ATE244564T1 - Felbamat-derivate - Google Patents

Felbamat-derivate

Info

Publication number
ATE244564T1
ATE244564T1 AT00907199T AT00907199T ATE244564T1 AT E244564 T1 ATE244564 T1 AT E244564T1 AT 00907199 T AT00907199 T AT 00907199T AT 00907199 T AT00907199 T AT 00907199T AT E244564 T1 ATE244564 T1 AT E244564T1
Authority
AT
Austria
Prior art keywords
derivatives
felbamate
felbamat
treat
epilepsy
Prior art date
Application number
AT00907199T
Other languages
English (en)
Inventor
Timothy L Macdonald
Thomas A Miller
Charles D Thompson
Christine M Dieckhaus
Original Assignee
Univ Virginia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Virginia filed Critical Univ Virginia
Application granted granted Critical
Publication of ATE244564T1 publication Critical patent/ATE244564T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/06—1,3-Oxazines; Hydrogenated 1,3-oxazines not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/12—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C07D263/24—Oxygen atoms attached in position 2 with hydrocarbon radicals, substituted by oxygen atoms, attached to other ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/06—1,3-Oxazines; Hydrogenated 1,3-oxazines not condensed with other rings
    • C07D265/08—1,3-Oxazines; Hydrogenated 1,3-oxazines not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D265/10—1,3-Oxazines; Hydrogenated 1,3-oxazines not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with oxygen atoms directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Compounds Of Iron (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hard Magnetic Materials (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Paper (AREA)
AT00907199T 1999-02-09 2000-02-08 Felbamat-derivate ATE244564T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US11925499P 1999-02-09 1999-02-09
US13688199P 1999-06-01 1999-06-01
US13720499P 1999-06-02 1999-06-02
PCT/US2000/003147 WO2000047202A1 (en) 1999-02-09 2000-02-08 Felbamate derived compounds

Publications (1)

Publication Number Publication Date
ATE244564T1 true ATE244564T1 (de) 2003-07-15

Family

ID=27382271

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00907199T ATE244564T1 (de) 1999-02-09 2000-02-08 Felbamat-derivate

Country Status (13)

Country Link
US (3) US6538024B1 (de)
EP (1) EP1156798B1 (de)
JP (1) JP2002536409A (de)
AT (1) ATE244564T1 (de)
AU (1) AU771936B2 (de)
CA (1) CA2360258A1 (de)
DE (1) DE60003791T2 (de)
DK (1) DK1156798T3 (de)
ES (1) ES2197078T3 (de)
MX (1) MXPA01007968A (de)
NZ (1) NZ513319A (de)
PT (1) PT1156798E (de)
WO (1) WO2000047202A1 (de)

Families Citing this family (46)

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MXPA02010837A (es) * 2000-05-05 2004-02-26 Univ Virginia Compuestos derivados del felbamato.
US20040023986A1 (en) * 2000-10-25 2004-02-05 Macdonald Timothy L. Substituted felbamate derived compounds
US20030166648A1 (en) * 2002-11-01 2003-09-04 Macdonald Timothy L Felbamate derived compounds
KR100888532B1 (ko) 2004-06-08 2009-03-11 란세스 도이치란트 게엠베하 열가소성 폴리에스테르를 기재로 하는 유동성이 개선된 성형 화합물
JP4620734B2 (ja) 2004-06-08 2011-01-26 ランクセス・ドイチュランド・ゲーエムベーハー 改良された流動性を有するポリアミド成形用組成物
PT1809273E (pt) * 2004-09-16 2010-05-10 Janssen Pharmaceutica Nv Utililização de 2-fenil-1,2-etanodiol-(di)carbamatos para tratamento de epileptogénese
CN101163699A (zh) * 2005-04-21 2008-04-16 美邦特保健有限公司 二氨甲酸酯化合物的合成方法及形成其的中间体
US20070021501A1 (en) * 2005-07-12 2007-01-25 Twyman Roy E Methods of treating epileptogenesis
DE102006020984A1 (de) * 2006-05-04 2007-11-08 Lanxess Deutschland Gmbh Leichtbauteil in Hybridbauweise
DE102007006493A1 (de) 2007-02-09 2008-08-14 Lanxess Deutschland Gmbh Leichtbauteil in Hybridbauweise
WO2009129181A1 (en) * 2008-04-14 2009-10-22 Concert Pharmaceuticals Inc. Propanediol-dicarbamate derivatives
DE102008032205A1 (de) 2008-07-09 2010-01-14 Lanxess Deutschland Gmbh Fließverbesserte Thermoplasten
DE202008015395U1 (de) 2008-11-19 2010-04-22 Lanxess Deutschland Gmbh Vorderwagenstruktur
DE202008015392U1 (de) 2008-11-19 2010-04-08 Lanxess Deutschland Gmbh Pedalstruktur
DE202008015396U1 (de) 2008-11-19 2010-04-08 Lanxess Deutschland Gmbh Fahrwerkstruktur
DE202008015398U1 (de) 2008-11-19 2010-04-08 Lanxess Deutschland Gmbh Ölwanne
DE102008058224A1 (de) * 2008-11-19 2010-05-20 Lanxess Deutschland Gmbh Leichtbauteil in Hybridbauweise
DE202008015399U1 (de) 2008-11-19 2010-04-08 Lanxess Deutschland Gmbh Dachstruktur
DE102008058225A1 (de) * 2008-11-19 2010-07-08 Lanxess Deutschland Gmbh Leichtbauteil in Hybridbauweise
DE202008015391U1 (de) 2008-11-19 2010-04-22 Lanxess Deutschland Gmbh Türen- und Klappenstrukturen
DE202008015400U1 (de) 2008-11-19 2010-04-08 Lanxess Deutschland Gmbh Instrumententafel
DE202008015401U1 (de) 2008-11-19 2010-04-08 Lanxess Deutschland Gmbh Sitzstrukturen
DE202008015394U1 (de) 2008-11-19 2010-04-08 Lanxess Deutschland Gmbh Längsträgerstruktur
DE202008015397U1 (de) 2008-11-19 2010-04-22 Lanxess Deutschland Gmbh Säulenstruktur
DE102009005763A1 (de) 2009-01-23 2010-07-29 Lanxess Deutschland Gmbh Rahmenseitenteil einer Kraftfahrzeug Karosserie
PL2233519T3 (pl) 2009-03-27 2012-01-31 Lanxess Deutschland Gmbh Poliester odporny na żarzący się drut
DE102009020090A1 (de) 2009-05-06 2010-11-11 Lanxess Deutschland Gmbh Reduktion des Einflusses der Wasseraufnahme auf die elektrische Leitfähigkeit von elektrisch leitfähigen Polyamid-Formmassen
DE102009034767A1 (de) * 2009-07-25 2011-01-27 Lanxess Deutschland Gmbh & Co. Kg Organoblechstrukturbauteil
US7964594B1 (en) * 2009-12-10 2011-06-21 Hoffmann-La Roche Inc. Amino oxazine derivatives
UA103272C2 (uk) * 2009-12-11 2013-09-25 Ф. Хоффманн-Ля Рош Аг 2-аміно-5,5-дифтор-5,6-дигідро-4h-оксазини як інгібітори bace1 і/або bace2
EP2365030B1 (de) 2010-03-10 2012-09-05 LANXESS Deutschland GmbH -N=C=N- enthaltende Verbindungen zur Verhinderung des thermischen Abbaus von Metall-dialkylphosphinat enthaltenden Polyalkylenterephthalaten in der Schmelze
DE102010053483A1 (de) 2010-12-04 2012-06-06 Lanxess Deutschland Gmbh =N=C=N- enthaltende Verbindung zur Verhinderung des thermischen Abbaus in Schmelzen
PL2365028T3 (pl) 2010-03-10 2013-03-29 Lanxess Deutschland Gmbh Związki zawierające ugrupowania -N=C=N- do zapobiegania rozkładowi termicznemu poli(tereftalanów alkilenowych) zawierających dialkilofosfiniany metali w stopach
PL2463338T3 (pl) 2010-12-13 2014-01-31 Lanxess Deutschland Gmbh Sposób optymalizacji postępowania podczas krystalizacji mas do formowania z poliestrów
EP2465896A1 (de) 2010-12-14 2012-06-20 LANXESS Deutschland GmbH Polyester Zusammensetzungen
US20140178479A1 (en) * 2011-08-12 2014-06-26 Perosphere, Inc. Concentrated Felbamate Formulations for Parenteral Administration
EP2818297B1 (de) 2013-06-25 2016-08-10 LANXESS Deutschland GmbH Spritzgießverfahren
EP2878625A1 (de) 2013-11-27 2015-06-03 LANXESS Deutschland GmbH Polyester Zusammensetzungen
DE102014000613A1 (de) 2014-01-18 2015-07-23 Lanxess Deutschland Gmbh Polyester Zusammensetzungen
IN2014DE03298A (de) 2013-11-27 2015-09-25 Lanxess Deutschland Gmbh
PL2878628T3 (pl) 2013-11-27 2017-08-31 Lanxess Deutschland Gmbh Kompozycje poliestrów
DE102014000612A1 (de) 2014-01-18 2015-07-23 Lanxess Deutschland Gmbh Polyester Zusammensetzungen
ES2899882T3 (es) 2013-11-27 2022-03-15 Lanxess Deutschland Gmbh Uso de composiciones de poliéster
ES2767296T3 (es) 2013-11-28 2020-06-17 Lanxess Deutschland Gmbh Composiciones de poliamida
EP2915841A1 (de) 2014-03-04 2015-09-09 LANXESS Deutschland GmbH Polyester Zusammensetzung
HUE039596T2 (hu) 2014-05-05 2019-01-28 Lanxess Deutschland Gmbh Poliészter vegyületek

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US2884444A (en) * 1956-01-13 1959-04-28 Carter Prod Inc 2-phenyl-1,3 propane diol dicarbamate
US4161582A (en) * 1976-11-22 1979-07-17 Hoffman-La Roche Inc. Process to produce oxazinomycin
US4384115A (en) * 1981-12-14 1983-05-17 The Dow Chemical Company Process for preparing tetrahydro-1,3-oxazin-2-ones
US4868327A (en) 1987-06-03 1989-09-19 Carter-Wallace, Inc. Synthesis of 2-phenyl-1,3-propanediol
US4978680A (en) 1989-09-26 1990-12-18 Carter-Wallace, Inc. Method for the prevention and control of epileptic seizure
US5292772A (en) 1989-09-26 1994-03-08 Carter-Wallace, Inc. Method for the prevention and control of epileptic seizure associated with Lennox-Gastaut syndrome
US5082861A (en) 1989-09-26 1992-01-21 Carter-Wallace, Inc. Method for the prevention and control of epileptic seizure associated with complex partial seizures
US5055489A (en) 1990-05-04 1991-10-08 Carter-Wallace, Inc. Method for the prevention and control of hypoxic damage resulting from cerebral ischemic events
WO1994006737A1 (en) * 1992-09-18 1994-03-31 Schering Corporation Process for preparing felbamate, 2-phenyl-1,3-propanediol and intermediates
US5462966A (en) 1993-10-15 1995-10-31 Carter-Wallace Inc. Methods for the prevention and control of cellular damage resulting from coronary artery occlusion-reperfusion
US5492930A (en) * 1994-04-25 1996-02-20 Schering Corporation Method and formulation for treating CNS disorders
US5728728A (en) 1996-04-10 1998-03-17 Kozachuk; Walter E. Methods of providing neuroprotection

Also Published As

Publication number Publication date
US6538024B1 (en) 2003-03-25
US20020156070A1 (en) 2002-10-24
EP1156798A4 (de) 2002-07-17
AU2873400A (en) 2000-08-29
EP1156798A1 (de) 2001-11-28
NZ513319A (en) 2003-08-29
EP1156798B1 (de) 2003-07-09
DK1156798T3 (da) 2003-11-03
JP2002536409A (ja) 2002-10-29
ES2197078T3 (es) 2004-01-01
CA2360258A1 (en) 2000-08-17
DE60003791D1 (de) 2003-08-14
DE60003791T2 (de) 2004-02-05
MXPA01007968A (es) 2003-07-14
US6759402B2 (en) 2004-07-06
US20030229086A1 (en) 2003-12-11
PT1156798E (pt) 2003-11-28
AU771936B2 (en) 2004-04-08
WO2000047202A1 (en) 2000-08-17
US6599935B2 (en) 2003-07-29

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