BRPI0413743A - inibidores de catepsina s - Google Patents

inibidores de catepsina s

Info

Publication number
BRPI0413743A
BRPI0413743A BRPI0413743-4A BRPI0413743A BRPI0413743A BR PI0413743 A BRPI0413743 A BR PI0413743A BR PI0413743 A BRPI0413743 A BR PI0413743A BR PI0413743 A BRPI0413743 A BR PI0413743A
Authority
BR
Brazil
Prior art keywords
cathepsin
present
provides compounds
methods
cathepsin inhibitors
Prior art date
Application number
BRPI0413743-4A
Other languages
English (en)
Inventor
Hong Liu
Arnab Chatterjee
David C Tully
Phillip B Alper
Badry Bursulaya
Jianhua Guo
David Woodmansee
Daniel Mutnick
Donald S Karanewsky
Yun He
Original Assignee
Irm Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Irm Llc filed Critical Irm Llc
Publication of BRPI0413743A publication Critical patent/BRPI0413743A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/14—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

"INIBIDORES DE CATEPSINA S". A presente invenção refere-se a compostos, composições e processos para a inibição seletiva de catepsina S. Em um aspecto preferido, a catepsina S é inibida seletivamente na presença de pelo menos uma outra isozima de catepsina. A presente invenção também refere-se a processos para tratamento de um estado de doença em um paciente por inibição seletiva de catepsina S.
BRPI0413743-4A 2003-08-20 2004-08-19 inibidores de catepsina s BRPI0413743A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US49698003P 2003-08-20 2003-08-20
US10/922,515 US7314872B2 (en) 2003-08-20 2004-08-18 Inhibitors of cathepsin S
PCT/US2004/026986 WO2005034848A2 (en) 2003-08-20 2004-08-19 Inhibitors of cathepsin s

Publications (1)

Publication Number Publication Date
BRPI0413743A true BRPI0413743A (pt) 2006-10-24

Family

ID=34437256

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0413743-4A BRPI0413743A (pt) 2003-08-20 2004-08-19 inibidores de catepsina s

Country Status (10)

Country Link
US (4) US7314872B2 (pt)
EP (1) EP1658267B1 (pt)
JP (1) JP2007502836A (pt)
AT (1) ATE445598T1 (pt)
AU (1) AU2004279331B2 (pt)
BR (1) BRPI0413743A (pt)
CA (1) CA2535930A1 (pt)
DE (1) DE602004023620D1 (pt)
MX (1) MXPA06001889A (pt)
WO (1) WO2005034848A2 (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2154138T3 (en) * 2007-04-19 2015-11-02 Youxin Li Novel compounds for the treatment of psychotic disorders, methods of preparation and uses thereof
US20090291945A1 (en) * 2008-04-09 2009-11-26 Teijin Pharma Limited Cysteine protease inhibitors
AU2020250933A1 (en) 2019-04-05 2021-10-28 Centre Hospitalier Régional Et Universitaire De Brest Protease-activated receptor-2 inhibitors for the treatment of sensory neuropathy induced by a marine neurotoxic poisoning

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5932737A (en) * 1994-12-02 1999-08-03 Fujisawa Pharmaceutical Co., Ltd. Peptide compounds for treatment of no-mediated diseases
US6504014B1 (en) 1997-05-19 2003-01-07 The John Hopkins University Tissue specific prodrug
WO1999007689A1 (en) * 1997-08-11 1999-02-18 Warner-Lambert Company Aniline derivatives as calcium channel blockers
ATE326454T1 (de) 1999-07-30 2006-06-15 Boehringer Ingelheim Pharma Neue bernsteinsäure derivative als cysteine- protease-inhibitoren
WO2001081613A2 (en) 2000-04-20 2001-11-01 The University Of Georgia Research Foundation, Inc. Method for the identification of active site protease inactivators
JP2004256525A (ja) 2003-02-06 2004-09-16 Sankyo Co Ltd Ｎ−［１−置換−２−（アリールアミノ）エチル］アミド誘導体
US20070015485A1 (en) 2005-07-14 2007-01-18 Scosche Industries, Inc. Wireless Media Source for Communication with Devices on Data Bus of Vehicle

Also Published As

Publication number Publication date
JP2007502836A (ja) 2007-02-15
EP1658267A2 (en) 2006-05-24
US20100204200A1 (en) 2010-08-12
MXPA06001889A (es) 2006-05-31
US7501408B2 (en) 2009-03-10
WO2005034848A2 (en) 2005-04-21
WO2005034848A3 (en) 2005-10-27
US7732449B2 (en) 2010-06-08
EP1658267B1 (en) 2009-10-14
ATE445598T1 (de) 2009-10-15
US7314872B2 (en) 2008-01-01
US20090137570A1 (en) 2009-05-28
AU2004279331A1 (en) 2005-04-21
CA2535930A1 (en) 2005-04-21
AU2004279331B2 (en) 2007-08-30
EP1658267A4 (en) 2007-08-01
US20050113356A1 (en) 2005-05-26
DE602004023620D1 (de) 2009-11-26
US20080108595A1 (en) 2008-05-08

Similar Documents

Publication Publication Date Title
TW200510405A (en) Bridged n-arylsulfonylpiperidines as gamma-secretase inhibitors
NO20070606L (no) Inhibitorer av IAP
NO20044807L (no) Heratitt C virus inhibitorer
NO20062185L (no) Hepatitt C virus-inhibitorer
ATE368031T1 (de) Neue gamma secretase inhibitoren
TW200510317A (en) Caspase inhibitors and uses thereof
DE602004021472D1 (en) Pyrimiidinverbindungen
NO20070557L (no) Ftalazinderivater som PARP-inhibitorer
NO20083207L (no) Inhibitorer av IAP
ZA200704910B (en) Pyrrolidine inhibitors of IAP
NO20062339L (no) Hepatitt C virus-inhibitoerer
UA84712C2 (en) N-substituted pyrazolyl-amidyl-benzimidazolyl c-kit inhibitors
MXPA05012061A (es) Preparacion y uso de derivados alquilarilo para el tratamiento de la obesidad.
NO20091704L (no) Inhibitorer av hepatitt C virus
NO20091707L (no) Inhibitorer av hepatitt C virus
NO20064351L (no) Caspaseinhibitorer og anvendelser derav
IL138402A0 (en) Heterocyclically substituted amides used as calpain inhibitors
EA200800444A1 (ru) 8-МЕТОКСИ-9Н-ИЗОТИАЗОЛО[5,4-b]ХИНОЛИН-3,4-ДИОНЫ И РОДСТВЕННЫЕ СОЕДИНЕНИЯ В КАЧЕСТВЕ ПРОТИВОИНФЕКЦИОННЫХ СРЕДСТВ
PL1685142T3 (pl) Pochodne kwasu fosfinowego, inhibitory beta-sekterazy do leczenia choroby Alzheimera
NO20054340L (no) Nye sammenkoplede heterocykler og deres anvendelse
DE602004008959D1 (de) Benzoäbüä1,4üdioxepinderivate
MY138466A (en) Aminoalkoxyndoles as 5-ht6-receptor ligands for the treatment of cns-disorders
RS94603A (en) Novel compounds and compositions as cathepsin inhibitors
TW200610522A (en) Substituted ethane-1,2-diamines for the treatment of alzheimer's disease
DE602004005881D1 (de) Substituierte pyrazinonverbindungen zur behandlung von entzündungen

Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: PARA INT.CL: C07D 209/04, C07D 265/30, C07D 295/13, C07D 411/12, C07D 413/12, C07D 417/12, A61K 31/404, A61K 31/423, A61K 31/454, A61K 31/5375, A61P 29/00

Ipc: C07D 209/04 (2011.01), C07D 265/30 (2011.01), C07D

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2159 DE 22/05/2012.