ATE299179T1 - Menschliche suppressor trna oligonukleotide und verfahren für deren verwendung - Google Patents
Menschliche suppressor trna oligonukleotide und verfahren für deren verwendungInfo
- Publication number
- ATE299179T1 ATE299179T1 AT99902219T AT99902219T ATE299179T1 AT E299179 T1 ATE299179 T1 AT E299179T1 AT 99902219 T AT99902219 T AT 99902219T AT 99902219 T AT99902219 T AT 99902219T AT E299179 T1 ATE299179 T1 AT E299179T1
- Authority
- AT
- Austria
- Prior art keywords
- suppressor trna
- oligonucleotides
- methods
- human suppressor
- human
- Prior art date
Links
Classifications
-
- H—ELECTRICITY
- H04—ELECTRIC COMMUNICATION TECHNIQUE
- H04B—TRANSMISSION
- H04B10/00—Transmission systems employing electromagnetic waves other than radio-waves, e.g. infrared, visible or ultraviolet light, or employing corpuscular radiation, e.g. quantum communication
- H04B10/25—Arrangements specific to fibre transmission
- H04B10/2589—Bidirectional transmission
- H04B10/25891—Transmission components
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases RNAses, DNAses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/028—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a herpesvirus
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Plant Pathology (AREA)
- Epidemiology (AREA)
- Electromagnetism (AREA)
- Computer Networks & Wireless Communication (AREA)
- Signal Processing (AREA)
- Biophysics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dermatology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US7141698P | 1998-01-14 | 1998-01-14 | |
PCT/US1999/000717 WO1999036519A1 (en) | 1998-01-14 | 1999-01-13 | HUMAN SUPPRESSOR tRNA OLIGONUCLEOTIDES AND METHODS OF USE FOR SAME |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE299179T1 true ATE299179T1 (de) | 2005-07-15 |
Family
ID=22101183
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT99902219T ATE299179T1 (de) | 1998-01-14 | 1999-01-13 | Menschliche suppressor trna oligonukleotide und verfahren für deren verwendung |
Country Status (9)
Country | Link |
---|---|
US (2) | US6309830B1 (de) |
EP (1) | EP1045902B1 (de) |
JP (1) | JP2002508959A (de) |
AT (1) | ATE299179T1 (de) |
AU (1) | AU2225199A (de) |
CA (1) | CA2318374C (de) |
DE (1) | DE69926052T2 (de) |
HK (1) | HK1033955A1 (de) |
WO (1) | WO1999036519A1 (de) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999036519A1 (en) * | 1998-01-14 | 1999-07-22 | Human Gene Therapy Research Institute | HUMAN SUPPRESSOR tRNA OLIGONUCLEOTIDES AND METHODS OF USE FOR SAME |
WO2000011154A1 (en) * | 1998-08-20 | 2000-03-02 | Cell Genesys, Inc. | USE OF SUPPRESSOR tRNA'S TO REGULATE CYTOTOXICITY DURING THE PRODUCTION OF RECOMBINANT GENE PRODUCTS |
US6964859B2 (en) * | 2001-10-16 | 2005-11-15 | Massachusetts Institute Of Technology | Suppressor tRNA system |
US20050261210A1 (en) * | 2004-02-19 | 2005-11-24 | Bhatnagar Rajiv S | Nonsense suppressor agents in treatment of cutaneous and gastrointestinal disorders |
US20080207538A1 (en) * | 2004-03-11 | 2008-08-28 | Lawrence David S | Enhanced Production of Functional Proteins From Defective Genes |
US7598040B2 (en) * | 2006-11-22 | 2009-10-06 | Trana Discovery, Inc. | Compositions and methods for the identification of inhibitors of protein synthesis |
CA2699370A1 (en) * | 2007-09-14 | 2009-03-19 | Trana Discovery | Compositions and methods for the identification of inhibitors of retroviral infection |
WO2010036795A2 (en) * | 2008-09-29 | 2010-04-01 | Trana Discovery, Inc. | Screening methods for identifying specific staphylococcus aureus inhibitors |
CN107177592B (zh) | 2016-03-10 | 2021-03-30 | 北京大学 | 抑制性tRNA通读提前终止密码子疾病中的截短蛋白 |
US11932856B2 (en) | 2017-03-03 | 2024-03-19 | The Regents Of The University Of California | RNA targeting of mutations via suppressor tRNAs and deaminases |
MX2020004647A (es) | 2017-11-02 | 2021-03-25 | Wistar Inst | Métodos de rescate de codones de detención por medio de reasignación genética con arn de transferencia editado anti-codones (ace-trna). |
US10905778B2 (en) | 2018-09-26 | 2021-02-02 | Case Western Reserve University | Methods and compositions for treating a premature stop codon-mediated disorder |
AU2019350869A1 (en) * | 2018-09-26 | 2021-05-20 | Case Western Reserve University | Methods and compositions for treating a premature stop codon-mediated disorder |
CA3136430A1 (en) * | 2019-04-11 | 2020-10-15 | Arcturus Therapeutics, Inc. | Synthetic transfer rna with extended anticodon loop |
LU101182B1 (en) * | 2019-04-11 | 2020-10-12 | Univ Hamburg | Synthetic transfer RNA with extended anticodon loop |
CN115038789A (zh) | 2019-12-02 | 2022-09-09 | 塑造治疗公司 | 治疗性编辑 |
WO2022125531A1 (en) * | 2020-12-07 | 2022-06-16 | President And Fellows Of Harvard College | Methods for making and using genomically recoded cells |
WO2023147348A1 (en) * | 2022-01-25 | 2023-08-03 | Hc Bioscience, Inc. | Universal suppressor trnas and uses thereof |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4687737A (en) | 1982-11-12 | 1987-08-18 | Massachusetts Institute Of Technology | Mammalian suppressor genes |
US4970155A (en) * | 1983-03-07 | 1990-11-13 | Abbott Laboratories | HSV helper virus independent vector |
US6111095A (en) * | 1995-06-07 | 2000-08-29 | Merck & Co., Inc. | Capped synthetic RNA, analogs, and aptamers |
WO1999036519A1 (en) * | 1998-01-14 | 1999-07-22 | Human Gene Therapy Research Institute | HUMAN SUPPRESSOR tRNA OLIGONUCLEOTIDES AND METHODS OF USE FOR SAME |
-
1999
- 1999-01-13 WO PCT/US1999/000717 patent/WO1999036519A1/en active IP Right Grant
- 1999-01-13 CA CA2318374A patent/CA2318374C/en not_active Expired - Fee Related
- 1999-01-13 AT AT99902219T patent/ATE299179T1/de not_active IP Right Cessation
- 1999-01-13 US US09/229,212 patent/US6309830B1/en not_active Expired - Lifetime
- 1999-01-13 EP EP99902219A patent/EP1045902B1/de not_active Expired - Lifetime
- 1999-01-13 DE DE69926052T patent/DE69926052T2/de not_active Expired - Lifetime
- 1999-01-13 JP JP2000540221A patent/JP2002508959A/ja active Pending
- 1999-01-13 AU AU22251/99A patent/AU2225199A/en not_active Abandoned
-
2001
- 2001-04-23 HK HK01102893A patent/HK1033955A1/xx not_active IP Right Cessation
- 2001-10-30 US US10/022,127 patent/US7029665B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CA2318374A1 (en) | 1999-07-22 |
AU2225199A (en) | 1999-08-02 |
EP1045902B1 (de) | 2005-07-06 |
CA2318374C (en) | 2012-09-04 |
EP1045902A1 (de) | 2000-10-25 |
US7029665B2 (en) | 2006-04-18 |
DE69926052D1 (de) | 2005-08-11 |
US20020156042A1 (en) | 2002-10-24 |
DE69926052T2 (de) | 2006-04-27 |
JP2002508959A (ja) | 2002-03-26 |
HK1033955A1 (en) | 2001-10-05 |
US6309830B1 (en) | 2001-10-30 |
WO1999036519A1 (en) | 1999-07-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |