ATE273021T1 - Gereinigtes vakuolisierendes toxin aus helicobacter pylori und methoden zu dessen verwendung - Google Patents
Gereinigtes vakuolisierendes toxin aus helicobacter pylori und methoden zu dessen verwendungInfo
- Publication number
- ATE273021T1 ATE273021T1 AT93906142T AT93906142T ATE273021T1 AT E273021 T1 ATE273021 T1 AT E273021T1 AT 93906142 T AT93906142 T AT 93906142T AT 93906142 T AT93906142 T AT 93906142T AT E273021 T1 ATE273021 T1 AT E273021T1
- Authority
- AT
- Austria
- Prior art keywords
- toxin
- methods
- purified
- helicobacter pylori
- vacuolizing
- Prior art date
Links
- 239000003053 toxin Substances 0.000 title abstract 3
- 231100000765 toxin Toxicity 0.000 title abstract 3
- 241000590002 Helicobacter pylori Species 0.000 title 1
- 229940037467 helicobacter pylori Drugs 0.000 title 1
- 230000002477 vacuolizing effect Effects 0.000 title 1
- 208000015181 infectious disease Diseases 0.000 abstract 2
- 108700030330 Helicobacter pylori VacA Proteins 0.000 abstract 1
- 208000008469 Peptic Ulcer Diseases 0.000 abstract 1
- 230000001147 anti-toxic effect Effects 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 206010017758 gastric cancer Diseases 0.000 abstract 1
- 208000010749 gastric carcinoma Diseases 0.000 abstract 1
- 208000011906 peptic ulcer disease Diseases 0.000 abstract 1
- 230000001681 protective effect Effects 0.000 abstract 1
- 201000000498 stomach carcinoma Diseases 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56911—Bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/205—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Campylobacter (G)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
- C07K16/121—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Helicobacter (Campylobacter) (G)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
- G01N2333/205—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Campylobacter (G)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US84164492A | 1992-02-26 | 1992-02-26 | |
PCT/US1993/001558 WO1993016723A1 (en) | 1992-02-26 | 1993-02-24 | Purified vacuolating toxin from helicobacter pylori and methods to use same |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE273021T1 true ATE273021T1 (de) | 2004-08-15 |
Family
ID=25285365
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT93906142T ATE273021T1 (de) | 1992-02-26 | 1993-02-24 | Gereinigtes vakuolisierendes toxin aus helicobacter pylori und methoden zu dessen verwendung |
Country Status (8)
Country | Link |
---|---|
US (2) | US6054132A (de) |
EP (1) | EP0629132B1 (de) |
JP (3) | JP3920320B2 (de) |
AT (1) | ATE273021T1 (de) |
AU (1) | AU3728293A (de) |
CA (1) | CA2117490C (de) |
DE (1) | DE69333585T2 (de) |
WO (1) | WO1993016723A1 (de) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5721349A (en) * | 1992-02-26 | 1998-02-24 | Vanderbilt University | Vacuolating toxin-deficient H. pylori |
US5859219A (en) * | 1992-02-26 | 1999-01-12 | Vanderbilt University | Purified vacuolating toxin from Helicobacter pylori and methods to use same |
EP0629132B1 (de) * | 1992-02-26 | 2004-08-11 | Vanderbilt University | Gereinigtes vakuolisierendes toxin aus helicobacter pylori und methoden zu dessen verwendung |
US7141244B1 (en) * | 1992-03-02 | 2006-11-28 | Chiron Srl | Helicobacter pylori proteins useful for vaccines and diagnostics |
MX9301706A (es) * | 1992-04-13 | 1994-05-31 | Oravax Inc | Composicion de vacuna para el tratamiento de la infeccion por helicobacter. |
US6290962B1 (en) * | 1992-11-03 | 2001-09-18 | Oravax, Inc. | Urease-based vaccine and treatment for helicobacter infection |
US6258359B1 (en) | 1993-05-19 | 2001-07-10 | Institut Pasteur | Immunogenic compositions against helicobacter infection, polypeptides for use in the compositions, and nucleic acid sequences encoding said polypeptides |
WO1995014093A1 (en) | 1993-05-19 | 1995-05-26 | Institut Pasteur | Immunogenic compositions against helicobacter infection, polypeptides for use in the compositions and nucleic acid sequences encoding said polypeptides |
US6406703B1 (en) | 1993-07-27 | 2002-06-18 | Csl Limited | Treatment of H. pylori associated gastroduodenal disease |
WO1995003824A1 (en) * | 1993-07-27 | 1995-02-09 | Csl Limited | Treatment of h. pylori associated gastroduodenal disease |
AUPM612494A0 (en) | 1994-06-08 | 1994-06-30 | Csl Limited | Treatment or prevention of helicobacter infection |
GB2290710B (en) * | 1994-06-29 | 1998-03-25 | Reckitt & Colmann Prod Ltd | Protease from helicobacter pylori for use in vaccines/therapeutic compositions |
ATE229978T1 (de) * | 1994-07-01 | 2003-01-15 | Chiron Corp | Helicobacter proteine und impstoffe |
GB9422331D0 (en) * | 1994-11-04 | 1994-12-21 | Biocine Spa | H. pylori fermentation process |
AU1463097A (en) | 1996-01-04 | 1997-08-01 | Rican Limited | Helicobacter pylori bacterioferritin |
EP0918858A1 (de) | 1996-05-10 | 1999-06-02 | Biogen, Inc. | Agenzien, die die gemeinsame gamma-kette blockieren |
US6902903B1 (en) * | 1996-12-19 | 2005-06-07 | Chiron Corporation | Helicobacter pylori diagnostics |
GB9807721D0 (en) * | 1998-04-08 | 1998-06-10 | Chiron Spa | Antigen |
JP4346821B2 (ja) | 1998-04-30 | 2009-10-21 | カイロン ソチエタ ア レスポンサビリタ リミタータ | H.Pyloriによる感染に対する免疫化および処置 |
FI20010019A (fi) * | 2001-01-05 | 2002-07-06 | Biohit Oyj | Menetelmä atrofisen diagnostisoimiseksi |
EP1373566B1 (de) * | 2001-04-02 | 2009-08-12 | Point-2-Point Genomics Ltd. | Analyse von polynukleotiden mittels kombinatorischer pcr |
WO2003018054A1 (en) * | 2001-08-31 | 2003-03-06 | Chiron Srl. | Helicobacter pylori vaccination |
US20030224401A1 (en) * | 2002-02-19 | 2003-12-04 | The Regents Of The University Of California | Proteins for helicobacter diagnosis |
US8647640B2 (en) * | 2009-06-24 | 2014-02-11 | Richard E. COWART | Vaccine compositions and methods of use to protect against infectious disease |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5459041A (en) * | 1988-02-18 | 1995-10-17 | Enteric Research Laboratories, Inc. | Campylobacter pylori antigens and uses thereof for detection of Campylobacter pylori infection |
US4882271A (en) * | 1988-03-10 | 1989-11-21 | Baylor College Of Medicine | Process for preparation of high molecular weight cell-associated protein of campylobacter pylori and use for serological detection of campylobacter pylori infection |
GB2223756A (en) * | 1988-09-29 | 1990-04-18 | Health Lab Service Board | Protein purification process |
AU644121B2 (en) * | 1989-12-04 | 1993-12-02 | Auspharm International Limited | Rapid in vitro test for helicobacter pylori using saliva |
US5567594A (en) * | 1991-04-26 | 1996-10-22 | Enteron, L.P. | Methods and compositions for the detection and treatment of diseases associated with antigens of microorganisms |
US5262156A (en) * | 1991-08-12 | 1993-11-16 | Hycor Biomedical, Inc. | Antigenic compositions and their use for the detection of Helicobacter pylori |
US5721349A (en) * | 1992-02-26 | 1998-02-24 | Vanderbilt University | Vacuolating toxin-deficient H. pylori |
EP0629132B1 (de) * | 1992-02-26 | 2004-08-11 | Vanderbilt University | Gereinigtes vakuolisierendes toxin aus helicobacter pylori und methoden zu dessen verwendung |
EP0967279B1 (de) * | 1992-03-02 | 2008-01-02 | Novartis Vaccines and Diagnostics S.r.l. | Helicobacter pylori Cytotoxin verwendbar in Impfstoffe und Diagnostik |
MX9301706A (es) * | 1992-04-13 | 1994-05-31 | Oravax Inc | Composicion de vacuna para el tratamiento de la infeccion por helicobacter. |
IT1258182B (it) * | 1992-08-12 | 1996-02-20 | Composizioni contenenti bafilomycina per l'inibizione di vacuolizzazione indotta da helicobacter pylori | |
US5403924A (en) * | 1992-10-13 | 1995-04-04 | Vanderbilt University | Taga gene and methods for detecting predisposition to peptic ulceration |
-
1993
- 1993-02-24 EP EP93906142A patent/EP0629132B1/de not_active Expired - Lifetime
- 1993-02-24 WO PCT/US1993/001558 patent/WO1993016723A1/en active IP Right Grant
- 1993-02-24 AT AT93906142T patent/ATE273021T1/de not_active IP Right Cessation
- 1993-02-24 CA CA002117490A patent/CA2117490C/en not_active Expired - Lifetime
- 1993-02-24 AU AU37282/93A patent/AU3728293A/en not_active Abandoned
- 1993-02-24 JP JP51500793A patent/JP3920320B2/ja not_active Expired - Fee Related
- 1993-02-24 DE DE69333585T patent/DE69333585T2/de not_active Expired - Lifetime
-
1994
- 1994-08-02 US US08/284,747 patent/US6054132A/en not_active Expired - Fee Related
-
1995
- 1995-06-07 US US08/473,265 patent/US6013463A/en not_active Expired - Lifetime
-
2003
- 2003-07-03 JP JP2003191445A patent/JP2004043469A/ja not_active Withdrawn
-
2005
- 2005-05-12 JP JP2005140422A patent/JP2005320335A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
CA2117490A1 (en) | 1993-09-02 |
DE69333585D1 (de) | 2004-09-16 |
US6013463A (en) | 2000-01-11 |
US6054132A (en) | 2000-04-25 |
JP3920320B2 (ja) | 2007-05-30 |
EP0629132B1 (de) | 2004-08-11 |
DE69333585T2 (de) | 2005-07-28 |
JP2004043469A (ja) | 2004-02-12 |
CA2117490C (en) | 2009-01-06 |
JPH07507444A (ja) | 1995-08-24 |
EP0629132A1 (de) | 1994-12-21 |
WO1993016723A1 (en) | 1993-09-02 |
JP2005320335A (ja) | 2005-11-17 |
AU3728293A (en) | 1993-09-13 |
EP0629132A4 (de) | 1997-02-26 |
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Legal Events
Date | Code | Title | Description |
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UEP | Publication of translation of european patent specification |
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REN | Ceased due to non-payment of the annual fee |