ATE293619T1 - Pyridinderivate als nmda-rezeptorliganden - Google Patents

Pyridinderivate als nmda-rezeptorliganden

Info

Publication number
ATE293619T1
ATE293619T1 AT02787541T AT02787541T ATE293619T1 AT E293619 T1 ATE293619 T1 AT E293619T1 AT 02787541 T AT02787541 T AT 02787541T AT 02787541 T AT02787541 T AT 02787541T AT E293619 T1 ATE293619 T1 AT E293619T1
Authority
AT
Austria
Prior art keywords
nmda receptor
receptor ligands
pyridine derivatives
pyridine
derivatives
Prior art date
Application number
AT02787541T
Other languages
German (de)
English (en)
Inventor
Alexander Alanine
Bernd Buettelmann
Neidhart Marie-Paule Heitz
Emmanuel Pinard
Rene Wyler
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of ATE293619T1 publication Critical patent/ATE293619T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT02787541T 2001-11-09 2002-11-02 Pyridinderivate als nmda-rezeptorliganden ATE293619T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01126467 2001-11-09
PCT/EP2002/012240 WO2003040128A1 (en) 2001-11-09 2002-11-02 Pyridine derivatives as nmda receptor ligands

Publications (1)

Publication Number Publication Date
ATE293619T1 true ATE293619T1 (de) 2005-05-15

Family

ID=8179179

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02787541T ATE293619T1 (de) 2001-11-09 2002-11-02 Pyridinderivate als nmda-rezeptorliganden

Country Status (16)

Country Link
US (1) US6831087B2 (enExample)
EP (1) EP1448547B1 (enExample)
JP (1) JP4188837B2 (enExample)
KR (1) KR100589995B1 (enExample)
CN (1) CN100516061C (enExample)
AR (1) AR037221A1 (enExample)
AT (1) ATE293619T1 (enExample)
AU (1) AU2002351816B8 (enExample)
BR (1) BR0213977A (enExample)
CA (1) CA2467973C (enExample)
DE (1) DE60203820T2 (enExample)
ES (1) ES2240829T3 (enExample)
MX (1) MXPA04004308A (enExample)
PL (1) PL369544A1 (enExample)
RU (1) RU2303037C2 (enExample)
WO (1) WO2003040128A1 (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007008816A (ja) * 2003-10-15 2007-01-18 Ube Ind Ltd 新規イソキノリン誘導体
US20050089559A1 (en) * 2003-10-23 2005-04-28 Istvan Szelenyi Combinations of potassium channel openers and sodium channel inhibitors or sodium channel-influencing active compounds for treating pains
RU2320654C1 (ru) * 2006-05-24 2008-03-27 Государственное образовательное учреждение высшего профессионального образования "Пермская государственная фармацевтическая академия Федерального агентства по здравоохранению и социальному развитию" (ГОУ ВПО ПГФА Росздрава) 2,2-ДИМЕТИЛ-4-(4,6-ДИМЕТИЛ-2-ПИРИДОН-3-ИЛ)-1,2-ДИГИДРО-БЕНЗО[f]ИЗОХИНОЛИНА ГИДРОХЛОРИД, ПРОЯВЛЯЮЩИЙ ПРЯМОЕ АНТИКОАГУЛЯНТНОЕ ДЕЙСТВИЕ
US8722929B2 (en) * 2006-10-10 2014-05-13 Valeant Pharmaceuticals International N-[2-amino-4-(phenylmethoxy)phenyl] amides and related compounds as potassium channel modulators
US8367684B2 (en) * 2007-06-13 2013-02-05 Valeant Pharmaceuticals International Derivatives of 4-(N-azacycloalkyl) anilides as potassium channel modulators
US8563566B2 (en) * 2007-08-01 2013-10-22 Valeant Pharmaceuticals International Naphthyridine derivatives as potassium channel modulators
US7786146B2 (en) * 2007-08-13 2010-08-31 Valeant Pharmaceuticals International Derivatives of 5-amino-4,6-disubstituted indole and 5-amino-4,6-disubstituted indoline as potassium channel modulators
EP2386558B1 (de) 2007-10-18 2014-10-01 Boehringer Ingelheim International GmbH CGRP-Antagonisten
EP2065381A1 (de) 2007-10-18 2009-06-03 Boehringer Ingelheim Pharma GmbH & Co. KG CGRP Antagonisten
US20120149698A1 (en) * 2007-11-22 2012-06-14 Boehringer Ingelheim International Gmbh Nouvel compounds
EP2062889A1 (de) * 2007-11-22 2009-05-27 Boehringer Ingelheim Pharma GmbH & Co. KG Verbindungen
US8829006B2 (en) 2007-11-22 2014-09-09 Boehringer Ingelheim International Gmbh Compounds
EA014100B1 (ru) * 2008-02-21 2010-08-30 Общество С Ограниченной Ответственностью "Валексфарм" Производные 2,4-диаминопиридина, фармацевтическая композиция, лекарственное средство на их основе для лечения или предупреждения заболеваний и нарушений, вызванных гиперактивацией nmda-рецепторов и/или в качестве стимуляторов когнитивных функций и способ лечения
RU2438672C1 (ru) 2010-04-30 2012-01-10 Общество с ограниченной ответственностью "Клевер Фарм" Агент, проявляющий свойства активатора когнитивных функций (варианты)
WO2025124571A1 (zh) * 2023-12-14 2025-06-19 斯莱普泰(上海)生物医药科技有限公司 Nmda受体拮抗剂及其用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA9610738B (en) 1995-12-22 1997-06-24 Warner Lambert Co Subtype selective nmda receptor ligands and the use thereof
JP4700192B2 (ja) * 1998-05-25 2011-06-15 アボット ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト 新規の複素環式の置換されたアミド、その製造および使用
DK1088818T3 (da) 1999-10-01 2005-03-14 Hoffmann La Roche Quinolin-4-yl-derivater
US6440995B1 (en) * 1999-10-01 2002-08-27 Hoffman-La Roche Inc. Quinolin-4-yl derivatives
US6339093B1 (en) 1999-10-08 2002-01-15 Hoffmann-La Roche Inc. Isoquinoline derivatives

