ATE251630T1 - Phosphinic pseudopeptide als matrix metalloprotease-inhibitoren - Google Patents
Phosphinic pseudopeptide als matrix metalloprotease-inhibitorenInfo
- Publication number
- ATE251630T1 ATE251630T1 AT00900598T AT00900598T ATE251630T1 AT E251630 T1 ATE251630 T1 AT E251630T1 AT 00900598 T AT00900598 T AT 00900598T AT 00900598 T AT00900598 T AT 00900598T AT E251630 T1 ATE251630 T1 AT E251630T1
- Authority
- AT
- Austria
- Prior art keywords
- amino acid
- natural
- metalloprotease inhibitors
- lateral chain
- pseudopeptides
- Prior art date
Links
- 239000011159 matrix material Substances 0.000 title abstract 2
- 239000003475 metalloproteinase inhibitor Substances 0.000 title abstract 2
- 150000001413 amino acids Chemical class 0.000 abstract 3
- 241000024188 Andala Species 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 101710204001 Zinc metalloprotease Proteins 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000000539 amino acid group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
- C07F9/301—Acyclic saturated acids which can have further substituents on alkyl
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/572—Five-membered rings
- C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9900509A FR2788525B1 (fr) | 1999-01-19 | 1999-01-19 | Pseudo-peptides phosphiniques, utilisables comme inhibiteurs des metalloproteases a zinc matricielles |
| PCT/FR2000/000093 WO2000043404A1 (fr) | 1999-01-19 | 2000-01-18 | Pseudo-peptides phosphiniques inhibiteurs des metalloproteases matricielles |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE251630T1 true ATE251630T1 (de) | 2003-10-15 |
Family
ID=9540989
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00900598T ATE251630T1 (de) | 1999-01-19 | 2000-01-18 | Phosphinic pseudopeptide als matrix metalloprotease-inhibitoren |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6630501B1 (de) |
| EP (1) | EP1144421B1 (de) |
| JP (1) | JP2003517450A (de) |
| AT (1) | ATE251630T1 (de) |
| CA (1) | CA2360787A1 (de) |
| DE (1) | DE60005788T2 (de) |
| DK (1) | DK1144421T3 (de) |
| ES (1) | ES2208260T3 (de) |
| FR (1) | FR2788525B1 (de) |
| WO (1) | WO2000043404A1 (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9922577D0 (en) * | 1999-09-23 | 1999-11-24 | Center For Clinical & Basic Re | Substituted phosphinate based peptide derivatives |
| PE20030701A1 (es) | 2001-12-20 | 2003-08-21 | Schering Corp | Compuestos para el tratamiento de trastornos inflamatorios |
| PL1685142T3 (pl) | 2003-11-11 | 2008-06-30 | Hoffmann La Roche | Pochodne kwasu fosfinowego, inhibitory beta-sekterazy do leczenia choroby Alzheimera |
| WO2007062376A2 (en) * | 2005-11-21 | 2007-05-31 | Florida Atlantic University | Selective inhibition of matrix metalloproteinases |
| FR2996003B1 (fr) | 2012-09-25 | 2014-10-17 | Commissariat Energie Atomique | Methode pour detecter specifiquement dans un echantillon une metalloprotease matricielle (mmp) d'interet uniquement dans sa forme active |
| TWI743023B (zh) * | 2014-05-21 | 2021-10-21 | 日商Ｋｍ生物醫藥股份有限公司 | 基質金屬蛋白酶 7(mmp-7)聚集體之單體化方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2676059B1 (fr) * | 1991-05-02 | 1993-07-23 | Commissariat Energie Atomique | Nouveaux derives de peptides utilisables comme inhibiteurs de collagenases bacteriennes. |
| JPH07503016A (ja) * | 1992-01-15 | 1995-03-30 | メルク エンド カンパニー インコーポレーテッド | 変形防止剤としての置換されたホスフィン酸含有ペプチジル誘導体 |
| FR2689764B1 (fr) | 1992-04-10 | 1995-05-12 | Commissariat Energie Atomique | Utilisation de dérivés de peptides pour la fabrication de médicaments inhibiteurs des endopeptidases 24.15 et 24.16. |
| FR2730235A1 (fr) | 1995-02-06 | 1996-08-09 | Commissariat Energie Atomique | Nouveaux derives de peptides utilisables comme inhibiteur de l'endopeptidase a zinc 24-15 |
| EP0923585B1 (de) * | 1996-07-18 | 2002-05-08 | Pfizer Inc. | Matrix metalloprotease-inhibitoren auf basis von phosphinsäuren |
-
1999
- 1999-01-19 FR FR9900509A patent/FR2788525B1/fr not_active Expired - Fee Related
-
2000
- 2000-01-18 CA CA002360787A patent/CA2360787A1/fr not_active Abandoned
- 2000-01-18 EP EP00900598A patent/EP1144421B1/de not_active Expired - Lifetime
- 2000-01-18 AT AT00900598T patent/ATE251630T1/de not_active IP Right Cessation
- 2000-01-18 JP JP2000594820A patent/JP2003517450A/ja active Pending
- 2000-01-18 ES ES00900598T patent/ES2208260T3/es not_active Expired - Lifetime
- 2000-01-18 DE DE60005788T patent/DE60005788T2/de not_active Expired - Fee Related
- 2000-01-18 US US09/869,303 patent/US6630501B1/en not_active Expired - Fee Related
- 2000-01-18 WO PCT/FR2000/000093 patent/WO2000043404A1/fr active IP Right Grant
- 2000-01-18 DK DK00900598T patent/DK1144421T3/da active
Also Published As
| Publication number | Publication date |
|---|---|
| DE60005788D1 (en) | 2003-11-13 |
| ES2208260T3 (es) | 2004-06-16 |
| US6630501B1 (en) | 2003-10-07 |
| FR2788525A1 (fr) | 2000-07-21 |
| CA2360787A1 (fr) | 2000-07-27 |
| DK1144421T3 (da) | 2004-02-16 |
| EP1144421B1 (de) | 2003-10-08 |
| FR2788525B1 (fr) | 2002-11-29 |
| WO2000043404A1 (fr) | 2000-07-27 |
| EP1144421A1 (de) | 2001-10-17 |
| DE60005788T2 (de) | 2004-08-19 |
| JP2003517450A (ja) | 2003-05-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |