ATE253862T1 - Krebsdiagnose durch laserinduzierte differential- normierte fluoreszenz - Google Patents

Krebsdiagnose durch laserinduzierte differential- normierte fluoreszenz

Info

Publication number
ATE253862T1
ATE253862T1 AT95935191T AT95935191T ATE253862T1 AT E253862 T1 ATE253862 T1 AT E253862T1 AT 95935191 T AT95935191 T AT 95935191T AT 95935191 T AT95935191 T AT 95935191T AT E253862 T1 ATE253862 T1 AT E253862T1
Authority
AT
Austria
Prior art keywords
laser
spectrum
normalized
tissue sample
induced fluorescence
Prior art date
Application number
AT95935191T
Other languages
English (en)
Inventor
Tuan Vo-Dinh
Masoud Panjehpour
Bergein F Overholt
Original Assignee
Ut Battelle Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ut Battelle Llc filed Critical Ut Battelle Llc
Application granted granted Critical
Publication of ATE253862T1 publication Critical patent/ATE253862T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/42—Detecting, measuring or recording for evaluating the gastrointestinal, the endocrine or the exocrine systems
    • A61B5/4222—Evaluating particular parts, e.g. particular organs
    • A61B5/4233—Evaluating particular parts, e.g. particular organs oesophagus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0075—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7235—Details of waveform analysis
    • A61B5/7239—Details of waveform analysis using differentiation including higher order derivatives

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Physics & Mathematics (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physiology (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Radiation-Therapy Devices (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT95935191T 1994-09-30 1995-09-29 Krebsdiagnose durch laserinduzierte differential- normierte fluoreszenz ATE253862T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/316,132 US5579773A (en) 1994-09-30 1994-09-30 Laser-induced differential normalized fluorescence method for cancer diagnosis
PCT/US1995/012456 WO1996010363A1 (en) 1994-09-30 1995-09-29 Laser-induced differential normalized fluorescence method for cancer diagnosis

Publications (1)

Publication Number Publication Date
ATE253862T1 true ATE253862T1 (de) 2003-11-15

Family

ID=23227611

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95935191T ATE253862T1 (de) 1994-09-30 1995-09-29 Krebsdiagnose durch laserinduzierte differential- normierte fluoreszenz

Country Status (11)

Country Link
US (1) US5579773A (de)
EP (1) EP0732889B1 (de)
JP (1) JP3752693B2 (de)
KR (1) KR100415850B1 (de)
AT (1) ATE253862T1 (de)
AU (1) AU711328B2 (de)
BR (1) BR9506399A (de)
DE (1) DE69532108T2 (de)
ES (1) ES2208696T3 (de)
NZ (1) NZ294488A (de)
WO (1) WO1996010363A1 (de)

Families Citing this family (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5987346A (en) * 1993-02-26 1999-11-16 Benaron; David A. Device and method for classification of tissue
US5865754A (en) * 1995-08-24 1999-02-02 Purdue Research Foundation Office Of Technology Transfer Fluorescence imaging system and method
US7328059B2 (en) 1996-08-23 2008-02-05 The Texas A & M University System Imaging of light scattering tissues with fluorescent contrast agents
US5953477A (en) 1995-11-20 1999-09-14 Visionex, Inc. Method and apparatus for improved fiber optic light management
US6174424B1 (en) 1995-11-20 2001-01-16 Cirrex Corp. Couplers for optical fibers
US6525862B2 (en) 1996-10-30 2003-02-25 Photogen, Inc. Methods and apparatus for optical imaging
US6119031A (en) * 1996-11-21 2000-09-12 Boston Scientific Corporation Miniature spectrometer
US6826422B1 (en) 1997-01-13 2004-11-30 Medispectra, Inc. Spectral volume microprobe arrays
US7865230B1 (en) 1997-02-07 2011-01-04 Texas A&M University System Method and system for detecting sentinel lymph nodes
EP1011422B1 (de) * 1997-02-07 2004-11-10 The Texas A & M University System Abbildung von lichtstreuenden geweben mittels fluoreszierender kontrastmittel
WO1998040007A1 (en) * 1997-03-13 1998-09-17 Biomax Technologies, Inc. Methods and apparatus for detecting the rejection of transplanted tissue
US6208783B1 (en) 1997-03-13 2001-03-27 Cirrex Corp. Optical filtering device
EP0973436A1 (de) * 1997-03-13 2000-01-26 Biomax Technologies, Inc. Gültigkeitsprüfung und verarbeitung von spektral-fluoreszenz-signalen zur anzeige von abstossungsreaktionen bezüglich gewebe-transplantaten
US6324418B1 (en) 1997-09-29 2001-11-27 Boston Scientific Corporation Portable tissue spectroscopy apparatus and method
US6096065A (en) 1997-09-29 2000-08-01 Boston Scientific Corporation Sheath for tissue spectroscopy
US5984861A (en) * 1997-09-29 1999-11-16 Boston Scientific Corporation Endofluorescence imaging module for an endoscope
US6238348B1 (en) 1997-07-22 2001-05-29 Scimed Life Systems, Inc. Miniature spectrometer system and method
US6185443B1 (en) 1997-09-29 2001-02-06 Boston Scientific Corporation Visible display for an interventional device
US8974363B2 (en) 1997-12-11 2015-03-10 Provectus Pharmatech, Inc. Topical medicaments and methods for photodynamic treatment of disease
US6055451A (en) 1997-12-12 2000-04-25 Spectrx, Inc. Apparatus and method for determining tissue characteristics
US6289229B1 (en) 1998-01-20 2001-09-11 Scimed Life Systems, Inc. Readable probe array for in vivo use
US6174291B1 (en) 1998-03-09 2001-01-16 Spectrascience, Inc. Optical biopsy system and methods for tissue diagnosis
US8557298B2 (en) 1998-08-06 2013-10-15 Provectus Pharmatech, Inc. Medicaments for chemotherapeutic treatment of disease
US6986740B2 (en) * 1998-11-02 2006-01-17 Xantech Pharmaceuticals, Inc. Ultrasound contrast using halogenated xanthenes
EP1161178A2 (de) 1998-12-23 2001-12-12 Medispectra Inc. Systeme und verfahren zur optischen untersuchung von proben
CN1341003A (zh) * 1999-01-26 2002-03-20 牛顿实验室公司 用于内窥镜的自发荧光成象系统
US6580935B1 (en) 1999-03-12 2003-06-17 Cirrex Corp. Method and system for stabilizing reflected light
US6205354B1 (en) 1999-06-18 2001-03-20 University Of Utah Method and apparatus for noninvasive measurement of carotenoids and related chemical substances in biological tissue
JP2001017379A (ja) * 1999-07-09 2001-01-23 Fuji Photo Film Co Ltd 蛍光診断装置
US7054002B1 (en) 1999-10-08 2006-05-30 The Texas A&M University System Characterization of luminescence in a scattering medium
CA2398029A1 (en) 2000-02-08 2001-08-16 Cornell Research Foundation, Inc. Multiphoton excitation through optical fibers for fluorescence spectroscopy
AU2001237066A1 (en) * 2000-02-18 2001-08-27 Argose, Inc. Generation of spatially-averaged excitation-emission map in heterogeneous tissue
JP2002098696A (ja) * 2000-09-26 2002-04-05 Inst Of Physical & Chemical Res 集積型生体分子センサー
WO2002064084A2 (en) * 2000-11-02 2002-08-22 Cornell Research Foundation, Inc. In vivo multiphoton diagnostic detection and imaging of a neurodegenerative disease
US20040038320A1 (en) * 2001-03-09 2004-02-26 Bhaskar Banerjee Methods of detecting cancer using cellular autofluorescence
US6796710B2 (en) * 2001-06-08 2004-09-28 Ethicon Endo-Surgery, Inc. System and method of measuring and controlling temperature of optical fiber tip in a laser system
US6921920B2 (en) * 2001-08-31 2005-07-26 Smith & Nephew, Inc. Solid-state light source
JP2003102672A (ja) * 2001-10-01 2003-04-08 Japan Science & Technology Corp 病変等の対象部位を自動的に検知かつ治療または採取する方法およびその装置
US6989140B2 (en) 2001-12-21 2006-01-24 Threshold Pharmaceuticals, Inc. Methods for cancer imaging
US7039452B2 (en) 2002-12-19 2006-05-02 The University Of Utah Research Foundation Method and apparatus for Raman imaging of macular pigments
US20030216626A1 (en) * 2002-03-28 2003-11-20 Fuji Photo Film Co., Ltd. Fluorescence judging method and apparatus
US6818903B2 (en) 2002-07-09 2004-11-16 Medispectra, Inc. Method and apparatus for identifying spectral artifacts
US6768918B2 (en) 2002-07-10 2004-07-27 Medispectra, Inc. Fluorescent fiberoptic probe for tissue health discrimination and method of use thereof
US20040254479A1 (en) 2003-02-20 2004-12-16 John Fralick Bio-photonic feedback control software and database
US7627363B2 (en) * 2003-03-18 2009-12-01 The General Hospital Corporation Polarized light imaging devices and methods
US7181219B2 (en) * 2003-05-22 2007-02-20 Lucent Technologies Inc. Wireless handover using anchor termination
CA2533621C (en) * 2003-06-20 2013-12-10 The Texas A & M University System Method and system for near-infrared fluorescence contrast-enhanced imaging with area illumination and area detection
US7869033B2 (en) * 2003-12-24 2011-01-11 Vadivel Masilamani Cancer detection by optical analysis of body fluids
US8208142B2 (en) * 2003-12-24 2012-06-26 King Salid University Lung cancer detection by optical analysis of body fluids
US8213005B2 (en) 2003-07-22 2012-07-03 King Saud University Method for discriminating between benign and malignant prostate tumors
JP4823906B2 (ja) * 2003-08-19 2011-11-24 コーネル リサーチ ファンデーション インコーポレーティッド 多光子顕微鏡観察、分光法、および内視鏡観察などの生物学的用途のための光ファイバー送集光システム
AU2004273992B2 (en) 2003-09-19 2010-01-21 The General Hospital Corporation Fluorescence polarization imaging devices and methods
US7103402B2 (en) * 2003-10-02 2006-09-05 Ut-Battelle, Llc Advanced synchronous luminescence imaging for chemical and medical diagnostics
US7166151B2 (en) * 2004-01-15 2007-01-23 Praxair Technology, Inc. Flow distributor for PSA vessel
US20050278184A1 (en) * 2004-06-10 2005-12-15 John Fralick Bio-photonic feedback control software and database
CA2583427A1 (en) * 2004-09-30 2006-04-20 Zila Biotechnology, Inc. Light-directed method for detecting and aiding further evaluation of abnormal mucosal tissue
US7365839B2 (en) * 2004-11-03 2008-04-29 Nu Skin International, Inc. Process and compositions for synthetic calibration of bio-photonic scanners
DE102006021343A1 (de) * 2006-05-05 2007-11-08 Mevitec Gmbh Vorrichtung zur optischen Untersuchung eines biologischen Gewebes
US20100305436A1 (en) * 2007-09-14 2010-12-02 Light Sciences Oncology , Inc. Systems, devices, and methods for photoactive assisted resection
EP2291640B1 (de) 2008-05-20 2018-12-26 University Health Network Vorrichtung und verfahren zur bildgebung und überwachung auf fluoreszenzbasis
JP4575474B2 (ja) * 2008-06-11 2010-11-04 国立大学法人東京工業大学 生体組織識別装置および方法
US8939966B2 (en) * 2008-08-21 2015-01-27 University Of Florida Research Foundation, Inc. Differential laser-induced perturbation (DLIP) for bioimaging and chemical sensing
EP2419712A4 (de) * 2009-04-14 2012-12-19 Gen Hospital Corp Verfahren und vorrichtung zur multimodalen abbildung von biologischem gewebe
JP5635282B2 (ja) * 2010-03-15 2014-12-03 ソニー株式会社 判別装置
CN101949845A (zh) * 2010-08-20 2011-01-19 浙江大学 小型化低成本的光致发光扫描测量装置
CN102599884A (zh) * 2011-01-19 2012-07-25 中国科学院安徽光学精密机械研究所 激光早期癌症诊断仪
US11717165B2 (en) * 2011-11-07 2023-08-08 Koninklijke Philips N.V. Detection apparatus for determining a state of tissue
WO2016011534A1 (en) 2014-07-24 2016-01-28 University Health Network Collection and analysis of data for diagnostic purposes
CN106993996A (zh) * 2016-01-25 2017-08-01 安徽省立医院 一种光纤锥探头及其制备方法与其在制备诊断胃癌的产品中的应用
WO2018195466A1 (en) * 2017-04-20 2018-10-25 Henry Ford Health System System and method for characterization of a brain tissue sample using raman marker regions

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4479499A (en) * 1982-01-29 1984-10-30 Alfano Robert R Method and apparatus for detecting the presence of caries in teeth using visible light
JPS60209146A (ja) * 1984-03-31 1985-10-21 Olympus Optical Co Ltd 螢光スペクトル分析装置
US4718417A (en) * 1985-03-22 1988-01-12 Massachusetts Institute Of Technology Visible fluorescence spectral diagnostic for laser angiosurgery
CN85100424B (zh) * 1985-04-01 1986-10-29 上海医疗器械研究所 恶性肿瘤固有荧光诊断仪
US5042494A (en) * 1985-11-13 1991-08-27 Alfano Robert R Method and apparatus for detecting cancerous tissue using luminescence excitation spectra
US4930516B1 (en) * 1985-11-13 1998-08-04 Laser Diagnostic Instr Inc Method for detecting cancerous tissue using visible native luminescence
JPH06105190B2 (ja) * 1988-03-31 1994-12-21 工業技術院長 信号解析装置
US4981138A (en) * 1988-06-30 1991-01-01 Yale University Endoscopic fiberoptic fluorescence spectrometer
SE8900612D0 (sv) * 1989-02-22 1989-02-22 Jonas Johansson Vaevnadskarakterisering utnyttjande ett blodfritt fluorescenskriterium
EP0466828A1 (de) * 1989-04-14 1992-01-22 Massachusetts Institute Of Technology Spektraldiagnose von erkranktem gewebe
US5421337A (en) * 1989-04-14 1995-06-06 Massachusetts Institute Of Technology Spectral diagnosis of diseased tissue
US5131398A (en) * 1990-01-22 1992-07-21 Mediscience Technology Corp. Method and apparatus for distinguishing cancerous tissue from benign tumor tissue, benign tissue or normal tissue using native fluorescence
US5315993A (en) * 1990-02-16 1994-05-31 The Boc Group, Inc. Luminescence monitoring with modulation frequency multiplexing
US5261410A (en) * 1991-02-07 1993-11-16 Alfano Robert R Method for determining if a tissue is a malignant tumor tissue, a benign tumor tissue, or a normal or benign tissue using Raman spectroscopy
US5303026A (en) * 1991-02-26 1994-04-12 The Regents Of The University Of California Los Alamos National Laboratory Apparatus and method for spectroscopic analysis of scattering media
US5348018A (en) * 1991-11-25 1994-09-20 Alfano Robert R Method for determining if tissue is malignant as opposed to non-malignant using time-resolved fluorescence spectroscopy
US5421339A (en) * 1993-05-12 1995-06-06 Board Of Regents, The University Of Texas System Diagnosis of dysplasia using laser induced fluoroescence

Also Published As

Publication number Publication date
JPH09506027A (ja) 1997-06-17
KR100415850B1 (ko) 2004-04-30
EP0732889A4 (de) 1999-04-14
WO1996010363A1 (en) 1996-04-11
EP0732889A1 (de) 1996-09-25
US5579773A (en) 1996-12-03
NZ294488A (en) 1997-12-19
ES2208696T3 (es) 2004-06-16
DE69532108D1 (de) 2003-12-18
DE69532108T2 (de) 2004-05-27
BR9506399A (pt) 1997-08-12
AU711328B2 (en) 1999-10-14
EP0732889B1 (de) 2003-11-12
JP3752693B2 (ja) 2006-03-08
AU3730795A (en) 1996-04-26

Similar Documents

Publication Publication Date Title
ATE253862T1 (de) Krebsdiagnose durch laserinduzierte differential- normierte fluoreszenz
AU638978B2 (en) Improvements in diagnosis by means of fluorescent light emission from tissue
JP4336673B2 (ja) 生物組織中のカロテノイドと関連する化学物質との非侵襲的測定方法および装置
US20040044287A1 (en) Identification of human tissue using optical spectroscopy
WO2001040771A3 (en) Apparatus and method for analyzing fluids
WO1996028084B1 (en) Optical method and apparatus for the diagnosis of cervical precancers using raman and fluorescence spectroscopies
WO1986002730A1 (en) A fluorescence imaging system
CA2063651A1 (en) Apparatus and method of use for a photosensitizer enhanced fluorescence based biopsy needle
AU1401599A (en) Method for non-invasive measurement of an analyte
ATE101270T1 (de) Spektroskopische verfahren und vorrichtung zur messung des zuckergehaltes.
MY120544A (en) Method and apparatus for generating basis sets for use in spectroscopic analysis.
DE69614528D1 (de) Verfahren und vorrichtung zur schnellen unblutigen bestimmung von blut-bestandteeilen
Andersson-Engels et al. Time-resolved laser-induced fluorescence spectroscopy for enhanced demarcation of human atherosclerotic plaques
Hibst et al. New approach on fluorescence spectroscopy for caries detection
WO2007060571A1 (en) A device for imaging an interior of a turbid medium
CA2514741A1 (en) Strokes shift emission spectroscopy for detection of disease and physiological state of specimen
JP2000146839A (ja) ガス成分濃度計測装置およびガス成分濃度計測方法
US6215554B1 (en) Laser diagnostic unit for detecting carcinosis
JP2003500094A (ja) 多光子の光活性化及び分子エージェントの改良検出方法及び装置
RU94010321A (ru) Способ диагностики злокачественных новообразований и устройство для его осуществления
JPH0414973B2 (de)
RU96114745A (ru) Способ диагностики онкологических заболеваний и устройство для его осуществления
Sa’adah et al. Fluorescence imaging system using high power LED to generate oral auto-fluoerscence of Sprague dawley rat
Thompson et al. Hyperspectral fluorescence lifetime fibre probe spectroscopy for use in the study and diagnosis of osteoarthritis and skin cancer
JPS58118948A (ja) 分光分析による異常細胞の検出方法及び装置

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 0732889

Country of ref document: EP

REN Ceased due to non-payment of the annual fee