DE60044247D1 - Humane cd80-mutante und zusammensetzungen und methoden zu deren herstellung und verwendung - Google Patents

Humane cd80-mutante und zusammensetzungen und methoden zu deren herstellung und verwendung

Info

Publication number
DE60044247D1
DE60044247D1 DE60044247T DE60044247T DE60044247D1 DE 60044247 D1 DE60044247 D1 DE 60044247D1 DE 60044247 T DE60044247 T DE 60044247T DE 60044247 T DE60044247 T DE 60044247T DE 60044247 D1 DE60044247 D1 DE 60044247D1
Authority
DE
Germany
Prior art keywords
methods
compositions
humane
mutant
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60044247T
Other languages
English (en)
Inventor
Rafick P Sekaly
Mark Holterman
David B Weiner
Michael G Agadjanyan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universite de Montreal
Institut de Recherches Cliniques de Montreal IRCM
University of Pennsylvania Penn
Original Assignee
Universite de Montreal
Institut de Recherches Cliniques de Montreal IRCM
University of Pennsylvania Penn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universite de Montreal, Institut de Recherches Cliniques de Montreal IRCM, University of Pennsylvania Penn filed Critical Universite de Montreal
Application granted granted Critical
Publication of DE60044247D1 publication Critical patent/DE60044247D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70532—B7 molecules, e.g. CD80, CD86
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Transplantation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
DE60044247T 1999-04-30 2000-04-27 Humane cd80-mutante und zusammensetzungen und methoden zu deren herstellung und verwendung Expired - Lifetime DE60044247D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13176499P 1999-04-30 1999-04-30
PCT/US2000/011310 WO2000066162A1 (en) 1999-04-30 2000-04-27 Mutant human cd80 and compositions for and methods of making and using the same

Publications (1)

Publication Number Publication Date
DE60044247D1 true DE60044247D1 (de) 2010-06-02

Family

ID=22450922

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60044247T Expired - Lifetime DE60044247D1 (de) 1999-04-30 2000-04-27 Humane cd80-mutante und zusammensetzungen und methoden zu deren herstellung und verwendung

Country Status (13)

Country Link
US (2) US7446189B1 (de)
EP (1) EP1173204B1 (de)
JP (1) JP2002542800A (de)
KR (2) KR20080052690A (de)
CN (1) CN1196495C (de)
AT (1) ATE464910T1 (de)
AU (1) AU779395B2 (de)
BR (1) BR0010155A (de)
CA (1) CA2369747A1 (de)
DE (1) DE60044247D1 (de)
IL (2) IL145795A0 (de)
MX (1) MXPA01011079A (de)
WO (1) WO2000066162A1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110104196A1 (en) * 2003-10-23 2011-05-05 Karp Nelson M Immunogenic composition and method of developing a vaccine based on fusion protein
US7786288B2 (en) * 2003-10-23 2010-08-31 Karp Nelson M Immunizing compositions encoding an epitope obtained from the HIV-1 capsid protein cyclophilin A binding site
EP1758558B1 (de) 2004-05-12 2013-10-16 Baxter International Inc. Oligonucleotid-haltige mikrokügelchen; ihre verwendung zur herstellung eines medikaments zur behandlung von diabetes typ 1
TW200613554A (en) 2004-06-17 2006-05-01 Wyeth Corp Plasmid having three complete transcriptional units and immunogenic compositions for inducing an immune response to HIV
WO2008037080A1 (en) * 2006-09-29 2008-04-03 Universite De Montreal Methods and compositions for immune response modulation and uses thereof
WO2014093118A1 (en) 2012-12-11 2014-06-19 Albert Einstein College Of Medicine Of Yeshiva University Methods for high throughput receptor:ligand identification
DK3283508T3 (en) 2015-04-17 2021-05-31 Alpine Immune Sciences Inc Immunomodulatory Proteins with Tunable Affinities
US10402438B2 (en) * 2015-07-20 2019-09-03 Disney Enterprises, Inc. Systems and methods of visualizing multimedia content
WO2017181152A2 (en) 2016-04-15 2017-10-19 Alpine Immune Sciences, Inc. Cd80 variant immunomodulatory proteins and uses thereof
BR112018073606A2 (pt) * 2016-05-18 2019-02-26 Cue Biopharma, Inc. polipeptídeos multiméricos moduladores de células t e métodos de uso dos mesmos
JP2019522466A (ja) 2016-05-18 2019-08-15 アルバート アインシュタイン カレッジ オブ メディシン，インコーポレイティド 変異ｐｄ−ｌ１ポリペプチド、ｔ細胞調節多量体ポリペプチド、及びそれらの使用方法
CN116970061A (zh) 2016-12-22 2023-10-31 库尔生物制药有限公司 T细胞调节性多聚体多肽及其使用方法
WO2018129474A1 (en) 2017-01-09 2018-07-12 Cue Biopharma, Inc. T-cell modulatory multimeric polypeptides and methods of use thereof
EP3596118A4 (de) 2017-03-15 2021-04-07 Cue Biopharma, Inc. Verfahren zur modulierung einer immunreaktion
AU2018235838B2 (en) 2017-03-16 2023-12-14 Alpine Immune Sciences, Inc. CD80 variant immunomodulatory proteins and uses thereof
EP3737689A4 (de) 2018-01-09 2021-12-01 Cue Biopharma, Inc. Multimere t-zell-modulierende polypeptide und verfahren zur verwendung davon
JP2022530628A (ja) * 2019-04-26 2022-06-30 スアンズ バイオファーマシューティカル カンパニー，リミテッド Ｃｄ８０バリアントタンパク質とその使用
CA3169949A1 (en) 2020-05-12 2021-11-18 Cue Biopharma, Inc. Multimeric t-cell modulatory polypeptides and methods of use thereof

