ATE253929T1 - Verwendung von löslichem rezeptor für fortgeschrittene glykosilierung-endprodukte (srage) zur unterdrückung der beschleunigter atheriosklerose - Google Patents
Verwendung von löslichem rezeptor für fortgeschrittene glykosilierung-endprodukte (srage) zur unterdrückung der beschleunigter atherioskleroseInfo
- Publication number
- ATE253929T1 ATE253929T1 AT98939876T AT98939876T ATE253929T1 AT E253929 T1 ATE253929 T1 AT E253929T1 AT 98939876 T AT98939876 T AT 98939876T AT 98939876 T AT98939876 T AT 98939876T AT E253929 T1 ATE253929 T1 AT E253929T1
- Authority
- AT
- Austria
- Prior art keywords
- soluble receptor
- subject
- atheriosclerosis
- srage
- end products
- Prior art date
Links
- 102100029599 Advanced glycosylation end product-specific receptor Human genes 0.000 title 1
- 101710168586 Advanced glycosylation end product-specific receptor Proteins 0.000 title 1
- 201000001320 Atherosclerosis Diseases 0.000 abstract 2
- 102000005622 Receptor for Advanced Glycation End Products Human genes 0.000 abstract 2
- 108010045108 Receptor for Advanced Glycation End Products Proteins 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 229920001184 polypeptide Polymers 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Epidemiology (AREA)
- Cell Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Child & Adolescent Psychology (AREA)
- Endocrinology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Plant Substances (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Producing Shaped Articles From Materials (AREA)
- Seasonings (AREA)
- Special Spraying Apparatus (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/905,709 US7101838B2 (en) | 1997-08-05 | 1997-08-05 | Method to prevent accelerated atherosclerosis using (sRAGE) soluble receptor for advanced glycation endproducts |
| PCT/US1998/016303 WO1999007402A1 (en) | 1997-08-05 | 1998-08-05 | METHOD TO PREVENT ACCELERATED ATHEROSCLEROSIS USING (sRAGE) SOLUBLE RECEPTOR FOR ADVANCED GLYCATION ENDPRODUCTS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE253929T1 true ATE253929T1 (de) | 2003-11-15 |
Family
ID=25421326
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98939876T ATE253929T1 (de) | 1997-08-05 | 1998-08-05 | Verwendung von löslichem rezeptor für fortgeschrittene glykosilierung-endprodukte (srage) zur unterdrückung der beschleunigter atheriosklerose |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US7101838B2 (https=) |
| EP (1) | EP1011706B1 (https=) |
| JP (2) | JP4426090B2 (https=) |
| AT (1) | ATE253929T1 (https=) |
| AU (1) | AU758252B2 (https=) |
| CA (1) | CA2299467A1 (https=) |
| DE (1) | DE69819751T8 (https=) |
| DK (1) | DK1011706T3 (https=) |
| ES (1) | ES2210800T3 (https=) |
| PT (1) | PT1011706E (https=) |
| WO (1) | WO1999007402A1 (https=) |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6790443B2 (en) * | 1996-11-22 | 2004-09-14 | The Trustees Of Columbia University In The City Of New York | Method for treating symptoms of diabetes |
| US7258857B2 (en) * | 1996-11-22 | 2007-08-21 | The Trustees Of Columbia University In The City Of New York | Rage-related methods for treating inflammation |
| US7101838B2 (en) * | 1997-08-05 | 2006-09-05 | The Trustees Of Columbia University In The City Of New York | Method to prevent accelerated atherosclerosis using (sRAGE) soluble receptor for advanced glycation endproducts |
| US6465422B1 (en) * | 1998-04-17 | 2002-10-15 | The Trustees Of Columbia University In The City Of New York | Method for inhibiting tumor invasion or spreading in a subject |
| AU765719B2 (en) * | 1998-10-06 | 2003-09-25 | Trustees Of Columbia University In The City Of New York, The | Extracellular novel rage binding protein (EN-RAGE) and uses thereof |
| EP1307219A4 (en) * | 1999-08-13 | 2005-04-06 | Univ Columbia | METHODS OF INHIBITING BETA FIBRILLE BINDING BETA TO RAGE RECEPTOR, AND CONSEQUENCES THEREOF |
| US6613801B2 (en) | 2000-05-30 | 2003-09-02 | Transtech Pharma, Inc. | Method for the synthesis of compounds of formula I and their uses thereof |
| US6908741B1 (en) | 2000-05-30 | 2005-06-21 | Transtech Pharma, Inc. | Methods to identify compounds that modulate RAGE |
| US7087632B2 (en) | 2001-03-05 | 2006-08-08 | Transtech Pharma, Inc. | Benzimidazole derivatives as therapeutic agents |
| US7919670B1 (en) | 2000-08-14 | 2011-04-05 | The Trustees Of Columbia University In The City Of New York | Transgenic mice over-expressing receptor for advanced glycation endproduct (RAGE) in brain and uses thereof |
| AU2002213192A1 (en) * | 2000-10-13 | 2002-04-22 | The Trustees Of Columbia University In The City Of New York | A method for inhibiting new tissue growth in blood vessels in a patient subjected to blood vessel injury |
| CN1494425B (zh) | 2001-03-05 | 2011-12-07 | 特兰斯泰克制药公司 | 用作治疗剂的羧酰胺衍生物 |
| JP3837494B2 (ja) | 2001-03-19 | 2006-10-25 | 国立大学法人金沢大学 | 可溶型rageタンパク質 |
| JP4481011B2 (ja) | 2002-03-05 | 2010-06-16 | トランス テック ファーマ,インコーポレイテッド | リガンドのrageとの相互作用を阻害する単環式および二環式アゾール誘導体 |
| MXPA05001758A (es) * | 2002-08-16 | 2005-08-19 | Wyeth Corp | Composiciones y metodos para el tratamiento de trastornos asociados a receptor para productos finales de glicatacion avanzada (rage). |
| US8067371B2 (en) * | 2003-05-09 | 2011-11-29 | The Trustees Of Columbia University In The City Of New York | RAGE G82S-related methods and compositions for treating inflammatory disorders |
| EP1635823A1 (en) * | 2003-05-20 | 2006-03-22 | TransTech Pharma Inc. | Rage antagonists as agents to reverse amyloidosis and diseases associated therewith |
| WO2006012415A2 (en) * | 2004-07-20 | 2006-02-02 | Critical Therapeutics, Inc. | Rage protein derivatives |
| KR20070057818A (ko) * | 2004-08-03 | 2007-06-07 | 트랜스테크 파르마, 인크. | Rage 융합 단백질 및 이의 사용 방법 |
| JP5188804B2 (ja) * | 2004-08-03 | 2013-04-24 | トランステック ファーマ,インコーポレイティド | Rage融合タンパク質及びその使用方法 |
| US20060084145A1 (en) | 2004-09-27 | 2006-04-20 | Anderson Glenn M | sRAGE mimetibody, compositions, methods and uses |
| MX2007011411A (es) * | 2005-03-17 | 2007-11-13 | Univ Columbia | Interaccion rage/diaphanous y composiciones relacionadas y metodos. |
| AU2006327353B2 (en) * | 2005-12-23 | 2011-11-24 | Gcoder Systems Ab | Positioning pattern |
| KR20080105066A (ko) * | 2006-02-09 | 2008-12-03 | 트랜스테크 파르마, 인크. | Rage 융합 단백질 및 이의 사용 방법 |
| AU2007248784B2 (en) | 2006-05-05 | 2013-11-21 | Vtv Therapeutics Llc | RAGE fusion proteins, formulations, and methods of use thereof |
| WO2008100470A2 (en) * | 2007-02-15 | 2008-08-21 | Transtech Pharma, Inc. | Rage - immunoglobulin fusion proteins |
| US20100254983A1 (en) * | 2007-06-07 | 2010-10-07 | Ann Marie Schmidt | Uses of rage antagonists for treating obesity and related diseases |
| EP2158210B1 (en) | 2007-06-14 | 2015-12-09 | Galactica Pharmaceuticals, Inc. | Rage fusion proteins |
| CL2008002053A1 (es) | 2007-07-17 | 2009-05-22 | Hoffmann La Roche | Metodo para la purificacion de una eritropoyetina monopeguilada (epompeg) que consiste en proporcionar una solucion que contiene eritropoyetina mono, poli y no peguilada y hacerla pasar por dos pasos de cromatografia de intercambio cationico y metodo para producir epo mpeg que incluye metodo de purificacion. |
| CL2008002054A1 (es) | 2007-07-17 | 2009-05-29 | Hoffmann La Roche | Metodo para la regeneracion de una columna de cromatografia de intercambio cationico despues de la elusion de eritropoyetina monopeguilada y metodo para obtener una eritropoyetina monopeguilada, incorporando el metodo de regeneracion de la columna de intercambio cationico. |
| MX2010012473A (es) | 2008-05-23 | 2011-02-23 | Siwa Corp | Metodos, composiciones y aparato para facilitar la regeneracion. |
| US9034341B2 (en) | 2009-04-20 | 2015-05-19 | Transtech Pharma, Llc | Control of RAGE fusion protein glycosylation and RAGE fusion protein compositions |
| ES2467923T3 (es) | 2009-09-30 | 2014-06-13 | Transtech Pharma, Llc | Derivados de imidazol substituidos para el tratamiento de la enfermedad de Alzheimer |
| ES2550667T3 (es) | 2010-02-18 | 2015-11-11 | Vtv Therapeutics Llc | Derivados de fenilheteroarilo y métodos de uso de los mismos |
| US9649376B2 (en) | 2010-09-27 | 2017-05-16 | Siwa Corporation | Selective removal of age-modified cells for treatment of atherosclerosis |
| US8721571B2 (en) | 2010-11-22 | 2014-05-13 | Siwa Corporation | Selective removal of cells having accumulated agents |
| WO2012135616A1 (en) * | 2011-03-31 | 2012-10-04 | Siwa Corporation | Vaccination against advanced glycation end-products |
| WO2013103688A1 (en) * | 2012-01-03 | 2013-07-11 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Human soluble receptors for advanced glycation end products (srage), methods of preparing human srage, and treatment methods using srage |
| US9717710B2 (en) | 2012-10-05 | 2017-08-01 | Vtv Therapeutics Llc | Treatment of mild and moderate Alzheimer's disease |
| CA2903946A1 (en) * | 2013-03-08 | 2014-09-12 | Zora Biosciences Oy | Non-high density lipoprotein derived cvd markers |
| CN107001459B (zh) | 2014-09-19 | 2021-11-23 | Siwa有限公司 | 用于治疗炎症和自身免疫紊乱的抗age抗体 |
| US9993535B2 (en) | 2014-12-18 | 2018-06-12 | Siwa Corporation | Method and composition for treating sarcopenia |
| US10358502B2 (en) | 2014-12-18 | 2019-07-23 | Siwa Corporation | Product and method for treating sarcopenia |
| PT3337829T (pt) | 2016-02-19 | 2020-02-10 | Siwa Corp | Método e composição para o tratamento do cancro, matando células cancerosas metastáticas e prevenindo as metástases do cancro usando anticorpos para produtos finais de glicação avançada (pga) |
| CA3057829A1 (en) | 2016-04-15 | 2017-10-19 | Siwa Corporation | Anti-age antibodies for treating neurodegenerative disorders |
| WO2017222535A1 (en) | 2016-06-23 | 2017-12-28 | Siwa Corporation | Vaccines for use in treating various diseases and disorders |
| US10925937B1 (en) | 2017-01-06 | 2021-02-23 | Siwa Corporation | Vaccines for use in treating juvenile disorders associated with inflammation |
| US10858449B1 (en) | 2017-01-06 | 2020-12-08 | Siwa Corporation | Methods and compositions for treating osteoarthritis |
| US10995151B1 (en) | 2017-01-06 | 2021-05-04 | Siwa Corporation | Methods and compositions for treating disease-related cachexia |
| US10961321B1 (en) | 2017-01-06 | 2021-03-30 | Siwa Corporation | Methods and compositions for treating pain associated with inflammation |
| CA3059803A1 (en) | 2017-04-13 | 2018-10-18 | Siwa Corporation | Humanized monoclonal advanced glycation end-product antibody |
| US11518801B1 (en) | 2017-12-22 | 2022-12-06 | Siwa Corporation | Methods and compositions for treating diabetes and diabetic complications |
| WO2019190822A1 (en) | 2018-03-28 | 2019-10-03 | Vtv Therapeutics Llc | Crystalline forms of [3-(4- {2-butyl-1-[4-(4-chloro-phenoxy)-phenyl]-1h-imidazol-4-yl} -phenoxy)-propyl]-diethyl-amine |
| WO2019190823A1 (en) | 2018-03-28 | 2019-10-03 | Vtv Therapeutics Llc | Pharmaceutically acceptable salts of [3-(4- {2-butyl-1-[4-(4-chlorophenoxy)-phenyl]-1h-imidazol-4-yl} -phenoxy)-propyl]-diethyl-amine |
| JP7464591B2 (ja) | 2018-10-10 | 2024-04-09 | ブイティーブイ・セラピューティクス・エルエルシー | [3-(4-{2-ブチル-1-[4-(4-クロロ-フェノキシ)-フェニル]-1h-イミダゾール-4-イル}-フェノキシ)-プロピル]-ジエチル-アミンの代謝産物 |
| WO2022089639A1 (zh) * | 2020-10-30 | 2022-05-05 | 深圳普罗吉医药科技有限公司 | 人血清白蛋白在治疗疾病中的应用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5585344A (en) | 1984-03-19 | 1996-12-17 | The Rockefeller University | Liver-derived receptors for advanced glycosylation endproducts and uses thereof |
| US5605885A (en) * | 1988-05-05 | 1997-02-25 | Entremed, Inc. | Method for stimulating the immune system |
| WO1992010579A1 (fr) | 1990-12-07 | 1992-06-25 | Kanegafuchi Kagaku Kogyo Kabushiki Kaisha | PROCEDE DE PRODUCTION DE D-α-AMINOACIDES |
| CN1134803A (zh) | 1996-01-24 | 1996-11-06 | 沈阳市大东副食品商场 | 乘车游乐自选购物系统 |
| AU1832797A (en) | 1996-01-26 | 1997-08-20 | Trustees Of Columbia University In The City Of New York, The | A polypeptide from lung extract which binds amyloid-beta peptide |
| US5864018A (en) | 1996-04-16 | 1999-01-26 | Schering Aktiengesellschaft | Antibodies to advanced glycosylation end-product receptor polypeptides and uses therefor |
| AU2696097A (en) | 1996-04-16 | 1997-11-07 | Schering Aktiengesellschaft | Advanced glycosylation end-product receptor peptides and uses therefor |
| US5688653A (en) | 1996-06-27 | 1997-11-18 | The Picower Institute For Medical Research | 3-alkylamino-2-hydroxy-4-hydroxymethyl-2-cyclopenten-1-one advanced glycosylation endproducts and methods of use therefor |
| US6790443B2 (en) | 1996-11-22 | 2004-09-14 | The Trustees Of Columbia University In The City Of New York | Method for treating symptoms of diabetes |
| US6555651B2 (en) | 1997-10-09 | 2003-04-29 | The Trustees Of Columbia University In The City Of New York | Ligand binding site of rage and uses thereof |
| US7101838B2 (en) | 1997-08-05 | 2006-09-05 | The Trustees Of Columbia University In The City Of New York | Method to prevent accelerated atherosclerosis using (sRAGE) soluble receptor for advanced glycation endproducts |
| EP1307219A4 (en) | 1999-08-13 | 2005-04-06 | Univ Columbia | METHODS OF INHIBITING BETA FIBRILLE BINDING BETA TO RAGE RECEPTOR, AND CONSEQUENCES THEREOF |
-
1997
- 1997-08-05 US US08/905,709 patent/US7101838B2/en not_active Expired - Fee Related
-
1998
- 1998-08-05 AU AU88239/98A patent/AU758252B2/en not_active Ceased
- 1998-08-05 WO PCT/US1998/016303 patent/WO1999007402A1/en not_active Ceased
- 1998-08-05 JP JP2000506991A patent/JP4426090B2/ja not_active Expired - Fee Related
- 1998-08-05 AT AT98939876T patent/ATE253929T1/de active
- 1998-08-05 DE DE69819751T patent/DE69819751T8/de active Active
- 1998-08-05 PT PT98939876T patent/PT1011706E/pt unknown
- 1998-08-05 ES ES98939876T patent/ES2210800T3/es not_active Expired - Lifetime
- 1998-08-05 EP EP98939876A patent/EP1011706B1/en not_active Expired - Lifetime
- 1998-08-05 CA CA002299467A patent/CA2299467A1/en not_active Abandoned
- 1998-08-05 DK DK98939876T patent/DK1011706T3/da active
-
2005
- 2005-12-27 US US11/319,949 patent/US7494972B2/en not_active Expired - Fee Related
-
2009
- 2009-10-13 JP JP2009236481A patent/JP4976475B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US20070099829A1 (en) | 2007-05-03 |
| AU8823998A (en) | 1999-03-01 |
| EP1011706A4 (en) | 2001-10-17 |
| JP2001513511A (ja) | 2001-09-04 |
| PT1011706E (pt) | 2004-04-30 |
| EP1011706A1 (en) | 2000-06-28 |
| DE69819751D1 (de) | 2003-12-18 |
| DK1011706T3 (da) | 2004-03-22 |
| HK1030742A1 (en) | 2001-05-18 |
| US20010039256A1 (en) | 2001-11-08 |
| WO1999007402A1 (en) | 1999-02-18 |
| US7101838B2 (en) | 2006-09-05 |
| JP4426090B2 (ja) | 2010-03-03 |
| DE69819751T2 (de) | 2004-09-30 |
| DE69819751T8 (de) | 2005-01-05 |
| JP2010065040A (ja) | 2010-03-25 |
| US7494972B2 (en) | 2009-02-24 |
| CA2299467A1 (en) | 1999-02-18 |
| AU758252B2 (en) | 2003-03-20 |
| JP4976475B2 (ja) | 2012-07-18 |
| EP1011706B1 (en) | 2003-11-12 |
| ES2210800T3 (es) | 2004-07-01 |
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Legal Events
| Date | Code | Title | Description |
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