ATE296879T1 - Verfahren zur herstellung von gliedern von spezifischen bindungspaaren - Google Patents
Verfahren zur herstellung von gliedern von spezifischen bindungspaarenInfo
- Publication number
- ATE296879T1 ATE296879T1 AT93906742T AT93906742T ATE296879T1 AT E296879 T1 ATE296879 T1 AT E296879T1 AT 93906742 T AT93906742 T AT 93906742T AT 93906742 T AT93906742 T AT 93906742T AT E296879 T1 ATE296879 T1 AT E296879T1
- Authority
- AT
- Austria
- Prior art keywords
- sbp
- recombination
- members
- take place
- rgdps
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2812—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3007—Carcino-embryonic Antigens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
- C07K16/4208—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
- C07K16/462—Igs containing a variable region (Fv) from one specie and a constant region (Fc) from another
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00718—Type of compounds synthesised
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
- C07K2319/41—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation containing a Myc-tag
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/735—Fusion polypeptide containing domain for protein-protein interaction containing a domain for self-assembly, e.g. a viral coat protein (includes phage display)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB929206318A GB9206318D0 (en) | 1992-03-24 | 1992-03-24 | Binding substances |
PCT/GB1992/000883 WO1992020791A1 (en) | 1990-07-10 | 1992-05-15 | Methods for producing members of specific binding pairs |
PCT/GB1993/000605 WO1993019172A1 (en) | 1992-03-24 | 1993-03-24 | Methods for producing members of specific binding pairs |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE296879T1 true ATE296879T1 (de) | 2005-06-15 |
Family
ID=10712668
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT93906742T ATE296879T1 (de) | 1992-03-24 | 1993-03-24 | Verfahren zur herstellung von gliedern von spezifischen bindungspaaren |
Country Status (4)
Country | Link |
---|---|
US (1) | US6140471A (de) |
AT (1) | ATE296879T1 (de) |
AU (1) | AU673515B2 (de) |
GB (1) | GB9206318D0 (de) |
Families Citing this family (72)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6828106B2 (en) * | 1999-02-26 | 2004-12-07 | Cyclacel Limited | Methods and compositions using coiled binding partners |
EP2308982B1 (de) * | 2000-04-17 | 2014-11-26 | Dyax Corp. | Verfahren zur Einrichtung von Bibliotheken für genetische Verpackungen unterschiedlicher Familien von Peptiden |
US8288322B2 (en) * | 2000-04-17 | 2012-10-16 | Dyax Corp. | Methods of constructing libraries comprising displayed and/or expressed members of a diverse family of peptides, polypeptides or proteins and the novel libraries |
US6743592B1 (en) * | 2000-07-25 | 2004-06-01 | The Trustees Of The University Of Pennsylvania | Methods, systems and kits for immuno-detection of epitopes expressed on molecules |
US7524628B2 (en) * | 2000-07-25 | 2009-04-28 | The Trustees Of The University Of Pennsylvania | Method for detecting molecules expressing a selected epitope via fluorescent dyes |
PT2316940E (pt) | 2000-12-18 | 2013-10-16 | Dyax Corp | Bibliotecas orientadas de pacotes genéticos |
