ATE265208T1 - Verwendung von allosterischen hämoglobinmodifikatoren zur verringerung der sauerstoffaffinität im blut - Google Patents
Verwendung von allosterischen hämoglobinmodifikatoren zur verringerung der sauerstoffaffinität im blutInfo
- Publication number
- ATE265208T1 ATE265208T1 AT92912561T AT92912561T ATE265208T1 AT E265208 T1 ATE265208 T1 AT E265208T1 AT 92912561 T AT92912561 T AT 92912561T AT 92912561 T AT92912561 T AT 92912561T AT E265208 T1 ATE265208 T1 AT E265208T1
- Authority
- AT
- Austria
- Prior art keywords
- blood
- oxygen affinity
- reduce oxygen
- allosteric hemoglobin
- compound
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/325—Carbamic acids; Thiocarbamic acids; Anhydrides or salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/24—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
- C07C233/29—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/67—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/68—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/73—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C235/38—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/40—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
- C07C271/58—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/56—Ring systems containing bridged rings
- C07C2603/58—Ring systems containing bridged rings containing three rings
- C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
- C07C2603/74—Adamantanes
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Emergency Medicine (AREA)
- Biomedical Technology (AREA)
- Dermatology (AREA)
- Diabetes (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/702,947 US5122539A (en) | 1990-02-12 | 1991-05-20 | Allosteric hemoglobin modifiers useful for decreasing oxygen affinity and preserving oxygen carrying capability of stored blood |
US07/885,721 US5248785A (en) | 1990-02-12 | 1992-05-18 | Using allosteric hemoglobin modifiers to decrease oxygen affinity in blood |
PCT/US1992/004229 WO1992020335A1 (en) | 1991-05-20 | 1992-05-19 | Using allosteric hemoglobin modifiers to decrease oxygen affinity in blood |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE265208T1 true ATE265208T1 (de) | 2004-05-15 |
Family
ID=27107045
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT02012781T ATE260886T1 (de) | 1991-05-20 | 1992-05-19 | Verwendung allosterischer hämoglobinmodifikatoren zur verringerung der sauerstoffaktivität im blut |
AT92912561T ATE265208T1 (de) | 1991-05-20 | 1992-05-19 | Verwendung von allosterischen hämoglobinmodifikatoren zur verringerung der sauerstoffaffinität im blut |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT02012781T ATE260886T1 (de) | 1991-05-20 | 1992-05-19 | Verwendung allosterischer hämoglobinmodifikatoren zur verringerung der sauerstoffaktivität im blut |
Country Status (9)
Country | Link |
---|---|
US (1) | US5248785A (de) |
EP (3) | EP1236711B1 (de) |
JP (1) | JP3023423B2 (de) |
AT (2) | ATE260886T1 (de) |
CA (1) | CA2109575C (de) |
DE (2) | DE69233320D1 (de) |
DK (2) | DK1236711T3 (de) |
ES (2) | ES2220857T3 (de) |
WO (1) | WO1992020335A1 (de) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5432191A (en) * | 1990-02-12 | 1995-07-11 | The Center For Innovative Technology | Allosteric hemoglobin modifiers to decrease oxygen affinity in blood |
US5677330A (en) * | 1990-02-12 | 1997-10-14 | The Center For Innovative Technology | Medical uses of allosteric hemoglobin modifier compounds in patient care |
US5705521A (en) * | 1990-02-12 | 1998-01-06 | The Center For Innovative Technology | Use of allosteric hemoglobin modifiers in combination with radiation therapy to treat carcinogenic tumors |
US6458762B1 (en) | 1994-03-28 | 2002-10-01 | Baxter International, Inc. | Therapeutic use of hemoglobin for preserving tissue viability and reducing restenosis |
EP0767675A4 (de) * | 1995-04-10 | 1998-08-05 | Baxter Int | Verwendung von vernetztem hämoglobin zur behandlung von subarachnoidalblutungen |
US5733869A (en) * | 1995-10-06 | 1998-03-31 | Baxter International, Inc. | Therapeutic administration of hemoglobin in cardiac arrest |
AU2657597A (en) * | 1996-03-21 | 1997-10-10 | Dana-Farber Cancer Institute | Use of allosteric haemoglobin modifier for treating solid tumors and inhibiting tumor metastases |
JP2002501887A (ja) * | 1998-01-28 | 2002-01-22 | ワーナー−ランバート・カンパニー | アルツハイマー病の治療方法 |
JP2003529543A (ja) * | 1999-08-24 | 2003-10-07 | ヴァージニア コモンウェルス ユニバーシティ | 置換キラル・アロステリック・ヘモグロビン調節剤 |
EP1223942A2 (de) * | 1999-08-25 | 2002-07-24 | GMP Companies, Inc. | Mittel zur verstärkten sauerstoffzufuhr bei säugern |
DE10031741A1 (de) * | 2000-06-29 | 2002-01-17 | Sanguibio Tech Ag | Einen Sauerstoffträger, ausgewählt aus Hämoglobin oder Hämoglobin- und Myoglobin-enthaltende Zubereitung als Externum zur natürlichen Regeneration der Haut bei Sauerstoff-Mangel |
AU2002222552A1 (en) * | 2000-11-29 | 2002-06-11 | Kyorin Pharmaceutical Co. Ltd. | Substituted carboxylic acid derivatives |
US7097825B2 (en) * | 2001-02-23 | 2006-08-29 | Allos Therapeutics, Inc. | Methods and reagents to acquire MRI signals and images |
US20030232887A1 (en) * | 2002-04-10 | 2003-12-18 | Johnson Douglas Giles | Preparation and use of a stable formulation of allosteric effector compounds |
WO2003099153A1 (en) * | 2002-05-21 | 2003-12-04 | Allos Therapeutics, Inc. | Device for using patient blood or blood fractions as diluent in administering pharmaceuticals |
JP2007534691A (ja) * | 2004-04-22 | 2007-11-29 | アロス・セラピューティクス・インコーポレーテッド | アロステリックヘモグロビン修飾体の組成物および前記組成物の製造法 |
US20070259966A1 (en) * | 2004-04-22 | 2007-11-08 | Allos Therapeutics, Inc. | Coadministration of Radiation, Efaproxiral Sodium, and Supplemental Oxygen for the Treatment of Cancer |
JP2007534683A (ja) * | 2004-04-22 | 2007-11-29 | アロス・セラピューティクス・インコーポレーテッド | 癌の治療のための放射線、エファプロキシラルナトリウム、及び酸素補給の併用 |
EP1765760A1 (de) * | 2004-07-01 | 2007-03-28 | F.Hoffmann-La Roche Ag | Eine acetylengruppe enthaltende phenylderivate |
WO2007123126A1 (ja) * | 2006-04-17 | 2007-11-01 | Juridical Foundation Osaka Industrial Promotion Organization | 慢性心不全における運動耐容能低下の改善剤 |
BRPI0705396B1 (pt) * | 2007-12-12 | 2021-10-05 | Universidade Estadual De Campinas - Unicamp | Compostos derivados ftalimídicos |
WO2015100235A1 (en) | 2013-12-27 | 2015-07-02 | Virginia Commonwealth University | Allosteric hemoglobin modifiers with nitric oxide releasing moiety |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2149070C3 (de) * | 1971-10-01 | 1978-03-23 | Boehringer Mannheim Gmbh, 6800 Mannheim | Phenoxyalkylcarbonsäurederivate und deren Salze, Verfahren zu deren Herstellung und Arzneimittel |
DE2432560A1 (de) * | 1974-07-06 | 1976-01-22 | Boehringer Mannheim Gmbh | Neue phenoxyalkylcarbonsaeurederivate und verfahren zur herstellung derselben |
DE2541342A1 (de) * | 1975-09-17 | 1977-03-31 | Boehringer Mannheim Gmbh | Neue phenoxyalkylcarbonsaeuren und verfahren zur herstellung derselben |
DE2546996C2 (de) * | 1975-10-21 | 1984-07-05 | Boehringer Mannheim Gmbh, 6800 Mannheim | Phenoxyalkylcarbonsäure-Derivate, Verfahren zur Herstellung derselben sowie Arzneimittel, die diese Verbindungen als Wirkstoff enthalten |
US4704402A (en) * | 1982-06-12 | 1987-11-03 | University Of Pittsburgh | Method of treating sickle cell anemia |
US4887995A (en) * | 1985-01-22 | 1989-12-19 | University Of Pittsburgh | Method of treating sickle cell anemia |
US4699926A (en) * | 1986-04-04 | 1987-10-13 | Merck & Co., Inc. | Compounds useful in treating sickle cell anemia |
US4751244A (en) * | 1986-04-04 | 1988-06-14 | Merck & Co., Inc. | Compounds useful in treating sickle cell anemia |
US4731381A (en) * | 1986-04-04 | 1988-03-15 | Merck & Co., Inc. | Method of treating a person for sickle cell anemia |
US4731473A (en) * | 1986-04-04 | 1988-03-15 | Merck & Co., Inc. | Compounds useful in treating sickle cell anemia |
US5049695A (en) * | 1990-02-12 | 1991-09-17 | Center For Innovative Technology | Allosteric hemoglobin modifiers |
US5122539A (en) * | 1990-02-12 | 1992-06-16 | Center For Innovative Technology | Allosteric hemoglobin modifiers useful for decreasing oxygen affinity and preserving oxygen carrying capability of stored blood |
-
1992
- 1992-05-18 US US07/885,721 patent/US5248785A/en not_active Expired - Lifetime
- 1992-05-19 DK DK02012781T patent/DK1236711T3/da active
- 1992-05-19 CA CA002109575A patent/CA2109575C/en not_active Expired - Fee Related
- 1992-05-19 DE DE69233320T patent/DE69233320D1/de not_active Expired - Fee Related
- 1992-05-19 DE DE69233348T patent/DE69233348T2/de not_active Expired - Fee Related
- 1992-05-19 DK DK92912561T patent/DK0585366T3/da active
- 1992-05-19 AT AT02012781T patent/ATE260886T1/de not_active IP Right Cessation
- 1992-05-19 EP EP02012781A patent/EP1236711B1/de not_active Expired - Lifetime
- 1992-05-19 ES ES02012781T patent/ES2220857T3/es not_active Expired - Lifetime
- 1992-05-19 EP EP04009908A patent/EP1468680A3/de not_active Ceased
- 1992-05-19 WO PCT/US1992/004229 patent/WO1992020335A1/en active IP Right Grant
- 1992-05-19 EP EP92912561A patent/EP0585366B1/de not_active Expired - Lifetime
- 1992-05-19 ES ES92912561T patent/ES2223042T3/es not_active Expired - Lifetime
- 1992-05-19 JP JP5500270A patent/JP3023423B2/ja not_active Expired - Fee Related
- 1992-05-19 AT AT92912561T patent/ATE265208T1/de not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
DE69233348T2 (de) | 2005-05-12 |
JPH07508973A (ja) | 1995-10-05 |
DE69233320D1 (de) | 2004-04-08 |
EP0585366B1 (de) | 2004-04-28 |
EP0585366A4 (de) | 1994-03-17 |
WO1992020335A1 (en) | 1992-11-26 |
CA2109575A1 (en) | 1992-11-26 |
EP0585366A1 (de) | 1994-03-09 |
EP1468680A3 (de) | 2005-04-13 |
ES2223042T3 (es) | 2005-02-16 |
DK0585366T3 (da) | 2004-08-09 |
DE69233348D1 (de) | 2004-06-03 |
EP1468680A2 (de) | 2004-10-20 |
CA2109575C (en) | 2000-02-01 |
JP3023423B2 (ja) | 2000-03-21 |
DK1236711T3 (da) | 2004-08-16 |
US5248785A (en) | 1993-09-28 |
ES2220857T3 (es) | 2004-12-16 |
EP1236711A3 (de) | 2002-09-18 |
EP1236711B1 (de) | 2004-03-03 |
ATE260886T1 (de) | 2004-03-15 |
EP1236711A2 (de) | 2002-09-04 |
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