ATE268774T1 - Substituierte pyridino pentaazamakrozykle komplexe mit superoxid-dismutase-aktivität - Google Patents
Substituierte pyridino pentaazamakrozykle komplexe mit superoxid-dismutase-aktivitätInfo
- Publication number
- ATE268774T1 ATE268774T1 AT00966722T AT00966722T ATE268774T1 AT E268774 T1 ATE268774 T1 AT E268774T1 AT 00966722 T AT00966722 T AT 00966722T AT 00966722 T AT00966722 T AT 00966722T AT E268774 T1 ATE268774 T1 AT E268774T1
- Authority
- AT
- Austria
- Prior art keywords
- complexes
- pentaazama
- crocycles
- superoxide dismutase
- dismutase activity
- Prior art date
Links
- 102000019197 Superoxide Dismutase Human genes 0.000 title 1
- 108010012715 Superoxide dismutase Proteins 0.000 title 1
- OUUQCZGPVNCOIJ-UHFFFAOYSA-M Superoxide Chemical compound [O-][O] OUUQCZGPVNCOIJ-UHFFFAOYSA-M 0.000 abstract 2
- HIWPNSZECWIVEV-UHFFFAOYSA-N 1,2,3,4,5-pentazacyclopentadecane Chemical compound C1CCCCCNNNNNCCCC1 HIWPNSZECWIVEV-UHFFFAOYSA-N 0.000 abstract 1
- PWHULOQIROXLJO-UHFFFAOYSA-N Manganese Chemical compound [Mn] PWHULOQIROXLJO-UHFFFAOYSA-N 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 150000002505 iron Chemical class 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 229910052748 manganese Inorganic materials 0.000 abstract 1
- 239000011572 manganese Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/06—Peri-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P35/04—Antineoplastic agents specific for metastasis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
- C07F13/005—Compounds without a metal-carbon linkage
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Toxicology (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Addiction (AREA)
- Biochemistry (AREA)
- Vascular Medicine (AREA)
- Oncology (AREA)
- Transplantation (AREA)
- Psychiatry (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Urology & Nephrology (AREA)
- Ophthalmology & Optometry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/398,120 US6214817B1 (en) | 1997-06-20 | 1999-09-16 | Substituted pyridino pentaazamacrocyle complexes having superoxide dismutase activity |
PCT/US2000/025154 WO2001019823A2 (en) | 1999-09-16 | 2000-09-14 | Substituted pyridino pentaazamacrocyle complexes having superoxide dismutase activity |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE268774T1 true ATE268774T1 (de) | 2004-06-15 |
Family
ID=23574065
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT04003751T ATE368039T1 (de) | 1999-09-16 | 2000-09-14 | Substituierte pyridino pentaazamakrozyklische liganden |
AT00966722T ATE268774T1 (de) | 1999-09-16 | 2000-09-14 | Substituierte pyridino pentaazamakrozykle komplexe mit superoxid-dismutase-aktivität |
AT04003746T ATE366254T1 (de) | 1999-09-16 | 2000-09-14 | Verwendung von substituierten pyridino pentaaazamykrozyklen komplexen mit superoxiddismutaseaktivität |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT04003751T ATE368039T1 (de) | 1999-09-16 | 2000-09-14 | Substituierte pyridino pentaazamakrozyklische liganden |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT04003746T ATE366254T1 (de) | 1999-09-16 | 2000-09-14 | Verwendung von substituierten pyridino pentaaazamykrozyklen komplexen mit superoxiddismutaseaktivität |
Country Status (12)
Country | Link |
---|---|
US (1) | US6214817B1 (de) |
EP (3) | EP1420019B1 (de) |
JP (2) | JP2003509423A (de) |
AT (3) | ATE368039T1 (de) |
AU (1) | AU784078B2 (de) |
CA (1) | CA2382105C (de) |
DE (3) | DE60035440T2 (de) |
DK (1) | DK1212323T3 (de) |
ES (3) | ES2222925T3 (de) |
HK (1) | HK1046689B (de) |
PT (1) | PT1212323E (de) |
WO (1) | WO2001019823A2 (de) |
Families Citing this family (68)
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US6127356A (en) | 1993-10-15 | 2000-10-03 | Duke University | Oxidant scavengers |
EP0846003A1 (de) * | 1995-08-17 | 1998-06-10 | Monsanto Company | Verfahren zur diagnostischen bildanalyse unter verwendung von biokonjugaten von metallkomplexen von stickstoffhaltigen makrocyclischen liganden |
US20050171198A1 (en) * | 1997-06-20 | 2005-08-04 | Metaphore Pharmaceuticals, Inc. | SODm therapy for treatment, prevention, inhibition and reversal of inflammatory disease |
DE69813898T2 (de) | 1997-11-03 | 2004-03-11 | Duke University | Substituierte porphyrinen |
MXPA01007451A (es) | 1999-01-25 | 2004-03-10 | Nat Jewish Med & Res Center | Porfirinas sustituidas. |
US20030069281A1 (en) * | 2000-06-14 | 2003-04-10 | Irwin Fridovich | Tetrapyrroles |
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US20040132706A1 (en) * | 2001-10-05 | 2004-07-08 | Daniela Salvemini | Composition comprising a catalyst for the dismutation of superoxide and use of the composition for preventing and treating hypotension |
KR100951606B1 (ko) * | 2001-12-14 | 2010-04-09 | 알콘 인코포레이티드 | 안과 질환 및 질병의 치료를 위한 과산화물 디스뮤타제모방체 |
CA2488500A1 (en) * | 2002-06-07 | 2003-12-18 | Duke University | Substituted porphyrins |
US6835387B2 (en) * | 2002-06-11 | 2004-12-28 | Scimed Life Systems, Inc. | Sustained release of superoxide dismutase mimics from implantable or insertable medical devices |
US20030232784A1 (en) * | 2002-06-14 | 2003-12-18 | Benedict James J. | Hyaluronic acid-associated superoxide dismutase mimics and their use in the treatment of joint pain |
CA2397684A1 (en) * | 2002-08-12 | 2004-02-12 | Michael P. Murphy | Mitochondrially targeted antioxidants |
EP1578413A2 (de) * | 2002-11-29 | 2005-09-28 | Yissum Research Development Company of The Hebrew University of Jerusalem | Ace-hemmer mit antioxidativer und no-donor-wirkung |
BR0317026A (pt) * | 2002-12-06 | 2005-10-25 | Alcon Inc | Mìmicos de superóxido dismutase para o tratamento de distúrbios e doenças oculares |
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LT2056675T (lt) | 2006-10-12 | 2019-05-27 | Galera Labs, Llc | Burnos gleivinės mukozito gydymo būdai |
WO2008114017A2 (en) * | 2007-03-19 | 2008-09-25 | Imperial Innovations Limited | Compositions and methods relating to influenza infection |
EP2296645B1 (de) | 2008-05-22 | 2014-11-19 | Galera Therapeutics, LLC | Antitumorale kombinationstherapie |
RU2506083C2 (ru) | 2008-05-23 | 2014-02-10 | Нэшнл Джуиш Хелт | Способ лечения поражений, ассоциированных с воздействием алкилирующих веществ |
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EA201992707A1 (ru) | 2013-11-18 | 2020-06-30 | Глобал Блад Терапьютикс, Инк. | Соединения и их применения для модуляции гемоглобина |
CN105899132B (zh) | 2013-12-31 | 2020-02-18 | 雅培糖尿病护理公司 | 自供电分析物传感器以及使用其的装置 |
PT3102208T (pt) | 2014-02-07 | 2021-04-05 | Global Blood Therapeutics Inc | Polimorfos cristalinos da base livre de 2-hidroxi-6-((2-(1-isopropil-1h-pirazol-5-il)piridin-3 il)metoxi)benzaldeído |
MA41841A (fr) | 2015-03-30 | 2018-02-06 | Global Blood Therapeutics Inc | Composés aldéhyde pour le traitement de la fibrose pulmonaire, de l'hypoxie, et de maladies auto-immunes et des tissus conjonctifs |
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TW202332423A (zh) | 2016-10-12 | 2023-08-16 | 美商全球血液治療公司 | 包含2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)吡啶-3-基)甲氧基)-苯甲醛之片劑 |
JP2020507598A (ja) | 2017-02-15 | 2020-03-12 | ガレラ・ラブス・リミテッド・ライアビリティ・カンパニーGalera Labs, Llc | 局所腸送達のためのペンタアザマクロ環錯体 |
AU2018252003A1 (en) * | 2017-04-13 | 2019-11-21 | Galera Labs, Llc | Combination cancer immunotherapy with pentaaza macrocyclic ring complex |
EA201992431A1 (ru) | 2017-10-13 | 2020-03-13 | ГАЛЕРА ЛЭБЗ, ЭлЭлСи | Комбинированная иммунотерапия рака с использованием пента-аза-макроциклического кольцевого комплекса |
JP2021512110A (ja) | 2018-01-31 | 2021-05-13 | ガレラ・ラブス・リミテッド・ライアビリティ・カンパニーGalera Labs, Llc | ペンタアザ大環状環複合体および白金を基にした抗癌剤による組み合わせ癌療法 |
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-
1999
- 1999-09-16 US US09/398,120 patent/US6214817B1/en not_active Expired - Lifetime
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2000
- 2000-09-14 ES ES00966722T patent/ES2222925T3/es not_active Expired - Lifetime
- 2000-09-14 EP EP04003751A patent/EP1420019B1/de not_active Expired - Lifetime
- 2000-09-14 AT AT04003751T patent/ATE368039T1/de not_active IP Right Cessation
- 2000-09-14 AT AT00966722T patent/ATE268774T1/de not_active IP Right Cessation
- 2000-09-14 JP JP2001523400A patent/JP2003509423A/ja not_active Withdrawn
- 2000-09-14 EP EP00966722A patent/EP1212323B1/de not_active Expired - Lifetime
- 2000-09-14 AT AT04003746T patent/ATE366254T1/de not_active IP Right Cessation
- 2000-09-14 DE DE60035440T patent/DE60035440T2/de not_active Expired - Lifetime
- 2000-09-14 ES ES04003751T patent/ES2291759T3/es not_active Expired - Lifetime
- 2000-09-14 ES ES04003746T patent/ES2293106T3/es not_active Expired - Lifetime
- 2000-09-14 DK DK00966722T patent/DK1212323T3/da active
- 2000-09-14 AU AU77024/00A patent/AU784078B2/en not_active Ceased
- 2000-09-14 WO PCT/US2000/025154 patent/WO2001019823A2/en active IP Right Grant
- 2000-09-14 PT PT00966722T patent/PT1212323E/pt unknown
- 2000-09-14 CA CA2382105A patent/CA2382105C/en not_active Expired - Fee Related
- 2000-09-14 DE DE60011446T patent/DE60011446T2/de not_active Expired - Lifetime
- 2000-09-14 EP EP04003746A patent/EP1420022B1/de not_active Expired - Lifetime
- 2000-09-14 DE DE60035724T patent/DE60035724T2/de not_active Expired - Lifetime
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2002
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ES2222925T3 (es) | 2005-02-16 |
ES2293106T3 (es) | 2008-03-16 |
EP1420019B1 (de) | 2007-07-25 |
EP1420022B1 (de) | 2007-07-04 |
US6214817B1 (en) | 2001-04-10 |
ES2291759T3 (es) | 2008-03-01 |
PT1212323E (pt) | 2004-10-29 |
EP1420022A1 (de) | 2004-05-19 |
EP1212323A2 (de) | 2002-06-12 |
DE60035724D1 (de) | 2007-09-06 |
JP2003509423A (ja) | 2003-03-11 |
HK1046689A1 (en) | 2003-01-24 |
WO2001019823A2 (en) | 2001-03-22 |
DE60035724T2 (de) | 2008-04-30 |
WO2001019823A9 (en) | 2002-09-26 |
EP1420019A1 (de) | 2004-05-19 |
DE60011446D1 (de) | 2004-07-15 |
CA2382105C (en) | 2012-01-10 |
AU7702400A (en) | 2001-04-17 |
ATE368039T1 (de) | 2007-08-15 |
EP1212323B1 (de) | 2004-06-09 |
HK1046689B (zh) | 2005-03-11 |
DE60035440D1 (de) | 2007-08-16 |
DK1212323T3 (da) | 2004-10-25 |
CA2382105A1 (en) | 2001-03-22 |
WO2001019823A3 (en) | 2001-09-07 |
JP2012097097A (ja) | 2012-05-24 |
DE60035440T2 (de) | 2008-03-13 |
AU784078B2 (en) | 2006-02-02 |
ATE366254T1 (de) | 2007-07-15 |
DE60011446T2 (de) | 2005-07-07 |
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