ATE247482T1 - Baff, dessen inhibitoren und dessen verwendung zur modulierung der b-zell-antwort - Google Patents

Baff, dessen inhibitoren und dessen verwendung zur modulierung der b-zell-antwort

Info

Publication number
ATE247482T1
ATE247482T1 AT00909970T AT00909970T ATE247482T1 AT E247482 T1 ATE247482 T1 AT E247482T1 AT 00909970 T AT00909970 T AT 00909970T AT 00909970 T AT00909970 T AT 00909970T AT E247482 T1 ATE247482 T1 AT E247482T1
Authority
AT
Austria
Prior art keywords
cell growth
baff
immunoglobulin production
ligand
cell
Prior art date
Application number
AT00909970T
Other languages
German (de)
English (en)
Inventor
Jeffrey Browning
Christine Ambrose
Fabienne Mackay
Jurg Tschopp
Pascal Schneider
Original Assignee
Biogen Inc
Apoxis Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26815006&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE247482(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Biogen Inc, Apoxis Sa filed Critical Biogen Inc
Application granted granted Critical
Publication of ATE247482T1 publication Critical patent/ATE247482T1/de

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
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    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2875—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
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    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
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    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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AT00909970T 1999-01-25 2000-01-25 Baff, dessen inhibitoren und dessen verwendung zur modulierung der b-zell-antwort ATE247482T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11716999P 1999-01-25 1999-01-25
US14322899P 1999-07-09 1999-07-09
PCT/US2000/001788 WO2000043032A2 (en) 1999-01-25 2000-01-25 Baff, inhibitors thereof and their use in the modulation of b-cell response

Publications (1)

Publication Number Publication Date
ATE247482T1 true ATE247482T1 (de) 2003-09-15

Family

ID=26815006

Family Applications (2)

Application Number Title Priority Date Filing Date
AT00909970T ATE247482T1 (de) 1999-01-25 2000-01-25 Baff, dessen inhibitoren und dessen verwendung zur modulierung der b-zell-antwort
AT03018879T ATE515267T1 (de) 1999-01-25 2000-01-25 Verwendung eines antikörpers gegen wasserlöslich baff zur krebsbehandlung

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT03018879T ATE515267T1 (de) 1999-01-25 2000-01-25 Verwendung eines antikörpers gegen wasserlöslich baff zur krebsbehandlung

Country Status (29)

Country Link
US (1) US6869605B2 (da)
EP (5) EP1146892B1 (da)
JP (5) JP5066314B2 (da)
KR (1) KR100834809B1 (da)
CN (1) CN100340292C (da)
AT (2) ATE247482T1 (da)
AU (1) AU762839B2 (da)
BR (1) BR0007719A (da)
CA (1) CA2360062A1 (da)
CY (2) CY1107453T1 (da)
CZ (1) CZ299819B6 (da)
DE (1) DE60004635T2 (da)
DK (2) DK1415659T3 (da)
EA (1) EA006108B1 (da)
EE (1) EE05699B1 (da)
ES (1) ES2204528T3 (da)
HK (1) HK1040628B (da)
HU (1) HUP0105283A3 (da)
IL (3) IL144202A0 (da)
IS (1) IS5993A (da)
MX (1) MXPA01007464A (da)
NO (2) NO20013641L (da)
NZ (1) NZ513284A (da)
PL (1) PL198934B1 (da)
PT (2) PT1146892E (da)
SI (1) SI1146892T1 (da)
SK (1) SK286665B6 (da)
TR (2) TR200102147T2 (da)
WO (1) WO2000043032A2 (da)

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US8212004B2 (en) * 1999-03-02 2012-07-03 Human Genome Sciences, Inc. Neutrokine-alpha fusion proteins
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EP0878552A1 (en) 1997-05-13 1998-11-18 Erasmus Universiteit Rotterdam Molecular detection of chromosome aberrations
JP2002513587A (ja) 1998-05-04 2002-05-14 ダコ エー エス 染色体異常を検出するための方法およびプローブ
GB9828628D0 (en) 1998-12-23 1999-02-17 Glaxo Group Ltd Novel ligand
WO2002094852A2 (en) 2001-05-24 2002-11-28 Zymogenetics, Inc. Taci-immunoglobulin fusion proteins
US7833529B1 (en) 1999-01-07 2010-11-16 Zymogenetics, Inc. Methods for inhibiting B lymphocyte proliferation with soluble ztnf4 receptor
PL198934B1 (pl) * 1999-01-25 2008-08-29 Apoxis Sa Zastosowanie przeciwciała swoistego wobec rozpuszczalnego BAFF lub aktywnego fragmentu przeciwciała i zastosowanie rozpuszczalnego BAFF lub jego aktywnego fragmentu
US20050100548A1 (en) * 2001-07-24 2005-05-12 Biogen Idec Ma Inc. BAFF, inhibitors thereof and their use in the modulation of B-cell response
US20030095967A1 (en) * 1999-01-25 2003-05-22 Mackay Fabienne BAFF, inhibitors thereof and their use in the modulation of B-cell response and treatment of autoimmune disorders
US6475987B1 (en) 1999-05-06 2002-11-05 National Jewish Medical And Research Center Tall-1 receptor homologues
EP1806143B1 (en) * 1999-08-17 2016-06-15 Biogen MA Inc. Baff receptor (BCMA), an immunoregulatory agent
UA74798C2 (uk) 1999-10-06 2006-02-15 Байоджен Айдек Ма Інк. Спосіб лікування раку у ссавця за допомогою поліпептиду, що протидіє взаємодії april з його рецепторами
ATE511857T1 (de) * 2000-02-16 2011-06-15 Genentech Inc Anti-april monoklonaler antikörper und deren verwendung zur behandlung von immunerkrankungen oder krebs
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KR20120053525A (ko) 2000-06-16 2012-05-25 캠브리지 안티바디 테크놀로지 리미티드 면역특이적으로 ＢＬｙＳ에 결합하는 항체
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UA83458C2 (uk) * 2000-09-18 2008-07-25 Байоджен Айдек Ма Інк. Виділений поліпептид baff-r (рецептор фактора активації в-клітин сімейства tnf)
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