ATE28402T1 - Stabile, waesserige, saure, zur einspritzung geeignete loesung von cis-platinum. - Google Patents
Stabile, waesserige, saure, zur einspritzung geeignete loesung von cis-platinum.Info
- Publication number
- ATE28402T1 ATE28402T1 AT84201425T AT84201425T ATE28402T1 AT E28402 T1 ATE28402 T1 AT E28402T1 AT 84201425 T AT84201425 T AT 84201425T AT 84201425 T AT84201425 T AT 84201425T AT E28402 T1 ATE28402 T1 AT E28402T1
- Authority
- AT
- Austria
- Prior art keywords
- aqueous
- stable
- solution
- cis
- acidic
- Prior art date
Links
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 title abstract 5
- 229910052697 platinum Inorganic materials 0.000 title abstract 4
- 230000002378 acidificating effect Effects 0.000 title 1
- 229940102223 injectable solution Drugs 0.000 title 1
- 239000000243 solution Substances 0.000 abstract 5
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 abstract 4
- 239000011780 sodium chloride Substances 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- 239000004615 ingredient Substances 0.000 abstract 1
- 238000002347 injection Methods 0.000 abstract 1
- 239000007924 injection Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/243—Platinum; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Medicinal Preparation (AREA)
- Escalators And Moving Walkways (AREA)
- Hydraulic Clutches, Magnetic Clutches, Fluid Clutches, And Fluid Joints (AREA)
- Excavating Of Shafts Or Tunnels (AREA)
- Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL8303657A NL8303657A (nl) | 1983-10-24 | 1983-10-24 | Voor injectie geschikte, stabiele, waterige, zoutzuur bevattende oplossing van cisplatine, alsmede werkwijze ter bereiding daarvan. |
| EP84201425A EP0143478B1 (de) | 1983-10-24 | 1984-10-04 | Stabile, wässerige, saure, zur Einspritzung geeignete Lösung von Cis-Platinum |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE28402T1 true ATE28402T1 (de) | 1987-08-15 |
Family
ID=19842603
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT84201425T ATE28402T1 (de) | 1983-10-24 | 1984-10-04 | Stabile, waesserige, saure, zur einspritzung geeignete loesung von cis-platinum. |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP0143478B1 (de) |
| JP (1) | JPS60172923A (de) |
| AT (1) | ATE28402T1 (de) |
| AU (1) | AU576204B2 (de) |
| DE (1) | DE3464849D1 (de) |
| DK (1) | DK160806C (de) |
| ES (1) | ES9300011A1 (de) |
| FI (1) | FI78837C (de) |
| IL (1) | IL72829A (de) |
| NL (1) | NL8303657A (de) |
| NO (1) | NO165277C (de) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL83380A (en) * | 1987-07-30 | 1991-04-15 | Teva Pharma | Stable aqueous cisplatin solutions |
| NL8901433A (nl) * | 1989-06-06 | 1991-01-02 | Pharmachemie Bv | Carboplatinpreparaat. |
| ATE173627T1 (de) * | 1992-09-04 | 1998-12-15 | Fuji Chem Ind Co Ltd | Medizinische zusammensetzung |
| US6861422B2 (en) | 2003-02-26 | 2005-03-01 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Dihydropteridinones, processes for preparing them and their use as pharmaceutical compositions |
| DE102004029784A1 (de) | 2004-06-21 | 2006-01-05 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue 2-Benzylaminodihydropteridinone, Verfahren zur deren Herstellung und deren Verwendung als Arzneimittel |
| DE102004033670A1 (de) | 2004-07-09 | 2006-02-02 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Pyridodihydropyrazinone, Verfahren zu Ihrer Herstellung und Ihre Verwendung als Arzneimittel |
| US20060058311A1 (en) | 2004-08-14 | 2006-03-16 | Boehringer Ingelheim International Gmbh | Combinations for the treatment of diseases involving cell proliferation |
| US20060074088A1 (en) | 2004-08-14 | 2006-04-06 | Boehringer Ingelheim International Gmbh | Dihydropteridinones for the treatment of cancer diseases |
| US7728134B2 (en) | 2004-08-14 | 2010-06-01 | Boehringer Ingelheim International Gmbh | Hydrates and polymorphs of 4[[(7R)-8-cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl]amino]-3-methoxy-N-(1-methyl-4-piperidinyl)-benzamide, process for their manufacture and their use as medicament |
