ATE228837T1 - Krebsmittel auf basis von cyclopropylpyrroloindol-oligopeptiden - Google Patents

Krebsmittel auf basis von cyclopropylpyrroloindol-oligopeptiden

Info

Publication number
ATE228837T1
ATE228837T1 AT96906176T AT96906176T ATE228837T1 AT E228837 T1 ATE228837 T1 AT E228837T1 AT 96906176 T AT96906176 T AT 96906176T AT 96906176 T AT96906176 T AT 96906176T AT E228837 T1 ATE228837 T1 AT E228837T1
Authority
AT
Austria
Prior art keywords
group
cyclopropylpyrroloindole
oligopeptides
cancer agent
novel
Prior art date
Application number
AT96906176T
Other languages
English (en)
Inventor
J William Lown
Yuqiang Wang
Weide Luo
Original Assignee
Univ Alberta
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Alberta filed Critical Univ Alberta
Application granted granted Critical
Publication of ATE228837T1 publication Critical patent/ATE228837T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
AT96906176T 1995-01-31 1996-01-31 Krebsmittel auf basis von cyclopropylpyrroloindol-oligopeptiden ATE228837T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/381,355 US5502068A (en) 1995-01-31 1995-01-31 Cyclopropylpyrroloindole-oligopeptide anticancer agents
PCT/US1996/000727 WO1996023497A1 (en) 1995-01-31 1996-01-31 Cyclopropylpyrroloindole-oligopeptide anticancer agents

Publications (1)

Publication Number Publication Date
ATE228837T1 true ATE228837T1 (de) 2002-12-15

Family

ID=23504694

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96906176T ATE228837T1 (de) 1995-01-31 1996-01-31 Krebsmittel auf basis von cyclopropylpyrroloindol-oligopeptiden

Country Status (8)

Country Link
US (1) US5502068A (de)
EP (1) EP0800390B1 (de)
JP (1) JPH11500427A (de)
AT (1) ATE228837T1 (de)
AU (1) AU698001B2 (de)
CA (1) CA2210093A1 (de)
DE (1) DE69625175T2 (de)
WO (1) WO1996023497A1 (de)

Families Citing this family (37)

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EP0877751B1 (de) * 1995-12-22 2003-10-15 University Technologies International Inc. Kupplungsarm für festträger oligonukleotid-synthese und verfahren zur herstellung davon
US5659022A (en) * 1996-01-05 1997-08-19 Epoch Pharmaceuticals, Inc. Oligonucleotide-cyclopropapyrroloindole conjugates as sequence specific hybridization and crosslinking agents for nucleic acids
US5843937A (en) * 1996-05-23 1998-12-01 Panorama Research, Inc. DNA-binding indole derivatives, their prodrugs and immunoconjugates as anticancer agents
GB9818730D0 (en) 1998-08-27 1998-10-21 Univ Portsmouth Collections of compounds
DE69930328T2 (de) 1998-08-27 2006-12-14 Spirogen Ltd., Ryde Dimere Pyrrolobenzodiazepine
JP3649617B2 (ja) * 1999-03-26 2005-05-18 独立行政法人科学技術振興機構 ２本鎖ｄｎａを切断できる化合物及びその使用方法
US6559125B1 (en) 2000-01-28 2003-05-06 California Institute Of Technology Polyamide-alkylator conjugates and related products and method
US6555693B2 (en) 2000-03-16 2003-04-29 Genesoft, Inc. Charged compounds comprising a nucleic acid binding moiety and uses therefor
US7078536B2 (en) * 2001-03-14 2006-07-18 Genesoft Pharmaceuticals, Inc. Charged compounds comprising a nucleic acid binding moiety and uses therefor
JP4061819B2 (ja) 2000-05-12 2008-03-19 独立行政法人科学技術振興機構 インターストランドクロスリンク剤の合成方法
KR20030011371A (ko) * 2000-06-27 2003-02-07 진랩스 테크놀러지스, 인크. 항세균, 항진균 또는 항암 활성을 갖는 신규 화합물
US7122626B2 (en) * 2001-04-26 2006-10-17 Genesoft Pharmceuticals, Inc. Halogen-substitued thienyl compounds
US7064218B2 (en) * 2001-12-26 2006-06-20 Genelabs Technologies, Inc. Aromatic compounds and poly(oxyalkylene) containing aromatic compounds possessing antibacterial, antifungal or antitumor activity
DE60326735D1 (de) 2002-08-02 2009-04-30 Genesoft Pharmaceuticals Inc Biaryl-verbindungen mit antiinfektiver wirkung
US7265129B2 (en) * 2002-10-25 2007-09-04 Genesoft Pharmaceuticals, Inc. Anti-infective biaryl compounds
GB0226593D0 (en) 2002-11-14 2002-12-24 Consultants Ltd Compounds
JP2006509027A (ja) 2002-12-10 2006-03-16 オーシェント ファーマシューティカルズ コーポレーション （ピロールカルボキサミド）−（ベンズアミド）−（イミダゾールカルボキサミド）モチーフを有する抗菌化合物
PL1651612T3 (pl) 2003-07-22 2012-09-28 Astex Therapeutics Ltd Związki 3,4-pochodne 1h-pirazolu i ich zastosowanie jako kinazy zależne od cyklin (cdk) i modulatory kinazy syntazy glikogenu-3 (gsk-3)
GB0321295D0 (en) 2003-09-11 2003-10-15 Spirogen Ltd Synthesis of protected pyrrolobenzodiazepines
US7745473B2 (en) 2004-03-13 2010-06-29 Kyoto University Indole derivative for alkylating specific base sequence of DNA and alkylating agent and drug containing the derivative
US20080139620A1 (en) * 2005-01-21 2008-06-12 Astex Therapeutics Limited Pyrazole Derivatives For The Inhibition Of Cdk's And Gsk's
CA2594477C (en) * 2005-01-21 2016-07-12 Astex Therapeutics Limited Pharmaceutical compounds
US8404718B2 (en) 2005-01-21 2013-03-26 Astex Therapeutics Limited Combinations of pyrazole kinase inhibitors
AR052559A1 (es) * 2005-01-21 2007-03-21 Astex Therapeutics Ltd Derivados de pirazol para inhibir cdk's y gsk's
AR054425A1 (es) * 2005-01-21 2007-06-27 Astex Therapeutics Ltd Sales de adicion de piperidin 4-il- amida de acido 4-(2,6-dicloro-benzoilamino) 1h-pirazol-3-carboxilico.
CN101146532B (zh) * 2005-01-21 2012-05-09 阿斯泰克斯治疗有限公司 药物化合物
AU2006207322A1 (en) * 2005-01-21 2006-07-27 Astex Therapeutics Limited Combinations of pyrazole kinase inhibitors and further antitumor agents
WO2006093271A1 (ja) * 2005-03-03 2006-09-08 Mitsubishi Rayon Co., Ltd. ポリマー粒子、これを含む樹脂組成物、成形体
AU2007246895A1 (en) * 2006-05-05 2007-11-15 Astex Therapeutics Limited 4- (2,6-dichloro-benzoylamino) -1H-pyrazole-3-carboxylic acid (1-methanesulphonyl-piperidin-4-yl) -amide for the treatment of cancer
US20090142337A1 (en) * 2006-05-08 2009-06-04 Astex Therapeutics Limited Pharmaceutical Combinations of Diazole Derivatives for Cancer Treatment
EP2049516A2 (de) * 2006-07-14 2009-04-22 Astex Therapeutics Limited Pharmazeutische verbindungen
US9901567B2 (en) 2007-08-01 2018-02-27 Syntarga B.V. Substituted CC-1065 analogs and their conjugates
PL2344478T3 (pl) 2008-11-03 2018-02-28 Syntarga B.V. Analogi CC-1065 oraz ich koniugaty
LT2560645T (lt) * 2010-04-21 2016-10-10 Syntarga B.V. Cc-1065 analogų ir bifunkcinių linkerių konjugatai
KR20160099725A (ko) 2014-01-10 2016-08-22 신톤 바이오파머슈티칼즈 비.브이. 자궁내막암의 치료에서 사용하기 위한 듀오카르마이신 adc
KR102323301B1 (ko) 2014-01-10 2021-11-09 비온디스 비.브이. Cys 연결된 항체-약물 접합체의 정제 방법
RU2769700C2 (ru) 2014-01-10 2022-04-05 Байондис Б.В. Дуокармициновые adc, демонстрирующие улучшенную противоопухолевую активность in vivo

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4978757A (en) * 1984-02-21 1990-12-18 The Upjohn Company 1,2,8,8a-tetrahydrocyclopropa (C) pyrrolo [3,2-e)]-indol-4(5H)-ones and related compounds
CA1308516C (en) * 1987-07-06 1992-10-06 J. William Lown Oligopeptide anticancer and antiviral agents
US5541339A (en) * 1988-09-12 1996-07-30 The Upjohn Company CC-1065 analogs having two CPI subunits

Also Published As

Publication number Publication date
US5502068A (en) 1996-03-26
DE69625175D1 (de) 2003-01-16
CA2210093A1 (en) 1996-08-08
EP0800390A1 (de) 1997-10-15
EP0800390B1 (de) 2002-12-04
JPH11500427A (ja) 1999-01-12
AU698001B2 (en) 1998-10-22
AU4964396A (en) 1996-08-21
WO1996023497A1 (en) 1996-08-08
DE69625175T2 (de) 2003-09-11
EP0800390A4 (de) 1999-01-20

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