DE69625175T2 - Krebsmittel auf basis von cyclopropylpyrroloindol-oligopeptiden - Google Patents

Krebsmittel auf basis von cyclopropylpyrroloindol-oligopeptiden

Info

Publication number
DE69625175T2
DE69625175T2 DE69625175T DE69625175T DE69625175T2 DE 69625175 T2 DE69625175 T2 DE 69625175T2 DE 69625175 T DE69625175 T DE 69625175T DE 69625175 T DE69625175 T DE 69625175T DE 69625175 T2 DE69625175 T2 DE 69625175T2
Authority
DE
Germany
Prior art keywords
group
oligopeptide
cyclopropylpyrroloindol
cancer agent
cyclopropylpyrroloindole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69625175T
Other languages
English (en)
Other versions
DE69625175D1 (de
Inventor
J William Lown
Yuqiang Wang
Weide Luo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Alberta
Original Assignee
University of Alberta
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Alberta filed Critical University of Alberta
Publication of DE69625175D1 publication Critical patent/DE69625175D1/de
Application granted granted Critical
Publication of DE69625175T2 publication Critical patent/DE69625175T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
DE69625175T 1995-01-31 1996-01-31 Krebsmittel auf basis von cyclopropylpyrroloindol-oligopeptiden Expired - Fee Related DE69625175T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/381,355 US5502068A (en) 1995-01-31 1995-01-31 Cyclopropylpyrroloindole-oligopeptide anticancer agents
PCT/US1996/000727 WO1996023497A1 (en) 1995-01-31 1996-01-31 Cyclopropylpyrroloindole-oligopeptide anticancer agents

Publications (2)

Publication Number Publication Date
DE69625175D1 DE69625175D1 (de) 2003-01-16
DE69625175T2 true DE69625175T2 (de) 2003-09-11

Family

ID=23504694

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69625175T Expired - Fee Related DE69625175T2 (de) 1995-01-31 1996-01-31 Krebsmittel auf basis von cyclopropylpyrroloindol-oligopeptiden

Country Status (8)

