ATE291615T1 - Testverfahren für agonisten und antagonisten des g protein gekoppelten rezeptors - Google Patents

Testverfahren für agonisten und antagonisten des g protein gekoppelten rezeptors

Info

Publication number
ATE291615T1
ATE291615T1 AT98938160T AT98938160T ATE291615T1 AT E291615 T1 ATE291615 T1 AT E291615T1 AT 98938160 T AT98938160 T AT 98938160T AT 98938160 T AT98938160 T AT 98938160T AT E291615 T1 ATE291615 T1 AT E291615T1
Authority
AT
Austria
Prior art keywords
protein coupled
coupled receptor
agonists
antagonists
pthr
Prior art date
Application number
AT98938160T
Other languages
English (en)
Inventor
F Richard Bringhurst
Hisashi Takasu
Original Assignee
Gen Hospital Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gen Hospital Corp filed Critical Gen Hospital Corp
Application granted granted Critical
Publication of ATE291615T1 publication Critical patent/ATE291615T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5041—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects involving analysis of members of signalling pathways
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Pathology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Endocrinology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT98938160T 1997-07-31 1998-07-30 Testverfahren für agonisten und antagonisten des g protein gekoppelten rezeptors ATE291615T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/903,977 US6183974B1 (en) 1997-07-31 1997-07-31 Screening assays for G protein coupled receptor agonists and antagonists
PCT/US1998/015877 WO1999006535A1 (en) 1997-07-31 1998-07-30 Screening assays for g protein coupled receptor agonists and antagonists

Publications (1)

Publication Number Publication Date
ATE291615T1 true ATE291615T1 (de) 2005-04-15

Family

ID=25418329

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98938160T ATE291615T1 (de) 1997-07-31 1998-07-30 Testverfahren für agonisten und antagonisten des g protein gekoppelten rezeptors

Country Status (8)

Country Link
US (2) US6183974B1 (de)
EP (1) EP1012241B1 (de)
JP (1) JP4261766B2 (de)
AT (1) ATE291615T1 (de)
AU (1) AU8675098A (de)
DE (1) DE69829483T2 (de)
ES (1) ES2239398T3 (de)
WO (1) WO1999006535A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000023594A1 (en) * 1998-10-22 2000-04-27 The General Hospital Corporation BIOACTIVE PEPTIDES AND PEPTIDE DERIVATIVES OF PARATHYROID HORMONE (PTH) AND PARATHYROID HORMONE-RELATED PEPTIDE (PTHrP)
AU7734800A (en) * 1999-09-29 2001-04-30 General Hospital Corporation, The Polypeptide derivatives of parathyroid hormone (pth)
US6756480B2 (en) 2000-04-27 2004-06-29 Amgen Inc. Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein
AU2002339843B2 (en) * 2001-07-23 2007-12-06 The General Hospital Corporation Conformationally constrained parathyroid hormone (PTH) analogs
US7166463B2 (en) * 2001-11-16 2007-01-23 The Regents Of The University Of Colorado Nucleic acids encoding modified olfactory cyclic nucleotide gated ion channels
AU2003220380A1 (en) * 2003-03-19 2004-11-19 Bristol-Myers Squibb Company CONFORMATIONALLY CONSTRAINED PARATHYROID HORMONES WITH Alpha-HELIX STABILIZERS
US7910544B2 (en) * 2003-07-17 2011-03-22 The General Hospital Corporation Conformationally constrained parthyroid hormone (PTH) analogs
DOP2006000008A (es) * 2005-01-10 2006-08-31 Arena Pharm Inc Terapia combinada para el tratamiento de la diabetes y afecciones relacionadas y para el tratamiento de afecciones que mejoran mediante un incremento de la concentración sanguínea de glp-1
PE20071221A1 (es) 2006-04-11 2007-12-14 Arena Pharm Inc Agonistas del receptor gpr119 en metodos para aumentar la masa osea y para tratar la osteoporosis y otras afecciones caracterizadas por masa osea baja, y la terapia combinada relacionada a estos agonistas
EA201101475A1 (ru) 2006-04-11 2012-07-30 Арена Фармасьютикалз, Инк. Способы применения рецептора gpr119 для идентификации соединений, которые можно использовать для увеличения костной массы субъекта
EP2054077A4 (de) * 2006-08-04 2010-10-13 Gen Hospital Corp Polypeptidderivate des parathyroidhormons (pth)
EP1961765A1 (de) * 2006-12-08 2008-08-27 Zealand Pharma A/S Verkürzte PTH-Peptide mit zyklischer Konformation
BRPI0814962B8 (pt) 2007-08-01 2021-05-25 Chugai Pharmaceutical Co Ltd métodos in vitro para determinar se um composto candidato é um agonista de longa duração ou de curta duração de um receptor acoplado à proteína g, polipeptídeo, seu uso e composição farmacêutica
EP2146210A1 (de) * 2008-04-07 2010-01-20 Arena Pharmaceuticals, Inc. Verfahren zur Verwendung eines AG-Protein-gekoppelten Rezeptors zur Identifikation von Peptid-YY (PPY)-Sekretagogen sowie Verbindungen zur Behandlung durch PYY modulierter Leiden
MX358161B (es) 2010-05-13 2018-08-06 The General Hospital Corp Star Analogos de hormona paratiroidea y usos para los mismos.
WO2015128894A1 (ja) * 2014-02-25 2015-09-03 国立大学法人東北大学 Ｇタンパク質共役型受容体のシグナル伝達の検出方法
WO2019178462A1 (en) 2018-03-16 2019-09-19 The General Hospital Corporation Parathyroid hormone polypeptide conjugates and methods of their use