AU2002251913A1 (en) * | 2001-02-02 | 2002-08-19 | Millennium Pharmaceuticals, Inc. | Hybrid antibodies and uses thereof |
US20040132042A1 (en) * | 2001-04-06 | 2004-07-08 | Frankard Valerie Marie-Noelle | Use of double and opposite recombination sites or the single step cloning of two dna segments |
US7341831B2 (en) | 2001-07-18 | 2008-03-11 | The Trustees Of The University Of Pennsylvania | Method for immuno-detection of epitopes |
US6833441B2 (en) | 2001-08-01 | 2004-12-21 | Abmaxis, Inc. | Compositions and methods for generating chimeric heteromultimers |
US7175983B2 (en) * | 2001-11-02 | 2007-02-13 | Abmaxis, Inc. | Adapter-directed display systems |
US20050069549A1 (en) | 2002-01-14 | 2005-03-31 | William Herman | Targeted ligands |
ATE512163T1 (de) | 2002-02-25 | 2011-06-15 | Elan Pharm Inc | Verabreichung von mitteln zur behandlung von entzündungen |
AU2003239966B9 (en) * | 2002-06-03 | 2010-08-26 | Genentech, Inc. | Synthetic antibody phage libraries |
US20040067532A1 (en) | 2002-08-12 | 2004-04-08 | Genetastix Corporation | High throughput generation and affinity maturation of humanized antibody |
CA2510003A1 (en) * | 2003-01-16 | 2004-08-05 | Genentech, Inc. | Synthetic antibody phage libraries |
CA2514125A1 (en) | 2003-01-24 | 2004-08-12 | Elan Pharmaceuticals, Inc. | Composition for and treatment of demyelinating diseases and paralysis by administration of remyelinating agents |
WO2005012531A2 (en) * | 2003-08-01 | 2005-02-10 | Genentech, Inc. | Antibody cdr polypeptide sequences with restricted diversity |
AU2005216136A1 (en) * | 2004-02-20 | 2005-09-09 | The Trustees Of The University Of Pennsylvania | Reagents, kits and methods for immunodetection of epitopes on molecules |
ZA200608130B (en) | 2004-03-31 | 2008-12-31 | Genentech Inc | Humanized anti-TGF-beta antibodies |
US7785903B2 (en) * | 2004-04-09 | 2010-08-31 | Genentech, Inc. | Variable domain library and uses |
EP1835922B1 (de) * | 2004-12-22 | 2009-05-20 | Merck Serono SA | Kombinationstherapie gegen multiple sklerose |
US8679490B2 (en) | 2005-11-07 | 2014-03-25 | Genentech, Inc. | Binding polypeptides with diversified and consensus VH/VL hypervariable sequences |
WO2007059312A2 (en) | 2005-11-16 | 2007-05-24 | Ambrx, Inc. | Methods and compositions comprising non-natural amino acids |
WO2007064919A2 (en) * | 2005-12-02 | 2007-06-07 | Genentech, Inc. | Binding polypeptides with restricted diversity sequences |
EP2016101A2 (de) * | 2006-05-09 | 2009-01-21 | Genentech, Inc. | Bindung von polypeptiden mit optimierten gerüsten |
US8874380B2 (en) | 2010-12-09 | 2014-10-28 | Rutgers, The State University Of New Jersey | Method of overcoming therapeutic limitations of nonuniform distribution of radiopharmaceuticals and chemotherapy drugs |
WO2008060813A2 (en) | 2006-10-19 | 2008-05-22 | Merck & Co., Inc. | High affinity antibody antagonists of interleukin-13 receptor alpha 1 |
TW200831528A (en) | 2006-11-30 | 2008-08-01 | Astrazeneca Ab | Compounds |
AR065368A1 (es) | 2007-02-15 | 2009-06-03 | Astrazeneca Ab | Anticuerpos para moleculas de ige |
MX2009010639A (es) | 2007-04-02 | 2009-10-23 | Philogen Spa | Nuevo antigeno asociado con la neovasculatura de metastasis tumoral. |
CN103212072B (zh) | 2007-07-25 | 2015-07-22 | 菲洛根股份公司 | 一种与肺癌和淋巴瘤相关的抗原 |