Also Published As

Publication number Publication date
JP4188837B2 (ja) 2008-12-03
EP1448547A1 (en) 2004-08-25
RU2303037C2 (ru) 2007-07-20
CA2467973C (en) 2009-09-01
ES2240829T3 (es) 2005-10-16
AU2002351816B8 (en) 2008-04-03
CA2467973A1 (en) 2003-05-15
EP1448547B1 (en) 2005-04-20
CN1585762A (zh) 2005-02-23
PL369544A1 (en) 2005-05-02
JP2005513004A (ja) 2005-05-12
KR100589995B1 (ko) 2006-06-19
KR20050042252A (ko) 2005-05-06
WO2003040128A1 (en) 2003-05-15
MXPA04004308A (es) 2004-08-11
US20030119870A1 (en) 2003-06-26
CN100516061C (zh) 2009-07-22
AU2002351816B2 (en) 2008-03-06
RU2004117595A (ru) 2006-01-10
DE60203820D1 (de) 2005-05-25
AR037221A1 (es) 2004-10-27
BR0213977A (pt) 2004-08-31
DE60203820T2 (de) 2006-02-23
US6831087B2 (en) 2004-12-14

Similar Documents

Publication Publication Date Title
ATE253067T1 (de) Diazabicyloderivate als nikotin-acetylcholin- rezeptorliganden
DK1414440T3 (da) N-phenylpyrrolguanidinderivater som melanocortinreceptorligander
HUP0400249A3 (en) Pyridine derivatives as 5-ht receptor ligands and uses thereof
DE60331444D1 (de) 1h-1,2,4- triazol-3- carboxamid derivate als cannabinoid-cb1 receptor liganden
DE60225274D1 (de) Chinolinderivate als liganden für den neuropeptid-y-rezeptor
DE60023167D1 (de) Pyrazol-derivate als cannabinoidrezeptor-antagonisten
NO20054082D0 (no) Pyrazol`1,5-A! 1,3,5! triazinderivater som kannabinoidreseptorligander
ATE319451T1 (de) Tetrahydrochinolin-derivate
ATE396191T1 (de) Azaindolylalkylaminderivate als 5- hydroxytryptamin-6-liganden
IL156829A0 (en) Cannabinoid receptor ligands
ATE312827T1 (de) 3-substituierte-4-pyrimidonderivate
ATE378317T1 (de) Pyridin-derivate als cb2-rezeptor-modulatoren
DE50213548D1 (de) Substituierte 2-carba-3,5-dicyano-4-aryl-6-aminopylektive liganden
ATE335477T1 (de) Indolylalkylamin-derivate als 5-hydroxytryptamin- 6 liganden
DE60203820D1 (de) Pyridinderivate als nmda-rezeptorliganden
ATE306265T1 (de) Benzothiazolderivate als adenosin-rezeptor- liganden
PL373953A1 (en) 7-amino-benzothiazole derivatives as adenosine receptor ligands
DE60122495D1 (de) TRANS-N-i4-(4-HYDROXYPHENYL)CYCLOHEXYLö-3-PHENYLPROPIONAMID ALS SUBTYP-SELEKTIVER NMDA REZEPTOR ANTAGONIST
EE200300447A (et) Asendatud bensofuraan-2-karboksamiidide derivaadid
DK1322654T3 (da) Platinkomplekser som antitumormidler
ATE325123T1 (de) Imidazoquinoline derivate als adenosine a3 rezeptor liganden
NO20043119L (no) Triazolokinolinderivater som kan anvendes som adenosinreseptorligander
DK1442036T3 (da) Heteroarylderivater som fortræffelige ligander for nociceptinreceptor ORL-1
DE60106974D1 (de) Aminotriazolopyridinderivate als adenosinrezeptorliganden
DE60223031D1 (de) Arylpiperazin gebundene tetrahydroindolonderivate

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1448547

Country of ref document: EP

REN Ceased due to non-payment of the annual fee