ATE268598T1 - Verfahren zur behandlung von zns-beteiligten lysosmalen speicherkrankheiten - Google Patents
Verfahren zur behandlung von zns-beteiligten lysosmalen speicherkrankheitenInfo
- Publication number
- ATE268598T1 ATE268598T1 AT98901673T AT98901673T ATE268598T1 AT E268598 T1 ATE268598 T1 AT E268598T1 AT 98901673 T AT98901673 T AT 98901673T AT 98901673 T AT98901673 T AT 98901673T AT E268598 T1 ATE268598 T1 AT E268598T1
- Authority
- AT
- Austria
- Prior art keywords
- disease
- cns
- storage diseases
- treating
- diseases involving
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7004—Monosaccharides having only carbon, hydrogen and oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7012—Compounds having a free or esterified carboxyl group attached, directly or through a carbon chain, to a carbon atom of the saccharide radical, e.g. glucuronic acid, neuraminic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/782,321 US5798366A (en) | 1993-05-13 | 1997-01-13 | Method for treatment of CNS-involved lysosomal storage diseases |
PCT/US1998/000031 WO1998030219A1 (en) | 1997-01-13 | 1998-01-13 | Method for treatment of cns-involved lysosomal storage diseases |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE268598T1 true ATE268598T1 (de) | 2004-06-15 |
Family
ID=25125672
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT98901673T ATE268598T1 (de) | 1997-01-13 | 1998-01-13 | Verfahren zur behandlung von zns-beteiligten lysosmalen speicherkrankheiten |
Country Status (11)
Country | Link |
---|---|
US (1) | US5798366A (de) |
EP (2) | EP1491196A3 (de) |
JP (1) | JP2001508064A (de) |
AT (1) | ATE268598T1 (de) |
AU (1) | AU5813898A (de) |
CA (1) | CA2278507C (de) |
DE (1) | DE69824421T2 (de) |
DK (1) | DK1007043T3 (de) |
ES (1) | ES2223118T3 (de) |
PT (1) | PT1007043E (de) |
WO (1) | WO1998030219A1 (de) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6465488B1 (en) | 1997-12-11 | 2002-10-15 | Chancellor, Masters & Scholars Of The University Of Oxford | Inhibition of glycolipid biosynthesis |
US6274597B1 (en) | 1998-06-01 | 2001-08-14 | Mount Sinai School Of Medicine Of New York University | Method of enhancing lysosomal α-Galactosidase A |
US6610703B1 (en) | 1998-12-10 | 2003-08-26 | G.D. Searle & Co. | Method for treatment of glycolipid storage diseases |
GB0100889D0 (en) | 2001-01-12 | 2001-02-21 | Oxford Glycosciences Uk Ltd | Compounds |
GB9909064D0 (en) | 1999-04-20 | 1999-06-16 | Oxford Glycosciences Uk Ltd | Therapies |
WO2000066105A2 (en) * | 1999-04-30 | 2000-11-09 | The Trustees Of Boston College | Treatment of epilepsy with imino sugars |
CA2378776A1 (en) | 1999-07-26 | 2001-02-01 | G.D. Searle & Co. | Use of long-chain n-alkyl derivatives of deoxynojirimycin and a glucocerebrosidase enzyme for the manufacture of medicament for the treatment of glycolipid storage diseases |
US6770468B1 (en) | 1999-09-14 | 2004-08-03 | Genzyme Glycobiology Research Institute, Inc. | Phosphodiester-α-GlcNAcase of the lysosomal targeting pathway |
US6537785B1 (en) | 1999-09-14 | 2003-03-25 | Genzyme Glycobiology Research Institute, Inc. | Methods of treating lysosomal storage diseases |
ATE384736T1 (de) * | 2001-04-30 | 2008-02-15 | Zystor Therapeutics Inc | Subzelluläres targeting von therapeutischen proteinen |
US7560424B2 (en) | 2001-04-30 | 2009-07-14 | Zystor Therapeutics, Inc. | Targeted therapeutic proteins |
US20040005309A1 (en) * | 2002-05-29 | 2004-01-08 | Symbiontics, Inc. | Targeted therapeutic proteins |
US7629309B2 (en) * | 2002-05-29 | 2009-12-08 | Zystor Therapeutics, Inc. | Targeted therapeutic proteins |
US20030072761A1 (en) * | 2001-10-16 | 2003-04-17 | Lebowitz Jonathan | Methods and compositions for targeting proteins across the blood brain barrier |
US20030124652A1 (en) * | 2001-12-21 | 2003-07-03 | Novazyme Pharmaceuticals, Inc. | Methods of producing high mannose glycoproteins in complex carbohydrate deficient cells |
US6800472B2 (en) | 2001-12-21 | 2004-10-05 | Genzyme Glycobiology Research Institute, Inc. | Expression of lysosomal hydrolase in cells expressing pro-N-acetylglucosamine-1-phosphodiester α-N-acetyl glucosimanidase |
US6905856B2 (en) * | 2001-12-21 | 2005-06-14 | Genzyme Glycobiology Research Institute, Inc. | Soluble GlcNAc phosphotransferase |
AU2003248960B2 (en) * | 2002-07-17 | 2009-06-25 | Idorsia Pharmaceuticals Ltd | Piperidinetriol derivatives as inhibitors of glycosylceramidsynthase |
AU2003246942B2 (en) * | 2002-07-17 | 2009-06-25 | Idorsia Pharmaceuticals Ltd | Piperidinetriol derivatives as inhibitors of glycosylceramide synthase |
WO2004055157A2 (en) * | 2002-08-13 | 2004-07-01 | Whitley Chester B | Methods of using vectors to treat metabolic disorders |
US20040180419A1 (en) | 2003-01-31 | 2004-09-16 | Mount Sinai School Of Medicine Of New York University | Combination therapy for treating protein deficiency disorders |
GB0313677D0 (en) * | 2003-06-13 | 2003-07-16 | Oxford Glycosciences Uk Ltd | Novel compound |
GB0313678D0 (en) * | 2003-06-13 | 2003-07-16 | Oxford Glycosciences Uk Ltd | Novel compounds |
CN1922313B (zh) * | 2004-02-10 | 2011-10-26 | 生物马林医药公司 | 酸性α-糖苷酶及其片段 |
US20050208090A1 (en) * | 2004-03-18 | 2005-09-22 | Medtronic, Inc. | Methods and systems for treatment of neurological diseases of the central nervous system |
DE102004029310A1 (de) * | 2004-06-17 | 2005-12-29 | Clariant Gmbh | Hochkonzentrierte, wässrige Formulierungen von Oligo-und Polyestern |
CA2568150A1 (en) * | 2004-06-21 | 2006-01-05 | Medtronic, Inc. | Medical systems and methods for delivering compositions to cells |
WO2006037069A1 (en) * | 2004-09-28 | 2006-04-06 | Allergan, Inc. | Compositions comprising nb-dnj, ne-dnj or d-glucaro-delta-lactam and their uses for the treatment of pain and other neurological conditions |
US8500720B2 (en) | 2005-05-09 | 2013-08-06 | Medtronic, Inc | Method and apparatus for treatment of cardiac disorders |
US9181184B2 (en) | 2005-05-17 | 2015-11-10 | Amicus Therapeutics, Inc. | Method for the treatment of pompe disease using 1-deoxynojirimycin and derivatives |
CA2669347A1 (en) * | 2006-11-13 | 2008-05-29 | Zystor Therapeutics, Inc. | Methods for treating pompe disease |
US8419710B2 (en) * | 2006-12-06 | 2013-04-16 | Medtronic, Inc. | Methods for infusing fluids via an implantable infusion system |
EP3778652A1 (de) | 2008-05-07 | 2021-02-17 | BioMarin Pharmaceutical Inc. | Auf lysosomen gerichtete peptide und verwendungen davon |
US20100119502A1 (en) * | 2008-11-11 | 2010-05-13 | Amicus Therapeutics, Inc. | Therapy regimens, dosing regimens and stable medicaments for the treatment of pompe disease |
US8785168B2 (en) | 2009-06-17 | 2014-07-22 | Biomarin Pharmaceutical Inc. | Formulations for lysosomal enzymes |
CA2731346A1 (en) * | 2010-02-09 | 2011-08-09 | The Hospital For Sick Children | Compounds for the treatment of lysosomal storage diseases |
EP3318277A1 (de) * | 2016-11-04 | 2018-05-09 | Institut du Cerveau et de la Moelle Epiniere-ICM | Inhibitoren der glucosylceramidsynthase zur behandlung von motoneuronerkrankungen |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1555654A (en) * | 1977-06-25 | 1979-11-14 | Exxon Research Engineering Co | Agricultural burner apparatus |
US4065562A (en) * | 1975-12-29 | 1977-12-27 | Nippon Shinyaku Co., Ltd. | Method and composition for reducing blood glucose levels |
NO154918C (no) * | 1977-08-27 | 1987-01-14 | Bayer Ag | Analogifremgangsmaate til fremstilling av terapeutisk aktive derivater av 3,4,5-trihydroksypiperidin. |
GB2020278B (en) * | 1978-05-03 | 1983-02-23 | Nippon Shinyaku Co Ltd | Moranoline dervitives |
US4849430A (en) * | 1988-03-09 | 1989-07-18 | Monsanto Company | Method of inhibiting virus |
US5011829A (en) * | 1989-06-02 | 1991-04-30 | G. D. Searle & Co. | Pharmaceutical composition and method of inhibiting virus |
US5030638A (en) * | 1990-02-26 | 1991-07-09 | G. D. Searle & Co. | Method of antiviral enhancement |
US6291657B1 (en) * | 1993-05-13 | 2001-09-18 | Monsanto Company | Deoxygalactonojirimycin derivatives |
-
1997
- 1997-01-13 US US08/782,321 patent/US5798366A/en not_active Expired - Lifetime
-
1998
- 1998-01-13 AT AT98901673T patent/ATE268598T1/de active
- 1998-01-13 ES ES98901673T patent/ES2223118T3/es not_active Expired - Lifetime
- 1998-01-13 DK DK98901673T patent/DK1007043T3/da active
- 1998-01-13 EP EP04013466A patent/EP1491196A3/de not_active Withdrawn
- 1998-01-13 EP EP98901673A patent/EP1007043B9/de not_active Expired - Lifetime
- 1998-01-13 AU AU58138/98A patent/AU5813898A/en not_active Abandoned
- 1998-01-13 CA CA002278507A patent/CA2278507C/en not_active Expired - Fee Related
- 1998-01-13 DE DE69824421T patent/DE69824421T2/de not_active Expired - Lifetime
- 1998-01-13 PT PT98901673T patent/PT1007043E/pt unknown
- 1998-01-13 WO PCT/US1998/000031 patent/WO1998030219A1/en active IP Right Grant
- 1998-01-13 JP JP53098198A patent/JP2001508064A/ja not_active Ceased
Also Published As
Publication number | Publication date |
---|---|
JP2001508064A (ja) | 2001-06-19 |
EP1007043A1 (de) | 2000-06-14 |
WO1998030219A1 (en) | 1998-07-16 |
EP1007043B9 (de) | 2004-12-22 |
AU5813898A (en) | 1998-08-03 |
DE69824421D1 (de) | 2004-07-15 |
US5798366A (en) | 1998-08-25 |
EP1491196A3 (de) | 2005-03-16 |
DE69824421T2 (de) | 2005-03-03 |
ES2223118T3 (es) | 2005-02-16 |
EP1491196A2 (de) | 2004-12-29 |
PT1007043E (pt) | 2004-10-29 |
EP1007043B1 (de) | 2004-06-09 |
CA2278507A1 (en) | 1998-07-16 |
CA2278507C (en) | 2007-08-28 |
DK1007043T3 (da) | 2004-10-11 |
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