MX344415B (es) | 2007-09-14 | 2016-12-15 | Adimab Inc | Bancos de anticuerpos sinteticos, designados racionalmente y usos para los mismos. |
US8877688B2 (en) | 2007-09-14 | 2014-11-04 | Adimab, Llc | Rationally designed, synthetic antibody libraries and uses therefor |
SI2209805T1 (sl) | 2007-10-30 | 2017-11-30 | Philogen S.P.A. | Antigen, povezan z revmatoidnim artritisom |
EP3257865A1 (de) | 2007-11-16 | 2017-12-20 | The Rockefeller University | Für die protofibrillenform des proteins beta-amyloid spezifische antikörper |
US8092804B2 (en) | 2007-12-21 | 2012-01-10 | Medimmune Limited | Binding members for interleukin-4 receptor alpha (IL-4Rα)-173 |
MX343594B (es) | 2007-12-21 | 2016-11-11 | Medimmune Ltd | Miembros de union para receptor alfa de interleucina-4 (il-4ra) - 173. |
US9873957B2 (en) * | 2008-03-13 | 2018-01-23 | Dyax Corp. | Libraries of genetic packages comprising novel HC CDR3 designs |
CN102356091A (zh) | 2008-03-14 | 2012-02-15 | 阿勒根公司 | 基于免疫的血清型a肉毒杆菌毒素活性测定 |
CA3049612C (en) | 2008-04-24 | 2023-01-10 | Dyax Corp. | Libraries of genetic packages comprising novel hc cdr1, cdr2, and cdr3 and novel lc cdr1, cdr2, and cdr3 designs |
US8298533B2 (en) | 2008-11-07 | 2012-10-30 | Medimmune Limited | Antibodies to IL-1R1 |
CA2748401C (en) | 2009-01-07 | 2017-09-12 | Philogen S.P.A. | Antigens associated with endometriosis |
DK3281953T3 (da) | 2009-03-13 | 2020-01-20 | Allergan Inc | Immun-baserede omdirigerede endopeptidase-aktivitetsassays |
ES2545792T5 (es) * | 2009-05-20 | 2018-09-14 | Novimmune Sa | Bancos de polipéptidos sintéticos y métodos para generar variantes de polipéptidos diversificados de forma natural |
CA2773564A1 (en) * | 2009-09-14 | 2011-03-17 | Dyax Corp. | Libraries of genetic packages comprising novel hc cdr3 designs |
CN103282560B (zh) | 2010-07-16 | 2016-08-03 | 阿迪马布有限责任公司 | 抗体文库 |
RS60565B1 (sr) | 2010-10-25 | 2020-08-31 | Biogen Ma Inc | Postupci za određivanje razlika u aktivnosti alfa-4 integrina putem uspostavljanja korelacije sa razlikama u nivoima svcam i/ili smadcam |
RU2013133846A (ru) | 2010-12-20 | 2015-01-27 | Медиммьюн Лимитед | Антитела против il-18 и их применение |
JP6323718B2 (ja) | 2011-05-17 | 2018-05-16 | ザ ロックフェラー ユニバーシティー | ヒト免疫不全ウイルスを無毒化する抗体、およびその使用方法。 |
US9575073B2 (en) | 2011-10-10 | 2017-02-21 | Rutgers, The State University Of New Jersey | Detection of high-risk intraductal papillary mucinous neoplasm and pancreatic adenocarcinoma |
HUE044927T2 (hu) | 2012-10-03 | 2019-11-28 | Philogen Spa | Ellenanyag-konjugátum, gyulladásos bélbetegség kezelésében történõ alkalmazásra |
PL2906597T3 (pl) | 2012-10-15 | 2020-09-21 | Medimmune Limited | Przeciwciała przeciwko amyloidowi beta |
BR112015008635B1 (pt) | 2012-10-18 | 2023-10-31 | The Rockefeller University | Anticorpos anti-hiv amplamente neutralizantes |
US9944693B2 (en) | 2013-12-08 | 2018-04-17 | Peptcell Limited | HIV antigens and antibodies and compositions, uses and methods thereof |
US8980273B1 (en) | 2014-07-15 | 2015-03-17 | Kymab Limited | Method of treating atopic dermatitis or asthma using antibody to IL4RA |
US8986691B1 (en) | 2014-07-15 | 2015-03-24 | Kymab Limited | Method of treating atopic dermatitis or asthma using antibody to IL4RA |
WO2016126488A1 (en) | 2015-02-02 | 2016-08-11 | Sea Lane Biotechnologies, Llc | Anti-surrogate light chain antibodies |
