ATE229012T1 - Neue taxanderivate - Google Patents
Neue taxanderivateInfo
- Publication number
- ATE229012T1 ATE229012T1 AT98943019T AT98943019T ATE229012T1 AT E229012 T1 ATE229012 T1 AT E229012T1 AT 98943019 T AT98943019 T AT 98943019T AT 98943019 T AT98943019 T AT 98943019T AT E229012 T1 ATE229012 T1 AT E229012T1
- Authority
- AT
- Austria
- Prior art keywords
- taxand
- derivatives
- new
- cycloalkyloxy
- trialkylsilyl
- Prior art date
Links
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000000 cycloalkoxy group Chemical group 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 125000002541 furyl group Chemical group 0.000 abstract 1
- -1 piperazino Chemical group 0.000 abstract 1
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
- 125000004665 trialkylsilyl group Chemical group 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
- C07D295/104—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/108—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epoxy Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP9251804A JPH1192468A (ja) | 1997-09-17 | 1997-09-17 | 新規なタキサン誘導体 |
| PCT/JP1998/004180 WO1999014209A1 (en) | 1997-09-17 | 1998-09-17 | New taxane derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE229012T1 true ATE229012T1 (de) | 2002-12-15 |
Family
ID=17228181
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98943019T ATE229012T1 (de) | 1997-09-17 | 1998-09-17 | Neue taxanderivate |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US6136808A (de) |
| EP (1) | EP1022277B1 (de) |
| JP (1) | JPH1192468A (de) |
| KR (1) | KR100514809B1 (de) |
| CN (1) | CN100369908C (de) |
| AT (1) | ATE229012T1 (de) |
| AU (1) | AU730174B2 (de) |
| BR (1) | BR9812218A (de) |
| CA (1) | CA2302445C (de) |
| DE (1) | DE69809959T2 (de) |
| DK (1) | DK1022277T3 (de) |
| ES (1) | ES2189234T3 (de) |
| PT (1) | PT1022277E (de) |
| WO (1) | WO1999014209A1 (de) |
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6268381B1 (en) * | 1997-12-19 | 2001-07-31 | Kabushiki Kaisha Yakult Honsha | Taxane derivatives |
| HUP0201266A3 (en) * | 1999-05-28 | 2005-02-28 | Bristol Myers Squibb Co | Semi-synthesis of paclitaxel using dialkyldichlorosilanes |
| US6649632B2 (en) | 2000-02-02 | 2003-11-18 | Fsu Research Foundation, Inc. | C10 ester substituted taxanes |
| IL145635A0 (en) * | 2000-02-02 | 2002-06-30 | Univ Florida State Res Found | Taxane formulations having improved solubility |
| PL350331A1 (en) | 2000-02-02 | 2002-12-02 | Univ Florida State Res Found | C10 carbamoyloxy substituted taxanes as antitumor agents |
| AU7007001A (en) | 2000-06-22 | 2002-01-02 | Nitromed Inc | Nitrosated and nitrosylated taxanes, compositions and methods of use |
| CA2354471A1 (en) * | 2001-07-31 | 2003-01-31 | Florida State University Research Foundation, Inc. | C10 ester substituted taxanes |
| US7351542B2 (en) | 2002-05-20 | 2008-04-01 | The Regents Of The University Of California | Methods of modulating tubulin deacetylase activity |
| DE60329497D1 (de) | 2002-06-26 | 2009-11-12 | Medigene Ag | Herstellung einer kationisch liposomalen zubereitung, einen lipophilen wirkstoff enthaltend |
| CA2525647A1 (en) | 2003-05-16 | 2005-02-24 | Intermune, Inc. | Synthetic chemokine receptor ligands and methods of use thereof |
| WO2005040758A2 (en) | 2003-10-24 | 2005-05-06 | Intermune, Inc. | Use of pirfenidone in therapeutic regimens |
| HN2005000054A (es) | 2004-02-13 | 2009-02-18 | Florida State University Foundation Inc | Taxanos sustituidos con esteres de ciclopentilo en c10 |
| MX2007009748A (es) * | 2005-02-14 | 2007-09-26 | Univ Florida State Res Found | Composiciones de taxano sustituidas con esteres ciclopropilicos en c10. |
| JP4954983B2 (ja) | 2005-05-18 | 2012-06-20 | ファーマサイエンス・インコーポレイテッド | Ｂｉｒドメイン結合化合物 |
| CA2922029C (en) | 2006-03-22 | 2017-11-28 | Medigene Ag | A combination of a cationic liposomal preparation comprising an antimitotic agent and a non-liposomal preparation comprising an antimitotic agent |
| JP5419685B2 (ja) | 2006-05-16 | 2014-02-19 | ファーマサイエンス・インコーポレイテッド | Ｉａｐｂｉｒドメイン結合タンパク質 |
| KR100847331B1 (ko) * | 2006-12-14 | 2008-07-21 | 한미약품 주식회사 | 도세탁셀의 제조방법 및 이에 사용되는 중간체 |
| WO2009145981A1 (en) | 2008-03-31 | 2009-12-03 | Florida State University Research Foundation, Inc. | C(10) ethyl ester and c(10) cyclopropyl ester substituted taxanes |
| WO2010005721A2 (en) * | 2008-06-16 | 2010-01-14 | Bind Biosciences, Inc. | Drug loaded polymeric nanoparticles and methods of making and using same |
| CA2724550C (en) | 2008-05-22 | 2017-01-03 | Kereos, Inc. | Combination antitumor therapy |
| WO2010005850A1 (en) | 2008-07-08 | 2010-01-14 | The J. David Gladstone Institutes | Methods and compositions for modulating angiogenesis |
| KR101014438B1 (ko) * | 2008-09-26 | 2011-02-14 | 동아제약주식회사 | 탁산 유도체의 제조방법 |
| MX340870B (es) | 2010-02-12 | 2016-07-27 | Pharmascience Inc | Compuestos de unión del dominio de repetición de inhibidores de proteínas de apoptosis de baculovirus. |
| WO2013119864A1 (en) | 2012-02-07 | 2013-08-15 | University Of Central Florida Research Foundation, Inc. | Increasing taxane sensitivity in cancer cells |
| US9181343B2 (en) | 2012-07-19 | 2015-11-10 | Redwood Bioscience Inc. | Antibody specific for CD22 and methods of use thereof |
| KR20150083121A (ko) | 2012-11-12 | 2015-07-16 | 레드우드 바이오사이언스 인코포레이티드 | 화합물, 및 컨쥬게이트의 제조방법 |
| ES2653487T3 (es) | 2013-02-15 | 2018-02-07 | The Regents Of The University Of California | Receptor de antígeno quimérico y métodos de uso del mismo |
| US9670162B2 (en) | 2013-03-14 | 2017-06-06 | The Board Of Trustees Of The Leland Stanford Junio | Mitochondrial aldehyde dehyrogenase-2 modulators and methods of use thereof |
| KR102320019B1 (ko) | 2013-11-27 | 2021-11-01 | 레드우드 바이오사이언스 인코포레이티드 | 히드라지닐-피롤로 화합물 및 콘쥬게이트 제조 방법 |
| US9879036B2 (en) | 2014-02-19 | 2018-01-30 | Aviv Therapeutics, Inc. | Mitochondrial aldehyde dehydrogenase-2 binding compounds and methods of use thereof |
| CR20210097A (es) | 2014-03-21 | 2022-04-27 | Abbvie Inc | Anticuerpos y conjugados de anticuerpo y fármaco anti-egfr |
| WO2015149001A1 (en) | 2014-03-27 | 2015-10-01 | The Brigham And Women's Hospital, Inc. | Metabolically-activated drug conjugates to overcome resistance in cancer therapy |
| EP3373977A4 (de) | 2015-11-12 | 2019-07-17 | The Board of Trustees of the Leland Stanford Junior University | Zellenpenetrierende, guanidiniumreiche oligophosphotriester zur wirkstoff- und sondenfreisetzung |
| TWI760319B (zh) | 2015-12-30 | 2022-04-11 | 杏國新藥股份有限公司 | 乳癌治療 |
| EP3231421A1 (de) | 2016-04-11 | 2017-10-18 | Greenaltech, S.L. | Verwendungen eines carotenoids bei der behandlung oder prävention von durch stress verursachten störungen |
| WO2017189432A1 (en) | 2016-04-26 | 2017-11-02 | R.P. Scherer Technologies, Llc | Antibody conjugates and methods of making and using the same |
| KR102783452B1 (ko) | 2016-06-01 | 2025-03-19 | 세르비에 아이피 유케이 리미티드 | 폴리알킬렌 옥시드-아스파라기나제의 제형, 및 그의 제조 및 사용 방법 |
| US20200147235A1 (en) | 2016-06-08 | 2020-05-14 | Abbvie Inc. | Anti-cd98 antibodies and antibody drug conjugates |
| US20200338209A1 (en) | 2016-06-08 | 2020-10-29 | Abbvie Inc. | Anti-b7-h3 antibodies and antibody drug conjugates |
| TWI762487B (zh) | 2016-06-08 | 2022-05-01 | 美商艾伯維有限公司 | 抗-b7-h3抗體及抗體藥物結合物 |
| EP3468598A1 (de) | 2016-06-08 | 2019-04-17 | AbbVie Inc. | Anti-cd98-antikörper und antikörper-wirkstoff-konjugate |
| CN109563167A (zh) | 2016-06-08 | 2019-04-02 | 艾伯维公司 | 抗b7-h3抗体和抗体药物偶联物 |
| TWI852903B (zh) | 2017-01-05 | 2024-08-21 | 杏國新藥股份有限公司 | 胰臟癌治療 |
| WO2018136570A1 (en) | 2017-01-18 | 2018-07-26 | F1 Oncology, Inc. | Chimeric antigen receptors against axl or ror2 and methods of use thereof |
| EP3388082A1 (de) | 2017-04-13 | 2018-10-17 | Galera Labs, LLC | Kombinationskrebsimmuntherapie mit makrocyclischem pentaaza-ringkomplex |
| EP3630189A4 (de) | 2017-05-24 | 2021-06-23 | The Board of Regents of The University of Texas System | Linker für antikörper-arzneimittelkonjugate |
| CA3096202A1 (en) | 2018-04-06 | 2019-10-10 | The Regents Of The University Of California | Methods of treating egfrviii expressing glioblastomas |
| US12090170B2 (en) | 2018-04-06 | 2024-09-17 | The Regents Of The University Of California | Methods of treating glioblastomas |
| JP2021530507A (ja) | 2018-07-18 | 2021-11-11 | マンザニータ ファーマシューティカルズ，インク． | 神経細胞に抗がん剤を送達するためのコンジュゲート、その使用方法及び製造方法 |
| JP7716623B2 (ja) | 2019-04-02 | 2025-08-01 | ウィリアム ロバート アラスーン リビング トラスト デイテッド オーガスト 29, 2016 | 排出ポンプ－癌抗原マルチ特異性抗体ならびにそれに関する組成物、試薬、キットおよび方法 |
| MX2022009355A (es) | 2020-01-29 | 2022-09-02 | Kenjockety Biotechnology Inc | Anticuerpo anti-mdr1 y uso del mismo. |
| US20230192902A1 (en) | 2020-06-04 | 2023-06-22 | Kenjockety Biotechnology, Inc. | Abcg2 efflux pump-cancer antigen multi-specific antibodies and compositions, reagents, kits and methods related thereto |
| US20230212305A1 (en) | 2020-06-04 | 2023-07-06 | Kenjockety Biotechnology, Inc. | Anti-abcg2 antibodies and uses thereof |
| WO2022051390A1 (en) | 2020-09-02 | 2022-03-10 | Kenjockety Biotechnology, Inc. | Anti-abcc1 antibodies and uses thereof |
| WO2022103603A1 (en) | 2020-11-13 | 2022-05-19 | Kenjockety Biotechnology, Inc. | Anti-mrp4 (encoded by abcc4 gene) antibodies and uses thereof |
| JP2023551203A (ja) | 2020-11-20 | 2023-12-07 | アール．ピー．シェーラー テクノロジーズ、エルエルシー | 抗体－薬物コンジュゲートのためのグリコシド二重切断リンカー |
| AR124681A1 (es) | 2021-01-20 | 2023-04-26 | Abbvie Inc | Conjugados anticuerpo-fármaco anti-egfr |
| WO2023114658A1 (en) | 2021-12-13 | 2023-06-22 | Kenjockety Biotechnology, Inc. | Anti-abcb1 antibodies |
| WO2023159220A1 (en) | 2022-02-18 | 2023-08-24 | Kenjockety Biotechnology, Inc. | Anti-cd47 antibodies |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4942184A (en) * | 1988-03-07 | 1990-07-17 | The United States Of America As Represented By The Department Of Health And Human Services | Water soluble, antineoplastic derivatives of taxol |
| US5250683A (en) * | 1991-09-23 | 1993-10-05 | Florida State University | Certain substituted taxanes and pharmaceutical compositions containing them |
| US5227400A (en) * | 1991-09-23 | 1993-07-13 | Florida State University | Furyl and thienyl substituted taxanes and pharmaceutical compositions containing them |
| US5243045A (en) * | 1991-09-23 | 1993-09-07 | Florida State University | Certain alkoxy substituted taxanes and pharmaceutical compositions containing them |
| FR2687151B1 (fr) * | 1992-02-07 | 1994-03-25 | Rhone Poulenc Rorer Sa | Nouveaux derives de la baccatine iii et de la desacetyl-10 baccatine iii, leur preparation et les compositions pharmaceutiques qui les contiennent. |
| JPH08253465A (ja) * | 1995-03-17 | 1996-10-01 | Dai Ichi Seiyaku Co Ltd | 四環性化合物 |
| FR2742753B1 (fr) * | 1995-12-22 | 1998-01-30 | Rhone Poulenc Rorer Sa | Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent |
| WO1998002426A1 (en) * | 1996-07-15 | 1998-01-22 | Kabushiki Kaisha Yakult Honsha | Taxane derivatives and drugs containing the same |
| US6017935A (en) * | 1997-04-24 | 2000-01-25 | Bristol-Myers Squibb Company | 7-sulfur substituted paclitaxels |
-
1997
- 1997-09-17 JP JP9251804A patent/JPH1192468A/ja active Pending
-
1998
- 1998-09-17 US US09/508,092 patent/US6136808A/en not_active Expired - Fee Related
- 1998-09-17 CA CA002302445A patent/CA2302445C/en not_active Expired - Fee Related
- 1998-09-17 WO PCT/JP1998/004180 patent/WO1999014209A1/ja not_active Ceased
- 1998-09-17 AT AT98943019T patent/ATE229012T1/de not_active IP Right Cessation
- 1998-09-17 EP EP98943019A patent/EP1022277B1/de not_active Expired - Lifetime
- 1998-09-17 PT PT98943019T patent/PT1022277E/pt unknown
- 1998-09-17 DK DK98943019T patent/DK1022277T3/da active
- 1998-09-17 AU AU90950/98A patent/AU730174B2/en not_active Ceased
- 1998-09-17 CN CNB988092395A patent/CN100369908C/zh not_active Expired - Fee Related
- 1998-09-17 BR BR9812218-5A patent/BR9812218A/pt not_active Application Discontinuation
- 1998-09-17 DE DE69809959T patent/DE69809959T2/de not_active Expired - Fee Related
- 1998-09-17 KR KR10-2000-7002637A patent/KR100514809B1/ko not_active Expired - Fee Related
- 1998-09-17 ES ES98943019T patent/ES2189234T3/es not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1022277A1 (de) | 2000-07-26 |
| US6136808A (en) | 2000-10-24 |
| AU9095098A (en) | 1999-04-05 |
| BR9812218A (pt) | 2000-07-18 |
| DE69809959T2 (de) | 2003-07-24 |
| WO1999014209A1 (en) | 1999-03-25 |
| DK1022277T3 (da) | 2003-01-06 |
| KR100514809B1 (ko) | 2005-09-13 |
| PT1022277E (pt) | 2003-04-30 |
| CN1270587A (zh) | 2000-10-18 |
| CN100369908C (zh) | 2008-02-20 |
| JPH1192468A (ja) | 1999-04-06 |
| CA2302445A1 (en) | 1999-03-25 |
| AU730174B2 (en) | 2001-03-01 |
| EP1022277B1 (de) | 2002-12-04 |
| EP1022277A4 (de) | 2000-07-26 |
| ES2189234T3 (es) | 2003-07-01 |
| DE69809959D1 (de) | 2003-01-16 |
| KR20010023937A (ko) | 2001-03-26 |
| CA2302445C (en) | 2008-04-29 |
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