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5077044A (en) 1980-05-19 1991-12-31 The Board Of Trustees Of The Leland Stanford Jr. University Novel non-reverting shigella live vaccines
US4873191A (en) 1981-06-12 1989-10-10 Ohio University Genetic transformation of zygotes
US5338683A (en) 1981-12-24 1994-08-16 Health Research Incorporated Vaccinia virus containing DNA sequences encoding herpesvirus glycoproteins
US5110587A (en) 1981-12-24 1992-05-05 Health Research, Incorporated Immunogenic composition comprising synthetically modified vaccinia virus
US5174993A (en) 1981-12-24 1992-12-29 Health Research Inc. Recombinant avipox virus and immunological use thereof
US4722848A (en) 1982-12-08 1988-02-02 Health Research, Incorporated Method for immunizing animals with synthetically modified vaccinia virus
US4736866A (en) 1984-06-22 1988-04-12 President And Fellows Of Harvard College Transgenic non-human mammals
US5036006A (en) 1984-11-13 1991-07-30 Cornell Research Foundation, Inc. Method for transporting substances into living cells and tissues and apparatus therefor
US4945050A (en) 1984-11-13 1990-07-31 Cornell Research Foundation, Inc. Method for transporting substances into living cells and tissues and apparatus therefor
GB8508845D0 (en) 1985-04-04 1985-05-09 Hoffmann La Roche Vaccinia dna
US5223424A (en) 1985-09-06 1993-06-29 Prutech Research And Development Attenuated herpesviruses and herpesviruses which include foreign DNA encoding an amino acid sequence
US5310668A (en) 1986-06-20 1994-05-10 Merck & Co., Inc. Varicella-zoster virus as a live recombinant vaccine
US5242829A (en) 1986-09-23 1993-09-07 Therion Biologics Corporation Recombinant pseudorabies virus
US5294441A (en) 1987-06-04 1994-03-15 Washington University Avirulent microbes and uses therefor: salmonella typhi
IL86583A0 (en) 1987-06-04 1988-11-15 Molecular Eng Ass Vaccine containing a derivative of a microbe and method for the production thereof
US5387744A (en) 1987-06-04 1995-02-07 Washington University Avirulent microbes and uses therefor: Salmonella typhi
US5554528A (en) * 1987-08-21 1996-09-10 Board Of Revents Of University Of Colorado Compositions and methods for inhibition of HIV production
US5112749A (en) 1987-10-02 1992-05-12 Praxis Biologics, Inc. Vaccines for the malaria circumsporozoite protein
US5585268A (en) * 1987-12-30 1996-12-17 Behringwerke Aktiengesellschaft Malaria-specific DNA sequences, expression products thereof, and the use thereof
US5225336A (en) 1989-03-08 1993-07-06 Health Research Incorporated Recombinant poxvirus host range selection system
DE4090351T1 (de) 1989-03-08 1997-07-24 Health Research Inc Rekombinantes Pockenvirus-Wirtsselektionssystem
US5703055A (en) 1989-03-21 1997-12-30 Wisconsin Alumni Research Foundation Generation of antibodies through lipid mediated DNA delivery
EP1026253B2 (de) 1989-03-21 2012-12-19 Vical Incorporated Expression von exogenen Polynukleotidsequenzen in Wirbeltieren
ES2090129T3 (es) 1989-03-31 1996-10-16 Univ Washington Vacunas que contienen microorganismos tipo phop avirulentos.
EP0431668B1 (de) 1989-12-04 1995-02-15 Akzo Nobel N.V. Rekombinantes Truthahn-Herpesvirus und davon abgeleiteter Lebendimpfstoffvektor
US5521288A (en) * 1990-03-26 1996-05-28 Bristol-Myers Squibb Company CD28IG fusion protein
US5294548A (en) 1990-04-02 1994-03-15 American Biogenetic Sciences, Inc Recombianant Hepatitis a virus
US5462734A (en) 1990-11-02 1995-10-31 Wisconsin Alumni Research Foundation Bovine herpesvirus vaccine and method of using same
US5240703A (en) 1991-03-01 1993-08-31 Syntro Corporation Attenuated, genetically-engineered pseudorabies virus s-prv-155 and uses thereof
ATE295895T1 (de) 1992-03-11 2005-06-15 Powderject Vaccines Inc Genetischer impfstoff gegen den immunschwäche virus
WO1993023552A1 (en) 1992-05-21 1993-11-25 Government Of The United States As Represented By Secretary Department Of Health And Human Services Targeting gene expression to living tissue using jet injection
US5593972A (en) 1993-01-26 1997-01-14 The Wistar Institute Genetic immunization
WO1994016737A1 (en) 1993-01-26 1994-08-04 Weiner David B Compositions and methods for delivery of genetic material
US5942607A (en) * 1993-07-26 1999-08-24 Dana-Farber Cancer Institute B7-2: a CTLA4/CD28 ligand
AU7405294A (en) 1993-07-26 1995-02-20 Dana-Farber Cancer Institute B7-2: ctl a4/cd 28 counter receptor
US6084067A (en) 1993-07-26 2000-07-04 Dana-Farber Cancer Institute CTLA4/CD28 ligands and uses therefor
US6218510B1 (en) * 1994-03-02 2001-04-17 Brigham & Woman's Hospital B7-1 and B7-2 polypeptides
US5739118A (en) 1994-04-01 1998-04-14 Apollon, Inc. Compositions and methods for delivery of genetic material
JP2531382B2 (ja) * 1994-05-26 1996-09-04 日本電気株式会社 ボ―ルグリッドアレイ半導体装置およびその製造方法
US5837533A (en) 1994-09-28 1998-11-17 American Home Products Corporation Complexes comprising a nucleic acid bound to a cationic polyamine having an endosome disruption agent
EP0789774A2 (de) 1994-10-03 1997-08-20 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES Erhöhte immunantwort durch einführen von einem zytokingen und/oder einem kostimulierenden b7-gen in einem rekombinanten virus-exprimierenden system
AU3107699A (en) * 1998-03-19 1999-10-11 Heska Corporation Novel forms of t cell costimulatory proteins, nucleic acid molecules, and uses thereof
US6248329B1 (en) * 1998-06-01 2001-06-19 Ramaswamy Chandrashekar Parasitic helminth cuticlin nucleic acid molecules and uses thereof