Country Link
US (1) US5502068A (de)
EP (1) EP0800390B1 (de)
JP (1) JPH11500427A (de)
AT (1) ATE228837T1 (de)
AU (1) AU698001B2 (de)
CA (1) CA2210093A1 (de)
DE (1) DE69625175T2 (de)
WO (1) WO1996023497A1 (de)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69630400T2 (de) * 1995-12-22 2005-04-14 University Technologies International Inc., Calgary Kupplungsarm für festträger oligonukleotid-synthese und verfahren zur herstellung davon
US5659022A (en) * 1996-01-05 1997-08-19 Epoch Pharmaceuticals, Inc. Oligonucleotide-cyclopropapyrroloindole conjugates as sequence specific hybridization and crosslinking agents for nucleic acids
US5843937A (en) * 1996-05-23 1998-12-01 Panorama Research, Inc. DNA-binding indole derivatives, their prodrugs and immunoconjugates as anticancer agents
GB9818730D0 (en) 1998-08-27 1998-10-21 Univ Portsmouth Collections of compounds
WO2000012508A2 (en) 1998-08-27 2000-03-09 Spirogen Limited Pyrrolbenzodiazepines
JP3649617B2 (ja) * 1999-03-26 2005-05-18 独立行政法人科学技術振興機構 ２本鎖ｄｎａを切断できる化合物及びその使用方法
US6559125B1 (en) 2000-01-28 2003-05-06 California Institute Of Technology Polyamide-alkylator conjugates and related products and method
EP1265921B1 (de) * 2000-03-16 2007-05-23 Genesoft, Inc. Geladene verbindungen mit einer nukleinsäure-bindenden einheit sowie deren verwendungen
US7078536B2 (en) * 2001-03-14 2006-07-18 Genesoft Pharmaceuticals, Inc. Charged compounds comprising a nucleic acid binding moiety and uses therefor
JP4061819B2 (ja) * 2000-05-12 2008-03-19 独立行政法人科学技術振興機構 インターストランドクロスリンク剤の合成方法
US6849713B2 (en) * 2000-06-27 2005-02-01 Genelabs Technologies, Inc. Compounds possessing antibacterial, antifungal or antitumor activity
US7122626B2 (en) * 2001-04-26 2006-10-17 Genesoft Pharmceuticals, Inc. Halogen-substitued thienyl compounds
AU2002364209A1 (en) * 2001-12-26 2003-07-24 Genelabs Technologies, Inc. Polyamide derivatives possessing antibacterial, antifungal or antitumor activity
WO2004012736A1 (en) 2002-08-02 2004-02-12 Genesoft Pharmaceuticals, Inc. Biaryl compounds having anti-infective activity
US7265129B2 (en) * 2002-10-25 2007-09-04 Genesoft Pharmaceuticals, Inc. Anti-infective biaryl compounds
GB0226593D0 (en) 2002-11-14 2002-12-24 Consultants Ltd Compounds
WO2004052304A2 (en) 2002-12-10 2004-06-24 Oscient Pharmaceuticals Corporation Antibacterial compounds having a (pyrrole carboxamide)-(benzamide)-(imidazole carboxamide) motif
CA2532965C (en) 2003-07-22 2013-05-14 Astex Therapeutics Limited 3, 4-disubstituted 1h-pyrazole compounds and their use as cyclin dependent kinases (cdk) and glycogen synthase kinase-3 (gsk-3) modulators
GB0321295D0 (en) 2003-09-11 2003-10-15 Spirogen Ltd Synthesis of protected pyrrolobenzodiazepines
EP1731519A4 (de) 2004-03-13 2008-10-15 Tmrc Co Ltd Neues indolderivat zur alkylierung spezifischer dna-basensequenzen und alkylierungsmittel und arzneimittel, die dieses jeweils enthalten
US20080139620A1 (en) * 2005-01-21 2008-06-12 Astex Therapeutics Limited Pyrazole Derivatives For The Inhibition Of Cdk's And Gsk's
AU2006207321B2 (en) * 2005-01-21 2012-09-06 Astex Therapeutics Limited Pharmaceutical compounds
AR054425A1 (es) 2005-01-21 2007-06-27 Astex Therapeutics Ltd Sales de adicion de piperidin 4-il- amida de acido 4-(2,6-dicloro-benzoilamino) 1h-pirazol-3-carboxilico.
US20090036435A1 (en) * 2005-01-21 2009-02-05 Astex Therapeutics Limited Pharmaceutical Compounds
US8404718B2 (en) 2005-01-21 2013-03-26 Astex Therapeutics Limited Combinations of pyrazole kinase inhibitors
AR053662A1 (es) * 2005-01-21 2007-05-16 Astex Therapeutics Ltd Compuestos de pirazol inhibidores de la actividad quinasa cdk y gsk
WO2006077425A1 (en) * 2005-01-21 2006-07-27 Astex Therapeutics Limited Combinations of pyrazole kinase inhibitors and further antitumor agents
EP1862478B1 (de) * 2005-03-03 2012-01-25 Mitsubishi Rayon Co., Ltd. Polymerteilchen, dieses enthaltende harzzusammensetzung und formkörper
JP2009536187A (ja) * 2006-05-05 2009-10-08 アステックス・セラピューティクス・リミテッド 癌の処置のための４−（２，６−ジクロロ−ベンゾイルアミノ）−１ｈ−ピラゾール−３−カルボン酸（１−メタンスルホニル−ピペリジン−４−イル）−アミド
WO2007129062A1 (en) * 2006-05-08 2007-11-15 Astex Therapeutics Limited Pharmaceutical combinations of diazole derivatives for cancer treatment
US20100004243A1 (en) * 2006-07-14 2010-01-07 Astex Therapeutics Limited Pharmaceutical compounds
US9901567B2 (en) 2007-08-01 2018-02-27 Syntarga B.V. Substituted CC-1065 analogs and their conjugates
CN102317283A (zh) 2008-11-03 2012-01-11 辛塔佳股份有限公司 新型cc-1065类似物及其缀合物
KR101901555B1 (ko) * 2010-04-21 2018-09-21 신타가 비.브이. Ｃｃ―１０６５ 유사체와 2작용성 링커의 신규한 콘쥬게이트
MY177390A (en) 2014-01-10 2020-09-14 Byondis Bv Method for purifying cys-linked antibody-drug conjugates
MY189713A (en) 2014-01-10 2022-02-28 Univ Yale Duocarmycin adcs for use in treatment of endometrial cancer
EP3069735B1 (de) 2014-01-10 2018-03-14 Synthon Biopharmaceuticals B.V. Duocarmycin-adcs zur behandlung von blasenkrebs

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4978757A (en) * 1984-02-21 1990-12-18 The Upjohn Company 1,2,8,8a-tetrahydrocyclopropa (C) pyrrolo [3,2-e)]-indol-4(5H)-ones and related compounds
CA1308516C (en) * 1987-07-06 1992-10-06 J. William Lown Oligopeptide anticancer and antiviral agents
AU632288B2 (en) * 1988-09-12 1992-12-24 Pharmacia & Upjohn Company Novel cc-1065 analogs having two cpi subunits

Also Published As

Publication number Publication date
AU4964396A (en) 1996-08-21
DE69625175D1 (de) 2003-01-16
AU698001B2 (en) 1998-10-22
JPH11500427A (ja) 1999-01-12
WO1996023497A1 (en) 1996-08-08
US5502068A (en) 1996-03-26
EP0800390B1 (de) 2002-12-04
EP0800390A1 (de) 1997-10-15
CA2210093A1 (en) 1996-08-08
ATE228837T1 (de) 2002-12-15
EP0800390A4 (de) 1999-01-20

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee