ATE255118T1 - Verfahren zur herstellung von platinverbindungen - Google Patents
Verfahren zur herstellung von platinverbindungenInfo
- Publication number
- ATE255118T1 ATE255118T1 AT97929532T AT97929532T ATE255118T1 AT E255118 T1 ATE255118 T1 AT E255118T1 AT 97929532 T AT97929532 T AT 97929532T AT 97929532 T AT97929532 T AT 97929532T AT E255118 T1 ATE255118 T1 AT E255118T1
- Authority
- AT
- Austria
- Prior art keywords
- cyclohexanediamine
- deoxygenated water
- platinum compounds
- oxygen
- complexes
- Prior art date
Links
- 150000003058 platinum compounds Chemical class 0.000 title abstract 2
- 229940045985 antineoplastic platinum compound Drugs 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 3
- 239000001301 oxygen Substances 0.000 abstract 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- SSJXIUAHEKJCMH-PHDIDXHHSA-N (1r,2r)-cyclohexane-1,2-diamine Chemical compound N[C@@H]1CCCC[C@H]1N SSJXIUAHEKJCMH-PHDIDXHHSA-N 0.000 abstract 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 abstract 1
- 238000010521 absorption reaction Methods 0.000 abstract 1
- 230000015556 catabolic process Effects 0.000 abstract 1
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical class N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 abstract 1
- SSJXIUAHEKJCMH-UHFFFAOYSA-N cyclohexane-1,2-diamine Chemical class NC1CCCCC1N SSJXIUAHEKJCMH-UHFFFAOYSA-N 0.000 abstract 1
- 238000006731 degradation reaction Methods 0.000 abstract 1
- 239000012535 impurity Substances 0.000 abstract 1
- 230000003647 oxidation Effects 0.000 abstract 1
- 238000007254 oxidation reaction Methods 0.000 abstract 1
- 229910052700 potassium Inorganic materials 0.000 abstract 1
- 239000011591 potassium Substances 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
- C07F15/0086—Platinum compounds
- C07F15/0093—Platinum compounds without a metal-carbon linkage
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Catalysts (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP17478896A JP3154399B2 (ja) | 1996-07-04 | 1996-07-04 | 白金化合物の製造方法 |
PCT/JP1997/002332 WO1998001454A1 (fr) | 1996-07-04 | 1997-07-04 | Procede de production de compose de platine |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE255118T1 true ATE255118T1 (de) | 2003-12-15 |
Family
ID=15984689
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT97929532T ATE255118T1 (de) | 1996-07-04 | 1997-07-04 | Verfahren zur herstellung von platinverbindungen |
Country Status (10)
Country | Link |
---|---|
US (1) | US5959133A (de) |
EP (1) | EP0881226B1 (de) |
JP (1) | JP3154399B2 (de) |
AT (1) | ATE255118T1 (de) |
DE (1) | DE69726408T2 (de) |
DK (1) | DK0881226T3 (de) |
ES (1) | ES2210543T3 (de) |
HK (1) | HK1055746A1 (de) |
PT (1) | PT881226E (de) |
WO (1) | WO1998001454A1 (de) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1404689A1 (de) * | 2001-07-02 | 2004-04-07 | Debiopharm S.A. | Aktive oxiplatinverbindung mit sehr niedrigem oxalsaüregehalt |
US6476068B1 (en) | 2001-12-06 | 2002-11-05 | Pharmacia Italia, S.P.A. | Platinum derivative pharmaceutical formulations |
CA2547275A1 (en) * | 2003-11-25 | 2005-06-09 | Platco Technologies (Proprietary) Limited | Platinum(ii) complexes, preparation and use |
PT1789427E (pt) | 2004-09-01 | 2009-07-31 | Platco Technologies Proprietar | Preparação de complexos de platina (ii) |
JP2006248978A (ja) * | 2005-03-10 | 2006-09-21 | Mebiopharm Co Ltd | 新規なリポソーム製剤 |
EP1879568B1 (de) * | 2005-03-28 | 2009-05-06 | Dabur Pharma Limited | Stabile pharmazeutische zusammensetzungen aus antitumoralen platin-(ii)-mitteln |
EP1874290A1 (de) * | 2005-04-09 | 2008-01-09 | Vuab Pharma A. S. | Verfahren zur herstellung einer oxaliplatin-zubereitung |
NZ587586A (en) * | 2005-07-18 | 2012-04-27 | Bipar Sciences Inc | Treatment of cancer |
CA2640621A1 (en) * | 2006-01-30 | 2007-08-02 | Platco Technologies (Proprietary) Limited | Preparation of platinum (ii) complexes |
AR060635A1 (es) | 2006-04-27 | 2008-07-02 | Banyu Pharma Co Ltd | Derivados de 1,2-dihidro-3h-pirazolo[3,4-d]pirimidin-3-ona, composiciones farmaceuticas que los comprenden y su uso en el tratamiento del cancer |
JP2008081492A (ja) | 2006-08-31 | 2008-04-10 | Banyu Pharmaceut Co Ltd | オーロラa選択的阻害作用を有する新規アミノピリジン誘導体 |
US8143447B2 (en) | 2006-09-05 | 2012-03-27 | Bipar Sciences, Inc. | Treatment of cancer |
CA2662337A1 (en) | 2006-09-05 | 2008-03-13 | Bipar Sciences, Inc. | Inhibition of fatty acid synthesis by parp inhibitors and methods of treatment thereof |
US7977336B2 (en) | 2006-12-28 | 2011-07-12 | Banyu Pharmaceutical Co. Ltd | Aminopyrimidine derivatives as PLK1 inhibitors |
EP2211854A4 (de) * | 2007-10-19 | 2011-01-12 | Bipar Sciences Inc | Verfahren und zusammensetzungen zur behandlung von krebs mit parp-inhibitoren vom benzopyrontyp |
CA2703489A1 (en) | 2007-10-23 | 2009-04-30 | Banyu Pharmaceutical Co., Ltd. | Pyridone-substituted-dihydropyrazolopyrimidinone derivative |
WO2009064738A2 (en) | 2007-11-12 | 2009-05-22 | Bipar Sciences, Inc. | Treatment of breast cancer with a parp inhibitor alone or in combination with anti-tumor agents |
EP2401281A4 (de) | 2009-02-25 | 2012-08-15 | Msd Kk | Pyrimidinpyrimidoindazolderivat |
EP2403339B1 (de) | 2009-03-06 | 2017-01-18 | Merck Sharp & Dohme Corp. | Tumorkombinationstherapie mit einem akt-hemmer und anderen antumormitteln |
EP2208731B1 (de) | 2009-06-26 | 2012-08-15 | Umicore AG & Co. KG | Verfahren zur Herstellung von 1,2-Diamino-Cyclohexan-Platin(II)-Komplexen |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH588505A5 (de) * | 1972-06-08 | 1977-06-15 | Research Corp | |
US4115418A (en) * | 1976-09-02 | 1978-09-19 | Government Of The United States Of America | 1,2-diaminocyclohexane platinum (ii) complexes having antineoplastic activity |
JPS6041077B2 (ja) * | 1976-09-06 | 1985-09-13 | 喜徳 喜谷 | 1,2‐ジアミノシクロヘキサン異性体のシス白金(2)錯体 |
GR75598B (de) * | 1980-04-29 | 1984-08-01 | Sanofi Sa | |
IL74449A (en) * | 1984-03-01 | 1988-07-31 | Us Commerce | Tetrahalo-1,2-cyclohexane-diamino platinum complexes and anti-neoplastic compositions comprising them |
US4550187A (en) * | 1984-04-12 | 1985-10-29 | The Research Foundation Of State University Of New York | Synthesis of platinum (IV) antineoplastic agents |
US4665210A (en) * | 1984-12-17 | 1987-05-12 | American Cyanamid Company | Platinum complexes of aliphatic tricarboxylic acids |
US4710557A (en) * | 1985-02-01 | 1987-12-01 | Eastman Kodak Company | Polymers of thiophenyl thioacrylate and thiomethacrylate monomers |
US4680308A (en) * | 1985-12-26 | 1987-07-14 | Andrulis Research Corporation | Stable soluble 1,2-diaminocyclohexane platinum complexes |
US5011959A (en) * | 1986-11-17 | 1991-04-30 | The Board Of Regents, The University Of Texas System | 1,2-diaminocyclohexane-platinum complexes with antitumor activity |
JPH02256690A (ja) * | 1988-12-27 | 1990-10-17 | Ss Pharmaceut Co Ltd | 新規白金錯体 |
EP0376076A1 (de) * | 1988-12-27 | 1990-07-04 | Ss Pharmaceutical Co., Ltd. | Platinkomplexe |
JPH05301884A (ja) * | 1992-04-22 | 1993-11-16 | Tanaka Kikinzoku Kogyo Kk | 白金錯化合物の製造方法 |
JPH06287021A (ja) * | 1992-04-22 | 1994-10-11 | Tanaka Kikinzoku Kogyo Kk | 光学活性な白金錯化合物の光学的分割方法 |
JP2673331B2 (ja) * | 1993-01-12 | 1997-11-05 | 田中貴金属工業 株式会社 | 光学的に高純度なシス―オキザラート(トランス―1―1,2―シクロヘキサンジアミン)白金(▲ii▼) |
JP3025602B2 (ja) * | 1993-05-21 | 2000-03-27 | デビオファーム エス.アー. | 光学的に高純度なシス−オキザラート(トランス−l−1,2−シクロヘキサンジアミン)白金(II)錯体の製造方法 |
JPH0725890A (ja) * | 1993-07-09 | 1995-01-27 | Tanaka Kikinzoku Kogyo Kk | 白金錯体の製造方法 |
-
1996
- 1996-07-04 JP JP17478896A patent/JP3154399B2/ja not_active Expired - Lifetime
-
1997
- 1997-07-04 AT AT97929532T patent/ATE255118T1/de active
- 1997-07-04 EP EP97929532A patent/EP0881226B1/de not_active Expired - Lifetime
- 1997-07-04 DE DE69726408T patent/DE69726408T2/de not_active Expired - Lifetime
- 1997-07-04 ES ES97929532T patent/ES2210543T3/es not_active Expired - Lifetime
- 1997-07-04 PT PT97929532T patent/PT881226E/pt unknown
- 1997-07-04 DK DK97929532T patent/DK0881226T3/da active
- 1997-07-04 US US09/029,682 patent/US5959133A/en not_active Expired - Lifetime
- 1997-07-04 WO PCT/JP1997/002332 patent/WO1998001454A1/ja active IP Right Grant
-
2003
- 2003-11-11 HK HK03108144A patent/HK1055746A1/xx unknown
Also Published As
Publication number | Publication date |
---|---|
HK1055746A1 (en) | 2004-01-21 |
PT881226E (pt) | 2004-03-31 |
DK0881226T3 (da) | 2004-03-29 |
ES2210543T3 (es) | 2004-07-01 |
WO1998001454A1 (fr) | 1998-01-15 |
DE69726408D1 (de) | 2004-01-08 |
JPH1017587A (ja) | 1998-01-20 |
US5959133A (en) | 1999-09-28 |
JP3154399B2 (ja) | 2001-04-09 |
EP0881226B1 (de) | 2003-11-26 |
DE69726408T2 (de) | 2004-05-19 |
EP0881226A4 (de) | 2000-03-15 |
EP0881226A1 (de) | 1998-12-02 |
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