Also Published As

Publication number Publication date
ATE464910T1 (de) 2010-05-15
US7446189B1 (en) 2008-11-04
KR20080052690A (ko) 2008-06-11
US8202847B2 (en) 2012-06-19
EP1173204B1 (de) 2010-04-21
KR20020047032A (ko) 2002-06-21
EP1173204A1 (de) 2002-01-23
EP1173204A4 (de) 2003-11-05
CN1384758A (zh) 2002-12-11
JP2002542800A (ja) 2002-12-17
BR0010155A (pt) 2002-01-15
IL145795A0 (en) 2002-07-25
AU4494700A (en) 2000-11-17
KR100903710B1 (ko) 2009-06-19
MXPA01011079A (es) 2002-07-22
IL145795A (en) 2010-02-17
CA2369747A1 (en) 2000-11-09
WO2000066162A9 (en) 2002-01-10
US20110002956A1 (en) 2011-01-06
AU779395B2 (en) 2005-01-20
WO2000066162A1 (en) 2000-11-09
CN1196495C (zh) 2005-04-13

Similar Documents

Publication Publication Date Title
DE60044247D1 (de) Humane cd80-mutante und zusammensetzungen und methoden zu deren herstellung und verwendung
DE122012000001I1 (de) Humane antikorper gegen CTLA-4 und deren verwendungen.
DE60314500D1 (de) Diaminopyrimidine und deren verwendung als angiogenesehemmer
BR0207775A (pt) Lipossomos anfotéricos métodos para carregamento dos mesmos com ingredientes ativos e sua utilização
NL300307I1 (nl) Werkwijzen voor de replicatie van influenzavirussen in celkweek en de influenzavirussen die verkrijgbaar zijn met behulp van de werkwijze
WO2003066661A3 (en) Human dr4 antibodies and uses thereof
ATE517125T1 (de) ANTIKÖRPER GEGEN ßDEATH RECEPTOR 4ß (DR4) UND DEREN VERWENDUNGEN
YU76100A (sh) Pirolo(2,3-d) pirimidin preparati i njihova primena
ATE322288T1 (de) Zusammensetzungen zur immunisierung sowie deren verwendung
ATE429450T1 (de) Chimärische dr4 antikörper und ihre verwendung
DE69711430D1 (de) PYRROLO[3,4-d]PYRIMIDINON-DERIVATE UND IHRE VERWENDUNG ALS IMMUNOSUPPRESSOREN
DE502005001632D1 (de) Verfahren zur herstellung von 1,3,5-triazincarbamaten und -harnstoffen
ATE290857T1 (de) Bretyliumhaltige zusammensetzungen und kits und deren verwendung zur vorbeugung und behandlung cardiovaskulärer erkrankungen
TR200000291T2 (tr) Taşikinin reseptör antagonistleri olarak 2-asilaminopropanaminler.
DE69517191D1 (de) Wasserlösliche derivate epipodophyllotoxine, verfahren zu ihrer herstellung, ihre verwendung als medikament und ihre verwendung zur herstellung eines antikrebsmittels
WO2003000199A3 (en) Ilt3 and ilt4-related compositions and methods
DE69711633T2 (de) Stabile derivate von ubiquinol, verfahren zu ihrer herstellung und ihre pharmazeutische anwendung
DE60134408D1 (de) Für akzessorische hiv proteine kodierende dna impfstoffe
AU2202301A (en) Cd45 inhibitors
ATE265526T1 (de) Genetisch veränderte fibroblasten und ihre verwendung
DE69917440D1 (de) 5-imino-13-deoxy-antracyclin-derivate, ihre verwendung sowie verfahren zu deren herstellung
ATE283063T1 (de) Allogene und xenogene transplantation
MY157231A (en) Aminocyclohexyl ether compounds and uses thereof

Legal Events

Date Code Title Description
8364 No opposition during term of opposition