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5462856A (en) 1990-07-19 1995-10-31 Bunsen Rush Laboratories, Inc. Methods for identifying chemicals that act as agonists or antagonists for receptors and other proteins involved in signal transduction via pathways that utilize G-proteins
CA2107569C (en) * 1991-04-05 2011-08-02 Gino V. Segre Parathyroid hormone receptor and dna encoding same
DE4138621A1 (de) 1991-11-25 1993-06-17 Boehringer Ingelheim Int Verfahren zum screenen von substanzen mit modulierender wirkung auf einen rezeptorabhaengigen zellulaeren signaluebertragungsweg

Also Published As

Publication number Publication date
US7033773B1 (en) 2006-04-25
AU8675098A (en) 1999-02-22
DE69829483D1 (de) 2005-04-28
JP2001512664A (ja) 2001-08-28
EP1012241B1 (de) 2005-03-23
DE69829483T2 (de) 2006-04-27
US6183974B1 (en) 2001-02-06
EP1012241A4 (de) 2001-10-10
WO1999006535A1 (en) 1999-02-11
ES2239398T3 (es) 2005-09-16
EP1012241A1 (de) 2000-06-28
JP4261766B2 (ja) 2009-04-30

Similar Documents

Publication Publication Date Title
ATE291615T1 (de) Testverfahren für agonisten und antagonisten des g protein gekoppelten rezeptors
Luck et al. The (1–14) fragment of parathyroid hormone (PTH) activates intact and amino-terminally truncated PTH-1 receptors
ATE218708T1 (de) Elektrochemischer affinitätsassay
IL120081A0 (en) Assay for evaluating the receptor binding characteristics of amylin agonists and antagonists
AU4593097A (en) Methods and compositions for identifying receptor effectors
PT1015608E (pt) Metodos de ensaio de actividade de receptor e construcoes uteis nesses metodos
SG149693A1 (en) Peptides acting as both glp-1 receptor agonists and glucagon receptor antagonists and their pharmacological methods of use
ATE361099T1 (de) Heilmittel für kachexie
DE69819751D1 (de) VERWENDUNG VON LÖSLICHEM REZEPTOR FÜR FORTGESCHRITTENE GLYKOSILIERUNG-ENDPRODUKTE (sRAGE) ZUR UNTERDRÜCKUNG DER BESCHLEUNIGTER ATHERIOSKLEROSE
EP1140079A4 (de) Bestimmungsmethode fur liganden der nuklearen rezeptoren
WO2000031261A3 (en) Methods and compositions for identifying effectors of the formyl peptide receptor like-1 (fprl-1) receptor
AU1208497A (en) Ligand polypeptides for the g-protein-coupled receptor protein, their production and use
DE69837811D1 (de) Menschlicher lysophosphatidsäure rezeptor und dessen verwendung
CA2279881A1 (en) A method of identifying modulators of cell surface membrane receptors useful in the treatment of disease
DE69738072D1 (de) Modifizierte steroid-hormon rezeptoren
AR010041A1 (es) Agonistas multifuncionales quimericos de receptores de hematopoyetina
ES2129120T3 (es) Un receptor de celulas t humanas de la familia de receptores acoplados a la proteina g.
Carr et al. The PDZ domain protein SYNJ2BP regulates GRK-dependent Sst2A phosphorylation and downstream MAPK signaling
ES2115750T3 (es) Ensayo de captura de proteinas de union.
ATE457317T1 (de) Chemokine rezeptor
ATE494554T1 (de) Auf enzymen basierender assay für g-protein- gekoppelte rezeptoren
SE9701010D0 (sv) Antibody
FR2762602B1 (fr) Moyens pour la detection precoce de pathologies auto-immunes inflammatoires
Thomas et al. Conformational changes in the parathyroid hormone receptor associated with activation by agonist
WO1998050546A3 (en) B cell receptor associated proteins

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties