ATE245419T1 - Verwendung von benzofuroxanderivaten zur behandlung von angina pectoris - Google Patents
Verwendung von benzofuroxanderivaten zur behandlung von angina pectorisInfo
- Publication number
- ATE245419T1 ATE245419T1 AT99918220T AT99918220T ATE245419T1 AT E245419 T1 ATE245419 T1 AT E245419T1 AT 99918220 T AT99918220 T AT 99918220T AT 99918220 T AT99918220 T AT 99918220T AT E245419 T1 ATE245419 T1 AT E245419T1
- Authority
- AT
- Austria
- Prior art keywords
- lower alkyl
- general formula
- discloses
- compounds
- oxygen
- Prior art date
Links
- OKEAMBAZBICIFP-UHFFFAOYSA-N 3-oxido-2,1,3-benzoxadiazol-3-ium Chemical class C1=CC=CC2=[N+]([O-])ON=C21 OKEAMBAZBICIFP-UHFFFAOYSA-N 0.000 title abstract 2
- 206010002383 Angina Pectoris Diseases 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 5
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
- 208000029078 coronary artery disease Diseases 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 239000001301 oxygen Substances 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000006467 substitution reaction Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/12—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN935CA1998 IN188837B (en:Method) | 1998-05-22 | 1998-05-22 | |
| PCT/IB1999/000893 WO1999061018A1 (en) | 1998-05-22 | 1999-05-17 | Use of benzofuroxan derivatives in treating angina pectoris |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE245419T1 true ATE245419T1 (de) | 2003-08-15 |
Family
ID=11085434
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99918220T ATE245419T1 (de) | 1998-05-22 | 1999-05-17 | Verwendung von benzofuroxanderivaten zur behandlung von angina pectoris |
| AT99918219T ATE270279T1 (de) | 1998-05-22 | 1999-05-17 | Benzofuroxanderivate und ihre verwendung zur behandlung von angina pectoris |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99918219T ATE270279T1 (de) | 1998-05-22 | 1999-05-17 | Benzofuroxanderivate und ihre verwendung zur behandlung von angina pectoris |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US6248895B1 (en:Method) |
| EP (2) | EP1079829B1 (en:Method) |
| JP (2) | JP3378239B2 (en:Method) |
| CN (2) | CN1302205A (en:Method) |
| AT (2) | ATE245419T1 (en:Method) |
| AU (2) | AU3623399A (en:Method) |
| BR (2) | BR9910637A (en:Method) |
| CA (2) | CA2333001A1 (en:Method) |
| CZ (1) | CZ20004072A3 (en:Method) |
| DE (2) | DE69918431T2 (en:Method) |
| ES (1) | ES2222029T3 (en:Method) |
| HU (2) | HUP0102057A3 (en:Method) |
| IN (1) | IN188837B (en:Method) |
| PT (1) | PT1080081E (en:Method) |
| RU (2) | RU2222532C2 (en:Method) |
| WO (2) | WO1999061430A1 (en:Method) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9801398D0 (en) | 1998-01-22 | 1998-03-18 | Anggard Erik E | Chemical compounds |
| WO2003053439A1 (en) * | 2001-12-20 | 2003-07-03 | Alangudi Sankaranarayanan | Use of benzofuroxan derivatives as antiplatelet agents |
| US7378438B2 (en) | 2002-04-19 | 2008-05-27 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Beta-agonist compounds comprising nitric oxide donor groups and reactive oxygen species scavenger groups and their use in the treatment of respiratory disorders |
| US20060247216A1 (en) * | 2002-10-25 | 2006-11-02 | Haj-Yehia Abdullah I | Steroid compounds comprising superoxide dismutase mimic groups and nitric oxide donor groups, and their use in the preparation of medicaments |