| US7759485B2 (en) | 2004-08-14 | 2010-07-20 | Boehringer Ingelheim International Gmbh | Process for the manufacture of dihydropteridinones |
| US20060035903A1 (en) | 2004-08-14 | 2006-02-16 | Boehringer Ingelheim International Gmbh | Storage stable perfusion solution for dihydropteridinones |
| EP1630163A1 (de) | 2004-08-25 | 2006-03-01 | Boehringer Ingelheim Pharma GmbH & Co.KG | Dihydropteridinonderivative, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel |
| DE102004058337A1 (de) | 2004-12-02 | 2006-06-14 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Herstellung von annelierten Piperazin-2-on Derivaten |
| US7439358B2 (en) | 2006-02-08 | 2008-10-21 | Boehringer Ingelheim International Gmbh | Specific salt, anhydrous and crystalline form of a dihydropteridione derivative |
| WO2009019205A1 (en) | 2007-08-03 | 2009-02-12 | Boehringer Ingelheim International Gmbh | Crystalline form of a dihydropteridione derivative |
| US9358233B2 (en) | 2010-11-29 | 2016-06-07 | Boehringer Ingelheim International Gmbh | Method for treating acute myeloid leukemia |
| US9370535B2 (en) | 2011-05-17 | 2016-06-21 | Boehringer Ingelheim International Gmbh | Method for treatment of advanced solid tumors |
| WO2015011236A1 (en) | 2013-07-26 | 2015-01-29 | Boehringer Ingelheim International Gmbh | Treatment of myelodysplastic syndrome |
| US9867831B2 (en) | 2014-10-01 | 2018-01-16 | Boehringer Ingelheim International Gmbh | Combination treatment of acute myeloid leukemia and myelodysplastic syndrome |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4310515A (en) * | 1978-05-30 | 1982-01-12 | Bristol-Myers Company | Pharmaceutical compositions of cisplatin |
| SE445172B (sv) * | 1978-05-30 | 1986-06-09 | Bristol Myers Co | Stabil, steril vattenlosning av cisplatin i enhetsdoseringsform |
| US4302446A (en) * | 1979-10-02 | 1981-11-24 | Bristol-Myers Company | Pharmaceutical compositions |
| CA1162479A (en) * | 1980-03-31 | 1984-02-21 | Murray A. Kaplan | Pharmaceutical formulations containing cisplatin |
| US4426372A (en) * | 1980-08-08 | 1984-01-17 | Regents Of The University Of Minnesota | Inhibition of undesired effects of platinum(II) compounds |
| IT1153974B (it) * | 1982-09-23 | 1987-01-21 | Erba Farmitalia | Composizioni farmacologiche a base di cisplatino e metodo per il loro ottenimento |
-
1983
- 1983-10-24 NL NL8303657A patent/NL8303657A/nl not_active Application Discontinuation
-
1984
- 1984-08-20 FI FI843286A patent/FI78837C/fi not_active IP Right Cessation
- 1984-08-22 AU AU32269/84A patent/AU576204B2/en not_active Expired
- 1984-08-31 IL IL72829A patent/IL72829A/xx not_active IP Right Cessation
- 1984-10-04 AT AT84201425T patent/ATE28402T1/de not_active IP Right Cessation
- 1984-10-04 DE DE8484201425T patent/DE3464849D1/de not_active Expired
- 1984-10-04 EP EP84201425A patent/EP0143478B1/de not_active Expired
- 1984-10-22 JP JP59222864A patent/JPS60172923A/ja active Pending
- 1984-10-23 DK DK504384A patent/DK160806C/da not_active IP Right Cessation
- 1984-10-23 NO NO844225A patent/NO165277C/no not_active IP Right Cessation
- 1984-10-24 ES ES537033A patent/ES9300011A1/es active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| IL72829A (en) | 1986-09-30 |
| EP0143478A1 (de) | 1985-06-05 |
| FI843286L (fi) | 1985-04-25 |
| DE3464849D1 (en) | 1987-08-27 |
| DK504384D0 (da) | 1984-10-23 |
| AU576204B2 (en) | 1988-08-18 |
| FI78837B (fi) | 1989-06-30 |
| EP0143478B1 (de) | 1987-07-22 |
| IL72829A0 (en) | 1984-11-30 |
| DK160806B (da) | 1991-04-22 |
| JPS60172923A (ja) | 1985-09-06 |
| ES9300011A1 (es) | 1993-10-16 |
| FI843286A0 (fi) | 1984-08-20 |
| NO165277C (no) | 1991-01-30 |
| FI78837C (fi) | 1989-10-10 |
| AU3226984A (en) | 1985-06-13 |
| DK160806C (da) | 1991-10-07 |
| NL8303657A (nl) | 1985-05-17 |
| DK504384A (da) | 1985-04-25 |
| NO844225L (no) | 1985-04-25 |
| NO165277B (no) | 1990-10-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| EELA | Cancelled due to lapse of time |