ATE294859T1 - Polypeptid, humanin, welches das absterben von nervenzellen hemmt - Google Patents

Polypeptid, humanin, welches das absterben von nervenzellen hemmt

Info

Publication number
ATE294859T1
ATE294859T1 AT00961024T AT00961024T ATE294859T1 AT E294859 T1 ATE294859 T1 AT E294859T1 AT 00961024 T AT00961024 T AT 00961024T AT 00961024 T AT00961024 T AT 00961024T AT E294859 T1 ATE294859 T1 AT E294859T1
Authority
AT
Austria
Prior art keywords
polypeptide
death
disease
alzheimer
neuronal
Prior art date
Application number
AT00961024T
Other languages
English (en)
Inventor
Ikuo Nishimoto
Original Assignee
Univ Keio
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Keio filed Critical Univ Keio
Application granted granted Critical
Publication of ATE294859T1 publication Critical patent/ATE294859T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT00961024T 1999-09-17 2000-09-14 Polypeptid, humanin, welches das absterben von nervenzellen hemmt ATE294859T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP26467999 1999-09-17
JP2000201456 2000-06-29
PCT/JP2000/006314 WO2001021787A1 (en) 1999-09-17 2000-09-14 Polypeptide humanin inhibiting nerve cell death

Publications (1)

Publication Number Publication Date
ATE294859T1 true ATE294859T1 (de) 2005-05-15

Family

ID=26546618

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00961024T ATE294859T1 (de) 1999-09-17 2000-09-14 Polypeptid, humanin, welches das absterben von nervenzellen hemmt

Country Status (9)

Country Link
US (2) US7410757B1 (de)
EP (1) EP1221480B1 (de)
JP (2) JP4628627B2 (de)
AT (1) ATE294859T1 (de)
AU (2) AU785216B2 (de)
CA (1) CA2385444C (de)
DE (1) DE60019948T2 (de)
ES (1) ES2241654T3 (de)
WO (2) WO2001021786A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4628627B2 (ja) 1999-09-17 2011-02-09 学校法人慶應義塾 疾患抑制遺伝子のスクリーニング方法
ATE358179T1 (de) * 2001-06-15 2007-04-15 Takeda Pharmaceutical Polypeptid mit zelltodhemmender wirkung
AU2002364124A1 (en) 2001-11-28 2003-06-10 The Burnham Institute Methods for identifying modulators of apoptosis
CA2468874A1 (en) * 2001-11-29 2003-06-05 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw Method to isolate genes involved in aging
US20050233413A1 (en) * 2002-05-16 2005-10-20 Ikuo Nishimoto Neuroprotective polypeptides and methods of use
WO2003106683A1 (ja) 2002-06-14 2003-12-24 武田薬品工業株式会社 新規スクリーニング方法
WO2004008141A1 (ja) * 2002-07-15 2004-01-22 Takeda Chemical Industries, Ltd. 新規スクリーニング方法
JP5250179B2 (ja) * 2002-11-08 2013-07-31 ザ アドミニストレイターズ オブ ザ テューレイン エデュケイショナル ファンド フラビウイルス融合インヒビター
JP4878551B2 (ja) * 2004-04-08 2012-02-15 貞和 相磯 運動ニューロン疾患治療薬
JP2008528480A (ja) * 2005-01-24 2008-07-31 イエダ リサーチ アンド デベロップメント カンパニー リミテッド 免疫調節用ＨＩＶ−１ｇｐ４１融合ペプチド
JP4694563B2 (ja) * 2005-04-22 2011-06-08 学校法人慶應義塾 ヒューマニン受容体又はヒュ−マニン様ポリペプチド受容体
WO2008153788A2 (en) * 2007-05-30 2008-12-18 Albert Einstein College Of Medicine Of Yeshiva University Treatment of type 2 diabetes, metabolic syndrome, myocardial injury and neurodegeneration with humanin and analogs thereof
KR20100057060A (ko) * 2007-09-11 2010-05-28 몬도바이오테크 래보래토리즈 아게 치료제로서의 펩티드의 용도
US8637470B2 (en) * 2008-05-01 2014-01-28 The Regents Of The University Of California Small humanin-like peptides
US20130109615A1 (en) * 2010-02-24 2013-05-02 Ben Gurion University Of The Negev Research And Development Authority Methods for inhibiting necrosis
CN108431021B (zh) * 2015-11-03 2021-09-07 珍白斯凯尔有限公司 具有神经元损失预防和再生效果的肽以及包含该肽的组合物
CN117164668B (zh) * 2023-08-01 2024-05-10 青岛双元泰和药业有限公司 多肽化合物、其组合物及其用途

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2116460A1 (en) * 1993-03-02 1994-09-03 Mitsubishi Chemical Corporation Preventive or therapeutic agents for alzheimer's disease, a screening method of alzheimer's disease and tau-protein kinase i originated from human being
AU732508B2 (en) * 1996-01-26 2001-04-26 Governing Council Of The University Of Toronto, The Nucleic acids and proteins related to Alzheimer's disease, and uses therefor
WO1998015179A1 (en) * 1996-10-08 1998-04-16 University Of Washington Therapeutic and diagnostic applications of laminin and laminin-derived protein fragments
JPH11146743A (ja) 1997-11-17 1999-06-02 Japan Science & Technology Corp アルツハイマー病モデル動物
AU5448399A (en) 1998-09-04 2000-03-27 Keio University Nerve cell death receptor
JP4628627B2 (ja) 1999-09-17 2011-02-09 学校法人慶應義塾 疾患抑制遺伝子のスクリーニング方法
WO2001076532A2 (en) 2000-04-11 2001-10-18 Cogent Neuroscience, Inc. Compositions and methods for diagnosing and treating conditions, disorders, or diseases involving cell death

Also Published As

Publication number Publication date
CA2385444C (en) 2011-01-18
AU7313900A (en) 2001-04-24
WO2001021786A1 (fr) 2001-03-29
AU7313800A (en) 2001-04-24
US7410757B1 (en) 2008-08-12
EP1221480B1 (de) 2005-05-04
AU785216B2 (en) 2006-11-09
US7314864B1 (en) 2008-01-01
JP4969006B2 (ja) 2012-07-04
EP1221480A4 (de) 2003-05-07
WO2001021787A1 (en) 2001-03-29
ES2241654T3 (es) 2005-11-01
DE60019948D1 (de) 2005-06-09
DE60019948T2 (de) 2006-02-02
JP4628627B2 (ja) 2011-02-09
EP1221480A1 (de) 2002-07-10
CA2385444A1 (en) 2001-03-29

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