ATE291615T1 - Testverfahren für agonisten und antagonisten des g protein gekoppelten rezeptors - Google Patents
Testverfahren für agonisten und antagonisten des g protein gekoppelten rezeptorsInfo
- Publication number
- ATE291615T1 ATE291615T1 AT98938160T AT98938160T ATE291615T1 AT E291615 T1 ATE291615 T1 AT E291615T1 AT 98938160 T AT98938160 T AT 98938160T AT 98938160 T AT98938160 T AT 98938160T AT E291615 T1 ATE291615 T1 AT E291615T1
- Authority
- AT
- Austria
- Prior art keywords
- protein coupled
- coupled receptor
- agonists
- antagonists
- pthr
- Prior art date
Links
- 239000000556 agonist Substances 0.000 title abstract 2
- 239000005557 antagonist Substances 0.000 title abstract 2
- 102000003688 G-Protein-Coupled Receptors Human genes 0.000 title 1
- 108090000045 G-Protein-Coupled Receptors Proteins 0.000 title 1
- 238000012360 testing method Methods 0.000 title 1
- 101001135738 Homo sapiens Parathyroid hormone-related protein Proteins 0.000 abstract 2
- 101000589873 Homo sapiens Parathyroid hormone/parathyroid hormone-related peptide receptor Proteins 0.000 abstract 2
- 102000003982 Parathyroid hormone Human genes 0.000 abstract 2
- 108090000445 Parathyroid hormone Proteins 0.000 abstract 2
- 102100036899 Parathyroid hormone-related protein Human genes 0.000 abstract 2
- 210000004027 cell Anatomy 0.000 abstract 2
- 239000000199 parathyroid hormone Substances 0.000 abstract 2
- 229960001319 parathyroid hormone Drugs 0.000 abstract 2
- 108020003175 receptors Proteins 0.000 abstract 2
- 102000005962 receptors Human genes 0.000 abstract 2
- 108091006068 Gq proteins Proteins 0.000 abstract 1
- 102000052606 Gq-G11 GTP-Binding Protein alpha Subunits Human genes 0.000 abstract 1
- 108091006065 Gs proteins Proteins 0.000 abstract 1
- 101100085138 Homo sapiens PTH1R gene Proteins 0.000 abstract 1
- 108700020797 Parathyroid Hormone-Related Proteins 0.000 abstract 1
- 102000043299 Parathyroid hormone-related Human genes 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 210000002919 epithelial cell Anatomy 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
- G01N33/5041—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects involving analysis of members of signalling pathways
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Pathology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- General Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Toxicology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Endocrinology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/903,977 US6183974B1 (en) | 1997-07-31 | 1997-07-31 | Screening assays for G protein coupled receptor agonists and antagonists |
| PCT/US1998/015877 WO1999006535A1 (en) | 1997-07-31 | 1998-07-30 | Screening assays for g protein coupled receptor agonists and antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE291615T1 true ATE291615T1 (de) | 2005-04-15 |
Family
ID=25418329
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98938160T ATE291615T1 (de) | 1997-07-31 | 1998-07-30 | Testverfahren für agonisten und antagonisten des g protein gekoppelten rezeptors |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US6183974B1 (https=) |
| EP (1) | EP1012241B1 (https=) |
| JP (1) | JP4261766B2 (https=) |
| AT (1) | ATE291615T1 (https=) |
| AU (1) | AU8675098A (https=) |
| DE (1) | DE69829483T2 (https=) |
| ES (1) | ES2239398T3 (https=) |
| WO (1) | WO1999006535A1 (https=) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4486256B2 (ja) * | 1998-10-22 | 2010-06-23 | ザ・ジェネラル・ホスピタル・コーポレイション | 副甲状腺ホルモン（ＰＴＨ）および副甲状腺ホルモン関連ペプチド（ＰＴＨｒＰ）の生物活性ペプチドおよびペプチド誘導体 |
| WO2001023521A2 (en) * | 1999-09-29 | 2001-04-05 | The General Hospital Corporation | Polypeptide derivatives of parathyroid hormone (pth) |
| US6756480B2 (en) | 2000-04-27 | 2004-06-29 | Amgen Inc. | Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein |
| AU2002339843B2 (en) * | 2001-07-23 | 2007-12-06 | The General Hospital Corporation | Conformationally constrained parathyroid hormone (PTH) analogs |
| US7166463B2 (en) * | 2001-11-16 | 2007-01-23 | The Regents Of The University Of Colorado | Nucleic acids encoding modified olfactory cyclic nucleotide gated ion channels |
| US7795220B2 (en) * | 2003-03-19 | 2010-09-14 | The General Hospital Corporation | Conformationally constrained parathyroid hormones with alpha-helix stabilizers |
| JP4871128B2 (ja) * | 2003-07-17 | 2012-02-08 | ザ ジェネラル ホスピタル コーポレイション | 高次構造的に制約された副甲状腺ホルモン（ｐｔｈ）アナログ |
| DOP2006000008A (es) * | 2005-01-10 | 2006-08-31 | Arena Pharm Inc | Terapia combinada para el tratamiento de la diabetes y afecciones relacionadas y para el tratamiento de afecciones que mejoran mediante un incremento de la concentración sanguínea de glp-1 |
| US7833730B2 (en) * | 2006-04-11 | 2010-11-16 | Arena Pharmaceuticals, Inc. | Methods of using GPR119 to identify compounds useful for increasing bone mass in an individual |
| PE20071221A1 (es) | 2006-04-11 | 2007-12-14 | Arena Pharm Inc | Agonistas del receptor gpr119 en metodos para aumentar la masa osea y para tratar la osteoporosis y otras afecciones caracterizadas por masa osea baja, y la terapia combinada relacionada a estos agonistas |
| WO2008019062A2 (en) * | 2006-08-04 | 2008-02-14 | The General Hospital Corporation | Polypeptide derivatives of parathyroid hormone (pth) |
| EP1961765A1 (en) * | 2006-12-08 | 2008-08-27 | Zealand Pharma A/S | Truncated PTH peptides with a cyclic conformation |
| CN104072606B (zh) * | 2007-08-01 | 2017-09-22 | 总医院有限公司 | 利用g蛋白偶联受体和相关组合物的筛选方法 |
| EP2108960A1 (en) | 2008-04-07 | 2009-10-14 | Arena Pharmaceuticals, Inc. | Methods of using A G protein-coupled receptor to identify peptide YY (PYY) secretagogues and compounds useful in the treatment of conditons modulated by PYY |
| MX358161B (es) | 2010-05-13 | 2018-08-06 | The General Hospital Corp Star | Analogos de hormona paratiroidea y usos para los mismos. |
| JP6093946B2 (ja) * | 2014-02-25 | 2017-03-15 | 国立大学法人東北大学 | Ｇタンパク質共役型受容体のシグナル伝達の検出方法 |
| US11975050B2 (en) | 2018-03-16 | 2024-05-07 | The General Hospital Corporation | Parathyroid hormone polypeptide conjugates and methods of their use |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5462856A (en) | 1990-07-19 | 1995-10-31 | Bunsen Rush Laboratories, Inc. | Methods for identifying chemicals that act as agonists or antagonists for receptors and other proteins involved in signal transduction via pathways that utilize G-proteins |
| DE69233472T2 (de) * | 1991-04-05 | 2006-02-09 | The General Hospital Corp., Charlestown | Parathormonrezeptor und dafür codierende DNA |
| DE4138621A1 (de) | 1991-11-25 | 1993-06-17 | Boehringer Ingelheim Int | Verfahren zum screenen von substanzen mit modulierender wirkung auf einen rezeptorabhaengigen zellulaeren signaluebertragungsweg |
-
1997
- 1997-07-31 US US08/903,977 patent/US6183974B1/en not_active Expired - Lifetime
-
1998
- 1998-07-30 EP EP98938160A patent/EP1012241B1/en not_active Expired - Lifetime
- 1998-07-30 DE DE69829483T patent/DE69829483T2/de not_active Expired - Lifetime
- 1998-07-30 ES ES98938160T patent/ES2239398T3/es not_active Expired - Lifetime
- 1998-07-30 JP JP2000505277A patent/JP4261766B2/ja not_active Expired - Lifetime
- 1998-07-30 AU AU86750/98A patent/AU8675098A/en not_active Abandoned
- 1998-07-30 AT AT98938160T patent/ATE291615T1/de not_active IP Right Cessation
- 1998-07-30 WO PCT/US1998/015877 patent/WO1999006535A1/en not_active Ceased
-
2000
- 2000-10-27 US US09/696,982 patent/US7033773B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| AU8675098A (en) | 1999-02-22 |
| JP4261766B2 (ja) | 2009-04-30 |
| DE69829483D1 (de) | 2005-04-28 |
| US6183974B1 (en) | 2001-02-06 |
| US7033773B1 (en) | 2006-04-25 |
| WO1999006535A1 (en) | 1999-02-11 |
| JP2001512664A (ja) | 2001-08-28 |
| EP1012241B1 (en) | 2005-03-23 |
| DE69829483T2 (de) | 2006-04-27 |
| EP1012241A1 (en) | 2000-06-28 |
| ES2239398T3 (es) | 2005-09-16 |
| EP1012241A4 (en) | 2001-10-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |