NO984164D0 - Biokonjugater av mangan eller jernkomplekser bestående av nitrogen-inneholdende makrocykliske ligander effektive som katalysatorer for dismutering av superoksid - Google Patents

Biokonjugater av mangan eller jernkomplekser bestående av nitrogen-inneholdende makrocykliske ligander effektive som katalysatorer for dismutering av superoksid

Info

Publication number
NO984164D0
NO984164D0 NO984164A NO984164A NO984164D0 NO 984164 D0 NO984164 D0 NO 984164D0 NO 984164 A NO984164 A NO 984164A NO 984164 A NO984164 A NO 984164A NO 984164 D0 NO984164 D0 NO 984164D0
Authority
NO
Norway
Prior art keywords
dismutation
bioconjugates
superoxide
catalysts
manganese
Prior art date
Application number
NO984164A
Other languages
English (en)
Other versions
NO984164L (no
Inventor
William L Neumann
Dennis P Riley
Randy H Weiss
Susan L Henke
Patrick J Lennon
Karl W Aston
Original Assignee
Monsanto Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US1996/012767 external-priority patent/WO1997006824A2/en
Application filed by Monsanto Co filed Critical Monsanto Co
Publication of NO984164D0 publication Critical patent/NO984164D0/no
Publication of NO984164L publication Critical patent/NO984164L/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00Compounds containing elements of Groups 7 or 17 of the Periodic Table
    • C07F13/005Compounds without a metal-carbon linkage
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D259/00Heterocyclic compounds containing rings having more than four nitrogen atoms as the only ring hetero atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • A61P39/06Free radical scavengers or antioxidants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/02Iron compounds
    • C07F15/025Iron compounds without a metal-carbon linkage

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Toxicology (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
NO984164A 1996-03-13 1998-09-10 Biokonjugater av mangan eller jernkomplekser bestÕende av nitrogen-inneholdende makrocykliske ligander effektive som katalysatorer for dismutering av superoksid NO984164L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1334896P 1996-03-13 1996-03-13
PCT/US1996/012767 WO1997006824A2 (en) 1995-08-17 1996-08-14 Bioconjugates of manganese complexes and their application as catalysts
PCT/US1997/002566 WO1997033877A1 (en) 1996-03-13 1997-03-04 Bioconjugates of manganese or iron complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide

Publications (2)

Publication Number Publication Date
NO984164D0 true NO984164D0 (no) 1998-09-10
NO984164L NO984164L (no) 1998-11-06

Family

ID=21759507

Family Applications (1)

Application Number Title Priority Date Filing Date
NO984164A NO984164L (no) 1996-03-13 1998-09-10 Biokonjugater av mangan eller jernkomplekser bestÕende av nitrogen-inneholdende makrocykliske ligander effektive som katalysatorer for dismutering av superoksid

Country Status (11)

Country Link
EP (1) EP0891338A1 (no)
JP (1) JP2000508625A (no)
KR (1) KR19990087784A (no)
CN (1) CN1225631A (no)
AU (1) AU1962497A (no)
BR (1) BR9708179A (no)
CA (1) CA2249011A1 (no)
CZ (1) CZ271198A3 (no)
IL (1) IL125889A0 (no)
NO (1) NO984164L (no)
WO (1) WO1997033877A1 (no)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6214817B1 (en) * 1997-06-20 2001-04-10 Monsanto Company Substituted pyridino pentaazamacrocyle complexes having superoxide dismutase activity
US6180620B1 (en) 1997-06-20 2001-01-30 G.D. Searle & Co. Analgesic methods using synthetic catalysts for the dismutation of superoxide radicals
WO2000043395A1 (en) 1999-01-25 2000-07-27 National Jewish Medical And Research Center Substituted porphyrins
WO2000054784A1 (en) * 1999-03-15 2000-09-21 Abdurafik Bakhramovich Akbarov Complex comprising the coordination compound manganese, its medical effects and the mode of its production
ATE291446T1 (de) * 1999-05-27 2005-04-15 Monsanto Co Biomaterialien, modifiziert mit superoxid- dismutase imitatoren
US20050176790A1 (en) 2001-02-28 2005-08-11 Johannes Bartholomaus Pharmaceutical salts
AU2002312194B8 (en) 2001-06-01 2008-05-15 Aeolus Sciences, Inc. Oxidant scavengers for treatment of diabetes or use in transplantation or induction of immune tolerance
JP5265762B2 (ja) 2008-05-13 2013-08-14 ユニバーシティ・オブ・カンザス 金属抽出ペプチド(map)タグおよび関連する方法
RU2506083C2 (ru) 2008-05-23 2014-02-10 Нэшнл Джуиш Хелт Способ лечения поражений, ассоциированных с воздействием алкилирующих веществ
US9187735B2 (en) 2012-06-01 2015-11-17 University Of Kansas Metal abstraction peptide with superoxide dismutase activity

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3155552B2 (ja) * 1991-07-19 2001-04-09 モンサント カンパニー 超酸化物の不均斉変化に有効な触媒としての窒素含有−大環状リガンドのマンガン錯体
ATE192047T1 (de) * 1991-12-10 2000-05-15 Dow Chemical Co Bicylclische, polyazamakrocyclocarbonsäure- komplexe, konjugate, herstellung und verwendung als kontraststoffe
US5747026A (en) * 1993-10-15 1998-05-05 University Of Alabama At Birmingham Research Foundation Antioxidants
WO1996039409A1 (en) * 1995-06-05 1996-12-12 Nitromed, Inc. Nitrosylated and nitrated superoxide oxidants and reductants
US6525041B1 (en) * 1995-06-06 2003-02-25 Pharmacia Corporation Manganese or iron complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide
EP0830351A1 (en) * 1995-06-07 1998-03-25 Monsanto Company Process for preparing substituted polyazamacrocycles

Also Published As

Publication number Publication date
NO984164L (no) 1998-11-06
CZ271198A3 (cs) 1999-01-13
CA2249011A1 (en) 1997-09-18
EP0891338A1 (en) 1999-01-20
KR19990087784A (ko) 1999-12-27
AU1962497A (en) 1997-10-01
IL125889A0 (en) 1999-04-11
WO1997033877A1 (en) 1997-09-18
CN1225631A (zh) 1999-08-11
JP2000508625A (ja) 2000-07-11
BR9708179A (pt) 1999-07-27

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