| WO2004050084A2 (en) * | 2002-11-29 | 2004-06-17 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Ace-inhibitors having antioxidant and nitricoxid-donor activity |
| TWI383975B (zh) * | 2004-03-31 | 2013-02-01 | Tibotec Pharm Ltd | 製備（３Ｒ，３ａＳ，６ａＲ）六氫-呋喃并〔２，３-ｂ〕呋喃-３-醇之方法 |
| US7093310B2 (en) * | 2005-01-03 | 2006-08-22 | Miranda Industries, Inc. | Beddress |
| US8822509B2 (en) | 2006-12-29 | 2014-09-02 | The University Of Queensland | Pain-relieving compositions and uses therefor |
| CN101270068B (zh) * | 2008-04-23 | 2011-05-18 | 常州亚邦齐晖医药化工有限公司 | 一种2-硝基-4-丙硫基苯胺的制备方法 |
| WO2010000019A1 (en) * | 2008-07-02 | 2010-01-07 | The University Of Queensland | Pain-relieving compositions of furoxan no donors and uses thereof |
| RU2515413C2 (ru) * | 2012-07-05 | 2014-05-10 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) | Производные 1,2,5-оксадиазолов, обладающие анти-вич активностью, фармацевтическая композиция, способ ингибирования интегразы вич-1 |
| US8945338B2 (en) | 2013-03-15 | 2015-02-03 | Henkel US IP LLC | Anaerobic curable compositions |
| CN104592145B (zh) * | 2015-01-15 | 2017-05-17 | 山东大学 | 一种苯并氧化呋咱组蛋白去乙酰化酶抑制剂及其制备方法和应用 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3567728A (en) * | 1968-07-05 | 1971-03-02 | Pfizer | Process for the preparation of phenazine di-n-oxides and related compounds |
| BE794742A (fr) * | 1972-02-01 | 1973-07-30 | Bayer Ag | Nouveaux di-n-oxydes (1,4) de benzo-1,2,4-triazine, leur procede de preparation et leur application comme medicaments et additifs de nutrition |
| US4014893A (en) * | 1973-05-11 | 1977-03-29 | Imperial Chemical Industries Limited | 3,4-Cycloalkano furoxans |
| US4185018A (en) * | 1978-08-21 | 1980-01-22 | Ciba-Geigy Corporation | Process for producing benzofurazan-1-oxides |
| US4544400A (en) * | 1982-02-22 | 1985-10-01 | Zoecon Corporation | Compositions |
| JPS6072874A (ja) * | 1983-09-28 | 1985-04-24 | Kazuhiro Imai | ２，１，３−ベンゾオキサジアゾ−ルの新規誘導体 |
| JPS6383078A (ja) * | 1986-09-25 | 1988-04-13 | Honsyu Kagaku Kogyo Kk | ベンゾフラザン−１−オキシドの製造方法 |
| US5272164A (en) | 1988-12-27 | 1993-12-21 | Kirin Beer Kabushiki Kaisha | Carboximidamide derivatives |
| US5032604A (en) * | 1989-12-08 | 1991-07-16 | Merck & Co., Inc. | Class III antiarrhythmic agents |
| RU2032678C1 (ru) * | 1991-06-28 | 1995-04-10 | Институт органической и физической химии им.А.Е.Арбузова Казанского филиала РАН | 4- или 6-нитро-5,7-дихлорбензофуроксан, обладающий фунгицидной активностью |
| RU2076803C1 (ru) * | 1992-04-22 | 1997-04-10 | Институт органической и физической химии им.А.Е.Арбузова Казанского филиала РАН | Фунгицидный состав |
| DE4218977A1 (de) * | 1992-06-10 | 1993-12-16 | Cassella Ag | Annellierte 1,2,5-Oxadiazol-2-oxide |
| DE4220264A1 (de) | 1992-06-20 | 1993-12-23 | Cassella Ag | Phenyl-1,2,5-oxadiazol-carbonamid-2-oxide |
| US5659095A (en) * | 1996-03-13 | 1997-08-19 | Uniroyal Chemical Company, Inc. | Composition for inhibiting the polymerization of aromatic vinyl monomers |
| US6110935A (en) * | 1997-02-13 | 2000-08-29 | The Regents Of The University Of California | Benzofurazan compounds for enhancing glutamatergic synaptic responses |
-
1998
- 1998-05-22 IN IN935CA1998 patent/IN188837B/en unknown
-
1999
- 1999-05-17 AU AU36233/99A patent/AU3623399A/en not_active Abandoned
- 1999-05-17 HU HU0102057A patent/HUP0102057A3/hu unknown
- 1999-05-17 DE DE69918431T patent/DE69918431T2/de not_active Expired - Fee Related
- 1999-05-17 CN CN99806440A patent/CN1302205A/zh active Pending
- 1999-05-17 AT AT99918220T patent/ATE245419T1/de not_active IP Right Cessation
- 1999-05-17 EP EP99918220A patent/EP1079829B1/en not_active Expired - Lifetime
- 1999-05-17 BR BR9910637-0A patent/BR9910637A/pt not_active IP Right Cessation
- 1999-05-17 EP EP99918219A patent/EP1080081B1/en not_active Expired - Lifetime
- 1999-05-17 AU AU36232/99A patent/AU3623299A/en not_active Abandoned
- 1999-05-17 ES ES99918219T patent/ES2222029T3/es not_active Expired - Lifetime
- 1999-05-17 CZ CZ20004072A patent/CZ20004072A3/cs unknown
- 1999-05-17 BR BR9910628-0A patent/BR9910628A/pt not_active IP Right Cessation
- 1999-05-17 WO PCT/IB1999/000892 patent/WO1999061430A1/en not_active Application Discontinuation
- 1999-05-17 JP JP2000550836A patent/JP3378239B2/ja not_active Expired - Fee Related
- 1999-05-17 RU RU2000132204/04A patent/RU2222532C2/ru not_active IP Right Cessation
- 1999-05-17 CN CN99806421A patent/CN1301258A/zh active Pending
- 1999-05-17 DE DE69909782T patent/DE69909782D1/de not_active Expired - Lifetime
- 1999-05-17 WO PCT/IB1999/000893 patent/WO1999061018A1/en active IP Right Grant
- 1999-05-17 HU HU0101584A patent/HUP0101584A3/hu unknown
- 1999-05-17 CA CA002333001A patent/CA2333001A1/en not_active Abandoned
- 1999-05-17 CA CA002332950A patent/CA2332950A1/en not_active Abandoned
- 1999-05-17 JP JP2000550478A patent/JP2002516275A/ja active Pending
- 1999-05-17 PT PT99918219T patent/PT1080081E/pt unknown
- 1999-05-17 AT AT99918219T patent/ATE270279T1/de not_active IP Right Cessation
- 1999-05-17 RU RU2000132206/14A patent/RU2209065C2/ru not_active IP Right Cessation
-
2000
- 2000-05-05 US US09/565,917 patent/US6248895B1/en not_active Expired - Fee Related
- 2000-10-18 US US09/690,805 patent/US6232331B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0102057A2 (hu) | 2001-11-28 |
| ES2222029T3 (es) | 2005-01-16 |
| HUP0102057A3 (en) | 2002-12-28 |
| BR9910637A (pt) | 2001-02-06 |
| CA2333001A1 (en) | 1999-12-02 |
| DE69909782D1 (de) | 2003-08-28 |
| CA2332950A1 (en) | 1999-12-02 |
| EP1080081B1 (en) | 2004-06-30 |
| JP2002516275A (ja) | 2002-06-04 |
| BR9910628A (pt) | 2001-01-30 |
| EP1079829A1 (en) | 2001-03-07 |
| WO1999061430A1 (en) | 1999-12-02 |
| AU3623299A (en) | 1999-12-13 |
| HUP0101584A2 (hu) | 2001-11-28 |
| RU2222532C2 (ru) | 2004-01-27 |
| RU2209065C2 (ru) | 2003-07-27 |
| CN1301258A (zh) | 2001-06-27 |
| US6248895B1 (en) | 2001-06-19 |
| WO1999061018A1 (en) | 1999-12-02 |
| DE69918431T2 (de) | 2005-07-14 |
| IN188837B (en:Method) | 2002-11-09 |
| PT1080081E (pt) | 2004-10-29 |
| DE69918431D1 (de) | 2004-08-05 |
| US6232331B1 (en) | 2001-05-15 |
| EP1079829B1 (en) | 2003-07-23 |
| EP1080081A1 (en) | 2001-03-07 |
| JP2002516317A (ja) | 2002-06-04 |
| HUP0101584A3 (en) | 2002-12-28 |
| JP3378239B2 (ja) | 2003-02-17 |
| AU3623399A (en) | 1999-12-13 |
| CN1302205A (zh) | 2001-07-04 |
| ATE270279T1 (de) | 2004-07-15 |
| CZ20004072A3 (cs) | 2001-08-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |