ATE23537T1 - Dipeptid-derivate von 4-0, 6-0-acyl-2-amin-2deoxy-d-glucose mit immunologischer wirkung und verfahren zu ihrer herstellung. - Google Patents

Dipeptid-derivate von 4-0, 6-0-acyl-2-amin-2deoxy-d-glucose mit immunologischer wirkung und verfahren zu ihrer herstellung.

Info

Publication number
ATE23537T1
ATE23537T1 AT81400608T AT81400608T ATE23537T1 AT E23537 T1 ATE23537 T1 AT E23537T1 AT 81400608 T AT81400608 T AT 81400608T AT 81400608 T AT81400608 T AT 81400608T AT E23537 T1 ATE23537 T1 AT E23537T1
Authority
AT
Austria
Prior art keywords
alkyl
hydrogen
phenyl
substituted
image
Prior art date
Application number
AT81400608T
Other languages
English (en)
Inventor
Tsung-Ying Shen
Philippe L Durette
Conrad P Dorn Jr
James B Doherty
Richard T Dean
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Application granted granted Critical
Publication of ATE23537T1 publication Critical patent/ATE23537T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure
    • C07K9/005—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure containing within the molecule the substructure with m, n > 0 and m+n > 0, A, B, D, E being heteroatoms; X being a bond or a chain, e.g. muramylpeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Saccharide Compounds (AREA)
AT81400608T 1980-04-17 1981-04-15 Dipeptid-derivate von 4-0, 6-0-acyl-2-amin-2deoxy-d-glucose mit immunologischer wirkung und verfahren zu ihrer herstellung. ATE23537T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/141,227 US4368190A (en) 1980-04-17 1980-04-17 Immunologically active dipeptidyl 4-O-,6-O-acyl-2-amino-2-deoxy-D-glucose derivatives and methods for their preparation
EP81400608A EP0038750B1 (de) 1980-04-17 1981-04-15 Dipeptid-Derivate von 4-0, 6-0-acyl-2-amin-2-deoxy-D-glucose mit immunologischer Wirkung und Verfahren zu ihrer Herstellung

Publications (1)

Publication Number Publication Date
ATE23537T1 true ATE23537T1 (de) 1986-11-15

Family

ID=22494746

Family Applications (1)

Application Number Title Priority Date Filing Date
AT81400608T ATE23537T1 (de) 1980-04-17 1981-04-15 Dipeptid-derivate von 4-0, 6-0-acyl-2-amin-2deoxy-d-glucose mit immunologischer wirkung und verfahren zu ihrer herstellung.

Country Status (10)

Country Link
US (1) US4368190A (de)
EP (1) EP0038750B1 (de)
JP (1) JPS56164196A (de)
AT (1) ATE23537T1 (de)
CA (1) CA1174232A (de)
DE (1) DE3175602D1 (de)
DK (1) DK172481A (de)
ES (1) ES501457A0 (de)
GR (1) GR76828B (de)
PT (1) PT72866B (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR851293B (de) * 1984-05-29 1985-11-25 Ciba Geigy Ag
US4640911A (en) * 1985-05-29 1987-02-03 Ciba-Geigy Corporation Acylated sugar derivatives, processes for their manufacture, and their use
US4937077A (en) * 1987-09-21 1990-06-26 Eastman Kodak Company Method for improving feed conversion of meat-producing animals by oral administration of 2-deoxy-D-hexose
US4866035A (en) * 1987-10-05 1989-09-12 Merck & Co., Inc. Dipeptidyl saccharides as host resistance enhancers in AIDS-immuno-compromised hosts and methods of use
WO1995031998A1 (en) * 1994-05-23 1995-11-30 The Research & Development Institute, Inc. Candida albicans adhesin as a vaccine
US6488929B2 (en) 1994-05-23 2002-12-03 Montana State University Candida albicans phosphomannan complex as a vaccine
US6309642B1 (en) 1997-04-28 2001-10-30 The Research And Development Institute, Inc. Peptides which mimic candida carbohydrate epitopes and their use in a vaccine
DE19631189A1 (de) * 1996-08-02 1998-02-05 Max Delbrueck Centrum Neuartige kationische Amphiphile für den liposomalen Gentransfer
US20030072775A1 (en) * 1997-04-28 2003-04-17 The Research And Development Institute Inc. Peptides which mimic candida carbohydrate epitopes and their use in a vaccine
CN1301847A (zh) * 1999-12-27 2001-07-04 上海博德基因开发有限公司 一种新的多肽——脂肪氧化酶10和编码这种多肽的多核苷酸
CN1313389A (zh) * 2000-03-15 2001-09-19 上海博德基因开发有限公司 一种新的多肽——人脂肪氧化酶9和编码这种多肽的多核苷酸
WO2009061208A1 (en) 2007-11-09 2009-05-14 Pronova Biopharma Norge As Lipid compounds for use in cosmetic products, as food supplement or as a medicament
EP2147910A1 (de) * 2008-07-15 2010-01-27 Pronova BioPharma Norge AS Neue Lipid-Verbindungen
MA33341B1 (fr) 2009-05-08 2012-06-01 Pronova Biopharma Norge As Acides gras polyinsaturés pour le traitement de maladies relatives au domaine des maladies cardiovasculaires, métaboliques et inflammatoires
CN102822175A (zh) * 2009-12-18 2012-12-12 埃迪尼克斯医药公司 5,5-稠合的亚芳基或亚杂芳基丙型肝炎病毒抑制剂
UA111475C2 (uk) 2010-11-05 2016-05-10 Пронова Байофарма Нордж Ас Способи лікування із застосуванням ліпідних сполук
ES2748562T3 (es) 2013-02-28 2020-03-17 Basf As Una composición que comprende un compuesto lipídico, un triglicérido y un tensioactivo, y procedimientos de uso de la misma
CN107530306A (zh) 2015-04-28 2018-01-02 普罗诺瓦生物医药挪威公司 结构增强的含硫脂肪酸在预防和/或治疗非酒精性脂肪性肝炎中的用途
SG11202005007VA (en) 2017-12-06 2020-06-29 Basf As Fatty acid derivatives for treating non-alcoholic steatohepatitis

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2288527A2 (fr) 1974-10-22 1976-05-21 Anvar Compositions contenant de la n-acetyl-muramyl- l-alanyl - d-isoglutamine ou de l'acide n-acetyl-muramyl-l-alanyl - d-glutamique, exemptes d'huile et ayant des proprietes adjuvantes
SE7607300L (sv) 1975-08-13 1977-02-14 Kefalas As Tiaxantenforeningar samt forfarande for framstellning av dem
CH613709A5 (en) * 1975-12-10 1979-10-15 Ciba Geigy Ag Process for the preparation of glucosamine derivatives
CH636887A5 (en) * 1976-04-26 1983-06-30 Syntex Inc Process for the preparation of novel immunological adjuvant compounds
US4082735A (en) * 1976-04-26 1978-04-04 Syntex (U.S.A.) Inc. Novel immunological adjuvant compounds and methods of preparation thereof
US4082736A (en) * 1976-04-26 1978-04-04 Syntex (U.S.A.) Inc. Novel immunological adjuvant compounds and methods of preparation thereof
JPS5479228A (en) * 1977-12-02 1979-06-25 Takeda Chem Ind Ltd Glucosamine derivative and its preparation
DE2862107D1 (en) * 1977-12-02 1982-11-18 Takeda Chemical Industries Ltd Glucosamine-peptide derivatives and their pharmaceutical compositions
JPS5479227A (en) * 1977-12-02 1979-06-25 Takeda Chem Ind Ltd Glucosamine derivative and its preparation
EP0003833B2 (de) * 1978-02-24 1990-12-19 Ciba-Geigy Ag Antigenderivate, Verfahren zu deren Herstellung, diese enthaltende pharmazeutische Präparate
FR2442241A2 (fr) * 1978-03-20 1980-06-20 Anvar Nouveaux composes esters de muramyl-peptide, leur preparation et les compositions pharmaceutiques les contenant, notamment sous forme de liposomes
JPS54130517A (en) * 1978-03-31 1979-10-09 Yuuichi Yamamura Muramyldipeptide higher fatty acid ester
HU186585B (en) * 1978-05-18 1985-08-28 Ciba Geigy Ag Process for producing new muramil-peptide derivatives
FR2428051A1 (fr) * 1978-06-05 1980-01-04 Anvar Nouveaux composes du type muramyl-peptide et medicaments les contenant
FR2449697A1 (fr) * 1979-02-20 1980-09-19 Anvar Nouveaux muramyl-peptides substitues sur un azote peptidique et medicaments les contenant
JPS55111499A (en) * 1979-02-21 1980-08-28 Takeda Chem Ind Ltd Glucosamine derivative and its preparation

Also Published As

Publication number Publication date
EP0038750A1 (de) 1981-10-28
GR76828B (de) 1984-09-04
DE3175602D1 (en) 1987-01-02
EP0038750B1 (de) 1986-11-12
PT72866B (en) 1985-11-25
JPS56164196A (en) 1981-12-17
ES8207553A1 (es) 1982-09-16
DK172481A (da) 1981-10-18
PT72866A (en) 1981-05-01
US4368190A (en) 1983-01-11
CA1174232A (en) 1984-09-11
ES501457A0 (es) 1982-09-16

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