ATE234278T1 - Aminosäurederivate als inhibitoren für extrazellulären matrix-metalloproteasen und der freisetzung von tnf alpha - Google Patents
Aminosäurederivate als inhibitoren für extrazellulären matrix-metalloproteasen und der freisetzung von tnf alphaInfo
- Publication number
- ATE234278T1 ATE234278T1 AT98922850T AT98922850T ATE234278T1 AT E234278 T1 ATE234278 T1 AT E234278T1 AT 98922850 T AT98922850 T AT 98922850T AT 98922850 T AT98922850 T AT 98922850T AT E234278 T1 ATE234278 T1 AT E234278T1
- Authority
- AT
- Austria
- Prior art keywords
- inhibitors
- release
- amino acid
- acid derivatives
- extracellular matrix
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
- C07C323/40—Y being a hydrogen or a carbon atom
- C07C323/41—Y being a hydrogen or an acyclic carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9704971A FR2762315B1 (fr) | 1997-04-22 | 1997-04-22 | Derives d'amino-acides inhibiteurs des metalloproteases de la matrice extracellulaire et de la liberation du tnf alpha |
PCT/FR1998/000801 WO1998047863A1 (fr) | 1997-04-22 | 1998-04-21 | DERIVES D'AMINO-ACIDES INHIBITEURS DES METALLOPROTEASES DE LA MATRICE EXTRACELLULAIRE ET DE LA LIBERATION DU TNF $g(a) |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE234278T1 true ATE234278T1 (de) | 2003-03-15 |
Family
ID=9506187
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT98922850T ATE234278T1 (de) | 1997-04-22 | 1998-04-21 | Aminosäurederivate als inhibitoren für extrazellulären matrix-metalloproteasen und der freisetzung von tnf alpha |
Country Status (13)
Country | Link |
---|---|
US (1) | US6344457B1 (de) |
EP (1) | EP0977730B1 (de) |
AR (1) | AR013077A1 (de) |
AT (1) | ATE234278T1 (de) |
AU (1) | AU7534698A (de) |
CA (1) | CA2287565A1 (de) |
CO (1) | CO4950539A1 (de) |
DE (1) | DE69812082T2 (de) |
ES (1) | ES2194319T3 (de) |
FR (1) | FR2762315B1 (de) |
TN (1) | TNSN98052A1 (de) |
WO (1) | WO1998047863A1 (de) |
ZA (1) | ZA983390B (de) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR9916004A (pt) | 1998-12-10 | 2001-10-02 | Hoffmann La Roche | Inibidores de proteinase c de pró-colágeno |
JP2002538151A (ja) | 1999-03-02 | 2002-11-12 | ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド | カテプシンの可逆的インヒビターとして有用な化合物 |
US6420364B1 (en) | 1999-09-13 | 2002-07-16 | Boehringer Ingelheim Pharmaceuticals, Inc. | Compound useful as reversible inhibitors of cysteine proteases |
US6808902B1 (en) | 1999-11-12 | 2004-10-26 | Amgen Inc. | Process for correction of a disulfide misfold in IL-1Ra Fc fusion molecules |
BRPI0210579B8 (pt) | 2001-06-26 | 2021-05-25 | Amgen Fremont Inc | anticorpo e composição farmacêutica |
WO2003002187A2 (en) * | 2001-06-26 | 2003-01-09 | Photomed Technologies, Inc. | Multiple wavelength illuminator |
RU2217196C2 (ru) * | 2002-02-28 | 2003-11-27 | Небольсин Владимир Евгеньевич | Способ индукции дифференцировки клеток |
CA2511823A1 (en) * | 2002-12-30 | 2004-07-22 | Amgen Inc. | Combination therapy with co-stimulatory factors |
EP1594459B1 (de) | 2002-12-30 | 2010-02-17 | Angiotech International Ag | Wirkstofffreisetzung von schnell gelierender polymerzusammensetzung |
EP2287326A1 (de) | 2003-08-08 | 2011-02-23 | Arriva Pharmaceuticals, Inc. | Verfahren zur Protein-Produktion in Hefe |
AU2005221151A1 (en) | 2004-03-09 | 2005-09-22 | Arriva Pharmaceuticals, Inc. | Treatment of chronic obstructive pulmonary disease by low dose inhalation of protease inhibitor |
US7638513B2 (en) | 2004-06-02 | 2009-12-29 | Schering Corporation | Compounds for the treatment of inflammatory disorders |
PE20060426A1 (es) * | 2004-06-02 | 2006-06-28 | Schering Corp | DERIVADOS DE ACIDO TARTARICO COMO INHIBIDORES DE MMPs, ADAMs, TACE Y TNF-alfa |
EP2594318B1 (de) * | 2005-04-15 | 2020-06-10 | University Of North Carolina At Chapel Hill | Verfahren zur ermöglichung des überlebens von nervenzellen mit neurotrophin-mimetika |
US8986253B2 (en) | 2008-01-25 | 2015-03-24 | Tandem Diabetes Care, Inc. | Two chamber pumps and related methods |
US8408421B2 (en) | 2008-09-16 | 2013-04-02 | Tandem Diabetes Care, Inc. | Flow regulating stopcocks and related methods |
US8650937B2 (en) | 2008-09-19 | 2014-02-18 | Tandem Diabetes Care, Inc. | Solute concentration measurement device and related methods |
JP2012519703A (ja) * | 2009-03-06 | 2012-08-30 | ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル | ニューロトロフィン・ミメティック及びその使用 |
US8641671B2 (en) | 2009-07-30 | 2014-02-04 | Tandem Diabetes Care, Inc. | Infusion pump system with disposable cartridge having pressure venting and pressure feedback |
US10273219B2 (en) | 2009-11-12 | 2019-04-30 | Pharmatrophix, Inc. | Crystalline forms of neurotrophin mimetic compounds and their salts |
CN104761515B (zh) | 2009-11-12 | 2018-03-09 | 特罗菲克斯制药股份有限公司 | 神经营养蛋白模拟化合物及其盐的晶型 |
US9180242B2 (en) | 2012-05-17 | 2015-11-10 | Tandem Diabetes Care, Inc. | Methods and devices for multiple fluid transfer |
US9173998B2 (en) | 2013-03-14 | 2015-11-03 | Tandem Diabetes Care, Inc. | System and method for detecting occlusions in an infusion pump |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH05125029A (ja) * | 1991-11-06 | 1993-05-21 | Yamanouchi Pharmaceut Co Ltd | 新規なアミド化合物又はその塩 |
WO1997003966A1 (en) * | 1995-07-19 | 1997-02-06 | British Biotech Pharmaceuticals Limited | N-(amino acid) substituted succinic acid amide derivatives as metalloproteinase inhibitors |
-
1997
- 1997-04-22 FR FR9704971A patent/FR2762315B1/fr not_active Expired - Fee Related
-
1998
- 1998-04-17 TN TNTNSN98052A patent/TNSN98052A1/fr unknown
- 1998-04-21 EP EP98922850A patent/EP0977730B1/de not_active Expired - Lifetime
- 1998-04-21 WO PCT/FR1998/000801 patent/WO1998047863A1/fr active IP Right Grant
- 1998-04-21 AT AT98922850T patent/ATE234278T1/de not_active IP Right Cessation
- 1998-04-21 US US09/403,037 patent/US6344457B1/en not_active Expired - Fee Related
- 1998-04-21 ES ES98922850T patent/ES2194319T3/es not_active Expired - Lifetime
- 1998-04-21 DE DE69812082T patent/DE69812082T2/de not_active Expired - Fee Related
- 1998-04-21 CO CO98021932A patent/CO4950539A1/es unknown
- 1998-04-21 CA CA002287565A patent/CA2287565A1/fr not_active Abandoned
- 1998-04-21 AU AU75346/98A patent/AU7534698A/en not_active Abandoned
- 1998-04-22 ZA ZA983390A patent/ZA983390B/xx unknown
- 1998-04-22 AR ARP980101853A patent/AR013077A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
DE69812082D1 (de) | 2003-04-17 |
ES2194319T3 (es) | 2003-11-16 |
TNSN98052A1 (fr) | 2005-03-15 |
ZA983390B (en) | 1999-02-09 |
FR2762315A1 (fr) | 1998-10-23 |
AR013077A1 (es) | 2000-12-13 |
EP0977730A1 (de) | 2000-02-09 |
DE69812082T2 (de) | 2003-11-06 |
EP0977730B1 (de) | 2003-03-12 |
CA2287565A1 (fr) | 1998-10-29 |
CO4950539A1 (es) | 2000-09-01 |
FR2762315B1 (fr) | 1999-05-28 |
US6344457B1 (en) | 2002-02-05 |
WO1998047863A1 (fr) | 1998-10-29 |
AU7534698A (en) | 1998-11-13 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |