PRODUCTOS DE OXIDACION DEL ACIDO ARAQUIDONICO PROVOCADORES DE VASOCONSTRICCION Y PROCESOS INFLAMATORIOS. ESTOS PRODUCTOS SE USAN PARA LA PREVENCION Y TRATAMIENTO DE RINITIS ALERGICA, ASMA BRONQUIAL ALERGICA Y OTROS ESTADOS OBSTRUCTIVOS DE LAS VIAS RESPIRATORIAS, O DE PROCESOS INFLAMATORIOS, COMO ARTRITIS REUMATOIDE, OSTEOARTRITIS, TENDINITIS Y SIMILARES. FORMULA
ES08803704A 1987-12-07 1988-12-05 Procedimiento para la preparacion de compuestos inhibidores de fosfolipasa a2 Expired - Lifetime ES2051652A6 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/129,259 US4788304A (en) 1987-12-07 1987-12-07 Phospholipase A2 inhibitors

Publications (1)

Publication Number Publication Date
ES2051652A6 true ES2051652A6 (es) 1994-06-16

Family

ID=22439150

Family Applications (1)

Application Number Title Priority Date Filing Date
ES08803704A Expired - Lifetime ES2051652A6 (es) 1987-12-07 1988-12-05 Procedimiento para la preparacion de compuestos inhibidores de fosfolipasa a2

Country Status (4)

Country Link
US (1) US4788304A (es)
AU (1) AU2927489A (es)
ES (1) ES2051652A6 (es)
WO (1) WO1989005142A1 (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4927629A (en) * 1987-12-17 1990-05-22 Huntington Medical Research Institutes Relaxation of smooth vascular muscle
JPH01199995A (ja) * 1988-02-04 1989-08-11 Kyowa Hakko Kogyo Co Ltd ホスホリパーゼａ↓２阻害ペプチド
US4933365A (en) * 1989-01-25 1990-06-12 American Home Products Corporation Phospholipase A2 inhibitors
AU643952B2 (en) * 1989-08-29 1993-12-02 Regents Of The University Of California, The Novel hydrolytic enzyme inhibitors and substrates and assays, methods and kits embodying same
CA2083512A1 (en) * 1990-05-23 1991-11-24 Asaf A. Qureshi Processes for recovering tocotrienols, tocopherols and tocotrienol-like compounds
US5736363A (en) * 1991-07-29 1998-04-07 British Bio-Technology Limited IGF-II analogues
EP0543417A1 (en) 1991-11-22 1993-05-26 Lipogenics, Incorporated Tocotrienols and tocotrienol-like compounds and methods for their use
US5478857A (en) * 1993-12-23 1995-12-26 Eli Lilly And Company Use of PLA2 inhibitors as treatment for alzheimer's disease
DE19705718A1 (de) * 1997-02-14 1998-08-20 Horst P O Dr Wolf Neue Oxirancarbonsäuren zur Behandlung des Diabetes Typ 2 und anderer insulinresistenter Zustände
US6187811B1 (en) 1998-10-28 2001-02-13 Lipogenics, Inc. Methods for treating benign prostatic hyperplasia using tocotrienols
KR100805907B1 (ko) * 1999-12-06 2008-02-21 웰리켐 바이오 테크 인크. 하이드록실스틸벤 및 신규의 스틸벤 유도체 및 동족체에의한 염증 및 건선 치료 및 단백질 키나제 억제
US7321050B2 (en) * 1999-12-06 2008-01-22 Welichem Biotech Inc. Anti-inflammatory and psoriasis treatment and protein kinase inhibition by hydroxy stilbenes and novel stilbene derivatives and analogues
US7705016B2 (en) 2003-02-13 2010-04-27 Albert Einstein College Of Medicine Of Yeshiva University Regulation of food intake by modulation of long-chain fatty acyl-CoA levels in the hypothalamus
WO2009002433A1 (en) * 2007-06-22 2008-12-31 Dara Biosciences, Inc. Compositions and methods for treating skin disorders
WO2010008473A1 (en) * 2008-06-24 2010-01-21 Dara Biosciences, Inc. Enzyme inhibitors and the use thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3063144D1 (en) * 1979-09-07 1983-06-16 Byk Gulden Lomberg Chem Fab Substituted oxirane carboxylic acids, process for their preparation, their use and medicines containing them
US4337267A (en) * 1980-08-25 1982-06-29 Byk Gulden Lomberg Chemische Fabrik Gmbh Phenalkoxyalkyl- and phenoxyalkyl-substituted oxiranecarboxylic acids, their use and medicaments containing them
US4430339A (en) * 1980-08-29 1984-02-07 Byk Gulden Lomberg Chemische Fabrik Gesellschaft Mit Beschrankter Haftung Substituted oxiranecarboxylic acids, their preparation and their use as medicaments
US4788306A (en) * 1987-04-03 1988-11-29 American Home Products Corporation Fluorooxirane carboxylates as hypoglycemic agents

Also Published As

Publication number Publication date
US4788304A (en) 1988-11-29
AU2927489A (en) 1989-07-05
WO1989005142A1 (en) 1989-06-15

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Legal Events

Date Code Title Description
FA2A Application withdrawn

Effective date: 19950211