ATE290859T1 - Indanderivate für antipsychotische mittel - Google Patents
Indanderivate für antipsychotische mittelInfo
- Publication number
- ATE290859T1 ATE290859T1 AT97903904T AT97903904T ATE290859T1 AT E290859 T1 ATE290859 T1 AT E290859T1 AT 97903904 T AT97903904 T AT 97903904T AT 97903904 T AT97903904 T AT 97903904T AT E290859 T1 ATE290859 T1 AT E290859T1
- Authority
- AT
- Austria
- Prior art keywords
- indanderivates
- antipsychotic agents
- compounds
- provides
- novel
- Prior art date
Links
- 239000000164 antipsychotic agent Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 102000014415 Muscarinic acetylcholine receptor Human genes 0.000 abstract 1
- 108050003473 Muscarinic acetylcholine receptor Proteins 0.000 abstract 1
- 208000028017 Psychotic disease Diseases 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
- C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
- C07C257/12—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to hydrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/20—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D333/70—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
- Pyridine Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Quinoline Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Indole Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Furan Compounds (AREA)
- Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1028796P | 1996-01-22 | 1996-01-22 | |
| PCT/US1997/000997 WO1997025983A1 (en) | 1996-01-22 | 1997-01-22 | Indane derivatives for antipsychotic compositions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE290859T1 true ATE290859T1 (de) | 2005-04-15 |
Family
ID=21745035
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97903904T ATE290859T1 (de) | 1996-01-22 | 1997-01-22 | Indanderivate für antipsychotische mittel |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6429317B1 (de) |
| EP (2) | EP0880558A1 (de) |
| JP (2) | JP2000504320A (de) |
| AT (1) | ATE290859T1 (de) |
| AU (2) | AU1834997A (de) |
| CA (2) | CA2243500A1 (de) |
| DE (1) | DE69732762T2 (de) |
| DK (1) | DK0874625T3 (de) |
| ES (1) | ES2237788T3 (de) |
| PT (1) | PT874625E (de) |
| WO (2) | WO1997026300A1 (de) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6083986A (en) * | 1996-07-26 | 2000-07-04 | Icagen, Inc. | Potassium channel inhibitors |
| JP2001510481A (ja) * | 1997-01-22 | 2001-07-31 | イーライ・リリー・アンド・カンパニー | インダン様化合物の製造方法 |
| AU8591898A (en) | 1997-07-22 | 1999-02-16 | Eli Lilly And Company | Pharmaceutical compounds |
| US6333337B1 (en) | 1998-01-27 | 2001-12-25 | Icagen, Inc. | Potassium channel inhibitors |
| EP1109544A4 (de) * | 1998-09-01 | 2004-10-27 | Bristol Myers Squibb Co | Kaluim-kanal inhibitoren und verwendungsmethode |
| EP1240147A1 (de) | 1999-12-21 | 2002-09-18 | Icagen, Inc. | Kaliumkanalblocker |
| US6566380B2 (en) | 2000-07-25 | 2003-05-20 | Icagen, Inc. | Potassium channel inhibitors |
| US6620849B2 (en) | 2000-07-26 | 2003-09-16 | Icafen, Inc. | Potassium channel inhibitors |
| US6849634B2 (en) | 2000-12-21 | 2005-02-01 | Icagen | Potassium channel inhibitors |
| CN1556788A (zh) * | 2001-09-21 | 2004-12-22 | 毒蕈碱受体激动剂 | |
| EP1608617B1 (de) * | 2003-03-21 | 2013-01-09 | Eli Lilly And Company | Muscarinagonisten |
| CA2518324A1 (en) * | 2003-03-21 | 2004-11-04 | Eli Lilly And Company | Muscarinic agonists |
| US7265246B2 (en) | 2003-07-03 | 2007-09-04 | Eli Lilly And Company | Indane derivates as muscarinic receptor agonists |
| SG121940A1 (en) * | 2004-10-06 | 2006-05-26 | Shimano Kk | Handle knob and handle assembly for a fishing reel |
| MX2007004661A (es) | 2004-10-18 | 2007-06-22 | Lilly Co Eli | Derivados de 1-(hetero)aril-3-amino-pirrolidina para usarse como antagonistas del receptor mglur3. |
| JP2013523679A (ja) | 2010-03-29 | 2013-06-17 | ビーエーエスエフ ソシエタス・ヨーロピア | 殺菌性イミノ誘導体 |
| JP6440625B2 (ja) | 2012-11-14 | 2018-12-19 | ザ・ジョンズ・ホプキンス・ユニバーシティー | 精神分裂病を処置するための方法および組成物 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL27999A (en) | 1966-05-25 | 1971-08-25 | Egyt Gyogyszervegyeszeti Gyar | Naphthyl-and tetrahydronaphthyl-formamidines |
| JPS6160610A (ja) | 1984-08-31 | 1986-03-28 | Otsuka Pharmaceut Co Ltd | 低酸素症改善剤 |
| US4775695A (en) | 1987-06-01 | 1988-10-04 | Merck & Co., Inc. | Substituted amidinoalkoxy and amidinoalkylamino indanones and salts thereof |
| US5650489A (en) * | 1990-07-02 | 1997-07-22 | The Arizona Board Of Regents | Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof |
| US5401848A (en) * | 1990-11-26 | 1995-03-28 | E. R. Squibb & Sons, Inc. | Indane and quinoline derivatives |
| US5175166A (en) * | 1991-08-27 | 1992-12-29 | The University Of Toledo | Muscarinic agonists |
| US5446057A (en) * | 1993-09-24 | 1995-08-29 | Warner-Lambert Company | Substituted tetrahydropyridine and piperidine carboxylic acids as muscarinic antagonists |
| WO1995018617A1 (en) | 1994-01-10 | 1995-07-13 | Teva Pharmaceutical Industries Ltd. | 1-aminoindan derivatives and compositions thereof |
| US5712171A (en) | 1995-01-20 | 1998-01-27 | Arqule, Inc. | Method of generating a plurality of chemical compounds in a spatially arranged array |
| IL117149A0 (en) * | 1995-02-23 | 1996-06-18 | Schering Corp | Muscarinic antagonists |
| JP2001510481A (ja) * | 1997-01-22 | 2001-07-31 | イーライ・リリー・アンド・カンパニー | インダン様化合物の製造方法 |
-
1997
- 1997-01-22 AU AU18349/97A patent/AU1834997A/en not_active Abandoned
- 1997-01-22 AU AU15821/97A patent/AU1582197A/en not_active Abandoned
- 1997-01-22 CA CA002243500A patent/CA2243500A1/en not_active Abandoned
- 1997-01-22 CA CA002243717A patent/CA2243717A1/en not_active Abandoned
- 1997-01-22 US US09/117,089 patent/US6429317B1/en not_active Expired - Fee Related
- 1997-01-22 EP EP97902067A patent/EP0880558A1/de not_active Withdrawn
- 1997-01-22 DE DE69732762T patent/DE69732762T2/de not_active Expired - Fee Related
- 1997-01-22 JP JP9526290A patent/JP2000504320A/ja active Pending
- 1997-01-22 WO PCT/US1997/001004 patent/WO1997026300A1/en not_active Ceased
- 1997-01-22 WO PCT/US1997/000997 patent/WO1997025983A1/en not_active Ceased
- 1997-01-22 AT AT97903904T patent/ATE290859T1/de not_active IP Right Cessation
- 1997-01-22 ES ES97903904T patent/ES2237788T3/es not_active Expired - Lifetime
- 1997-01-22 JP JP52629297A patent/JP2001521484A/ja active Pending
- 1997-01-22 DK DK97903904T patent/DK0874625T3/da active
- 1997-01-22 EP EP97903904A patent/EP0874625B1/de not_active Expired - Lifetime
- 1997-01-22 PT PT97903904T patent/PT874625E/pt unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2000504320A (ja) | 2000-04-11 |
| EP0874625B1 (de) | 2005-03-16 |
| WO1997026300A1 (en) | 1997-07-24 |
| AU1582197A (en) | 1997-08-11 |
| JP2001521484A (ja) | 2001-11-06 |
| DE69732762D1 (de) | 2005-04-21 |
| DE69732762T2 (de) | 2006-04-13 |
| PT874625E (pt) | 2005-07-29 |
| EP0874625A4 (de) | 2001-03-14 |
| EP0880558A1 (de) | 1998-12-02 |
| WO1997025983A1 (en) | 1997-07-24 |
| DK0874625T3 (da) | 2005-06-20 |
| CA2243500A1 (en) | 1997-07-24 |
| US6429317B1 (en) | 2002-08-06 |
| ES2237788T3 (es) | 2005-08-01 |
| EP0874625A1 (de) | 1998-11-04 |
| CA2243717A1 (en) | 1997-07-24 |
| AU1834997A (en) | 1997-08-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 0874625 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |