ATE252571T1 - Tocotrienole und geranylgeraniol aus nebenprodukten von bixa orellana - Google Patents
Tocotrienole und geranylgeraniol aus nebenprodukten von bixa orellanaInfo
- Publication number
- ATE252571T1 ATE252571T1 AT00932733T AT00932733T ATE252571T1 AT E252571 T1 ATE252571 T1 AT E252571T1 AT 00932733 T AT00932733 T AT 00932733T AT 00932733 T AT00932733 T AT 00932733T AT E252571 T1 ATE252571 T1 AT E252571T1
- Authority
- AT
- Austria
- Prior art keywords
- geranylgeraniol
- component
- tocotrienols
- products
- bixa orellana
- Prior art date
Links
- 244000017106 Bixa orellana Species 0.000 title abstract 4
- OJISWRZIEWCUBN-QIRCYJPOSA-N (E,E,E)-geranylgeraniol Chemical compound CC(C)=CCC\C(C)=C\CC\C(C)=C\CC\C(C)=C\CO OJISWRZIEWCUBN-QIRCYJPOSA-N 0.000 title abstract 3
- 239000006227 byproduct Substances 0.000 title abstract 3
- XWRJRXQNOHXIOX-UHFFFAOYSA-N geranylgeraniol Natural products CC(C)=CCCC(C)=CCOCC=C(C)CCC=C(C)C XWRJRXQNOHXIOX-UHFFFAOYSA-N 0.000 title abstract 3
- OJISWRZIEWCUBN-UHFFFAOYSA-N geranylnerol Natural products CC(C)=CCCC(C)=CCCC(C)=CCCC(C)=CCO OJISWRZIEWCUBN-UHFFFAOYSA-N 0.000 title abstract 3
- 229930003802 tocotrienol Natural products 0.000 title abstract 3
- 239000011731 tocotrienol Substances 0.000 title abstract 3
- 235000019148 tocotrienols Nutrition 0.000 title abstract 3
- 235000006010 Bixa orellana Nutrition 0.000 title abstract 2
- 235000012978 bixa orellana Nutrition 0.000 title abstract 2
- GJJVAFUKOBZPCB-ZGRPYONQSA-N (r)-3,4-dihydro-2-methyl-2-(4,8,12-trimethyl-3,7,11-tridecatrienyl)-2h-1-benzopyran-6-ol Chemical class OC1=CC=C2OC(CC/C=C(C)/CC/C=C(C)/CCC=C(C)C)(C)CCC2=C1 GJJVAFUKOBZPCB-ZGRPYONQSA-N 0.000 title 1
- 229940068778 tocotrienols Drugs 0.000 title 1
- GJJVAFUKOBZPCB-UHFFFAOYSA-N 2-methyl-2-(4,8,12-trimethyltrideca-3,7,11-trienyl)-3,4-dihydrochromen-6-ol Chemical compound OC1=CC=C2OC(CCC=C(C)CCC=C(C)CCC=C(C)C)(C)CCC2=C1 GJJVAFUKOBZPCB-UHFFFAOYSA-N 0.000 abstract 2
- 235000012665 annatto Nutrition 0.000 abstract 2
- 239000010362 annatto Substances 0.000 abstract 2
- 239000000463 material Substances 0.000 abstract 2
- 239000006286 aqueous extract Substances 0.000 abstract 1
- 239000003125 aqueous solvent Substances 0.000 abstract 1
- 239000000284 extract Substances 0.000 abstract 1
- 238000011084 recovery Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/74—Separation; Purification; Use of additives, e.g. for stabilisation
- C07C29/76—Separation; Purification; Use of additives, e.g. for stabilisation by physical treatment
- C07C29/80—Separation; Purification; Use of additives, e.g. for stabilisation by physical treatment by distillation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
- C07D311/72—3,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyrane Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13546399P | 1999-05-24 | 1999-05-24 | |
| PCT/US2000/014212 WO2000071531A1 (en) | 1999-05-24 | 2000-05-24 | Tocotrienols and geranylgeraniol from bixa orellana byproducts |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE252571T1 true ATE252571T1 (de) | 2003-11-15 |
Family
ID=22468222
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00932733T ATE252571T1 (de) | 1999-05-24 | 2000-05-24 | Tocotrienole und geranylgeraniol aus nebenprodukten von bixa orellana |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US6350453B1 (de) |
| EP (1) | EP1235822B1 (de) |
| AT (1) | ATE252571T1 (de) |
| AU (1) | AU5041400A (de) |
| DE (1) | DE60006151T2 (de) |
| ES (1) | ES2209890T3 (de) |
| WO (1) | WO2000071531A1 (de) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU5467799A (en) | 1998-08-07 | 2000-02-28 | Liya Chen | Estrogen receptor modulators |
| US20030104090A1 (en) * | 2000-05-05 | 2003-06-05 | Levy Pedro E. | Supplements containing annatto extracts and carotenoids and methods for using the same |
| US6838104B2 (en) | 2000-12-20 | 2005-01-04 | Archer Daniels Midland Company | Process for the production of tocotrienols |
| CA2847543C (en) * | 2003-04-08 | 2018-05-15 | Barrie Tan | Annatto extract compositions, including geranyl geraniols and methods of use |
| US7989006B2 (en) * | 2003-04-08 | 2011-08-02 | American River Nutrition, Inc. | Annatto extract compositions, including geranyl geraniols and methods of use |
| US8586109B2 (en) * | 2003-04-10 | 2013-11-19 | American River Nutrition, Inc. | Annatto extract compositions including tocotrienols and tocopherols and methods of use |
| US20050037102A1 (en) * | 2003-07-18 | 2005-02-17 | Barrie Tan | Annatto extract compositions including tocotrienols and tocopherols and methods of use |
| ES2505252T3 (es) * | 2003-04-10 | 2014-10-09 | Barrie Tan | Composiciones de extracto de achiote que incluyen tocotrienoles y tocoferoles y métodos de uso |
| JP2007238508A (ja) * | 2006-03-09 | 2007-09-20 | Tama Seikagaku Kk | ゲラニルゲラニオールの製造方法 |
| BRPI1000300A2 (pt) * | 2010-01-29 | 2011-09-20 | José Dos Reis Aloísio | extrato vegetal promotor de cicatrização da epiderme e das mucosas, para uso tópico e por via oral |
| WO2011153353A1 (en) | 2010-06-02 | 2011-12-08 | The Board Of Trustees For The University Of Arkansas | Tocopherol derivatives and methods of use |
| US8759547B2 (en) | 2011-08-04 | 2014-06-24 | Ramaswamy Rajendran | Extraction of vitamin E from plant matter |
| US9039898B2 (en) | 2011-11-15 | 2015-05-26 | Engineering Research Associates, Inc. | Method for separating components in natural oil |
| ES2394338B1 (es) * | 2012-11-30 | 2013-12-09 | Universidad De Granada | Procedimiento de obtención de all-trans-geranilgeraniol |
| CA2924126C (en) | 2013-09-13 | 2023-05-02 | The Board Of Trustees Of The University Of Arkansas | Preparation and use of a composition for prevention and mitigation of the effects of radiation |
| CA2938343A1 (en) | 2014-02-11 | 2015-08-20 | Evonik Membrane Extraction Technology Ltd. | Method for producing vitamine e-enriched, especially tocotrienol-enriched, compositions from natural oils |
| US20160324914A1 (en) | 2015-05-05 | 2016-11-10 | Tocol Pharmaceuticals, Llc | Use of rice bran oil distillate extract for prevention and mitigation of the effects of radiation |
| SG11202004169SA (en) * | 2017-11-10 | 2020-06-29 | American River Nutrition Llc | Annatto extracts for insect repellency, larvicidal activity and methods of use |
| BR102019027219A2 (pt) * | 2019-12-19 | 2021-06-29 | Universidade Estadual De Campinas - Unicamp | Complexo oleaginoso a partir da semente de urucum e seus usos |
| IT202100011825A1 (it) | 2021-05-07 | 2022-11-07 | Effegilab Srl | Kit per la prevenzione ed il trattamento dell’invecchiamento cutaneo e sistemico e metodo cosmetico |
| WO2025064994A1 (en) * | 2023-09-22 | 2025-03-27 | American River Nutrition, Llc | High purity geranylgeraniol and tocotrienol, methods of preparations and uses thereof |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2486541A (en) | 1946-07-19 | 1949-11-01 | Distillation Products Inc | Delta-tocopherol |
| US4603142A (en) | 1984-06-01 | 1986-07-29 | Wisconsin Alumni Research Foundation | Cholesterol lowering method of use |
| JPS6396155A (ja) | 1986-10-13 | 1988-04-27 | Kuraray Co Ltd | 新規なテルペン化合物およびこれを含有する抗炎症剤 |
| JPS63250315A (ja) | 1987-04-03 | 1988-10-18 | Shiseido Co Ltd | 意識水準を高揚させる組成物 |
| US5217992A (en) | 1989-10-04 | 1993-06-08 | Bristol-Myers Squibb Company | Tocotrienols in the treatment of hypercholesterolemia, hyperlipidemia and thromboembolic disorders |
| KR910007523A (ko) | 1989-10-04 | 1991-05-30 | 브리스톨-마이어즈 스퀴브 컴페니 | 과콜레스테린혈증, 과지방혈증 및 혈전색전증 질병 치료용 토코트리엔올 |
| US5157132A (en) | 1990-05-18 | 1992-10-20 | Carotech Associates | Integrated process for recovery of carotenoids and tocotrienols from oil |
| WO1993009777A1 (en) | 1991-11-22 | 1993-05-27 | Lipogenics, Inc. | Tocotrienols and tocotrienol-like compounds and methods for their use |
| US5393776A (en) | 1990-09-14 | 1995-02-28 | Bristol-Myers Squibb Company | Tocotrienol analogs in the treatment of hypercholesterolemia and hyperlipidemia |
| US5602184A (en) | 1993-03-03 | 1997-02-11 | The United States Of America As Represented By Department Of Health And Human Services | Monoterpenes, sesquiterpenes and diterpenes as cancer therapy |
| US5318993A (en) | 1993-04-16 | 1994-06-07 | Bristol-Myers Squibb Company | Antihyperlipidemic benzoquinones |
| JPH07188119A (ja) | 1993-12-24 | 1995-07-25 | Takasago Internatl Corp | アミン誘導体およびその製造方法 |
| JP3657298B2 (ja) | 1994-11-08 | 2005-06-08 | 株式会社クラレ | ゲラニルゲラニオ−ルの製造方法 |
| US5660691A (en) | 1995-11-13 | 1997-08-26 | Eastman Chemical Company | Process for the production of tocotrienol/tocopherol blend concentrates |
| JPH09238692A (ja) | 1996-03-05 | 1997-09-16 | Mitsui Petrochem Ind Ltd | ゲラニルゲラニオールおよびその誘導体の生産性向上方法 |
| US5670668A (en) | 1996-07-03 | 1997-09-23 | Eastman Chemical Company | Crystalline tocotrienol esters |
| JPH1025226A (ja) | 1996-07-10 | 1998-01-27 | Kao Corp | 養毛・育毛料 |
| JPH1087480A (ja) | 1996-09-13 | 1998-04-07 | Eisai Co Ltd | 抗動脈硬化治療剤 |
| US5756109A (en) | 1996-09-27 | 1998-05-26 | Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. | Skin care compositions containing geranyl geraniol and retinol or retinyl esters |
| JPH11130670A (ja) | 1997-10-27 | 1999-05-18 | Oyo Seikagaku Kenkyusho | 骨粗鬆症治療剤 |
| BR9907278A (pt) | 1998-01-29 | 2000-10-24 | Eastman Chem Co | Processos para separar um tocotrienol de uma primeira mistura de tocol, e, composição |
| JP2002518448A (ja) | 1998-06-24 | 2002-06-25 | メルク エンド カムパニー インコーポレーテッド | 高血中コレステロールを治療する組成物および方法 |
-
2000
- 2000-05-24 EP EP00932733A patent/EP1235822B1/de not_active Expired - Lifetime
- 2000-05-24 US US09/577,086 patent/US6350453B1/en not_active Expired - Lifetime
- 2000-05-24 WO PCT/US2000/014212 patent/WO2000071531A1/en not_active Ceased
- 2000-05-24 AU AU50414/00A patent/AU5041400A/en not_active Abandoned
- 2000-05-24 ES ES00932733T patent/ES2209890T3/es not_active Expired - Lifetime
- 2000-05-24 DE DE60006151T patent/DE60006151T2/de not_active Expired - Lifetime
- 2000-05-24 AT AT00932733T patent/ATE252571T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE60006151T2 (de) | 2004-07-22 |
| EP1235822B1 (de) | 2003-10-22 |
| ES2209890T3 (es) | 2004-07-01 |
| EP1235822A1 (de) | 2002-09-04 |
| WO2000071531A1 (en) | 2000-11-30 |
| AU5041400A (en) | 2000-12-12 |
| DE60006151D1 (de) | 2003-11-27 |
| US6350453B1 (en) | 2002-02-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |