ATE271065T1 - Schwefel-überführungs-reagenz für oligonukleotid- synthese - Google Patents
Schwefel-überführungs-reagenz für oligonukleotid- syntheseInfo
- Publication number
- ATE271065T1 ATE271065T1 AT98923757T AT98923757T ATE271065T1 AT E271065 T1 ATE271065 T1 AT E271065T1 AT 98923757 T AT98923757 T AT 98923757T AT 98923757 T AT98923757 T AT 98923757T AT E271065 T1 ATE271065 T1 AT E271065T1
- Authority
- AT
- Austria
- Prior art keywords
- sulfur
- compounds
- reagents
- transfer
- transfer reagents
- Prior art date
Links
- 239000003153 chemical reaction reagent Substances 0.000 title abstract 6
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 title abstract 2
- 229910052717 sulfur Inorganic materials 0.000 title abstract 2
- 239000011593 sulfur Substances 0.000 title abstract 2
- 238000006243 chemical reaction Methods 0.000 title 1
- 238000002515 oligonucleotide synthesis Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- YWZHEXZIISFIDA-UHFFFAOYSA-N 5-amino-1,2,4-dithiazole-3-thione Chemical compound NC1=NC(=S)SS1 YWZHEXZIISFIDA-UHFFFAOYSA-N 0.000 abstract 3
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 abstract 3
- JUDOLRSMWHVKGX-UHFFFAOYSA-N 1,1-dioxo-1$l^{6},2-benzodithiol-3-one Chemical compound C1=CC=C2C(=O)SS(=O)(=O)C2=C1 JUDOLRSMWHVKGX-UHFFFAOYSA-N 0.000 abstract 2
- 108091034117 Oligonucleotide Proteins 0.000 abstract 2
- RYYWUUFWQRZTIU-UHFFFAOYSA-N Thiophosphoric acid Chemical class OP(O)(S)=O RYYWUUFWQRZTIU-UHFFFAOYSA-N 0.000 abstract 2
- 238000005457 optimization Methods 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 239000007790 solid phase Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/15—Six-membered rings
- C07D285/16—Thiadiazines; Hydrogenated thiadiazines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/865,666 US6096881A (en) | 1997-05-30 | 1997-05-30 | Sulfur transfer reagents for oligonucleotide synthesis |
| PCT/US1998/010653 WO1998054198A1 (en) | 1997-05-30 | 1998-05-26 | Novel sulfur transfer reagents for oligonucleotide synthesis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE271065T1 true ATE271065T1 (de) | 2004-07-15 |
Family
ID=25345990
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98923757T ATE271065T1 (de) | 1997-05-30 | 1998-05-26 | Schwefel-überführungs-reagenz für oligonukleotid- synthese |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6096881A (enExample) |
| EP (1) | EP0986571B1 (enExample) |
| JP (1) | JP4393594B2 (enExample) |
| AT (1) | ATE271065T1 (enExample) |
| AU (1) | AU7597498A (enExample) |
| CA (1) | CA2291688C (enExample) |
| DE (1) | DE69825051T2 (enExample) |
| ES (1) | ES2226135T3 (enExample) |
| WO (1) | WO1998054198A1 (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7098325B2 (en) * | 1998-10-08 | 2006-08-29 | Pierre Martin | Process for the sulfurization of a phosphorus-containing compound |
| DE69910140T2 (de) * | 1998-10-08 | 2004-06-03 | Novartis Ag | Verfahren zur Sulfurierung von Phosphor-enthaltenden Verbindungen |
| GB0004889D0 (en) | 2000-03-01 | 2000-04-19 | Avecia Ltd | Synthesis of oligonucleotides |
| EP1343802B1 (en) * | 2000-12-05 | 2012-05-30 | Avecia Biotechnology Inc | Process for the preparation of oligonucleotides |
| US6768005B2 (en) * | 2000-12-20 | 2004-07-27 | Avecia Limited | Process |
| AR036122A1 (es) * | 2001-07-03 | 2004-08-11 | Avecia Biotechnology Inc | Un complejo de sal que comprende un n-alquilimidazol y una 1,1-dioxo-1,2-dihidro-1l6-benzo [d]-isotiazol-3-ona y un metodo para sintetizar oligonucleotidos utilizando la quimica de fosforamidita |
| JP4825375B2 (ja) * | 2001-08-28 | 2011-11-30 | 株式会社 資生堂 | ジチアゾール化合物及びマトリックスメタロプロテアーゼ活性阻害剤、皮膚外用剤 |
| GB0209539D0 (en) * | 2002-04-26 | 2002-06-05 | Avecia Ltd | Monomer Polymer and process |
| CA2561741C (en) * | 2004-04-05 | 2016-09-27 | Alnylam Pharmaceuticals, Inc. | Processes and reagents for oligonucleotide synthesis and purification |
| CN104086516B (zh) * | 2014-07-18 | 2016-01-06 | 成都樵枫科技发展有限公司 | R-(+)-硫代四氢呋喃-2-甲酸的合成方法 |
| KR20190100225A (ko) | 2016-12-28 | 2019-08-28 | 다이이찌 산쿄 가부시키가이샤 | 알포트 증후군 치료약 |
| WO2019111791A1 (ja) * | 2017-12-07 | 2019-06-13 | 第一三共株式会社 | ジストロフィン遺伝子のイントロンリテンションを解消するアンチセンスオリゴヌクレオチド |
| CN115976028B (zh) | 2018-03-09 | 2025-03-25 | 第一三共株式会社 | 糖原病Ia型治疗药 |
| US20210207136A1 (en) | 2018-06-13 | 2021-07-08 | Daiichi Sankyo Company, Limited | Myocardial dysfunction therapeutic agent |
| WO2020246560A1 (ja) | 2019-06-05 | 2020-12-10 | 学校法人福岡大学 | 化学修飾核酸を導入した安定型標的編集ガイドｒｎａ |
| JP7715345B2 (ja) | 2019-06-26 | 2025-07-30 | 神戸天然物化学株式会社 | ミオスタチン遺伝子のｍＲＮＡの産生を抑制する核酸医薬 |
| US20220364086A1 (en) | 2019-07-12 | 2022-11-17 | Daiichi Sankyo Company, Limited | ANTISENSE OLIGONUCLEOTIDE CAPABLE OF ALTERING SPLICING OF DUX4 pre-mRNA |
| CA3150715A1 (en) | 2019-09-10 | 2021-03-18 | Makoto Koizumi | Conjugate of galnac-oligonucleotide for delivery to liver and manufacturing method thereof |
| TW202128704A (zh) | 2019-10-18 | 2021-08-01 | 日商第一三共股份有限公司 | 雙環亞磷醯胺之製造方法 |
| EP4119167A4 (en) | 2020-03-11 | 2025-08-06 | Biocomber Co Ltd | SINGLE-STRANDED NUCLEIC ACID MOLECULE FOR INDUCING FRAME SHIFT-1 AND COMPOSITION |
| US20230272403A1 (en) | 2020-07-28 | 2023-08-31 | Knc Laboratories Co., Ltd. | Antisense oligonucleotide inducing exon skipping of angiotensin converting enzyme 2 gene |
| WO2022124345A1 (ja) | 2020-12-08 | 2022-06-16 | 学校法人福岡大学 | 化学修飾核酸を導入した安定型標的編集ガイドｒｎａ |
| CA3211057A1 (en) | 2021-02-26 | 2022-09-01 | Knc Laboratories Co., Ltd. | Nucleic acid medicine expressing splicing variant of myostatin |
| CN118891366A (zh) | 2022-03-16 | 2024-11-01 | 第一三共株式会社 | 抑制转铁蛋白受体2的表达的siRNA |
| CN118871585A (zh) | 2022-03-16 | 2024-10-29 | 第一三共株式会社 | 具有RNAi活性的化学-修饰的寡核苷酸 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3753908A (en) * | 1971-08-30 | 1973-08-21 | Chevron Res | Oxidation inhibited lubricating oil compositions with extreme pressure properties |
| DE4320157A1 (de) * | 1993-06-18 | 1994-12-22 | Bayer Ag | Verwendung von 1,2,4-Dithiazolium-Salzen als Chemotherapeutica |
-
1997
- 1997-05-30 US US08/865,666 patent/US6096881A/en not_active Expired - Lifetime
-
1998
- 1998-05-26 AT AT98923757T patent/ATE271065T1/de not_active IP Right Cessation
- 1998-05-26 EP EP98923757A patent/EP0986571B1/en not_active Expired - Lifetime
- 1998-05-26 DE DE69825051T patent/DE69825051T2/de not_active Expired - Lifetime
- 1998-05-26 JP JP50080299A patent/JP4393594B2/ja not_active Expired - Lifetime
- 1998-05-26 AU AU75974/98A patent/AU7597498A/en not_active Abandoned
- 1998-05-26 ES ES98923757T patent/ES2226135T3/es not_active Expired - Lifetime
- 1998-05-26 CA CA002291688A patent/CA2291688C/en not_active Expired - Lifetime
- 1998-05-26 WO PCT/US1998/010653 patent/WO1998054198A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| CA2291688C (en) | 2008-01-29 |
| DE69825051D1 (de) | 2004-08-19 |
| CA2291688A1 (en) | 1998-12-03 |
| JP2002501534A (ja) | 2002-01-15 |
| JP4393594B2 (ja) | 2010-01-06 |
| WO1998054198A1 (en) | 1998-12-03 |
| AU7597498A (en) | 1998-12-30 |
| DE69825051T2 (de) | 2005-10-06 |
| EP0986571B1 (en) | 2004-07-14 |
| ES2226135T3 (es) | 2005-03-16 |
| WO1998054198A9 (en) | 1999-04-01 |
| US6096881A (en) | 2000-08-01 |
| EP0986571A1 (en) | 2000-03-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 0986571 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |