ATE277128T1 - 4,7-dichlororhodaminfarbstoffe als molekulare sonden - Google Patents
4,7-dichlororhodaminfarbstoffe als molekulare sondenInfo
- Publication number
- ATE277128T1 ATE277128T1 AT00916662T AT00916662T ATE277128T1 AT E277128 T1 ATE277128 T1 AT E277128T1 AT 00916662 T AT00916662 T AT 00916662T AT 00916662 T AT00916662 T AT 00916662T AT E277128 T1 ATE277128 T1 AT E277128T1
- Authority
- AT
- Austria
- Prior art keywords
- hydrogen
- lower alkyl
- linking group
- sulfonate
- chlorine
- Prior art date
Links
- 239000003068 molecular probe Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 5
- 125000005647 linker group Chemical group 0.000 abstract 4
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 3
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 3
- 150000001336 alkenes Chemical class 0.000 abstract 3
- 150000001345 alkine derivatives Chemical class 0.000 abstract 3
- 229910052801 chlorine Inorganic materials 0.000 abstract 3
- 239000000460 chlorine Substances 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 229910052731 fluorine Inorganic materials 0.000 abstract 3
- 239000011737 fluorine Substances 0.000 abstract 3
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000003368 amide group Chemical group 0.000 abstract 2
- 125000005605 benzo group Chemical group 0.000 abstract 2
- 239000003153 chemical reaction reagent Substances 0.000 abstract 2
- 239000000975 dye Substances 0.000 abstract 2
- 150000002825 nitriles Chemical class 0.000 abstract 2
- 239000002157 polynucleotide Substances 0.000 abstract 2
- 102000040430 polynucleotide Human genes 0.000 abstract 2
- 108091033319 polynucleotide Proteins 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- 150000003457 sulfones Chemical class 0.000 abstract 2
- 238000004458 analytical method Methods 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 150000007942 carboxylates Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- -1 deoxynucleotides Chemical class 0.000 abstract 1
- 239000005546 dideoxynucleotide Substances 0.000 abstract 1
- 125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 abstract 1
- 239000007850 fluorescent dye Substances 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 238000012163 sequencing technique Methods 0.000 abstract 1
- 125000003258 trimethylene group Chemical group [H]C([H])([*:2])C([H])([H])C([H])([H])[*:1] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/277,793 US6080852A (en) | 1996-06-27 | 1999-03-27 | 4,7-dichlororhodamine dyes |
| PCT/US2000/008003 WO2000058406A1 (en) | 1999-03-27 | 2000-03-24 | 4,7-dichlororhodamine dyes useful as molecular probes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE277128T1 true ATE277128T1 (de) | 2004-10-15 |
Family
ID=23062373
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00916662T ATE277128T1 (de) | 1999-03-27 | 2000-03-24 | 4,7-dichlororhodaminfarbstoffe als molekulare sonden |
| AT03025777T ATE438691T1 (de) | 1999-03-27 | 2000-03-24 | Verfahren zur dna-sequenzierung unter verwendung von 4,7-dichlorrhodaminfarbstoffen |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03025777T ATE438691T1 (de) | 1999-03-27 | 2000-03-24 | Verfahren zur dna-sequenzierung unter verwendung von 4,7-dichlorrhodaminfarbstoffen |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US6080852A (https=) |
| EP (2) | EP1386946B1 (https=) |
| JP (3) | JP3848838B2 (https=) |
| AT (2) | ATE277128T1 (https=) |
| AU (1) | AU772329B2 (https=) |
| CA (1) | CA2367868C (https=) |
| DE (2) | DE60042706D1 (https=) |
| ES (2) | ES2329562T3 (https=) |
| WO (1) | WO2000058406A1 (https=) |
Families Citing this family (72)
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| US7550570B2 (en) * | 2000-05-25 | 2009-06-23 | Applied Biosystems, Llc. | 4,7-dichlororhodamine dyes labeled polynucleotides |
| US5936087A (en) | 1997-11-25 | 1999-08-10 | The Perkin-Elmer Corporation | Dibenzorhodamine dyes |
| US6583168B1 (en) * | 1997-11-25 | 2003-06-24 | Applera Corporation | Sulfonated diarylrhodamine dyes |
| US6372907B1 (en) * | 1999-11-03 | 2002-04-16 | Apptera Corporation | Water-soluble rhodamine dye peptide conjugates |
| AU2001279185B2 (en) * | 2000-08-04 | 2005-07-07 | Molecular Probes, Inc. | Derivatives of 1,2-dihydro-7-hydroxyquinolines containing fused rings |
| US7169922B2 (en) * | 2000-08-04 | 2007-01-30 | Invitrogen Corporation | Derivatives of 1,2-dihydro-7-hydroxyquinolines containing fused rings |
| AU1312502A (en) * | 2000-10-11 | 2002-04-22 | Pe Corp Ny | Fluorescent nucleobase conjugates having anionic linkers |
| US6916492B2 (en) | 2001-03-30 | 2005-07-12 | Council Of Scientific & Industrial Research | Natural nontoxic multicolor fluorescent protein dye from a marine invertebrate, compositions containing the said dye and its uses |
| DE10117303A1 (de) | 2001-03-30 | 2002-10-31 | Council Scient Ind Res | Ein natürlicher Fluoreszenzfarbstoff, gewonnen aus einem marinen Invertebraten, Zusammensetzungen die diesen Farbstoff enthalten und ihre Verwendung |
| US6689391B2 (en) | 2001-03-30 | 2004-02-10 | Council Of Scientific & Industrial Research | Natural non-polar fluorescent dye from a non-bioluminescent marine invertebrate, compositions containing the said dye and its uses |
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| EP3242690B1 (en) | 2015-01-06 | 2020-09-16 | De Haas, Anthony H. | Near-infrared fluorescent surgical dye markers |
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| BR112021012154A2 (pt) | 2018-12-20 | 2021-09-08 | Life Technologies Corporation | Corante de rodamina assimétrica e uso da mesma em ensaios biológicos |
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Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE45263C (de) | Badische Anilin- und Sodafabrik in Ludwigshafen a. Rh | Neuerung in dem Verfahren zur Darstellung von Farbstoffen aus der Gruppe des m - Amidophenol - Phtalei'ns | ||
| DE108347C (https=) | ||||
| DE47451C (de) | Badische Anilin- und Sodafabrik in Ludwigshafen a. Rh | Neuerung in dem Verfahren zur Darstellung von Farbstoffen aus der Gruppe des Metaamidophenolpbtalelns. (4 | ||
| BE755141A (fr) | 1969-08-21 | 1971-02-22 | Hoechst Ag | Procede de teinture ou d'impression de matieres textiles a basede polymeres ou de copolymeres de l'acrylonitrile |
| JPS488725B1 (https=) | 1969-10-08 | 1973-03-17 | ||
| FR2065117A5 (https=) | 1969-10-08 | 1971-07-23 | Fuji Photo Film Co Ltd | |
| US4318846A (en) | 1979-09-07 | 1982-03-09 | Syva Company | Novel ether substituted fluorescein polyamino acid compounds as fluorescers and quenchers |
| US4622400A (en) | 1983-12-29 | 1986-11-11 | The United States Of America As Represented By The United States Department Of Energy | Preparation of certain m-aminophenols and the use thereof for preparation of laser dyes |
| DE3425631A1 (de) | 1984-07-12 | 1986-01-16 | Basf Ag, 6700 Ludwigshafen | Rhodaminfarbstoffe |
| US4855225A (en) | 1986-02-07 | 1989-08-08 | Applied Biosystems, Inc. | Method of detecting electrophoretically separated oligonucleotides |
| CA1340806C (en) | 1986-07-02 | 1999-11-02 | James Merrill Prober | Method, system and reagents for dna sequencing |
| US4965349A (en) | 1987-12-24 | 1990-10-23 | Applied Biosystems, Inc. | Method of synthesizing oligonucleotides labeled with ammonia-labile groups on solid phase supports |
| EP0333649B1 (de) | 1988-03-01 | 1994-06-08 | Ciba-Geigy Ag | 3-Basisch substituierte 2-Methylfluorane |