US9969792B2 (en) | 2015-06-12 | 2018-05-15 | Axiomx, Inc. | Methods and compositions for producing a chimeric polypeptide |
GB2562933B (en) | 2016-01-08 | 2022-06-29 | Maxion Therapeutics Ltd | Binding members with altered diversity scaffold domains |
WO2017121880A1 (en) | 2016-01-15 | 2017-07-20 | Philogen S.P.A | Intestinal antigens for pharmacodelivery applications |
EP3312290A1 (de) | 2016-10-18 | 2018-04-25 | Ipsen Biopharm Limited | Zellulärer vamp-spaltungstest |
ES2893249T3 (es) | 2016-11-09 | 2022-02-08 | Philogen Spa | Inmunoconjugados que comprenden IL-2, anticuerpo anti-fibronectina y TNF-alfa mutante |
EP3634999A1 (de) | 2017-06-07 | 2020-04-15 | Philogen S.p.A. | Gefässendothelwachstumsfaktor-/antifibronectin-antikörper-fusionsproteine |
GB201711208D0 (en) | 2017-07-12 | 2017-08-23 | Iontas Ltd | Ion channel inhibitors |
WO2019012015A1 (en) | 2017-07-12 | 2019-01-17 | Iontas Limited | POTASIC CHANNEL INHIBITORS |
JP2021500851A (ja) | 2017-08-18 | 2021-01-14 | ケンブリッジ・エンタープライズ・リミテッドCambridge Enterprise Limited | モジュラー結合タンパク質 |
MX2020006372A (es) | 2017-12-19 | 2020-09-03 | Univ Rockefeller | Variantes de dominio de fc de igg humana con funcion efectora mejorada. |
EP3502139A1 (de) | 2017-12-19 | 2019-06-26 | Philogen S.p.A. | Antikörper gegen tumorantigene |
KR20210005097A (ko) | 2018-04-30 | 2021-01-13 | 메디뮨 리미티드 | 응집체를 표적화하고 제거하는 접합체 |
GB201902392D0 (en) | 2019-02-21 | 2019-04-10 | Cambridge Entpr Ltd | Modular binding proteins |
WO2020169840A1 (en) | 2019-02-21 | 2020-08-27 | Cambridge Enterprise Limited | Bispecific proteins with a chimeric scaffold |
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WO1991010737A1 (en) * | 1990-01-11 | 1991-07-25 | Molecular Affinities Corporation | Production of antibodies using gene libraries |
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ATE164395T1 (de) * | 1990-12-03 | 1998-04-15 | Genentech Inc | Verfahren zur anreicherung von proteinvarianten mit geänderten bindungseigenschaften |
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US5885793A (en) * | 1991-12-02 | 1999-03-23 | Medical Research Council | Production of anti-self antibodies from antibody segment repertoires and displayed on phage |
US5733743A (en) * | 1992-03-24 | 1998-03-31 | Cambridge Antibody Technology Limited | Methods for producing members of specific binding pairs |
EP0656941B1 (de) * | 1992-03-24 | 2005-06-01 | Cambridge Antibody Technology Limited | Verfahren zur herstellung von gliedern von spezifischen bindungspaaren |
GB9227055D0 (en) * | 1992-12-29 | 1993-02-24 | Fujisawa Pharmaceutical Co | New use |
US5380530A (en) * | 1992-12-29 | 1995-01-10 | Whitehill Oral Technologies | Oral care composition coated gum |
-
1992
- 1992-03-24 GB GB929206318A patent/GB9206318D0/en active Pending
-
1993
- 1993-03-24 AT AT93906742T patent/ATE296879T1/de not_active IP Right Cessation
- 1993-03-24 AU AU37638/93A patent/AU673515B2/en not_active Ceased
-
1998
- 1998-03-30 US US09/050,783 patent/US6140471A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
GB9206318D0 (en) | 1992-05-06 |
AU3763893A (en) | 1993-10-21 |
US6140471A (en) | 2000-10-31 |
AU673515B2 (en) | 1996-11-14 |
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