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| US5188934A (en) * | 1989-11-14 | 1993-02-23 | Applied Biosystems, Inc. | 4,7-dichlorofluorescein dyes as molecular probes |
| US5750409A (en) * | 1991-11-18 | 1998-05-12 | Boehringer Mannheim Gmbh | Pentacyclic compounds and their use as absorption or fluorescent dyes |
| US5256799A (en) | 1992-07-14 | 1993-10-26 | The United States Of Americas As Represented By The United States Department Of Energy | Preparation of 6-hydroxyindolines and their use for preparation of novel laser dyes |
| DE69324494T2 (de) | 1992-09-03 | 1999-09-23 | The Perkin-Elmer Corp., Foster City | 4,7-dichlorofluoroszein-farbestoffe als molekulare sonden |
| US5283336A (en) | 1992-09-08 | 1994-02-01 | The United States Of America As Represented By The United States Department Of Energy | Method for preparation of 7-hydroxy-1,2,3,4-tetrahydroquinoline from 1,2,3,4-tetrahydroquinoline |
| JPH08503604A (ja) | 1992-09-18 | 1996-04-23 | アモコ・コーポレーション | プローブで用いるための緑色蛍光標識ヌクレオチド |
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| US5847162A (en) * | 1996-06-27 | 1998-12-08 | The Perkin Elmer Corporation | 4, 7-Dichlororhodamine dyes |
| US6017712A (en) | 1996-06-27 | 2000-01-25 | Lee; Linda | 4,7-dichlororhodamine dyes |
| US6080852A (en) * | 1996-06-27 | 2000-06-27 | The Perkin-Elmer Corporation | 4,7-dichlororhodamine dyes |
| US5770716A (en) * | 1997-04-10 | 1998-06-23 | The Perkin-Elmer Corporation | Substituted propargylethoxyamido nucleosides, oligonucleotides and methods for using same |
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-
1999
- 1999-03-27 US US09/277,793 patent/US6080852A/en not_active Expired - Lifetime
-
2000
- 2000-03-24 AU AU37732/00A patent/AU772329B2/en not_active Ceased
- 2000-03-24 EP EP03025777A patent/EP1386946B1/en not_active Expired - Lifetime
- 2000-03-24 AT AT00916662T patent/ATE277128T1/de not_active IP Right Cessation
- 2000-03-24 AT AT03025777T patent/ATE438691T1/de not_active IP Right Cessation
- 2000-03-24 EP EP00916662A patent/EP1165694B1/en not_active Expired - Lifetime
- 2000-03-24 ES ES03025777T patent/ES2329562T3/es not_active Expired - Lifetime
- 2000-03-24 JP JP2000608692A patent/JP3848838B2/ja not_active Expired - Lifetime
- 2000-03-24 CA CA002367868A patent/CA2367868C/en not_active Expired - Fee Related
- 2000-03-24 DE DE60042706T patent/DE60042706D1/de not_active Expired - Lifetime
- 2000-03-24 WO PCT/US2000/008003 patent/WO2000058406A1/en not_active Ceased
- 2000-03-24 DE DE60014051T patent/DE60014051T8/de active Active
- 2000-03-24 ES ES00916662T patent/ES2226801T3/es not_active Expired - Lifetime
- 2000-05-25 US US09/578,920 patent/US6713622B1/en not_active Expired - Lifetime
-
2005
- 2005-11-04 JP JP2005321635A patent/JP4732130B2/ja not_active Expired - Fee Related
-
2010
- 2010-08-20 JP JP2010185648A patent/JP2011016813A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| AU3773200A (en) | 2000-10-16 |
| DE60014051D1 (de) | 2004-10-28 |
| EP1386946A1 (en) | 2004-02-04 |
| DE60014051T8 (de) | 2006-04-27 |
| CA2367868A1 (en) | 2000-10-05 |
| DE60014051T2 (de) | 2006-02-23 |
| JP2011016813A (ja) | 2011-01-27 |
| JP2002540280A (ja) | 2002-11-26 |
| EP1386946B1 (en) | 2009-08-05 |
| WO2000058406A1 (en) | 2000-10-05 |
| ATE438691T1 (de) | 2009-08-15 |
| JP3848838B2 (ja) | 2006-11-22 |
| EP1165694B1 (en) | 2004-09-22 |
| JP4732130B2 (ja) | 2011-07-27 |
| ES2329562T3 (es) | 2009-11-27 |
| US6080852A (en) | 2000-06-27 |
| AU772329B2 (en) | 2004-04-22 |
| US6713622B1 (en) | 2004-03-30 |
| JP2006151973A (ja) | 2006-06-15 |
| EP1165694A1 (en) | 2002-01-02 |
| DE60042706D1 (de) | 2009-09-17 |
| ES2226801T3 (es) | 2005-04-01 |
| CA2367868C (en) | 2007-06-19 |
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